TW202039545A - 靶向腫瘤抗原、ＴＧＦ-β、和免疫檢查點的組合型ＴＣＲ-Ｔ細胞療法 - Google Patents

靶向腫瘤抗原、ＴＧＦ-β、和免疫檢查點的組合型ＴＣＲ-Ｔ細胞療法 Download PDF

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TW202039545A
TW202039545A TW108144761A TW108144761A TW202039545A TW 202039545 A TW202039545 A TW 202039545A TW 108144761 A TW108144761 A TW 108144761A TW 108144761 A TW108144761 A TW 108144761A TW 202039545 A TW202039545 A TW 202039545A
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cells
tcr
engineered
cell
seq
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TW108144761A
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李思
品 王
保羅 拜森
彼得 亞歷山大
陳銳
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大陸商廣東天科雅生物醫藥科技有限公司
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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TW108144761A 2018-12-06 2019-12-06 靶向腫瘤抗原、ＴＧＦ-β、和免疫檢查點的組合型ＴＣＲ-Ｔ細胞療法 TW202039545A (zh)

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US201862776012P 2018-12-06 2018-12-06
US62/776,012 2018-12-06

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US (2) US20210369776A1 (https=)
JP (1) JP7571021B2 (https=)
KR (1) KR20210112310A (https=)
CN (1) CN113226335B (https=)
SG (1) SG11202105975SA (https=)
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WO2020014285A2 (en) 2018-07-09 2020-01-16 Intrexon Corporation Fusion constructs and methods of using thereof
CN111718409B (zh) * 2020-06-17 2021-03-02 深圳豪石生物科技有限公司 一种t细胞受体及其应用
EP4178680A4 (en) * 2020-07-10 2024-07-31 Precigen, Inc. FUSION CONSTRUCTS AND THEIR METHODS OF USE
CN112940108B (zh) * 2021-03-19 2022-10-14 河南省肿瘤医院 识别ebv抗原的t细胞受体以及该t细胞受体的应用
EP4334361A1 (en) 2021-05-05 2024-03-13 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding prame
CN116179493A (zh) * 2021-09-29 2023-05-30 成都美杰赛尔生物科技有限公司 敲除两种免疫检测点基因的免疫细胞及其制备方法与应用
US20260078163A1 (en) * 2022-09-06 2026-03-19 Board Of Regents, The University Of Texas System T-cell receptor that targets egfr mutation and methods of using the same
WO2024173916A1 (en) * 2023-02-17 2024-08-22 Dana-Farber Cancer Institute, Inc. Compositions and methods of preventing t cell exhaustion
CN119390814B (zh) * 2023-10-26 2025-06-27 上海市第一人民医院 一种t细胞受体及其制备方法和用途
CN119978143B (zh) * 2025-01-26 2025-10-21 湖南大学 一种基于synNotch的工程化巨噬细胞及其应用

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US20060002941A1 (en) * 2004-01-23 2006-01-05 Vievax Corp. Compositions comprising immune response altering agents and methods of use
ES2635335T3 (es) * 2010-09-20 2017-10-03 Biontech Cell & Gene Therapies Gmbh Receptores de células T específicos de antígeno y epítopos de células T
US9676863B2 (en) * 2014-02-10 2017-06-13 Merck Patent Gmbh Targeted TGFβ inhibitors
US11161907B2 (en) * 2015-02-02 2021-11-02 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
EP3286211A1 (en) * 2015-04-23 2018-02-28 Novartis AG Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
WO2017040945A1 (en) * 2015-09-04 2017-03-09 Memorial Sloan Kettering Cancer Center Immune cell compositions and methods of use
WO2017133175A1 (en) * 2016-02-04 2017-08-10 Nanjing Legend Biotech Co., Ltd. Engineered mammalian cells for cancer therapy
KR20190003938A (ko) * 2016-02-25 2019-01-10 셀 메디카 스위처란트 아게 면역치료를 위한 변형된 세포
US11549099B2 (en) * 2016-03-23 2023-01-10 Novartis Ag Cell secreted minibodies and uses thereof
US12060394B2 (en) * 2016-04-28 2024-08-13 The Trustees Of Dartmouth College Nucleic acid constructs for co-expression of chimeric antigen receptor and transcription factor, cells containing and therapeutic use thereof
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JP7340458B2 (ja) * 2017-05-09 2023-09-07 アメリカ合衆国 Ｈｐｖ＋悪性腫瘍を有する患者におけるｐｄｌ１とｔｇｆベータの遮断の組み合わせ

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WO2020118094A9 (en) 2020-10-01
CN113226335B (zh) 2023-10-13
CN113226335A (zh) 2021-08-06
WO2020118094A1 (en) 2020-06-11
KR20210112310A (ko) 2021-09-14
JP7571021B2 (ja) 2024-10-22
SG11202105975SA (en) 2021-07-29
US20250243293A1 (en) 2025-07-31
US20210369776A1 (en) 2021-12-02

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