TW201821062A - 溴結構域抑制劑 - Google Patents

Info

Publication number

TW201821062A

TW201821062A TW106136093A TW106136093A TW201821062A TW 201821062 A TW201821062 A TW 201821062A TW 106136093 A TW106136093 A TW 106136093A TW 106136093 A TW106136093 A TW 106136093A TW 201821062 A TW201821062 A TW 201821062A

Authority

TW

Taiwan

Prior art keywords

pharmaceutical composition

cyclopropylmethoxy

polymer

compound

methylisoquinolin

Prior art date

2016-10-20

Links

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• Global Dossier
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• 229940125763 bromodomain inhibitor Drugs 0.000 title abstract description 4
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 124
• UWZAJPITKGWMFJ-UHFFFAOYSA-N 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one Chemical compound Cn1cc(-c2cc(ccc2OCC2CC2)S(C)(=O)=O)c2ccccc2c1=O UWZAJPITKGWMFJ-UHFFFAOYSA-N 0.000 claims abstract description 71
• 239000007787 solid Substances 0.000 claims abstract description 64
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• 238000000034 method Methods 0.000 claims description 63
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• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 45
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 31
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 31
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• 238000001046 rapid expansion of supercritical solution Methods 0.000 claims description 5
• VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 claims description 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
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