JP7571021B2 - 腫瘍抗原、ＴＧＦ－β、および免疫チェックポイントを標的とする組み合わせＴＣＲ－Ｔ細胞療法 - Google Patents

腫瘍抗原、ＴＧＦ－β、および免疫チェックポイントを標的とする組み合わせＴＣＲ－Ｔ細胞療法 Download PDF

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JP7571021B2
JP7571021B2 JP2021532126A JP2021532126A JP7571021B2 JP 7571021 B2 JP7571021 B2 JP 7571021B2 JP 2021532126 A JP2021532126 A JP 2021532126A JP 2021532126 A JP2021532126 A JP 2021532126A JP 7571021 B2 JP7571021 B2 JP 7571021B2
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シ リ
ポール ブライソン
ピーター アレキサンダー
ルイ チェン
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グアンドン ティーシーアールキュア バイオファーマ テクノロジー カンパニー リミテッド
ティーシーアールキュア バイオファーマ コーポレイション
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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JP2021532126A 2018-12-06 2019-12-05 腫瘍抗原、ＴＧＦ－β、および免疫チェックポイントを標的とする組み合わせＴＣＲ－Ｔ細胞療法 Active JP7571021B2 (ja)

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US201862776012P 2018-12-06 2018-12-06
US62/776,012 2018-12-06
PCT/US2019/064757 WO2020118094A1 (en) 2018-12-06 2019-12-05 Combinational tcr-t cell therapy targeting tumor antigens, tgf-beta, and immune checkpoints

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EP4178680A4 (en) * 2020-07-10 2024-07-31 Precigen, Inc. FUSION CONSTRUCTS AND THEIR METHODS OF USE
CN112940108B (zh) * 2021-03-19 2022-10-14 河南省肿瘤医院 识别ebv抗原的t细胞受体以及该t细胞受体的应用
EP4334361A1 (en) 2021-05-05 2024-03-13 Immatics Biotechnologies GmbH Antigen binding proteins specifically binding prame
CN116179493A (zh) * 2021-09-29 2023-05-30 成都美杰赛尔生物科技有限公司 敲除两种免疫检测点基因的免疫细胞及其制备方法与应用
US20260078163A1 (en) * 2022-09-06 2026-03-19 Board Of Regents, The University Of Texas System T-cell receptor that targets egfr mutation and methods of using the same
WO2024173916A1 (en) * 2023-02-17 2024-08-22 Dana-Farber Cancer Institute, Inc. Compositions and methods of preventing t cell exhaustion
CN119390814B (zh) * 2023-10-26 2025-06-27 上海市第一人民医院 一种t细胞受体及其制备方法和用途
CN119978143B (zh) * 2025-01-26 2025-10-21 湖南大学 一种基于synNotch的工程化巨噬细胞及其应用

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JP2017506217A (ja) 2014-02-10 2017-03-02 メルク パテント ゲーエムベーハー 標的ＴＧＦβ阻害
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