TW201803605A - Method of cleaning dialysate production apparatus - Google Patents

Abstract

A dialysate production apparatus (1) is provided with an electrolyzed water producing device (7) for dissolving hydrogen in raw water, and a reverse osmosis membrane treatment device (9) that is connected to the electrolyzed water producing device (7) and performs reverse osmosis membrane treatment upon water in which hydrogen has been dissolved. After treatment with dialysate (27) has finished, raw water (2) that has not been treated by the electrolyzed water producing device (7) is fed to the reverse osmosis membrane treatment device (9) via the electrolyzed water producing device (7).

Description

Cleaning method of dialysate manufacturing device

The invention relates to a cleaning method for a dialysate manufacturing device.

Hemodialysis is widely known as one of the effective treatments for patients with renal failure who cannot excrete urine due to low kidney function. Among them, excretion of urine is to regulate the amount of water and remove harmful substances in the body including urea and other metabolites substance.

This hemodialysis is performed continuously: a blood pump is used to draw blood out of the body, and a dialyzer is brought into contact with the blood through a dialyzer, thereby utilizing the diffusion phenomenon caused by the concentration gradient to remove harmful substances and water from the blood. After that, the blood is returned to the body (blood return).

In addition, in recent years, oxidative stress has been known to occur in dialysis patients during hemodialysis. It can be considered that this is caused by active oxygen generated during dialysis, and a solution to eliminate the active oxygen to reduce oxidative stress has been proposed.

For example, a method has been proposed which produces hydrogen with high solubility by dissolving hydrogen in purified water (hereinafter referred to as "reverse osmosis water") treated with a reverse osmosis membrane (RO membrane). Hydrogen-containing dialysate. In addition, by using this dialysate, hydrogen can react with hydroxyl radicals in the body, thereby suppressing oxidative stress and inflammatory reactions.

In addition, conventionally, before the treatment with the above-mentioned reverse osmosis membrane, The following process is performed by subjecting raw water to electrolytic treatment to generate water (dissolved hydrogen) in which hydrogen is dissolved (dissolved) for use as dialysate preparation water (for example, refer to Patent Document 1). .

[Prior technical literature]

[Patent Literature]

Patent Document 1: Japanese Patent Application Laid-Open No. 2000-350989.

In general, hydrogen bacteria that grow in the free state and fix carbonic acid with energy generated by the reaction between hydrogen and oxygen are known. However, the hydrogen bacteria are sometimes It uses hydrogen in dissolved hydrogen water for reproduction.

By this means, for example, in a reverse osmosis membrane supplied with dissolved hydrogen water produced by electrolytic treatment, if hydrogen bacteria reproduce by using hydrogen in the dissolved hydrogen, the dissolved hydrogen concentration of the dissolved hydrogen water will decrease. Therefore, there is a problem that a desired dissolved hydrogen concentration cannot be obtained in a terminal dialysate (that is, a dialysate used to be supplied to a dialysis device and a patient's blood is purified by a dialyzer).

Then, this invention is made in view of the said subject, The objective is to provide the dialysate manufacturing apparatus which can suppress the reduction of the dissolved hydrogen concentration by a hydrogen bacterium, and obtain the desired dissolved hydrogen concentration in a terminal dialysate. the cleaning method.

In order to achieve the above object, the cleaning of the apparatus for producing a dialysate of the present invention The washing method includes at least a washing method of a dialysate manufacturing device including a hydrogen dissolving device for dissolving hydrogen in pretreatment water and a device to which the hydrogen dissolving water connected to the hydrogen dissolving device and dissolved hydrogen is supplied, the dialysate manufacturing device described above. The method of washing is characterized in that, after the treatment with the dialysate is completed, pretreatment water that has not been treated by the hydrogen dissolution device is supplied to the following device by a hydrogen dissolution device, and dissolved hydrogen water is supplied to the device. Device.

According to the above configuration, since the pretreated water having a very low dissolved hydrogen concentration compared with the dissolved hydrogen water is supplied to the device, the device to which the dissolved hydrogen water is supplied can reduce the amount of hydrogen that becomes the active energy source of the hydrogen bacteria, thereby enabling Inhibits the proliferation of hydrogen bacteria in the device. As a result, when the patient is treated again with the dialysate, it is possible to suppress a decrease in the dissolved hydrogen concentration caused by the hydrogen bacteria.

According to the present invention, the decrease in the concentration of dissolved hydrogen caused by hydrogen bacteria is suppressed, and a desired concentration of dissolved hydrogen can be obtained in the dialysate at the end.

1‧‧‧ manufacturing equipment for dialysate

2‧‧‧ raw water

3‧‧‧ pre-filter

4‧‧‧soft hydration device

5‧‧‧carbon filter (activated carbon treatment device)

7‧‧‧ Electrolyzed water generation device (hydrogen dissolution device)

8‧‧‧ Electrolytic water tank

9‧‧‧ reverse osmosis membrane processing device

10‧‧‧ solid polymer film

11‧‧‧Anode

12‧‧‧ cathode

13‧‧‧ Dielectric layer

15‧‧‧ electrolytic cell body

16‧‧‧ entrance

17‧‧‧ treated water (dissolved hydrogen water)

18‧‧‧ water delivery

19‧‧‧ Dissolved oxygen water

20‧‧‧ electrolytic cell

21‧‧‧Drainage

25‧‧‧ reverse osmosis water

26‧‧‧dialysate preparation device

27‧‧‧ dialysate

30‧‧‧UF module

32‧‧‧control device

33‧‧‧ electrolytic current determining unit

34‧‧‧ Electrolytic current supply unit

35‧‧‧Storage unit

36‧‧‧ reverse osmosis membrane

37‧‧‧Reverse Osmosis Water Tank

40‧‧‧dialysis device

50‧‧‧patients

80‧‧‧ manufacturing equipment for dialysate

81‧‧‧membrane module

82‧‧‧Pressure Box

84‧‧‧pressure regulating valve

85‧‧‧ Hydrogen pressurization device

FIG. 1 is a schematic diagram illustrating a configuration of a dialysate manufacturing apparatus according to an embodiment of the present invention.

FIG. 2 is a view showing an electrolytic cell in an electrolyzed water generating device of a dialysate manufacturing apparatus according to an embodiment of the present invention.

FIG. 3 is a flowchart for describing a cleaning method of a dialysate manufacturing apparatus according to an embodiment of the present invention.

FIG. 4 shows a manufacturing apparatus for a dialysate according to a modification of the present invention. Schematic diagram of the structure.

FIG. 5 is a schematic diagram showing a configuration of a dialysate manufacturing apparatus according to a modification of the present invention.

FIG. 1 is a schematic diagram illustrating a configuration of a dialysate manufacturing apparatus according to an embodiment of the present invention. In addition, FIG. 2 is a diagram showing an electrolytic cell in an electrolyzed water generating apparatus of a dialysate manufacturing apparatus according to the first embodiment of the present invention.

The dialysate manufacturing apparatus 1 includes a pre-filter 3, a soft hydration device 4 connected to the pre-filter 3, a carbon filter (activated carbon treatment device) 5 connected to the soft hydration device 4, and an electrolyzed water generation device 7 connected to the carbon filter 5. An electrolytic water tank 8 connected to the electrolytic water generating device 7, a reverse osmosis membrane processing device 9 connected to the electrolytic water tank 8, and a UF (Ultra Filter) module 30 connected to the reverse osmosis membrane processing device 9.

The pre-filter 3 is used to remove impurities (for example, rust, grit) from the raw water 2 (hard water containing dissolved solids such as calcium ions and magnesium ions as hardness components).

The soft hydration device 4 is used to perform a process of removing the hardness component from the raw water 2 by a substitution reaction through ion exchange to change the raw water 2 into soft water. In addition, in this embodiment, as the raw water 2, tap water, well water, ground water, etc. can be used.

The carbon filter 5 is used to remove the residual chlorine, chloramine, organic matter, etc. contained in the raw water by using a porous adsorption substance, namely activated carbon, for the raw water treated by the softening device 4 through physical adsorption. .

In addition, as said softening apparatus 4 and the carbon filter 5, the well-known apparatus can be used.

The electrolyzed water generating device 7 functions as a hydrogen dissolving device for performing electrolytic treatment on the raw water 2 treated by the carbon filter 5 to generate hydrogen-dissolved water (dissolved hydrogen) used as dialysate preparation water. water).

The electrolyzed water generating device 7 of the present embodiment includes an electrolytic cell 20 having a solid polymer membrane (solid polymer electrolyte membrane) 10 as shown in FIG. 2.

As shown in FIG. 2, the electrolytic cell 20 includes the above-mentioned solid polymer film 10, an anode 11 and a cathode 12, and a solid polymer film 10 is provided between the anode 11 and the cathode 12, and the anode 11 and the cathode 12 are configured as As opposed to each other, the anode 11 and the cathode 12 are power supply bodies for supplying electricity to the electrolytic cell 20; and the dielectric layer 13 is disposed between the polymer film 10 and the anode 11 and between the polymer film 10 and the cathode 12 between.

It should be noted that, as shown in FIG. 2, the anode 11 and the cathode 12 are electrically connected, and the above-mentioned solid polymer film 10, the anode 11, the cathode 12, and the dielectric layer 13 are housed inside the electrolytic cell body 15.

In addition, as shown in FIG. 2, an introduction path 16 is formed in the electrolytic cell body 15, and the introduction path 16 is used to electrolyze the raw water 2 processed by the pre-filter 3, the softening device 4, and the carbon filter 5 ( This is hereinafter referred to as "pretreatment water") and is introduced into the electrolytic cell body 15.

Examples of the material of the anode 11 and the cathode 12 include titanium and platinum.

Examples of the material for forming the dielectric layer 13 include, for example, Titanium, platinum, etc.

In addition, the solid polymer film 10 functions to move oxonium ions (H ₃ O ⁺ ) generated on the anode 11 side toward the cathode 12 side by electrolysis.

As the solid polymer film 10, for example, a material made of a fluororesin material having a sulfonic acid group can be used. More specifically, commercially available products such as perfluorosulfonic acid resin (Nafion, manufactured by DuPont), Flemion (made by Asahi Glass), and Aciplex (made by Asahi Glass) can be used as the solid polymer film 10 in the present invention. .

In the electrolysis performed in the electrolyzed water generator 7 using the solid polymer film 10 as described above, the following reactions occur on the anode 11 side and the cathode 12 side, respectively.

Anode _{side: 6H 2 O → 4H 3 O} + + O 2 + 4e -

The _{^{cathode: 4H 3 O + + 4e -}} → 2H 2 + 4H 2 O

Then, the treated water (dissolved hydrogen water) 17 generated by the above-mentioned electrolytic treatment is transported to the electrolytic water tank 8 connected to the electrolytic water generating device 7 through the water supply path 18 formed on the cathode side of the electrolytic cell body 15. It should be noted that the dissolved oxygen water 19 generated on the anode side by the electrolytic treatment is discharged to the outside through the drain path 21 formed on the anode side of the electrolytic cell body 15.

The electrolytic water tank 8 is used to store dissolved hydrogen water generated by the electrolytic water generating device 7.

The reverse osmosis membrane processing device 9 is used to apply a pressure to the high-concentration solution side by applying a pressure to a high-concentration solution side (permeation) when a solution having different concentrations exists with a semi-permeable membrane as a boundary. ,Make Water moves from the solution on the high-concentration side to the solution on the low-concentration side to obtain a treatment (reverse osmosis membrane treatment) for the water permeating into the low-concentration side.

Therefore, the reverse osmosis membrane treatment device 9 can further remove impurities such as trace metals from the pre-treated water obtained by the above-mentioned series of treatments. Therefore, it is possible to obtain water quality that meets the requirements of ISO13959 (Water Standard for Dialysis). Standard water (reverse osmosis water).

As shown in FIG. 1, the reverse osmosis membrane treatment device 9 includes a reverse osmosis membrane 36 and a reverse osmosis water tank 37. The reverse osmosis membrane 36 performs the above-mentioned reverse osmosis membrane treatment on the dissolved hydrogen water generated by the electrolyzed water generation device 7. The osmosis water tank 37 is used to store reverse osmosis water subjected to a reverse osmosis membrane treatment.

The UF module 30 is used to remove bacteria and microorganisms contained in the reverse osmosis water 25.

As shown in FIG. 1, a dialysate preparation device 26 is connected to the UF module 30, and the reverse osmosis water 25 processed by the UF module 30 is supplied to the dialysate preparation device 26.

The dialysate preparation device 26 prepares a dialysate 27 obtained by mixing the supplied reverse osmosis water 25 and the dialysis raw solution, and the dialysate 27 is supplied to a dialysis device 40 connected to the dialysate preparation device 26 and is then passed to a patient. The blood of 50 is purified, and the treatment performed on the patient 50 by the dialysate 27 is performed. That is, the dialysate preparation device 26 also functions as a dialysate supply device that supplies the prepared dialysate 27 to the dialysis device 40.

Next, a cleaning method of the dialysate manufacturing apparatus 1 will be described.

FIG. 3 is a flowchart for describing a cleaning method of a dialysate manufacturing apparatus according to an embodiment of the present invention.

First, after the treatment of the patient 50 using the dialysate 27 is completed (step S1), the switch of the electrolyzed water generating device 7 is turned off, and the electrolysis treatment (that is, dissolution) performed by the electrolyzed water generating device 7 is ended. Generation of hydrogen water) (step S2).

Next, as in the case where the patient 50 is treated with the dialysate 27 described above, the pre-treated water is supplied to the electrolyzed water generator 7 (step S3). At this time, as described above, since the switch of the electrolyzed water generation device 7 is in the OFF state, the reverse osmosis membrane processing device 9 (ie, the reverse osmosis membrane 36) is supplied without being electrolyzed by the electrolyzed water generation device 7. Instead of supplying pre-treated water (processed water (dissolved hydrogen water)) 17 produced by electrolytic treatment (step S4).

That is, the present embodiment is configured such that after the treatment with the dialysate 27 is completed, the pre-treatment without supplying the electrolytic treatment by the electrolytic water generating device 7 is supplied to the reverse osmosis membrane processing device 9 through the electrolytic water generating device 7. water.

As a result, the pretreated water having a very low dissolved hydrogen concentration compared to the dissolved hydrogen water 17 (including the case where the dissolved hydrogen is 0) is supplied to the reverse osmosis membrane processing device 9. Therefore, the reverse osmosis membrane 36 is reduced to become hydrogen bacteria. Hydrogen, which is the active energy source, can suppress the proliferation of hydrogen bacteria at the reverse osmosis membrane 36 (step S5). As a result, when the patient 50 is treated again with the dialysate 27, the decrease in the concentration of dissolved hydrogen caused by the hydrogen bacteria is suppressed, so that the desired dialysate 27 can be obtained at the distal dialysate 27.

It should be noted that, in the present invention, it can be considered that, for example, according to The method of using the water circulation to inhibit the growth of plant floats is the same principle. The hydrogen bacteria at the reverse osmosis membrane 36 are alternately exposed to the dissolved hydrogen water 17 with high dissolved hydrogen concentration and the treated water with extremely low dissolved hydrogen concentration. As a result, the reproduction function of the hydrogen bacteria is reduced.

In addition, the supply time of the pretreatment water for washing is not particularly limited, and for example, it can be configured to supply 10 to 60 minutes after the treatment of the patient 50 with the dialysate 27 is completed.

In addition, the said embodiment can also be changed as follows.

The above embodiment is configured such that, after the treatment with the dialysate is completed, the pre-treated water that has not been processed by the electrolytic water generating device 7 is supplied to the reverse osmosis membrane 36 through the electrolytic water generating device 7. However, as shown in FIG. 4, the carbon filter 5 may be connected to the reverse osmosis membrane 36 so that the pretreated water treated by the carbon filter 5 is supplied to the reverse osmosis membrane 36 without passing through the electrolyzed water generating device 7.

That is, after completion of the treatment with the dialysate 27, the pre-treated water that has not been processed by the electrolytic water generating device 7 may be supplied to the reverse osmosis membrane 36 without passing through the electrolytic water generating device 7. According to such a configuration, it is possible to supply the pretreated water to the reverse osmosis membrane 36 without turning off the power of the electrolyzed water generating device 7, and it is not generated to be discharged on the anode side of the electrolyzed water generating device 7. Since the dissolved oxygen water 19 is used, the pre-treated water can be efficiently used.

In addition, a washing water supply device (not shown) for supplying washing water for washing may be connected to the reverse osmosis membrane processing device 9 and From the washing water supply device, the washing water corresponding to the pretreatment water is supplied to the reverse osmosis membrane processing device 9.

In the above-mentioned embodiment, the electrolytic water generating device 7 is used as the hydrogen dissolving device. However, any configuration may be adopted as long as it can dissolve hydrogen in the raw water 2 treated by the carbon filter 5.

For example, a configuration may be adopted in which hydrogen is brought into contact with the raw water 2 treated by the activated carbon treatment device 5 to thereby dissolve the hydrogen.

More specifically, as the hydrogen dissolving device, it is possible to use a membrane module including a sleeve and a hollow fiber disposed inside the sleeve and having a plurality of holes formed therein, so that holes formed by the hollow fibers can be used. A method of bringing hydrogen into contact with raw water 2 treated by a carbon filter 5, wherein the hydrogen is supplied to the sleeve.

Alternatively, the hydrogen water-dissolved raw water 2 may be pressurized to increase the concentration of hydrogen contained in the raw water 2 so that the concentration of dissolved hydrogen in the raw water 2 treated by the carbon filter 5 is maintained at a desired level. High concentration.

More specifically, as shown in FIG. 5, the dialysate production device 80 includes a hydrogen pressurizing device 85 instead of the electrolytic water generating device 7 shown in FIG. 1. The hydrogen pressurizing device 85 includes: A membrane module 81 in which the hydrogen gas is in contact with the raw water 2; and a pressure tank 82 connected to the membrane module 81 and dissolving hydrogen in the raw water 2 by pressurizing the hydrogen gas.

The hydrogen pressurizing device 85 includes a pressure regulating valve 84 connected to a pressurizing tank 82. Thus, by controlling the pressure regulating valve 84, the pressure when hydrogen is pressurized by the pressurizing tank 82 is controlled, and the concentration of hydrogen contained in the raw water 2 is adjusted.

In addition, in the above-mentioned embodiment, the case where the reverse osmosis membrane processing apparatus 9 was provided as an example was explained on the downstream side of the electrolyzed water generating apparatus 7, However, it may be comprised so that it may be provided on the downstream side of the reverse osmosis membrane processing apparatus 9. Hydrogen dissolving devices such as the electrolyzed water generating device 7.

More specifically, for example, it may be configured such that an electrolytic water generating device 7 is provided at a position downstream of the reverse osmosis membrane processing device 9 and upstream of the UF module 30, and the dissolved hydrogen generated by the electrolytic water generating device 7 Water is supplied to devices such as the UF module 30 and the dialysate preparation device 26.

In this case, as in the above embodiment, after the treatment with the dialysate is completed, the pre-treated water that is not processed by the electrolytic water generating device 7 is supplied to the UF module through the electrolytic water generating device 7. 30, dialysate preparation device 26 and other devices. It should be noted that, in this case, a configuration may be adopted in which the reverse osmosis water 25 supplied from the reverse osmosis membrane processing device 9 is supplied instead of the pretreatment water.

According to such a configuration, in devices such as the UF module 30 and the dialysate preparation device 26, hydrogen, which is an active energy source of hydrogen bacteria, is reduced, and the proliferation of hydrogen bacteria in the device can be suppressed.

As described above, in the present invention, after the treatment with the dialysate 27 is completed, the pretreated water (or reverse osmosis water 25) is supplied to all the devices to which the dissolved hydrogen water is supplied, whereby the dialysate 27 is reused. When the patient 50 is treated, a decrease in the dissolved hydrogen concentration caused by the hydrogen bacteria can be suppressed.

It should be noted that, in this case, the same configuration as in the above embodiment may be adopted: the pre-treated water (or The reverse osmosis water 25) is supplied to the UF module 30 and the dialysate preparation device 26.

[Industrial availability]

In summary, the present invention is particularly useful for a method of cleaning a manufacturing apparatus for a dialysate in which hydrogen is dissolved.

1‧‧‧ manufacturing equipment for dialysate

2‧‧‧ raw water

3‧‧‧ pre-filter

4‧‧‧soft hydration device

5‧‧‧ carbon filter

7‧‧‧ Electrolyzed water generation device (hydrogen dissolution device)

8‧‧‧ Electrolytic water tank

9‧‧‧ reverse osmosis membrane processing device

25‧‧‧ reverse osmosis water

26‧‧‧dialysate preparation device

27‧‧‧ dialysate

30‧‧‧UF module

36‧‧‧ reverse osmosis membrane

37‧‧‧Reverse Osmosis Water Tank

40‧‧‧dialysis device

50‧‧‧patients

Claims (4)

A cleaning method for a dialysate manufacturing apparatus, the dialysate manufacturing apparatus includes at least: a hydrogen dissolving device for dissolving hydrogen in pre-treated water; and a device to which dissolved hydrogen water that is connected to the hydrogen dissolving device and dissolves the hydrogen is supplied The cleaning method of the dialysate manufacturing device includes the steps of: after the treatment using the dialysate is completed, supplying the pretreated water that has not been processed by the hydrogen dissolving device to the device via the hydrogen dissolving device. A cleaning method for a dialysate manufacturing apparatus, the dialysate manufacturing apparatus includes at least: a hydrogen dissolving device for dissolving hydrogen in pre-treated water; and a device to which dissolved hydrogen water that is connected to the hydrogen dissolving device and dissolves the hydrogen is supplied The cleaning method of the dialysate manufacturing device includes the steps of: after the treatment using the dialysate is completed, supplying the pretreated water that has not been processed by the hydrogen dissolving device to the device without passing through the hydrogen dissolving device. The cleaning method for a dialysate manufacturing apparatus according to claim 1 or 2, wherein the apparatus is a reverse osmosis membrane processing apparatus that performs a reverse osmosis membrane process on the dissolved hydrogen water. The cleaning method for a dialysate manufacturing device according to any one of claims 1 to 3, wherein the hydrogen dissolving device is a hydrogen pressurizing device, The hydrogen pressurizing device contacts hydrogen gas with the pretreatment water and pressurizes the hydrogen gas, thereby dissolving the hydrogen in the pretreatment water.