TW201929667A - Synergistic acaricide composition including nitrophenol compound and acaricidally active compound - Google Patents

Abstract

The purpose of the invention is to provide an acaricide composition having even better preventing/controlling effects against harmful mites/ticks. The invention relates to a synergistic acaricide composition comprising (A) a nitrophenol compound and (B) an acaricidally active compound. The invention relates to a method for preventing/controlling mites/ticks, characterized by treating a habitat (except for human beings) of pests with said synergistic acaricide composition. The invention relates to a plant protection method characterized by treating a plant infested with pests, or the vicinity thereof, with said synergistic acaricide composition. The invention relates to a method for using a nitrophenol compound for enhancing acaricidal activity. The invention relates to an acaricidal activity enhancer comprising a nitrophenol compound.

Description

Synergistic acaricide composition containing nitrophenol compound and acaricidal active compound

FIELD OF THE INVENTION The present invention relates to a synergistic acaricide composition comprising a nitrophenol compound and an acaricidal active compound.

BACKGROUND OF THE INVENTION The development of acaricides has been previously carried out for the purpose of preventing pests that are harmful to crops, and various agents have been put into practical use. However, in recent years, there has been a group of individuals with reduced sensitivity to existing acaricides, and the effectiveness of the existing acaricides has been significantly reduced.

In this regard, various developments have been made in order to improve the control activity against such pests. For example, an acaricide composition which combines two or more kinds of existing acaricidal active compounds and synergistically enhances acaricidal activity has been developed (Patent Document 1).

On the other hand, it has been revealed that a nitrophenol compound has a growth promoting effect of a plant (Patent Document 2) and a production promoting effect of a BT toxin (insecticidal protein) (Patent Document 3), but the nitrophenol is a cockroach control agent. The case of the activity enhancer is not described or implied.
[Advanced technical literature]
[Patent Literature]

[Patent Document 1] Japanese Laid-Open Patent Publication No. 2016-199527
[Patent Document 2] Chinese Patent Application Publication No. 104628481
[Patent Document 3] International Publication No. 2004/013286

Summary of invention
[Problem to be Solved by the Invention] An object of the present invention is to provide an acaricide composition which has a further excellent synergistic control effect against hydrazine.
[Means to solve the problem]

The present inventors have intensively studied in order to solve the above problems, and as a result, it has been found that the nitrophenol compound enhances the control activity of the acaricidal active compound. The present invention has been completed based on such findings.

That is, the present invention relates to an acaricide composition containing the nitrophenol compound and the acaricidal active compound described below.

Item 1.
A synergistic acaricide composition comprising (A) a nitrophenol compound and (B) an acaricidal active compound.
Item 2.
The synergistic acaricide composition according to Item 1, wherein (B) the acaricidal active compound is selected from the group consisting of
(b1) an acetylcholinesterase inhibitor,
(b2) GABA-activated chloride channel antagonists,
(b3) sodium channel regulator,
(b4) nicotinic acetylcholine receptor antagonist modulator,
(b5) a nicotinic acetylcholine receptor ectopic modulator,
(b6) glutamic acid-activated chloride channel ectopic modulator,
(b7) juvenile hormone mimicking agent,
(b8) other non-specific (multi-site) inhibitors,
(b9) String organ TRPV channel conditioner,
(b10) steroid growth inhibitors,
(b11) Insecticides derived from microorganisms,
(b12) mitochondrial ATP biosynthetic enzyme inhibitor,
(b13) oxidative phosphorylation uncoupler,
(b14) a nicotinic acetylcholine receptor channel blocker,
(b15) Chitin biosynthesis inhibitor,
(b16) ecdysone inhibitor,
(b17) ecdysone receptor agonist,
(b18) Octopamine receptor agonist,
(b19) mitochondrial electron transport chain complex III inhibitor,
(b20) mitochondrial electron transport chain complex I inhibitor,
(b21) a potential-dependent sodium channel blocker,
(b22) acetaminophen coenzyme A carboxylase inhibitor,
(b23) mitochondrial electron transport chain complex IV inhibitor,
(b24) mitochondrial electron transport chain complex II inhibitor,
(b25) ryanodine receptor modulator,
(b26) string organ adjustment agent, and
(b27) at least one compound of the group consisting of an insecticide/acaricide that is not specific to the mechanism of action.
Item 3.
The synergistic acaricide composition according to Item 1 or 2, wherein (B) the acaricidal active compound is selected from the group consisting of
(b6) glutamic acid-activated chloride channel ectopic modulator,
(b8) methyl bromide, chloropicrin, cryolite, sulfonium fluoride, borax, tartar-emetic, dazome, metam,
(b10) steroid growth inhibitors,
(b12) mitochondrial ATP biosynthetic enzyme inhibitor,
(b13) oxidative phosphorylation uncoupler,
(b18) Octopamine receptor agonist,
(b19) mitochondrial electron transport chain complex III inhibitor,
(b20) mitochondrial electron transport chain complex I inhibitor,
(b22) acetaminophen coenzyme A carboxylase inhibitor,
(b24) mitochondrial electron transport chain complex II inhibitor,
(b27) at least one compound of the group consisting of azadirachtin, cilantro, chlorpyrifos, sulphate, grammidine, acetamiprid, and sulfaguanidine.
Item 4.
The synergistic acaricide composition according to any one of items 1 to 3, wherein (B) the acaricidal active compound is selected from the group consisting of
(b6) glutamic acid-activated chloride channel ectopic modulator,
(b10) steroid growth inhibitors,
(b12) mitochondrial ATP biosynthetic enzyme inhibitor,
(b13) oxidative phosphorylation uncoupler,
(b18) Octopamine receptor agonist,
(b19) mitochondrial electron transport chain complex III inhibitor,
(b20) mitochondrial electron transport chain complex I inhibitor,
(b22) an acetaminophen coenzyme A carboxylase inhibitor, and
(b24) mitochondrial electron transport chain complex II inhibitor,
At least one compound of the group formed.
Item 5.
The synergistic acaricide composition according to any one of items 1 to 4, wherein (B) the acaricidal active compound is selected from the group consisting of abatatin, methiophene, ketone, triamcinolone, fen At least one compound consisting of a group consisting of acaricidal, defensulfuric, oxazolidine, butaflurane, anthraquinone, bifenfen, anthraquinone, rifampin, kefan, and vegan.
Item 6.
The synergistic acaricide composition according to any one of items 1 to 4, wherein (B) the acaricidal active compound is selected from the group consisting of abatatin, metostatin, triterpenoid, and fentan. At least one compound of the group consisting of fenre, oxazolidine, butaflurane, azine, bifene, guando, fenfen, kefan, and vegan.
Item 7.
The synergistic acaricide composition according to any one of items 1 to 6, wherein the (A) nitrophenol compound is a phenol compound having one nitro group.
Item 8.
The synergistic acaricide composition according to any one of items 1 to 7, wherein the blending ratio of the (A) nitrophenol compound is from 0.5 to 18,000 by weight based on 100 parts by weight of the (B) acaricidal active ingredient. Share.
Item 9.
A method for controlling cockroaches, which comprises treating a living place of a pest (except for humans) with the synergistic acaricide composition according to any one of items 1 to 8.
Item 10.
A method for controlling cockroaches, which comprises treating a living place of a pest with a synergistic acaricide composition according to any one of items 1 to 8.
Item 11.
A plant protection method characterized in that the synergistic acaricide composition according to any one of items 1 to 8 is used to treat a plant parasitic to a pest or a nearby plant thereof.
Item 12.
A method of using a nitrophenol compound for enhancing acaricidal activity.
Item 13.
A method for using a nitrophenol compound for enhancing acaricidal activity of acaricidal active compound (except for human use), and the aforementioned acaricidal active compound is selected from the group consisting of abatatin and a thiocyanate Groups of Ting, Sanya, Fenicide, Defenil, Azathioprine, Butaflurane, Aachen, Bifend, Polydip, Rifron, Kefan, and Schiffen At least one compound.
Item 14.
The method of use according to Item 12 or 13, wherein the nitrophenol compound is a phenol compound having one nitro group.
Item 15.
An acaricidal activity enhancer comprising a nitrophenol compound.
Item 16.
An acaricidal activity enhancer, wherein the acaricidal active compound comprises a nitrophenol compound, and the acaricidal active compound is selected from the group consisting of abatatin, methiophene, triamcinolone, fentanyl, At least one compound of the group consisting of fentanyl, oxazolidine, butaflurane, alum, bifene, guando, fenfen, kefan, and vegan.
Item 17.
The acaricidal activity enhancer according to Item 15 or 16, wherein the nitrophenol compound is a phenol compound having one nitro group.
[Effect of the invention]

The synergistic acaricide compositions of the present invention exhibit efficacy against disease pests in low doses.

The synergistic acaricide composition of the present invention exhibits an equally excellent control effect even in the case of pests which are resistant to the existing acaricidal active compound.

Further, according to the synergistic acaricide composition of the present invention, the amount of the treatment agent can be reduced as compared with the case where the respective acaricidal active compound is used alone, and thus the pests can be inhibited for killing each other. The resistance of the active compound is developed.

Synergistic acaricide composition for carrying out the invention. The synergistic acaricide composition containing the (A) nitrophenol compound and (B) acaricidal active compound of the present invention (hereinafter, also The time is referred to as "the composition of the present invention"), and will be described below.

(A) Nitrophenol compound The (A) nitrophenol compound is not particularly limited as long as it is an aromatic ring compound having one or more nitro groups and one or more hydroxyl groups (OH groups), and the compound may be further There are substituents other than the above nitro group and hydroxyl group.

The substituent is not particularly limited, and examples thereof include a halogen atom, a C _{1 to 6} alkyl group, a C _{1 to 6} haloalkyl group, a C _{1 to 6} alkoxy group, a C _{1 to 6} haloalkoxy group, and C _{2 . ～6} alkenyl, C _{2 -6} alkenyl, C _{2 -6} alkenyloxy, C _{2 -6} haloenyloxy, C _{2 -6} alkynyl, C _{2 -6} haloalkynyl, C _{2 -6} alkyne An oxy group, a C _{2 -6} haloalkynyl group or the like.

The nitrophenol compound in the present specification may also contain a nitrophenol compound (salt of a nitrophenol compound) which has formed a salt.

Examples of the salt in the present specification include an alkali metal salt (sodium salt, potassium salt, etc.), an alkaline earth metal salt (calcium salt, magnesium salt, etc.), an ammonium salt (ammonia; morpholine, piperidine, pyrrolidine, and a lower grade). A salt which is water-soluble and agrochemically advantageous, such as a mono-, di- or trialkylamine, an organic amine such as a lower mono-, di- or trihydroxyalkylamine, or the like, is preferably an alkali metal salt.

In addition, examples of the nitrophenol compound include a nitrophenol compound represented by the following formula (1) or a salt thereof:
[Chemical Formula 1]

(wherein X represents a C-R' group or a nitrogen atom;
R and R' are the same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a C _{1 - 6} alkyl group, a C _{1 - 6} haloalkyl group, a C _{1 - 6} alkoxy group, a C _{1 - 6} haloalkyl group. An oxy group, a C _{2 - 6} alkenyl group, a C _{2 - 6} haloalkenyl group, a C _{2 - 6} alkenyloxy group, a C _{2 - 6} haloalkenyloxy group, a C _{2 - 6} alkynyl group, a C _{2 - 6} haloalkynyl group, C _{2 to 6} alkynyloxy or C _{2 to 6} haloalkoxy).

In addition, examples of the nitrophenol compound include a nitrophenol compound represented by the following formula (2) or a salt thereof:





[Chemical Formula 2]

Wherein R ¹ , R ² , R ³ , R ⁴ and R ^{5 are the} same or different and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a C _{1 -6} alkyl group, a C _{1 -6} haloalkyl group. a C _{1 - 6} alkoxy group, a C _{1 - 6} haloalkoxy group, a C _{2 - 6} alkenyl group, a C _{2 - 6} haloalkenyl group, a C _{2 - 6} alkenyloxy group, a C _{2 - 6} haloenyloxy group, C _{2 -6} alkynyl, C _{2 -6} haloalkynyl, C _{2 -6} alkynyloxy, or C _{2 -6} haloalkynyloxy).

The respective bases in the present specification will be described below.

The halogen atom is not particularly limited, and examples thereof include a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom.

The C _{1 to 6} alkyl group is not particularly limited, and examples thereof include a methyl group, an ethyl group, a n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a second butyl group, and a t-butyl group. A linear or branched alkyl group having 1 to 6 carbon atoms such as a pentyl group, an isopentyl group, a neopentyl group, an n-hexyl group or an isohexyl group. Furthermore, in the present specification, "positive (n-)" means normal, "second (s-)" means secondary, and "third (t-)" means tertiary.

The C _{1 to 6} haloalkyl group is not particularly limited, and examples thereof include a fluoromethyl group, a chloromethyl group, a bromomethyl group, an iodomethyl group, a difluoromethyl group, a trifluoromethyl group, and a 1-fluoroethyl group. 2-fluoroethyl, 2-chloroethyl, 2,2,2-trifluoroethyl, pentafluoroethyl, 1-fluoropropyl, 2-chloropropyl, 3-fluoropropyl, 3-chloropropane a linear or branched alkane having 1 to 6 carbon atoms, such as 1-fluorobutyl, 1-chlorobutyl or 4-fluorobutyl, substituted by 1 to 9 and preferably 1 to 5 halogen atoms base.

The C _{1 - 6} alkoxy group is not particularly limited, and examples thereof include a methoxy group, an ethoxy group, a n-propoxy group, an isopropoxy group, a n-butoxy group, an isobutoxy group, and a second butoxy group. A linear or branched alkoxy group having 1 to 6 carbon atoms such as a group, a third butoxy group, a n-pentyloxy group, an isopentyloxy group, a neopentyloxy group, a n-hexyloxy group or an isohexyloxy group.

The C _{1 - 6} haloalkoxy group is not particularly limited, and examples thereof include a fluoromethoxy group, a chloromethoxy group, a bromomethoxy group, an iodomethoxy group, a difluoromethoxy group, and a trifluoromethoxy group. , 1-fluoroethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2,2-trifluoroethoxy, pentafluoroethoxy, 1-fluoropropoxy, 2-chloro 1 to 9, preferably 1 to 5, such as propoxy, 3-fluoropropoxy, 3-chloropropoxy, 1-fluorobutyl, 1-chlorobutoxy or 4-fluorobutoxy a linear or branched alkoxy group having 1 to 6 carbon atoms substituted by a halogen atom

The C _{2 to 6} alkenyl group is not particularly limited, and examples thereof include a vinyl group, a 1-propenyl group, an allyl group, an isopropenyl group, a 1-butenyl group, a 2-butenyl group, and a 3-butenyl group. A linear or branched alkenyl group having 2 to 6 carbon atoms such as a 1-methyl-2-propenyl group or a 1,3-butadienyl group.

The C _{2 to 6} haloalkenyl group is not particularly limited, and examples thereof include 2,2-dichlorovinyl, 2,2-dibromovinyl, 3-chloro-2-propenyl, and 3,3-di. Fluoro-2-allyl, 3,3-dichloro-2-allyl, 4-chloro-2-butenyl, 4,4,4-trifluoro-2-butenyl, 4,4, 4-trichloro-3-butenyl, 5-chloro-3-pentenyl, 6-fluoro-2-hexenyl is equivalent to a linear chain having 2 to 6 carbon atoms having at least one double bond at any position Or a branched alkenyl group and an alkenyl group substituted by 1 to 13, preferably 1 to 7 halogen atoms.

The C _{2 to 6} alkenyloxy group is not particularly limited, and examples thereof include a vinyloxy group, a 1-propenyloxy group, an allyloxy group, an isopropenyloxy group, a 1-butenyloxy group, and a 2-buteneoxy group. A linear or branched alkenyloxy group having 2 to 6 carbon atoms such as a 3-butenyloxy group, a 1-methyl-2-propenyloxy group or a 1,3-butadienyloxy group.

The C _{2 - 6} haloalkenyloxy group is not particularly limited, and examples thereof include a 2,2-dichloroethyleneoxy group, a 2,2-dibromoethoxy group, and a 3-chloro-2-propenyloxy group. ,3-difluoro-2-allyloxy, 3,3-dichloro-2-allyloxy, 4-chloro-2-butenyloxy, 4,4,4-trifluoro-2-butyl Alkenyloxy, 4,4,4-trichloro-3-butenyloxy, 5-chloro-3-pentenyloxy, 6-fluoro-2-hexenyloxy is equivalent to any position having at least one double A linear or branched alkenyl group having 2 to 6 carbon atoms in the bond, and an alkenyl group substituted with 1 to 13, preferably 1 to 7 halogen atoms.

Examples of the C _{2 to 6} alkynyl group include an ethynyl group, a 1-propynyl group, a 2-propynyl group, a 1-methyl-2-propynyl group, a 1-butynyl group, and a 2-butynyl group. A linear or branched alkynyl group having 2 to 6 carbon atoms such as a 3-butynyl group.

The C _{2 - 6} haloalkynyl group is not particularly limited, and examples thereof include 3,3,3-trifluoropropynyl, 3,3-difluoropropynyl, and 3,3,3-trifluorobutyne. a 4,4,4-trifluoro-2-butynyl group, a 3,3-difluoro-butynyl group, which is a linear or branched chain having 2 to 6 carbon atoms having at least one triple bond at any position An alkynyl group, and an alkynyl group substituted by 1 to 13, preferably 1 to 7 halogen atoms.

The C _{2 to 6} alkynyloxy group is not particularly limited, and examples thereof include an ethynyloxy group, a 1-propynyloxy group, a 2-propynyloxy group, and a 1-methyl-2-propynyloxy group. A linear or branched alkynyloxy group having 2 to 6 carbon atoms such as a butynyloxy group, a 2-butynyloxy group or a 3-butynyloxy group.

The C _{2 - 6} haloalkynyloxy group is not particularly limited, and examples thereof include 3,3,3-trifluoropropynyloxy, 3,3-difluoropropynyloxy, and 3,3,3-tri Flubutynoyloxy, 4,4,4-trifluoro-2-butynyloxy, 3,3-difluoro-butynyloxy is equal to any number of carbon atoms having 2 to 6 triple bonds at any position A linear or branched alkynyloxy group, and an alkynyloxy group substituted by 1 to 13, preferably 1 to 7 halogen atoms.

The aromatic ring compound is not particularly limited, and examples thereof include carbocyclic compounds such as benzene, naphthalene and anthracene; and pyridine, pyrimidine and anthracene. Pyr a heterocyclic compound such as pyrazole.

In the nitrophenol compound represented by the above formula (1), X is preferably a C-R' group.

In the nitrophenol compound represented by the above formula (1), R is preferably a hydrogen atom, a halogen atom, a C _{1 - 6} alkyl group or a C _{1 - 6} alkoxy group, more preferably a hydrogen atom or a methoxy group.

Of the above formula nitrophenol compound (2) represented by the, R ¹ is appropriate for the hydrogen atom, halogen atom, nitro group, C _{1 ~ 6} alkyl or C _{1 ~ 6} alkoxy group, more suitably a hydrogen atom, Nitro, or methoxy.

In the nitrophenol compound represented by the above formula (2), R ^{2 is} preferably a hydrogen atom, a halogen atom, a nitro group, a C _{1 -6} alkyl group or a C _{1 -6} alkoxy group, more preferably a hydrogen atom. Nitro, or methoxy.

In the nitrophenol compound represented by the above formula (2), R ^{3 is} preferably a hydrogen atom, a halogen atom, a nitro group, a C _{1 -6} alkyl group or a C _{1 -6} alkoxy group, more preferably a hydrogen atom. Nitro, or methoxy.

In the nitrophenol compound represented by the above formula (2), R ^{4 is} preferably a hydrogen atom, a halogen atom, a nitro group, a C _{1 -6} alkyl group or a C _{1 -6} alkoxy group, more preferably a hydrogen atom. Nitro, or methoxy.

In the general formula (2) compound represented by the nitrophenol, R ⁵ is a hydrogen atom is desirable, a halogen atom, a nitro group, C _{1 ~ 6} alkyl or C _{1 ~ 6} alkoxy group, more suitably a hydrogen atom, Nitro, or methoxy.

Further, among them, a nitro group such as 4-nitrophenol, 4-nitrophenol sodium salt, 3-nitrophenol, 3-nitrophenol sodium salt, 2-nitrophenol, 2-nitrophenol sodium salt, etc. Phenol compound or its salt; 5-nitroguaiacol, 5-nitroguaiacol sodium, 4-nitroguaiacol, 4-nitroguaiacol sodium, guaiacol (Abbreviation: a guaethoxyl compound) or a salt thereof is preferred.

The nitrophenol compound contained in the composition of the present invention is a known compound, and a compound produced by a commercially available product (ATONIK [registered trademark]) or a known production method can be used. The manufacturing method is described, for example, in Japanese Patent Laid-Open No. Hei 10-67716. The aforementioned ATONIK system contains an aqueous solution of 4-nitrophenol (0.3%), 2-nitrophenol (0.2%) and 5-nitroguaiacol (0.1%).

The acaricidal active compound to be contained in the composition of the present invention is not particularly limited as long as it is a compound known as a compound having a controlling effect against hydrazine. Further, as long as the composition of the present invention exerts the effects of the present invention, other insecticides and fungicides may be suitably used together as the agrochemical substance.

(B) Acaricidal active compound is not particularly limited as the (B) acaricidal active compound, and examples thereof include those classified by the IRAC (Insecticide Resistance Action Committee). Groups 1 to 29, compounds of group UN, and the like. Among them, the following groups 1 to 8, 10 to 25, 28, and 29 are preferable, and the following groups 1 to 3, 6, 10, 12, 13, 18 to 25, 29, and UN are more preferable, in particular, the following Groups 6, 10, 12, 13, 18 to 20, 22, and 24 are preferred.

(b1) Group 1: Acetylcholinesterase inhibitors as inhibitors of acetylcholinesterase (AChE), for example, alanycarb, aldicarb, bendiocarb ), benfuracarb, butocarboxim, butoxycarboxim, carbaryl (NAC), carbofuran, carbosulfan, affine (ethiofencarb), fenobucarb (BPMC), fenothiocarb, formetanate, furathiocarb, isoprocarb (MIPC), metimocarb ,methomyl, metolcarb, oxamyl, pirimicarb, propoxur (PHC), thiodicarb, thiofanox , urethane-based compounds such as triazamate, trimethacarb, and xylylcarb (1A); acephate, azamethiphos, and ianmen phosphorus (azinphos-ethyl), azinphos-methyl, cadusafos, chlorethoxyfos, chlorfenvinphos, chlorme Phos), chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos (CYAP), demeton-S-methyl, diazinon, Dichlorvos (DDVP), dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, puffer Ethoprophos, famphur, fenamiphos, fenitrothion (MEP), fenthion (MPP), fosthiazate, heptenophos, Isocyphos, isofenphos, O-(methoxyaminothiophosphino) isopropyl salicylate or isopropyl-O-(methoxyaminothiophosphoryl) salicylate or Isocarbophos), isoxathion, malathion, mecarbam, methamidophos, methidathion (DMTP), mevinphos, monocrotophos, Naled (BRP), omethoate, oxydemeton-methyl, parathion, methyl Parathion-methyl, phenthoate (PAP), phorate, phosalone, phosmet (PMP), phosphamidon, phoxim ( Phoxim), pirimiphos-methyl, profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos , sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, An organophosphorus compound (1B) such as trichlorfon (DEP) or vamidothion.

(b2) Group 2: GABA-activated chloride channel antagonists as GABA-activated chloride channel antagonist (blocking) agents, for example, chlordane, endosulfan, and proguanil ( A cyclic diene organochlorine compound (2A) such as dienochlor; a phenylpyrazole compound (2B) such as ethiprole, fipronil or flufiprole.

(b3) Group 3: sodium channel modulators as sodium channel modulators, for example, acrinathrin, allethrin, bifenthrin, kappa-bifenthrin, baiyaliein (bioallethrin), bioresmethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma xeronine -cyhalothrin), lambda-cyhalothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin , zeta-cypermethrin, sigma-cypermethrin, cyphenothrin, deltamethrin, empenthrin, esfenvalerate, Etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, fluvalinate, fluvalinate (tau- Fluvalinate), halfenprox, heptafluthrin, imiprothrin, kadeth Rin), meperfluthrin, momfluorothrin, permethrin, phenothrin, prallethrin, pyrethrins ), resmethrin, silafluofen, tefluthrin, kappa-tefluthrin, tetramethrin, tetramethylfluthrin ), tralomethrin, transfluthrin, benfluthrin, flufenoprox, flumethrin, furamethrin, beauty Pyrethroid-based (pyrethrin-based) compound (3A), etc., such as metofluthrin, profluthrin, and dimefluthrin.

(b4) Group 4: a nicotinic acetylcholine receptor antagonist modulator as a nicotinic acetylcholine receptor (nAChR) antagonist modulator, for example, acetamiprid, cotinine (clothianidin), dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, cycloxaprid, dichloro Neonicotinoid compound (4A) such as dicloromezotiaz; butene such as 4-[6-chloro-3-pyridylmethyl 2,2-difluoroethylamino]furan-25H-one (flupyradifurone) A hydroxy acid lactone-based compound (4D); a sulfonimide-based compound (4C) such as sulfoxaflor; a ionic compound (4E) such as triflumezopyrim or the like.

(b5) Group 5: A nicotinic acetylcholine receptor ectopic modulator as an ectopic modulator of nicotinic acetylcholine receptor (nAChR), for example, spinosad, A spinosyn compound such as spinetoram.

(b6) Group 6: glutamic acid-activated chloride channel ectopic modulator as a glutamate agonistic chloride channel (GluCl) ectopic modulator, for example, abamectin, indomethacin Abataline-based compounds such as (emamectin-benzoate); milbemycin-based compounds such as lepimectin and milbemectin.

(b7) Group 7: Juvenile hormone mimetic as a juvenile hormone mimetic (similar) agent, for example, hydroprene, kinoprene, metoprene, etc. Juvenile hormone analogous compound (7A); fenoxycarb (7B); pyriproxyfen (7C) and the like.

(b8) Group 8: Other non-specific (multi-site) inhibitors as other non-specific (multi-site) inhibitors, for example, halogenated alkane (8A) such as methyl bromide; chlorination Chloropicrin (8B); fluorite compound (8C) such as cryolite or sulfuryl fluoride; borate (8D) such as borax or boric acid; tartar (8E); Dazomet), methyl isothiocyanate generator (8F), etc., such as metam.

(b9) Group 9: TRPV channel modulator of the string organ as a TRPV channel modulator of the string organ, for example, pyridylmethylazo derivatives such as pymetrozine and pyrifluquinazon (9B) )Wait.

(b10) Group 10: steroid growth inhibitors as steroid growth inhibitors, for example, clefentezine, fluoroquinone (diflovidazin), hexythiazox, etoxazole.

(b11) Group 11: Insect-derived intestinal decomposing agent derived from microorganisms As an insect-derived midgut destroying agent derived from microorganisms, for example, Bacillus thuringiensis, BD#32 strain, AQ52 strain, etc., 鲶泽亚Species (subsp. aizawai, ABTS-1857 strain, etc.), Cusco subspecies (subsp. kurstaki, HD-1 strain, BMP 123 strain, etc.), Tenebrisosis subspecies (subsp., NB 176 strain, etc.), Israeli subspecies ( Var. israelensis), var. aegypti, var. colmeri, var. darmstadiensis, var. dendrolimus, var. Galleriae), Japanese variant (var. japonensis), subsp. morrisoni, var. san diego, subsp. thuringiensis, MPPL002, 7216 variant (var. 7216), T36 variant (var. T36), δ-endotoxin (Cry1A, Cry1Ab, modified Cry1Ab, Cry1Ab, Cry1Ac, Cry1Ab-Ac) that confer tolerance to lepidopteran insects (Hybrids fused with Cry1Ab and Cry1Ac), Cry1C, Cry1F, Cry1Fa2 (modified cry1F), moCry1F (modified C ry1F), Cry1A.105 (hybrid protein fused with Cry1Ab, Cry1Ac, Cry1F), Cry2Ab2, Cry2Ae, Cry9C, Vip3A, Vip3Aa20, etc.), δ-endotoxin (Cry3A, mCry3A) conferring tolerance to coleopteran insects Modified Cry3A), Cry3Bb1, Cry34Ab1, Cry35Ab1, etc.), such as Bacillus thuringiensis and the production of insecticidal protein (11A); Bacillus sphaericus (11B) and the like.

(b12) Group 12: mitochondrial ATP biosynthesis enzyme inhibitor as a mitochondrial ATP biosynthesis enzyme inhibitor, for example, diafenthiuron (12A); azocyclotin, tin bismuth Organic tin-based acaricides (12B) such as cyhexatin and fenbutatin oxide; propargite (12C); tetradifon (12D) and the like.

(b13) Group 13: oxidative phosphorylation uncoupler As the oxidative phosphorylation uncoupler, for example, a pyrrole compound such as chlorfenapyr; a dinitrophenol compound such as DNOC; and flubendiamide ( Sulframid) and so on.

(b14) Group 14: a nicotinic acetylcholine receptor channel blocker as a nicotinic acetylcholine receptor (nAChR) channel blocker, for example, benzultap, Peidan (cartap), cartap hydrochloride, thiocyclam, 2-dimethylamino-1,3-dithiosulfonate sodium propane or thiasultap-disodium or bisultap ), a silkworm toxin compound such as sodium 1-thiosulfonate-2-dimethylamino-3-thiosulfonylpropane or thiosultap-monosodium or monosultap.

(b15) Groups 15 and 16: Chitin biosynthesis inhibitors as chitin biosynthesis inhibitors, for example, bistrifluron, chlorfluazuron, diflubenzuron, Flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noififlumuron, teflubenzuron, Sanfu A benzoic acid-based compound such as triflumuron or buprofezin.

(b16) Group 17: A ecdysone inhibitor is used as a ecdysone inhibitor, and examples thereof include cyromazine.

(b17) Group 18: ecdysone receptor agonist as an ecdysone receptor agonist, for example, chromafenozide, hafenfenzide, and fenfenolone (methoxyfenozide), dibufenozide and other diterpenoid compounds.

(b18) Group 19: Octopamine receptor agonist As the octopamine receptor agonist, for example, amitraz or the like can be mentioned.

(b19) Group 20: a mitochondrial electron transport chain complex III inhibitor as a mitochondrial electron transport chain complex III inhibitor, and examples thereof include hydramethylnon, acequinocyl, and pyridoxine. Flucrypyrim, bifenazate, and the like.

(b20) Group 21: a mitochondrial electron transport chain complex I inhibitor as a mitochondrial electron transport chain complex I inhibitor, and examples thereof include fenpyroximate and pyridaben. METI agents (21A) such as tebufenpyrad, tolfenpyrad, fenazaquin, pyrimidifen, rotenone (21B), and the like.

(b21) Group 22: a potential-dependent sodium channel blocker as a potential-dependent sodium channel blocker, and examples thereof include an oxadiazepine compound (22A) such as indoxacarb; A urea compound such as metaflumizone (22B) or the like.

(b22) Group 23: Acetyl-CoA carboxylase inhibitor as an acetoin-CoA carboxylase inhibitor, for example, spirodiclofen, spiromesifen, and chlorpyrifos ( Spirotetramat) and other special window acid or tetramic acid derivatives.

(b23) Group 24: mitochondrial electron transport chain complex IV inhibitor as a mitochondrial electron transport chain complex IV inhibitor, for example, aluminum phosphide, calcium phosphide, phosphine, zinc phosphide A phosphine compound (24A), a cyanide compound such as a cyanide salt (24B), or the like.

(b24) Group 25: mitochondrial electron transport chain complex II inhibitor as a mitochondrial electron transport chain complex II inhibitor, and examples thereof include cyflumetofen, cyenopyrafen, and the like. --ketonitrile derivative (25A); 3'-isobutyl-isobutyl decyl-1,3,5-trimethyl-4'-[2,2,2,-trifluoro-1-methoxy- A carboxanilide-based compound such as 1-(trifluoromethyl)-ethyl]-pyrazolyl-4-pyridinium (pyflubumide).

(b25) Group 28: Lianodine receptor modulators are modulators of liannidine receptors, and examples thereof include chlorantraniliprole, cyantraniliprole, and cyclopilinamide ( Cycloneiliprole), a diammonium compound such as flubendiamide, tetraniliprole, or cyhalodiamide.

(b26) Group 29: String organ adjustment agent As the string organ adjustment agent, for example, flonicamid or the like can be mentioned.

(b27) Group UN: Insecticide/Acaricide which is not specific to the mechanism of action as an action mechanism. The insecticide/acaricide is not specified, and for example, azadirachtin and dexamethasone (Azadirachtin) Benzoximate), bromopropylate, quinomethionat, dicofol, pyridalyl, amidoflumet, and the like.

In addition to the above, known agricultural and horticultural insecticides and acaricides are also mentioned. These acaricidal active compounds are known compounds, and since they are commercially available, they can be easily obtained.

Among them, as a more suitable acaricide, it is abatatin, metostatin, kefenoxime, triammonium, fentanyl, defensulfur, oxazolidine, butaflurane, azine, bifen螨, 殴螨多, 延芬隆, Kefanpai, 派派芬, analin, sulfamethoxazole, Cyclodextrin, West mites, new mites, big gram, chlorpyrifos, chlorpyrifos, fen Bruce, Fenixine, Fenpanning, Fenpion, Pyridoxine, Fenicide, Fenfen, Hexide, 3'-Isobutyl-Isobutylin-1,3,5-Trimethyl-4 '-[2,2,2,-Trifluoro-1-methoxy-1-(trifluoromethyl)-ethyl]-pyrazolyl-4-carboxanilide, bis, Bendifen, Give away, and flunidom.

Among them, as a more suitable acaricide, it is abatatin, metostatin, kefenoxime, triammonium, fentanyl, defensulfur, oxazolidine, butaflurane, azine, bifen螨, 殴螨多, Riffin, Kefan, and Schiffin.

In the present invention, it is necessary to use a nitrophenol compound in combination with any one or more of the acaricidal active compounds. By using a nitrophenol compound in combination with an acaricidal active compound, a significant control effect against the pest is exhibited. The synergistic acaricide composition refers to an acaricide composition having a synergistic control effect (synergistic effect).

In the present invention, the cerium-doped active compound is usually added in an amount of from 0.1 to 20,000 parts by weight, preferably from 1 to 10,000 parts by weight, more preferably from 3 to 7,000 parts by weight, based on 100 parts by weight of the nitrophenol compound of the formula (1).

In the composition of the present invention, only the nitrophenol compound and the acaricidal active compound may be blended without adding other components, but usually a solid carrier, a liquid carrier, a gaseous carrier (spraying agent) may be mixed, and interface activity may be added as needed. The agent and other preparation auxiliary agents are used according to a usual formulation method to prepare an oil-forming agent, an emulsion, a hydrating agent, a suspending agent, a granule, a powder, an aerosol, an aerosol, and the like.

The preparation may usually contain 0.01 to 95% by weight, preferably 0.1 to 50% by weight, based on the total amount of the nitrophenol compound and the acaricidal active compound as active ingredients.

Examples of the solid carrier used in the formulation include clays (kaolin clay, diatomaceous earth, synthetic aqueous cerium oxide, bentonite, Fubasami clay, acid white clay, etc.), talc, ceramics, and other inorganic minerals. Micro-powder or granules such as algae, quartz, sulfur, activated carbon, calcium carbonate, hydrated cerium oxide, etc., chemical fertilizers (ammonium sulfate, ammonium phosphate, ammonium nitrate, urea, muriate, etc.) .

Examples of the liquid carrier include water, alcohols (such as methanol and ethanol), ketones (such as acetone and methyl ethyl ketone), and aromatic hydrocarbons (benzene, toluene, xylene, ethylbenzene, and methyl group). Naphthalene, etc., aliphatic hydrocarbons (hexane, cyclohexane, kerosene, diesel, etc.), esters (ethyl acetate, butyl acetate, etc.), nitriles (acetonitrile, isobutyronitrile, etc.), ethers (two Isopropyl ether, dioxane, etc.), guanamines (N,N-dimethylformamide, N,N-dimethylacetamide, etc.), halogenated hydrocarbons (dichloromethane, trichloroethane) , carbon tetrachloride, etc.), dimethyl hydrazine, soybean oil, cottonseed oil and other vegetable oils.

Examples of the gaseous carrier include butane gas, LPG (liquefied petroleum gas), dimethyl ether, and carbon dioxide gas.

Examples of the surfactant include alkyl sulfates, alkanesulfonates, alkylarylsulfonates, alkylaryl ethers, polyoxyethylenes thereof, and polyethylene glycol ethers. Polyol esters, sugar alcohol derivatives, and the like.

Examples of the auxiliary agent for the preparation include a fixing agent, a dispersing agent, and a stabilizer.

Examples of the fixing agent and/or the dispersing agent include casein, gelatin, polysaccharides (starch, gum arabic, cellulose derivatives, alginic acid, etc.), lignin derivatives, bentonite, sugars, and high synthetic water solubility. Molecules (polyvinyl alcohol, polyvinylpyrrolidone, polyacrylic acid, etc.). Examples of the stabilizer include PAP (isopropyl acid phosphate), BHT (2,6-di-tert-butyl-4-methylphenol), and BHA (2-tert-butyl-4-methoxy). a mixture of a phenol and 3-tert-butyl-4-methoxyphenol), a vegetable oil, a mineral oil, a fatty acid or an ester thereof, and the like.

The synergistic acaricide composition of the present invention can be used as it is or diluted with water or the like. In addition, it can be mixed with other insecticides, nematicides, acaricides, fungicides, herbicides, plant growth regulators, synergists, soil conditioners, animal feeds, etc., or simultaneously without mixing. .

In the case where the composition of the present invention is used as a composition for agricultural synergistic acaricide, the application amount thereof is usually 0.1 g to 500 g, preferably 1 to 100 g per 1000 m ² . When the synergistic acaricide composition of the present invention in the form of an emulsion, a hydrating agent, a suspending agent or the like is used by dilution with water, the application concentration is usually 1 to 1000 ppm, preferably 10 to 500 ppm, and granules and powders. It is administered directly in the form of a formulation without any dilution. More specifically, the application concentration of the nitrophenol compound may be usually about 0.5 to 800 ppm, preferably about 12.5 to 400 ppm, more preferably about 100 to 200 ppm, and the application concentration of the acaricidal active compound may be usually about 0.1 to 200 ppm. It is preferably about 0.1 to 50 ppm, more preferably about 0.4 to 20 ppm.

The application amount and the application concentration are different depending on the type of the preparation, the application period, the application site, the application method, the type of the pest, the degree of the damage, and the like, and may be increased or decreased without being limited to the above range.

The use of the nitrophenol compound and the acaricidal active compound in the synergistic acaricide composition of the present invention is described, but the nitrophenol compound may be separately prepared from the acaricidal active compound. When the composition is contained, the two components are used sequentially or simultaneously at the time of prevention, and it is preferred to use them simultaneously. In this case, the nitrophenol compound and the acaricidal active compound may be used in the same ratio as described above.

When the synergistic acaricide composition of the present invention is used as an acaricide, the quinone which can be used as a composition is not particularly limited, and examples thereof include, for example:
Panonychus citri, Panonychus ulmi, Tetranychus urticae Koch, Tetranychu kanzawai Kishida, Tetranychus cinnabarinus, spotted leaf Eucalyptus (Tetranychus viennensis Zacher), purple red whisker (Brevipalpus phoenicis), grape urchin (Brevipalpus lewisi) and other leaf mites;
Tea carp (Calacarus carinatus), Aculops pelekassi, Epitrimerus pyri, Eriophyes chibaensis, etc.;
Polyphagotarsonemus, cockroaches such as Tyrophagus putrescentiae, etc.
Among them, the cockroaches for drug resistance showed excellent synergistic effects.

The synergistic acaricide composition of the present invention is, for example, in the field of veterinary medicine or animal industry relating to warm-blooded vertebrates such as cattle, sheep, goats, horses, pigs, chickens, dogs, cats, etc.; Can be used for parasitic mites. Examples of the mites include: Haemaphysalis longicornis, Haemaphysalis japonica, Dermacentor reticulatus, Dermacentor taiwanensis, and Haemaphysalis flava. ), cockroaches such as Ixodes ovatus, Ixodes persulcatus, and Boophilus microplus.

The control of mites in animals can be carried out, for example, by oral administration, drip to animals, dispersion, and the like.

The useful plant which can use the synergistic acaricide composition of the present invention is not particularly limited, and examples thereof include cereals such as rice, barley, wheat, rye, oats, and corn; soybeans, adzuki beans, broad beans, and peas. Beans, peanuts and other beans;
Fruit trees/fruits such as apples, citrus, pears, grapes, peaches, plums, cherries, walnuts, chestnuts, almonds, bananas, strawberries;
Cabbage, tomato, spinach, broccoli, lettuce, onion, onion, sweet pepper, eggplant, pepper and other leaves/fruits;
Carrots, potatoes, sweet potatoes, taro, radish, alfalfa, broccoli, burdock, garlic and other root vegetables;
Cotton, hemp, beet, hops, sugar cane, leeks, olives, rubber, coffee, tobacco, tea, etc.
Pumpkin, cucumber, oriental melon, watermelon, melon, etc.;
Orchard grass, sorghum, steppe grass, alfalfa, sable, etc.;
Korean grass, bentgrass (Bentgrass) and other grasses;
Flavored lavender, rosemary, thyme, parsley, pepper, ginger, etc.
Chrysanthemum, rose, carnation, orchid and other flowers;
Ginkgo, cherry, coral, etc.;
Abies sachalinensis, Picea jezoensis, pine, Luohanbai, cedar, alfalfa and other forests.

The synergistic acaricide composition of the present invention can protect the above plants by treating the habitat of such cockroaches, or the plants parasitized by cockroaches or their vicinity.

The living place of the disease pest or the plant parasitized by the disease pest or its vicinity can be applied to the vegetation inhabited by the disease pest to be repelled, especially the stem, leaf, seed, bulb or seed potato (hereinafter, the seed, the bulb Or seed potatoes are referred to as seeds); fruits and so on. Examples of the application method include dispersion of leaves or stems, spraying, seed treatment (for example, seed coating of seed soaking or granules, etc.), soil application (for example, field spread of granules, field spray, etc.). Wait.

Acaricidal activity enhancer containing a nitrophenol compound The above nitrophenol compound can enhance acaricidal activity by being added to a known acaricide. That is, in order to enhance the acaricidal activity, a nitrophenol compound can be used.
[Examples]

Hereinafter, the present invention will be further clarified by showing examples, reference examples, reference examples and test examples, but the present invention is not limited thereto.

The formulations are exemplified below. In addition, the term "parts" means "parts by weight".

Reference formulation example 1 (emulsion)
10 parts of each of the composition of the present invention was dissolved in 45 parts of Solvesso 150 and 35 parts of N-methylpyrrolidone, and 10 parts of an emulsifier (trade name: Sorpol 3005X, manufactured by Toho Chemical Co., Ltd.) was added thereto, followed by stirring. Each 10% emulsion was obtained by mixing.

Reference Formulation Example 2 (Hydrating Agent)
20 parts of each of the composition of the present invention was added to a mixture of 2 parts of sodium lauryl sulfate, 4 parts of sodium lignin sulfonate, 20 parts of synthetic hydrous cerium oxide fine powder and 54 parts of clay, and stirred and mixed by a juice blender. A 20% hydrating agent is obtained.

Reference Formulation Example 3 (granules)
To 5 parts of each of the compositions of the present invention, 2 parts of sodium dodecylbenzenesulfonate, 10 parts of bentonite, and 83 parts of clay were added and thoroughly stirred and mixed. A suitable amount of water was added, and further stirred, granulated by a granulator, and ventilated and dried to obtain 5% granules.

Reference formulation example 4 (powder)
One part of the composition of the present invention was dissolved in an appropriate amount of acetone, and 5 parts of synthetic aqueous cerium oxide micropowder, 0.3 parts of acidic isopropyl phosphate (PAP) and 93.7 parts of clay were added thereto, and stirred and mixed by a juice blender. The acetone was removed by evaporation to obtain a 1% powder.

Reference formulation example 5 (suspending agent)
20 parts each of the composition of the present invention, 3 parts of polyoxyethylene tristyrylphenyl ether phosphate triethanolamine and 20 parts of Rhodorsil 426R 0.2 parts of water were mixed, wet-pulverized using a ball mill, and propylene glycol-containing 8 The mixture and 60 parts of 0.32 parts of Sanxian gum were mixed to obtain a suspension of 20% water.

<nitrophenol compound>
Formulation A
0.9 parts of sodium 4-nitrophenolate (manufactured by Asahi Kasei Co., Ltd.), 0.6 parts of sodium 2-nitrophenolate (manufactured by Asahi Kasei Co., Ltd.), and 5-nitroguaiacol sodium salt ( 0.3 parts by mass of Asahi Chemical Industry Co., Ltd. was dissolved in 998.2 parts of water to prepare an aqueous solvent. Hereinafter, the water solvent is referred to as "Formulation A".

Formulation B
An aqueous solvent was prepared by dissolving 0.9 parts of sodium 4-nitrophenolate (manufactured by Asahi Kasei Co., Ltd.) in 999.1 parts of water. Hereinafter, the water solvent is referred to as "formulation B".

Formulation C
An aqueous solvent was prepared by dissolving 0.6 parts of sodium 2-nitrophenolate (manufactured by Asahi Kasei Co., Ltd.) in 999.4 parts of water. Hereinafter, the water solvent is referred to as "formulation C".

Formulation D
An aqueous solvent was prepared by dissolving 0.3 parts of 5-nitroguaiacol sodium salt (manufactured by Asahi Kasei Co., Ltd.) in 999.7 parts of water. Hereinafter, the water solvent is referred to as "formulation D".

<killing active compound>
Formulation E
25 parts of Ceflon (Wako Pure Chemicals Co., Ltd.) was dissolved in 500 parts of acetone (Wako Pure Chemicals Co., Ltd.), and 2 parts of water of 2% water of a dialkyl ester sulfonate (surfactant) was added thereto. An emulsion is prepared. Hereinafter, the emulsion is referred to as "Formulation E".

Formulation F
25 parts of fentanyl (Wako Pure Chemicals Co., Ltd.) was dissolved in 500 parts of acetone (Wako Pure Chemicals Co., Ltd.), and 2 parts of water of 2% water of a dialkyl ester sulfonate (surfactant) was added thereto. An emulsion is prepared. Hereinafter, the emulsion is referred to as "Formulation F".

Formulation G
Kumiai Piranika (registered trademark) EW (10% by weight of EW agent containing Fenrui) manufactured by Kumiai Chemical Industry Co., Ltd. was prepared as an EW agent containing Defenid. Hereinafter, this preparation is referred to as "Formulation G".

Formulation H
Kanemite (registered trademark) Flowable (containing 15% by weight of a suspension of hydrazine) manufactured by Agrokanesho Co., Ltd. was prepared as a suspending agent containing hydrazine. Hereinafter, this preparation is referred to as "Formulation H".

Formulation I
Maitokone (registered trademark) Flowable (containing 20% by weight of a suspending agent), manufactured by Nissan Chemical Industries Co., Ltd., was prepared as a suspending agent containing Bifene. Hereinafter, this preparation is referred to as "Formulation I".

Formulation J
An emulsion of Agrimek (registered trademark) manufactured by Syngenta Japan Co., Ltd. (containing an emulsion of abatatin 1.8% by weight) was prepared as an emulsion containing abatatin. Hereinafter, this preparation is referred to as "Formulation J".

Formulation K
A Danicut (registered trademark) emulsion (20% by weight of triterpenoid emulsion) manufactured by Nissan Chemical Industries Co., Ltd. was prepared as an emulsion containing Sanlium. Hereinafter, this preparation is referred to as "Formulation K".

Formulation L
Starmaito (registered trademark) Flowable (30% by weight of a suspension of oxazolidine) manufactured by Nissan Chemical Industries Co., Ltd. was prepared as a suspending agent containing oxazolidine. Hereinafter, this preparation is referred to as "formulation L".

Formulation M
Kotetsu (registered trademark) Flowable (containing 10% by weight of suspending agent) of Kawasaki Co., Ltd. manufactured by Japan Soda Co., Ltd. was prepared as a suspending agent containing Kofai. This preparation was designated as "Formulation M".

Formulation N
A Nichino Omayito (registered trademark) hydrating agent (a hydrating agent containing 30% by weight of hydrazine) manufactured by Japan Pesticide Co., Ltd. was prepared as a hydrating agent containing hydrazine. This preparation was designated as "Formulation N".

Formulation O
A Gamba (registered trademark) hydrating agent (a 50% by weight of a hydrating agent containing rifampin) manufactured by Syngenta Japan Co., Ltd. was prepared as a hydrating agent containing fenfen. This preparation was referred to as "Formulation O".

Formulation P
A Koromaito (registered trademark) emulsion (an emulsion containing 1% by weight of dexamethasone) manufactured by Syngenta Japan Co., Ltd. was prepared as an emulsion containing dexamethasone. This preparation was designated as "Formulation P".

Formulation Q
Prepare Daniemon (registered trademark) Flowable (containing 30% by weight of suspending agent) from Bayer Cropscience as a suspending agent containing Schiffin. Hereinafter, this preparation is referred to as "Formulation Q".

Formulation R
A Danisaraba (registered trademark) Flowable (a suspension containing 20% by weight of butyl fluoride) manufactured by OAT Agrio Co., Ltd. was prepared as a suspending agent containing butaflurane ester. This preparation was referred to as "Formulation R".

Formulation T
0.9 parts of 4-nitrophenol potassium salt (manufactured by Asahi Kasei Co., Ltd.), 0.6 parts of 2-nitrophenol potassium salt (manufactured by Asahi Kasei Co., Ltd.), and 5-nitroguaiacol potassium salt ( Anthra Chemical Industry Co., Ltd. manufactured 0.3 parts of water was dissolved in 998.2 parts of water to prepare an aqueous solvent. Hereinafter, the water solvent is referred to as "formulation T".

Formulation U
An aqueous solvent was prepared by dissolving 0.9 parts of potassium 4-nitrophenolate (manufactured by Asahi Kasei Co., Ltd.) in 999.1 parts of water. Hereinafter, the water solvent is referred to as "formulation U".

Formulation V
An aqueous solvent was prepared by dissolving 0.6 parts of 2-nitrophenol potassium salt (manufactured by Asahi Chemical Industry Co., Ltd.) in 999.4 parts of water. Hereinafter, the water solvent is referred to as "formulation V".

Formulation W
An aqueous solvent was prepared by dissolving 0.3 parts of 5-nitroguaiacol potassium salt (manufactured by Asahi Kasei Co., Ltd.) in 999.7 parts of water. Hereinafter, the water solvent is referred to as "formulation W".

<Composition of the present invention>
Example 1
The preparation E (kefene) and the preparation A (nitrophenol compound) were mixed and adjusted so as to have the test concentrations shown in Table 1, to prepare a preparation E+A of the composition of the present invention.

Example 2-21
Formulation E was replaced with Formulation F, Formulation G, Formulation H, Formulation I, Formulation J, Formulation K, Formulation L, Formulation M, Formulation N, Formulation O, Formulation P, and Formulation Q, respectively, as described in Tables 1 and 2, Except for the same procedure as in Example 1, the preparations F+A, Formulation G+A, Formulation H+A, Formulation I+A, Formulation J+A, Formulation K+A, Formulation L+A, Formulation M+A, respectively, were prepared at the test concentrations shown in Tables 1 and 2. Preparation N+A, preparation O+A, preparation P+A, and preparation Q+A.

Example 22
The preparation I (Benfen) and the preparation A (nitrophenol compound) were mixed and adjusted so as to have the test concentrations shown in Table 3, and the preparation I+A of the composition of the present invention was produced.

Examples 23 and 24
The preparation I+B and the preparation I+C of the test concentrations described in Table 3 were prepared in the same manner as in Example 23 except that the preparation A was replaced with the preparation B and the preparation C described in Table 3, respectively.

Example 25
The preparation I (Benfen) and the preparation T (nitrophenol compound) were mixed and adjusted so as to have the test concentrations shown in Table 4, and the preparation I+T of the composition of the present invention was produced.

Examples 26-28
The preparations I+U and the preparation I+V of the diluted concentrations described in Table 4 were prepared in the same manner as in Example 25 except that the preparation T was replaced with the preparation U, the preparation V, and the preparation W described in Table 4, respectively. And preparation I + W.

Test Example 1: Efficacy test for low-sensitivity T. striata (adults, larvae) for the drug The low-sensitivity T. urticae used in Aomori Prefecture was used for the test. The preparations A to D, the preparations E to Q, and the preparations E+A to Q+A of Examples 1 to 21 were used as test reagents.

Tap water was added to a plastic cup having a diameter of 8.5 mm and a height of 4 cm (trade name: KP-120, manufactured by KOHNOIKE PLASTIC Co., Ltd.), and a cover for cutting the slit was placed. A slit of about 4 cm was cut along the long side of the non-woven fabric (4.5 x 5.5 cm) by a width of 1 cm, and placed on the lid so as to hang from the slit into the cup. The primary leaves of the kidney beans (early green) cut into 2 × 3 cm were placed on the non-woven fabric which was sufficiently absorbed by water, and the female adults of the two-spotted spider mites were placed in a single cup of 15 pieces. The kidney bean leaves were allowed to stand in a constant temperature room at 25 ° C ± 2 ° C and a humidity of 60% for 1 day. One day later, the individual who died and the weak individual were removed from each cup and then tested.

Using a scatter tower (Potter Spray Tower, manufactured by BURKARD, UK, with a spread pressure of 5 lb/inch), 2 ml of the test solution was separately dispensed. The kidney bean leaves were allowed to stand in a constant temperature room at 25 ± 2 ° C and a humidity of 60%. The number of births and deaths of female adults of T. urticae was counted after 3 days, and mortality (%) was determined according to the following formula.

Mortality = {1 - (survival rate of treatment area) / (survival rate without treatment area)} × 100
The results are shown in Table 1.

Further, on the third day of the chemical treatment, the female adult mites were completely removed from the leaves of the bean, and the leaves of the beans were allowed to stand in a constant temperature room at 25 ± 2 ° C and a humidity of 60% for 4 days. After 4 days, the number of life and death individuals of the two-spotted larvae was counted, and the mortality was determined in the same manner. The results are shown in Table 2.

Further, the expected effectiveness (E) of the acaricide composition of the present invention was calculated according to the Colby formula (Weeds, 15, 20-22 (1967)), and the calculated effective degree (%) was determined.

E=x+y-(x·y/100)
In the formula, E is expressed by % in the case where the nitrophenol compound and the acaricidal active compound are used in the respective concentrations p and q. x represents the effectiveness when the nitrophenol compound is used at a concentration p, and y represents the effectiveness when the acaricidal active compound is used at a concentration q.

The theoretical values (%) obtained by the Colby formula described above are shown together in Tables 1 to 4. The values in Tables 1 to 4 are the degree of validity (%). If the control effect of the nitrophenol compound of the present invention and the acaricidal active compound is actually higher than the E (expected value), the combination exhibits a synergistic effect.

[Table 1]

<test result>
As a result, it was found that the mortality (%) of the acaricide compositions (Examples 1 to 12) of the present invention had a larger value (measured value) than the theoretical value and had a synergistic effect. Therefore, by using a nitrophenol compound in combination with an acaricidal active compound, the control effect against hydrazine is improved as compared with the case of only the existing acaricide.

[Table 2]

<test result>
As a result, it was found that the mortality (%) of the acaricide compositions (Examples 13 to 21) of the present invention has a numerical value (measured value) larger than the theoretical value and has a synergistic effect. Therefore, by using the nitrophenol compound in combination with the acaricidal active compound, the control effect against hydrazine is improved as compared with the case of only the existing acaricide.

Test Example 2: Efficacy test for two-spotted spider mites (adults) Formulation A, Formulation B, Formulation C, Formulation D, and Formulation I, which are test agents, were each diluted to a specific concentration with tap water. Then, Formulation I, Preparation A, Formulation B, and Formulation C were separately mixed to prepare test solutions of Examples 22 to 24. The effect on female adults of T. urticae is shown in Table 3.

[table 3]

<test result>
As a result, the acaricide composition of the present invention (Examples 22 to 24) is compared with the case of only the nitrophenol compound (formulations A to D) or only the existing acaricide (formulation I). The control effect of cockroaches has been significantly improved.

Test Example 3: Efficacy test for two-spotted spider mites (larvae) Formulation T, Formulation U, Formulation V, Formulation W, and Formulation I, which are used as test agents, were each diluted to a specific concentration using tap water. Then, the preparation liquids of Examples 25 to 28 were prepared by mixing the preparation I, the preparation T, the preparation U, the preparation V, and the preparation W, respectively. The effect on the larvae of T. urticae is shown in Table 4.


[Table 4]

<test result>
As a result, the acaricide composition of the present invention (Examples 25 to 28) is compared with the case of only the nitrophenol compound (formulation T to W) or only the existing acaricide (formulation I). The control effect of cockroaches has been significantly improved.

Claims (15)

A synergistic acaricide composition comprising (A) a nitrophenol compound and (B) an acaricidal active compound. The synergistic acaricide composition of claim 1, wherein (B) the acaricidal active compound is selected from the group consisting of (b1) an acetylcholinesterase inhibitor, (b2) GABA-activated chloride channel antagonists, (b3) sodium channel regulator, (b4) nicotinic acetylcholine receptor antagonist modulator, (b5) a nicotinic acetylcholine receptor ectopic modulator, (b6) glutamic acid-activated chloride channel ectopic modulator, (b7) juvenile hormone mimicking agent, (b8) other non-specific (multi-site) inhibitors, (b9) String organ TRPV channel conditioner, (b10) steroid growth inhibitors, (b11) Insecticides derived from microorganisms, (b12) mitochondrial ATP biosynthetic enzyme inhibitor, (b13) oxidative phosphorylation uncoupler, (b14) a nicotinic acetylcholine receptor channel blocker, (b15) Chitin biosynthesis inhibitor, (b16) ecdysone inhibitor, (b17) ecdysone receptor agonist, (b18) Octopamine receptor agonist, (b19) mitochondrial electron transport chain complex III inhibitor, (b20) mitochondrial electron transport chain complex I inhibitor, (b21) a potential-dependent sodium channel blocker, (b22) acetaminophen coenzyme A carboxylase inhibitor, (b23) mitochondrial electron transport chain complex IV inhibitor, (b24) mitochondrial electron transport chain complex II inhibitor, (b25) ryanodine receptor modulator, (b26) string organ adjustment agent, and (b27) Insecticide/Acaricide At least one compound of the group formed. The synergistic acaricide composition of claim 1 or 2, wherein (B) the acaricidal active compound is selected from the group consisting of (b6) glutamic acid-activated chloride channel ectopic modulator, (b8) methyl bromide, chloropicrin, cryolite, sulfonium fluoride, borax, tartar, dazome, metam, (b10) steroid growth inhibitors, (b12) mitochondrial ATP biosynthetic enzyme inhibitor, (b13) oxidative phosphorylation uncoupler, (b18) Octopamine receptor agonist, (b19) mitochondrial electron transport chain complex III inhibitor, (b20) mitochondrial electron transport chain complex I inhibitor, (b22) acetaminophen coenzyme A carboxylase inhibitor, (b24) mitochondrial electron transport chain complex II inhibitor, (b27) Azadirachtin, benzoximate, bromopropylate, quinomethionat, dicofol, pyridalyl, and sulfamethacrylate (amidoflumet) At least one compound of the group formed. The synergistic acaricide composition according to any one of claims 1 to 3, wherein (B) the acaricidal active compound is selected from the group consisting of (b6) glutamic acid-activated chloride channel ectopic modulator, (b10) steroid growth inhibitors, (b12) mitochondrial ATP biosynthetic enzyme inhibitor, (b13) oxidative phosphorylation uncoupler, (b18) Octopamine receptor agonist, (b19) mitochondrial electron transport chain complex III inhibitor, (b20) mitochondrial electron transport chain complex I inhibitor, (b22) an acetaminophen coenzyme A carboxylase inhibitor, and (b24) Granulocyte electron transport chain complex II inhibitor At least one compound of the group formed. The synergistic acaricide composition according to any one of claims 1 to 4, wherein (B) the acaricidal active compound is selected from the group consisting of abamectin, milbemectin, and triamcinolone. (amitraz), fenazaquin, tebufenpyrad, cyenopyrafen, cyflumetofen, acequinocyl, bifenazate, 殴螨多At least one compound of the group consisting of (propargite), diafenthiuron, chlorfenapyr, and spirodiclofen. The synergistic acaricide composition according to any one of claims 1 to 5, wherein the (A) nitrophenol compound is a phenol compound having one nitro group. The synergistic acaricide composition according to any one of claims 1 to 6, wherein the blending ratio of the (A) nitrophenol compound is from 0.5 to 18,000 by weight based on 100 parts by weight of the (B) acaricidal active ingredient. Share. A method for controlling cockroaches, which comprises treating a living place of a pest (except for humans) with a synergistic acaricide composition according to any one of claims 1 to 7. A plant protection method characterized by treating a plant parasitic to a pest or a nearby plant thereof with the synergistic acaricide composition according to any one of claims 1 to 7. A method of using a nitrophenol compound for enhancing acaricidal activity. A method of using a nitrophenol compound for enhancing the acaricidal activity of acaricidal active compounds (except for human applications), and The acaricidal active compound is selected from the group consisting of abatatin, metostatin, triterpene, fentanyl, defensulfuric acid, oxazolidine, butaflurane ester, azulene, bifenfen, and anthraquinone. At least one compound of the group consisting of Rifen, Kefan, and Schiffen. The method of use of claim 10 or 11, wherein the nitrophenol compound is a phenol compound having one nitro group. An acaricidal activity enhancer comprising a nitrophenol compound. An acaricidal activity enhancer which comprises a nitrophenol compound for acaricidal active compound, and The acaricidal active compound is selected from the group consisting of abatatin, metostatin, triterpene, fentanyl, defensulfuric acid, oxazolidine, butaflurane ester, azulene, bifenfen, and anthraquinone. At least one compound of the group consisting of Rifen, Kefan, and Schiffen. The acaricidal activity enhancer according to claim 13 or 14, wherein the nitrophenol compound is a phenol compound having one nitro group.