JP6479140B2 - Cleaning method for dialysate production equipment - Google Patents

Description

  The present invention relates to a method for cleaning a dialysate manufacturing apparatus.

  Hemodialysis is one of the effective treatments for renal failure patients who have impaired kidney function and cannot excrete urine to regulate water content and remove harmful substances such as urea. Are known.

  In this hemodialysis, blood is extracted from the body using a blood pump, and the dialysate and blood are brought into contact with each other through a dialyzer, thereby utilizing a diffusion phenomenon due to a concentration gradient to remove harmful substances from the body. In addition, after removing water, the blood is returned to the body again (returning blood).

  In recent years, it is known that oxidative stress occurs in dialysis patients during hemodialysis. This is considered to be caused by active oxygen generated during dialysis, and it has been proposed to eliminate this active oxygen to reduce oxidative stress.

  For example, a method for producing a dialysate in which high-concentration hydrogen is dissolved by dissolving hydrogen in purified water (hereinafter referred to as “reverse osmosis water”) treated with a reverse osmosis membrane (RO membrane) is proposed. Has been. By using this dialysate, hydrogen can be reacted with hydroxy radicals in the living body to suppress oxidative stress and inflammatory reaction.

  In addition, conventionally, water used as dialysate preparation water is dissolved (dissolved) by performing electrolysis on the raw water before the treatment with the reverse osmosis membrane (dissolved hydrogen water). Generation is performed (for example, refer to Patent Document 1).

JP 2000-350989 A

  Here, in general, hydrogen bacteria are known that oxidize hydrogen in liberation and fix carbon dioxide by utilizing energy generated by the reaction between hydrogen and oxygen, and this hydrogen bacterium is dissolved in dissolved hydrogen water. May be propagated using hydrogen.

  Therefore, for example, in a reverse osmosis membrane supplied with dissolved hydrogen water generated by electrolysis, if hydrogen bacteria propagate using hydrogen in the dissolved hydrogen, the dissolved hydrogen concentration of the dissolved hydrogen water decreases. In the dialysate at the end (that is, the dialysate supplied to the dialyzer and used to purify the blood of the patient through the dialyzer), a desired dissolved hydrogen concentration cannot be obtained.

  Accordingly, the present invention has been made in view of the above-described problems, and can produce a desired dissolved hydrogen concentration in a terminal dialysate by suppressing a decrease in the dissolved hydrogen concentration due to hydrogen bacteria. An object is to provide a method for cleaning an apparatus.

  In order to achieve the above object, a method for cleaning a dialysate production apparatus according to the present invention includes a hydrogen dissolving apparatus for dissolving hydrogen in pretreated water, and a dissolved hydrogen water that is connected to the hydrogen dissolving apparatus and dissolved in hydrogen. In the cleaning method of the dialysate production apparatus, which includes at least a cleaning device and a cleaning water supply device that is connected to the device and supplies cleaning water for cleaning the device, the cleaning water is processed by a hydrogen dissolving device. There is no pretreatment water, and after the treatment with the dialysate is completed, the cleaning water is supplied to the apparatus via the cleaning water supply apparatus.

  According to this configuration, since cleaning water, which is pretreatment water having a very low dissolved hydrogen concentration compared to dissolved hydrogen water, is supplied to the apparatus, in the apparatus to which dissolved hydrogen water is supplied, Hydrogen that is the source of active energy can be reduced, and the growth of hydrogen bacteria in the device can be suppressed. As a result, when the patient is treated again with the dialysate, the decrease in the dissolved hydrogen concentration caused by hydrogen bacteria can be suppressed.

  ADVANTAGE OF THE INVENTION According to this invention, the reduction | decrease of the dissolved hydrogen concentration by hydrogen bacteria can be suppressed, and a desired dissolved hydrogen concentration can be obtained in the terminal dialysate.

It is a conceptual diagram which shows the structure of the manufacturing apparatus of the dialysate which concerns on embodiment of this invention. It is a figure which shows the electrolytic vessel in the electrolyzed water production | generation apparatus of the manufacturing apparatus of the dialysate which concerns on embodiment of this invention. It is a flowchart for demonstrating the washing | cleaning method of the dialysate manufacturing apparatus which concerns on embodiment of this invention. It is a conceptual diagram which shows the structure of the manufacturing apparatus of the dialysate which concerns on the modification of this invention. It is a conceptual diagram which shows the structure of the manufacturing apparatus of the dialysate which concerns on the modification of this invention.

  FIG. 1 is a conceptual diagram showing a configuration of a dialysate manufacturing apparatus according to an embodiment of the present invention. Moreover, FIG. 2 is a figure which shows the electrolytic cell in the electrolyzed water production | generation apparatus of the dialysate manufacturing apparatus based on the 1st Embodiment of this invention.

  The dialysate production apparatus 1 is connected to a prefilter 3, a water softening device 4 connected to the prefilter 3, a carbon filter (activated carbon treatment device) 5 connected to the water softening device 4, and a carbon filter 5. The electrolyzed water generating device 7, the electrolyzed water tank 8 connected to the electrolyzed water generating device 7, the reverse osmosis membrane treatment device 9 connected to the electrolyzed water tank 8, and the UF connected to the reverse osmosis membrane treatment device 9 (Ultra Filter) module 30.

  The prefilter 3 is for removing impurities (for example, iron rust and sand particles) from the raw water 2 (hard water containing dissolved solids such as calcium ions and magnesium ions which are hardness components).

  The water softening device 4 is for removing the hardness component from the raw water 2 by ion exchange and performing softening water by ion exchange. In the present embodiment, tap water, well water, ground water, or the like can be used as the raw water 2.

  The carbon filter 5 removes residual chlorine, chloramine, organic matter, etc. contained in the raw water from the raw water treated by the water softening device 4 by a physical adsorption action using activated carbon, which is a porous adsorbent. It is for performing the process to perform.

  In addition, a well-known thing can be used as the above-mentioned water softening apparatus 4 and the carbon filter 5. FIG.

  The electrolyzed water generating device 7 functions as a hydrogen dissolving device, and hydrogen used as dialysate preparation water is dissolved by subjecting the raw water 2 treated by the carbon filter 5 to electrolysis. It is for producing water (dissolved hydrogen water).

  Moreover, the electrolyzed water generating apparatus 7 of this embodiment is equipped with the electrolytic cell 20 which has the solid polymer membrane (solid polymer electrolyte membrane) 10 shown in FIG.

  As shown in FIG. 2, the electrolytic cell 20 is a power supply body that is disposed to face each other with the solid polymer film 10 and the solid polymer film 10 interposed therebetween, and that supplies power to the electrolytic cell 20. An anode 11 and a cathode 12, and a dielectric layer 13 disposed between the solid polymer film 10 and the anode 11 and between the solid polymer film 10 and the cathode 12 are provided.

  As shown in FIG. 2, the anode 11 and the cathode 12 are electrically connected, and the solid polymer film 10, the anode 11, the cathode 12, and the dielectric layer 13 are connected to the electrolytic cell body 15. Housed inside.

  Moreover, as shown in FIG. 2, the electrolytic cell main body 15 is subjected to electrolysis, and raw water 2 treated by the prefilter 3, the water softening device 4, and the carbon filter 5 (hereinafter referred to as “pretreated water”). .) Is introduced into the electrolytic cell main body 15.

  Examples of the material of the anode 11 and the cathode 12 include titanium and platinum.

  Moreover, as a material which forms the dielectric material layer 13, titanium, platinum, etc. are mentioned, for example.

The solid polymer film 10 has a role of moving oxonium ions (H ₃ O ⁺ ) generated on the anode 11 side to the cathode 12 side by electrolysis.

  As the solid polymer film 10, for example, a film formed of a fluorine-based resin material having a sulfonic acid group can be used. More specifically, commercially available products such as Nafion (manufactured by DuPont), Flemion (manufactured by Asahi Glass), and Aciplex (manufactured by Asahi Glass) can be used as the solid polymer film 10 in the present invention.

In the electrolysis in the electrolyzed water generating apparatus 7 using such a solid polymer membrane 10, the following reactions occur on the anode 11 side and the cathode 12 side, respectively.
Anode side: 6H ₂ O → 4H ₃ O ⁺ + O ₂ + 4e ⁻
Cathode side: 4H ₃ O ⁺ + 4e ⁻ → 2H ₂ + 4H ₂ O

  And the treated water (dissolved hydrogen water) 17 produced | generated by the above-mentioned electrolysis process is sent to the electrolyzed water tank 8 connected to the electrolyzed water production | generation apparatus 7 by the water supply path 18 formed in the cathode side of the electrolytic cell main body 15. FIG. Sent. In addition, the dissolved oxygen water 19 generated on the anode side by the electrolysis treatment is discharged to the outside through the drainage channel 21 formed on the anode side of the electrolytic cell body 15.

  The electrolyzed water tank 8 is for storing the dissolved hydrogen water generated by the electrolyzed water generator 7.

  The reverse osmosis membrane treatment device 9 is configured to prevent a phenomenon (osmosis) in which water moves from a low-concentration solution to a high-concentration solution when there are solutions having different concentrations at the semipermeable membrane as a boundary. By applying pressure to the water, the water is transferred from the high-concentration side solution to the low-concentration side solution to obtain water permeated to the low-concentration side (reverse osmosis membrane treatment).

  And since this reverse osmosis membrane processing apparatus 9 can further remove impurities, such as trace metals, from the pretreatment water obtained by the above-mentioned series of processing, it is prescribed in ISO13959 (dialysis water standard). It becomes possible to obtain water (reverse osmosis water) that satisfies water quality standards.

  As shown in FIG. 1, the reverse osmosis membrane treatment device 9 includes a reverse osmosis membrane 36 that performs the above-mentioned reverse osmosis membrane treatment on the dissolved hydrogen water produced by the electrolyzed water production device 7, and a reverse osmosis membrane treatment. A reverse osmosis water tank 37 is provided for storing the reverse osmosis water made.

  The UF module 30 is for performing a process of removing bacteria and microorganisms contained in the reverse osmosis water 25.

  As shown in FIG. 1, the dialysate preparation device 26 is connected to the UF module 30, and the reverse osmosis water 25 that has been processed by the UF module 30 is supplied to the dialysate preparation device 26. The

  In the dialysate preparation device 26, a dialysate 27 is prepared by mixing the supplied reverse osmosis water 25 and the dialysate stock solution, and this dialysate 27 is supplied to the dialyzer 40 connected to the dialysate preparation device 26. Then, the blood of the patient 50 is purified, and the patient 50 is treated with the dialysate 27. That is, the dialysate preparation device 26 also functions as a dialysate supply device that supplies the prepared dialysate 27 to the dialyzer 40.

  Next, the washing | cleaning method of the dialysate manufacturing apparatus 1 is demonstrated.

  FIG. 3 is a flowchart for explaining a cleaning method of the dialysate manufacturing apparatus according to the embodiment of the present invention.

  First, after the treatment of the patient 50 with the dialysate 27 described above (step S1), the electrolyzed water generating device 7 is turned off, and the electrolysis process (ie, generation of dissolved hydrogen water) by the electrolyzed water generating device 7 is completed. (Step S2).

  Next, pretreatment water is supplied to the electrolyzed water generating device 7 as in the case of the treatment of the patient 50 with the dialysate 27 described above (step S3). At this time, as described above, since the switch of the electrolyzed water generating device 7 is OFF, the electrolyzed process by the electrolyzed water generating device 7 is performed instead of the treated water (dissolved hydrogen water) 17 generated by the electrolyzed process. Untreated pretreatment water is supplied to the reverse osmosis membrane treatment device 9 (that is, the reverse osmosis membrane 36) (step S4).

  That is, in the present embodiment, after the treatment with the dialysate 27 is completed, pretreated water that has not been subjected to electrolysis treatment by the electrolyzed water generating device 7 is supplied to the reverse osmosis membrane processing device 9 via the electrolyzed water generating device 7. It is configured to supply.

  Therefore, since the pretreated water having a very low dissolved hydrogen concentration (including the case where the dissolved hydrogen is 0) is supplied as compared with the dissolved hydrogen water 17, the reverse osmosis membrane 36 has the activity energy of hydrogen bacteria. By reducing the original hydrogen, the propagation of hydrogen bacteria in the reverse osmosis membrane 36 can be suppressed (step S5). As a result, when the patient 50 is treated again with the dialysate 27, it is possible to suppress a decrease in the dissolved hydrogen concentration caused by hydrogen bacteria and obtain a desired dissolved hydrogen concentration in the terminal dialysate 27. become.

  In the present invention, for example, in the reverse osmosis membrane 36 using the same principle as the method for suppressing the growth of phytoplankton by the circulation of water using a stratified water fountain device or a climax lowering circulation facility (intermittent pumping cylinder). It is considered that the reproductive function of hydrogen bacteria is lowered by being alternately exposed to dissolved hydrogen water 17 having a high dissolved hydrogen concentration and treated water having a very low dissolved hydrogen concentration.

  Moreover, the supply time of the pretreatment water for washing | cleaning is not specifically limited, For example, after completion | finish of the treatment of the patient 50 by the dialysate 27, it can be set as the structure supplied for 10 to 60 minutes.

  In addition, you may change the said embodiment as follows.

  In the above embodiment, after the treatment with the dialysate is finished, the pretreated water that has not been processed by the electric water generating device 7 is supplied to the reverse osmosis membrane 36 via the electric water generating device 7. As shown in FIG. 4, the carbon filter 5 and the reverse osmosis membrane 36 are connected, and the pretreated water treated by the carbon filter 5 is supplied to the reverse osmosis membrane 36 without passing through the electrolyzed water generating device 7. It is good.

  That is, after the treatment with the dialysate 27 is completed, pretreatment water that has not been subjected to treatment by the electrolyzed water generating device 7 may be supplied to the reverse osmosis membrane 36 without going through the electrolyzed water generating device 7. With such a configuration, it becomes possible to supply the pretreated water to the reverse osmosis membrane 36 without turning off the power of the electrolyzed water generating device 7, and it is discharged on the anode side of the electrolyzed water generating device 7. Since the dissolved oxygen water 19 is not generated, the pretreated water can be used efficiently.

  In addition, a washing water supply device (not shown) for supplying washing water for washing is connected to the reverse osmosis membrane treatment device 9, and from the washing water supply device to the reverse osmosis membrane treatment device 9, corresponding to the pretreatment water. The cleaning water to be supplied may be supplied.

  Moreover, in the said embodiment, although it was set as the structure which uses the electrolyzed water generating apparatus 7 as a hydrogen dissolving apparatus, if it can dissolve hydrogen with respect to the raw | natural water 2 processed with the carbon filter 5, Any configuration may be used.

  For example, hydrogen may be dissolved by bringing hydrogen gas into contact with the raw water 2 treated by the activated carbon treatment apparatus 5.

  More specifically, as a hydrogen dissolving apparatus, a hollow fiber is formed using a membrane module including a sleeve to which hydrogen gas is supplied and a hollow fiber disposed inside the sleeve and having a plurality of holes formed therein. A method of bringing hydrogen gas into contact with the raw water 2 treated by the carbon filter 5 through the formed holes can be employed.

  Moreover, the structure which keeps the dissolved hydrogen concentration in the raw | natural water 2 processed by the carbon filter 5 at a desired high density | concentration by pressurizing the raw | natural water 2 which hydrogen gas melt | dissolved, and raising the density | concentration of the hydrogen gas contained in the raw | natural water 2 It is good.

  More specifically, as shown in FIG. 5, the dialysate production apparatus 80 is connected to the carbon filter 5 instead of the electrolyzed water generation apparatus 7 shown in FIG. A hydrogen gas pressurizing device 85 having a module 81 and a pressurizing tank 82 which is connected to the membrane module 81 and dissolves hydrogen in the raw water 2 by pressurizing hydrogen gas is provided.

  The hydrogen gas pressurizing device 85 includes a pressure adjusting valve 84 connected to the pressurizing tank 82. Then, by controlling the pressure adjusting valve 84, the pressure when hydrogen is pressurized by the pressurizing tank 82 is controlled to adjust the concentration of hydrogen gas contained in the raw water 2.

  Moreover, in the said embodiment, although the case where the reverse osmosis membrane processing apparatus 9 was provided in the downstream of the electrolyzed water generating apparatus 7 was mentioned as an example, the electrolyzed water generating apparatus was provided in the downstream of the reverse osmosis membrane processing apparatus 9. It is good also as a structure which provides hydrogen dissolving apparatuses, such as 7.

  More specifically, for example, the electrolyzed water generating device 7 is provided on the downstream side of the reverse osmosis membrane treatment device 9 and upstream of the UF module 30, and the dissolved hydrogen water generated by the electric water generating device 7 is It is good also as a structure supplied to apparatuses, such as UF module 30 and the dialysate adjustment apparatus 26. FIG.

  Also in this case, as in the above embodiment, after the treatment with the dialysate is completed, the pretreated water that has not been subjected to the treatment by the electric water generating device 7 is supplied to the UF module 30 or the dialysis via the electric water generating device 7. It supplies to apparatuses, such as the liquid adjustment apparatus 26. In this case, instead of the pretreatment water, the reverse osmosis water 25 supplied from the reverse osmosis membrane treatment device 9 may be supplied.

  With such a configuration, in the devices such as the UF module 30 and the dialysate adjusting device 26, it is possible to reduce the hydrogen that is the source of the active energy of hydrogen bacteria and to suppress the growth of hydrogen bacteria in these devices. .

  Thus, in the present invention, dialysis is again performed by supplying pretreatment water (or reverse osmosis water 25) to all devices to which dissolved hydrogen water is supplied after the treatment with the dialysate 27 is completed. When treating the patient 50 with the liquid 27, it is possible to suppress a decrease in dissolved hydrogen concentration caused by hydrogen bacteria.

  In this case as well, as in the above embodiment, the pretreated water (or reverse osmosis water 25) may be supplied to the UF module 30 and the dialysate adjusting device 26 without passing through the electrolyzed water generating device 7. Good.

  As described above, the present invention is particularly useful for a method for cleaning a dialysate production apparatus in which hydrogen is dissolved.

DESCRIPTION OF SYMBOLS 1 Dialysate manufacturing apparatus 2 Raw water 3 Pre-filter 4 Water softening device 5 Carbon filter 7 Electrolyzed water production device (hydrogen dissolving device)
DESCRIPTION OF SYMBOLS 8 Electrolyzed water tank 9 Reverse osmosis membrane processing apparatus 10 Solid polymer film 11 Anode 12 Cathode 13 Dielectric layer 15 Electrolyzer main body 16 Introductory path 17 Treated water 18 Water supply path 19 Dissolved oxygen water 20 Electrolytic tank 21 Drainage path 25 Reverse osmosis water 26 Dialysate Preparation Device 27 Dialysate 32 Control Device 33 Electrolytic Current Determination Means 34 Electrolysis Current Supply Means 35 Storage Means 36 Reverse Osmosis Membrane 37 Reverse Osmosis Water Tank 40 Dialysis Device 50 Patient 80 Dialysate Production Device 81 Membrane Module 82 Pressurization Tank 84 Pressure adjustment valve 85 Hydrogen gas pressurizer

Claims (2)

A hydrogen dissolution apparatus for dissolving hydrogen in pretreated water;
A reverse osmosis membrane treatment device connected to the hydrogen dissolution device, supplied with dissolved hydrogen water in which the hydrogen is dissolved, and performing reverse osmosis membrane treatment on the dissolved hydrogen water ;
A reverse osmosis water connected to the reverse osmosis membrane treatment device and subjected to reverse osmosis membrane treatment by the reverse osmosis membrane treatment device is supplied, and a dialysate is prepared by mixing the reverse osmosis water and the dialysis stock solution. A dialysate adjusting device;
Connected to said reverse osmosis membrane treatment apparatus, in the cleaning method of least comprising dialysate preparation device and a cleaning water supply device for supplying cleaning water for cleaning the reverse osmosis membrane treatment apparatus,
The washing water corresponds to the pretreated water that has not been treated by the hydrogen dissolving device,
A cleaning method for a dialysate manufacturing apparatus, wherein the cleaning water is supplied from the cleaning water supply device to the reverse osmosis membrane treatment device after completion of treatment with dialysate. The hydrogen dissolving apparatus is a hydrogen gas pressurizing apparatus for dissolving the hydrogen in the pretreated water by bringing hydrogen gas into contact with the pretreated water and pressurizing the hydrogen gas. 2. A method for cleaning a dialysate production apparatus according to 1 .

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