TW201536278A - 雙脫水半乳糖醇及其類似物與衍生物用於治療復發性惡性神經膠瘤或進行性繼發腦瘤之用途 - Google Patents

Info

Publication number

TW201536278A

TW201536278A TW103118945A TW103118945A TW201536278A TW 201536278 A TW201536278 A TW 201536278A TW 103118945 A TW103118945 A TW 103118945A TW 103118945 A TW103118945 A TW 103118945A TW 201536278 A TW201536278 A TW 201536278A

Authority

TW

Taiwan

Prior art keywords

combination

group

derivative

inhibitor

hexitol derivative

Prior art date

2013-05-31

Links

• Espacenet
• Global Dossier
• Discuss

• 238000011282 treatment Methods 0.000 title claims abstract description 96
• 208000003174 Brain Neoplasms Diseases 0.000 title claims abstract description 76
• 229950000758 dianhydrogalactitol Drugs 0.000 title claims abstract description 75
• 230000000750 progressive effect Effects 0.000 title claims abstract description 71
• AAFJXZWCNVJTMK-GUCUJZIJSA-N (1s,2r)-1-[(2s)-oxiran-2-yl]-2-[(2r)-oxiran-2-yl]ethane-1,2-diol Chemical compound C([C@@H]1[C@H](O)[C@H](O)[C@H]2OC2)O1 AAFJXZWCNVJTMK-GUCUJZIJSA-N 0.000 title claims abstract description 68
• 230000000306 recurrent effect Effects 0.000 title claims abstract description 63
• 230000003211 malignant effect Effects 0.000 title claims description 5
• FBPFZTCFMRRESA-UHFFFAOYSA-N hexane-1,2,3,4,5,6-hexol Chemical class OCC(O)C(O)C(O)C(O)CO FBPFZTCFMRRESA-UHFFFAOYSA-N 0.000 claims abstract description 247
• 238000000034 method Methods 0.000 claims abstract description 119
• 201000011510 cancer Diseases 0.000 claims abstract description 103
• -1 dianhydrogalactitol Chemical class 0.000 claims abstract description 84
• 239000000203 mixture Substances 0.000 claims abstract description 69
• 206010018338 Glioma Diseases 0.000 claims abstract description 49
• 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims abstract description 49
• 239000003814 drug Substances 0.000 claims description 116
• 230000001965 increasing effect Effects 0.000 claims description 94
• 239000003795 chemical substances by application Substances 0.000 claims description 92
• 239000003112 inhibitor Substances 0.000 claims description 92
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 88
• 229940079593 drug Drugs 0.000 claims description 83
• 150000001875 compounds Chemical class 0.000 claims description 79
• 230000000694 effects Effects 0.000 claims description 67
• 125000000217 alkyl group Chemical group 0.000 claims description 63
• 230000006872 improvement Effects 0.000 claims description 63
• 206010028980 Neoplasm Diseases 0.000 claims description 56
• 239000000651 prodrug Substances 0.000 claims description 55
• 229940002612 prodrug Drugs 0.000 claims description 55
• 210000004027 cell Anatomy 0.000 claims description 52
• 238000002512 chemotherapy Methods 0.000 claims description 52
• IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 claims description 49
• 238000002560 therapeutic procedure Methods 0.000 claims description 45
• 108090000623 proteins and genes Proteins 0.000 claims description 42
• 201000010099 disease Diseases 0.000 claims description 38
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 38
• 230000001976 improved effect Effects 0.000 claims description 35
• 239000008194 pharmaceutical composition Substances 0.000 claims description 35
• RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims description 34
• 229940043355 kinase inhibitor Drugs 0.000 claims description 33
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 30
• 230000001225 therapeutic effect Effects 0.000 claims description 30
• 229910052799 carbon Inorganic materials 0.000 claims description 29
• 230000001186 cumulative effect Effects 0.000 claims description 27
• 239000003757 phosphotransferase inhibitor Substances 0.000 claims description 27
• VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims description 26
• DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 claims description 24
• 102000001253 Protein Kinase Human genes 0.000 claims description 24
• 108060006633 protein kinase Proteins 0.000 claims description 24
• 206010065553 Bone marrow failure Diseases 0.000 claims description 23
• 102000004190 Enzymes Human genes 0.000 claims description 23
• 108090000790 Enzymes Proteins 0.000 claims description 23
• 229960001338 colchicine Drugs 0.000 claims description 23
• 102000004169 proteins and genes Human genes 0.000 claims description 23
• 229940124597 therapeutic agent Drugs 0.000 claims description 23
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 22
• 235000018102 proteins Nutrition 0.000 claims description 22
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 21
• 238000004458 analytical method Methods 0.000 claims description 21
• 150000001721 carbon Chemical group 0.000 claims description 21
• 230000005764 inhibitory process Effects 0.000 claims description 21
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 21
• 230000001988 toxicity Effects 0.000 claims description 21
• 231100000419 toxicity Toxicity 0.000 claims description 21
• 230000027455 binding Effects 0.000 claims description 20
• 208000005017 glioblastoma Diseases 0.000 claims description 20
• 239000000126 substance Substances 0.000 claims description 20
• 239000002904 solvent Substances 0.000 claims description 19
• WVTKBKWTSCPRNU-KYJUHHDHSA-N (+)-Tetrandrine Chemical compound C([C@H]1C=2C=C(C(=CC=2CCN1C)OC)O1)C(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2C[C@@H]2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-KYJUHHDHSA-N 0.000 claims description 18
• DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 18
• 229940093265 berberine Drugs 0.000 claims description 18
• QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims description 18
• 230000006870 function Effects 0.000 claims description 18
• 230000014509 gene expression Effects 0.000 claims description 18
• ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 claims description 18
• 125000005843 halogen group Chemical group 0.000 claims description 18
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 18
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 18
• 238000012544 monitoring process Methods 0.000 claims description 18
• LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims description 17
• 229940100198 alkylating agent Drugs 0.000 claims description 17
• 239000002168 alkylating agent Substances 0.000 claims description 17
• YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims description 17
• 229960001948 caffeine Drugs 0.000 claims description 17
• VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims description 17
• 229960002949 fluorouracil Drugs 0.000 claims description 17
• 229940045109 genistein Drugs 0.000 claims description 17
• 235000006539 genistein Nutrition 0.000 claims description 17
• TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 claims description 17
• 125000005647 linker group Chemical group 0.000 claims description 17
• 238000002360 preparation method Methods 0.000 claims description 17
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 16
• ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical compound CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 claims description 16
• 239000003534 dna topoisomerase inhibitor Substances 0.000 claims description 16
• 150000002148 esters Chemical class 0.000 claims description 16
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
• 229940044693 topoisomerase inhibitor Drugs 0.000 claims description 16
• 206010006187 Breast cancer Diseases 0.000 claims description 15
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 15
• 239000003085 diluting agent Substances 0.000 claims description 15
• 239000002552 dosage form Substances 0.000 claims description 15
• 238000012377 drug delivery Methods 0.000 claims description 15
• 229910052739 hydrogen Inorganic materials 0.000 claims description 15
• 238000001802 infusion Methods 0.000 claims description 15
• 230000017128 negative regulation of NF-kappaB transcription factor activity Effects 0.000 claims description 15
• 229920001223 polyethylene glycol Polymers 0.000 claims description 15
• 230000002829 reductive effect Effects 0.000 claims description 15
• 108090001008 Avidin Proteins 0.000 claims description 14
• 229940022399 cancer vaccine Drugs 0.000 claims description 14
• 238000009566 cancer vaccine Methods 0.000 claims description 14
• 229960004316 cisplatin Drugs 0.000 claims description 14
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims description 14
• 229960000684 cytarabine Drugs 0.000 claims description 14
• 239000001257 hydrogen Substances 0.000 claims description 14
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 14
• 230000002503 metabolic effect Effects 0.000 claims description 14
• 230000004048 modification Effects 0.000 claims description 14
• 238000012986 modification Methods 0.000 claims description 14
• FAWLNURBQMTKEB-URDPEVQOSA-N 213546-53-3 Chemical compound N([C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1[C@@H](CCC1)C(O)=O)C(C)C)C(C)C)C(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)N)C(C)C FAWLNURBQMTKEB-URDPEVQOSA-N 0.000 claims description 13
• 229940122803 Vinca alkaloid Drugs 0.000 claims description 13
• 239000002253 acid Substances 0.000 claims description 13
• 229940117893 apigenin Drugs 0.000 claims description 13
• 235000008714 apigenin Nutrition 0.000 claims description 13
• KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 claims description 13
• XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 claims description 13
• 229940109262 curcumin Drugs 0.000 claims description 13
• 235000012754 curcumin Nutrition 0.000 claims description 13
• 239000004148 curcumin Substances 0.000 claims description 13
• VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims description 13
• DOUMFZQKYFQNTF-MRXNPFEDSA-N rosemarinic acid Natural products C([C@H](C(=O)O)OC(=O)C=CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-MRXNPFEDSA-N 0.000 claims description 13
• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 claims description 12
• 108020004414 DNA Proteins 0.000 claims description 12
• 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims description 12
• 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims description 12
• 102000003964 Histone deacetylase Human genes 0.000 claims description 12
• 108090000353 Histone deacetylase Proteins 0.000 claims description 12
• 206010027476 Metastases Diseases 0.000 claims description 12
• ZZAFFYPNLYCDEP-HNNXBMFYSA-N Rosmarinsaeure Natural products OC(=O)[C@H](Cc1cccc(O)c1O)OC(=O)C=Cc2ccc(O)c(O)c2 ZZAFFYPNLYCDEP-HNNXBMFYSA-N 0.000 claims description 12
• BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 claims description 12
• 230000015572 biosynthetic process Effects 0.000 claims description 12
• 229940127093 camptothecin Drugs 0.000 claims description 12
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims description 12
• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 claims description 12
• 230000009401 metastasis Effects 0.000 claims description 12
• 102000005962 receptors Human genes 0.000 claims description 12
• 108020003175 receptors Proteins 0.000 claims description 12
• TVHVQJFBWRLYOD-UHFFFAOYSA-N rosmarinic acid Natural products OC(=O)C(Cc1ccc(O)c(O)c1)OC(=Cc2ccc(O)c(O)c2)C=O TVHVQJFBWRLYOD-UHFFFAOYSA-N 0.000 claims description 12
• 150000003839 salts Chemical class 0.000 claims description 12
• 230000011664 signaling Effects 0.000 claims description 12
• 102000004127 Cytokines Human genes 0.000 claims description 11
• 108090000695 Cytokines Proteins 0.000 claims description 11
• 206010059866 Drug resistance Diseases 0.000 claims description 11
• FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 11
• 206010041067 Small cell lung cancer Diseases 0.000 claims description 11
• 229940121363 anti-inflammatory agent Drugs 0.000 claims description 11
• 239000002260 anti-inflammatory agent Substances 0.000 claims description 11
• 230000000340 anti-metabolite Effects 0.000 claims description 11
• 230000000692 anti-sense effect Effects 0.000 claims description 11
• 229940100197 antimetabolite Drugs 0.000 claims description 11
• 239000002256 antimetabolite Substances 0.000 claims description 11
• 230000006907 apoptotic process Effects 0.000 claims description 11
• 201000008274 breast adenocarcinoma Diseases 0.000 claims description 11
• 230000000973 chemotherapeutic effect Effects 0.000 claims description 11
• 201000001441 melanoma Diseases 0.000 claims description 11
• 208000000587 small cell lung carcinoma Diseases 0.000 claims description 11
• 229960004964 temozolomide Drugs 0.000 claims description 11
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 claims description 11
• 239000005483 tyrosine kinase inhibitor Substances 0.000 claims description 11
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 10
• 239000012661 PARP inhibitor Substances 0.000 claims description 10
• 108091000080 Phosphotransferase Proteins 0.000 claims description 10
• 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 claims description 10
• RADKZDMFGJYCBB-UHFFFAOYSA-N Pyridoxal Chemical compound CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 10
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 10
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 10
• 239000008186 active pharmaceutical agent Substances 0.000 claims description 10
• 235000019445 benzyl alcohol Nutrition 0.000 claims description 10
• 238000002651 drug therapy Methods 0.000 claims description 10
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims description 10
• 238000009472 formulation Methods 0.000 claims description 10
• FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 claims description 10
• 229960000485 methotrexate Drugs 0.000 claims description 10
• 230000036457 multidrug resistance Effects 0.000 claims description 10
• 102000020233 phosphotransferase Human genes 0.000 claims description 10
• 150000003057 platinum Chemical class 0.000 claims description 10
• 238000001959 radiotherapy Methods 0.000 claims description 10
• 239000003734 thymidylate synthase inhibitor Substances 0.000 claims description 10
• 208000032612 Glial tumor Diseases 0.000 claims description 9
• 239000002202 Polyethylene glycol Substances 0.000 claims description 9
• 239000002246 antineoplastic agent Substances 0.000 claims description 9
• 125000002619 bicyclic group Chemical group 0.000 claims description 9
• 210000004369 blood Anatomy 0.000 claims description 9
• 239000008280 blood Substances 0.000 claims description 9
• 229960005420 etoposide Drugs 0.000 claims description 9
• 229930003935 flavonoid Natural products 0.000 claims description 9
• 150000002215 flavonoids Chemical class 0.000 claims description 9
• 235000017173 flavonoids Nutrition 0.000 claims description 9
• 108020001507 fusion proteins Proteins 0.000 claims description 9
• 210000000987 immune system Anatomy 0.000 claims description 9
• 230000004060 metabolic process Effects 0.000 claims description 9
• 239000002207 metabolite Substances 0.000 claims description 9
• 230000003285 pharmacodynamic effect Effects 0.000 claims description 9
• 229920000642 polymer Polymers 0.000 claims description 9
• 210000002307 prostate Anatomy 0.000 claims description 9
• 239000003909 protein kinase inhibitor Substances 0.000 claims description 9
• WVTKBKWTSCPRNU-UHFFFAOYSA-N rac-Tetrandrin Natural products O1C(C(=CC=2CCN3C)OC)=CC=2C3CC(C=C2)=CC=C2OC(=C2)C(OC)=CC=C2CC2N(C)CCC3=CC(OC)=C(OC)C1=C23 WVTKBKWTSCPRNU-UHFFFAOYSA-N 0.000 claims description 9
• 230000008439 repair process Effects 0.000 claims description 9
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims description 8
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
• 230000001062 anti-nausea Effects 0.000 claims description 8
• 239000011230 binding agent Substances 0.000 claims description 8
• 230000008499 blood brain barrier function Effects 0.000 claims description 8
• 210000001218 blood-brain barrier Anatomy 0.000 claims description 8
• 238000013270 controlled release Methods 0.000 claims description 8
• ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 claims description 8
• 102000037865 fusion proteins Human genes 0.000 claims description 8
• 238000001415 gene therapy Methods 0.000 claims description 8
• 230000003993 interaction Effects 0.000 claims description 8
• 238000001990 intravenous administration Methods 0.000 claims description 8
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims description 8
• 229960001156 mitoxantrone Drugs 0.000 claims description 8
• 150000002924 oxiranes Chemical group 0.000 claims description 8
• 230000005855 radiation Effects 0.000 claims description 8
• 238000011084 recovery Methods 0.000 claims description 8
• 238000013268 sustained release Methods 0.000 claims description 8
• 239000012730 sustained-release form Substances 0.000 claims description 8
• 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 claims description 8
• 229920000858 Cyclodextrin Polymers 0.000 claims description 7
• 102000001301 EGF receptor Human genes 0.000 claims description 7
• 108060006698 EGF receptor Proteins 0.000 claims description 7
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 7
• 108090001061 Insulin Proteins 0.000 claims description 7
• 102000004877 Insulin Human genes 0.000 claims description 7
• 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 claims description 7
• 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 claims description 7
• 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 claims description 7
• 102000004338 Transferrin Human genes 0.000 claims description 7
• 108090000901 Transferrin Proteins 0.000 claims description 7
• OXQKEKGBFMQTML-UHFFFAOYSA-N alpha-Glucoheptitol Chemical class OCC(O)C(O)C(O)C(O)C(O)CO OXQKEKGBFMQTML-UHFFFAOYSA-N 0.000 claims description 7
• 239000004359 castor oil Substances 0.000 claims description 7
• 235000019438 castor oil Nutrition 0.000 claims description 7
• 238000006243 chemical reaction Methods 0.000 claims description 7
• 108091006116 chimeric peptides Proteins 0.000 claims description 7
• 229940127089 cytotoxic agent Drugs 0.000 claims description 7
• 229940088679 drug related substance Drugs 0.000 claims description 7
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
• 239000012729 immediate-release (IR) formulation Substances 0.000 claims description 7
• 229940125396 insulin Drugs 0.000 claims description 7
• 230000036210 malignancy Effects 0.000 claims description 7
• 238000007726 management method Methods 0.000 claims description 7
• 230000007246 mechanism Effects 0.000 claims description 7
• 239000003607 modifier Substances 0.000 claims description 7
• 229920000056 polyoxyethylene ether Polymers 0.000 claims description 7
• 229940051841 polyoxyethylene ether Drugs 0.000 claims description 7
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 7
• 210000000130 stem cell Anatomy 0.000 claims description 7
• 208000024891 symptom Diseases 0.000 claims description 7
• 238000003786 synthesis reaction Methods 0.000 claims description 7
• 231100000331 toxic Toxicity 0.000 claims description 7
• 230000002588 toxic effect Effects 0.000 claims description 7
• 239000012581 transferrin Substances 0.000 claims description 7
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
• VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 claims description 6
• PLLBRTOLHQQAQQ-UHFFFAOYSA-N 8-methylnonan-1-ol Chemical compound CC(C)CCCCCCCO PLLBRTOLHQQAQQ-UHFFFAOYSA-N 0.000 claims description 6
• 108010088751 Albumins Proteins 0.000 claims description 6
• 102000009027 Albumins Human genes 0.000 claims description 6
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
• 102000004031 Carboxy-Lyases Human genes 0.000 claims description 6
• 108090000489 Carboxy-Lyases Proteins 0.000 claims description 6
• 238000009007 Diagnostic Kit Methods 0.000 claims description 6
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 6
• 101000634975 Homo sapiens Tripartite motif-containing protein 29 Proteins 0.000 claims description 6
• 108010074338 Lymphokines Proteins 0.000 claims description 6
• 102000008072 Lymphokines Human genes 0.000 claims description 6
• 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 claims description 6
• MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 6
• REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims description 6
• 229940122149 Thymidylate synthase inhibitor Drugs 0.000 claims description 6
• 230000004913 activation Effects 0.000 claims description 6
• 239000003963 antioxidant agent Substances 0.000 claims description 6
• 235000006708 antioxidants Nutrition 0.000 claims description 6
• 229960000397 bevacizumab Drugs 0.000 claims description 6
• 238000001815 biotherapy Methods 0.000 claims description 6
• 210000001185 bone marrow Anatomy 0.000 claims description 6
• 239000000872 buffer Substances 0.000 claims description 6
• 239000002775 capsule Substances 0.000 claims description 6
• 230000003828 downregulation Effects 0.000 claims description 6
• 239000000839 emulsion Substances 0.000 claims description 6
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
• 239000002502 liposome Substances 0.000 claims description 6
• 239000007788 liquid Substances 0.000 claims description 6
• 230000010534 mechanism of action Effects 0.000 claims description 6
• 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 claims description 6
• 229960003966 nicotinamide Drugs 0.000 claims description 6
• 235000005152 nicotinamide Nutrition 0.000 claims description 6
• 239000011570 nicotinamide Substances 0.000 claims description 6
• 239000002773 nucleotide Substances 0.000 claims description 6
• 125000003729 nucleotide group Chemical group 0.000 claims description 6
• 239000000816 peptidomimetic Substances 0.000 claims description 6
• NDTYTMIUWGWIMO-UHFFFAOYSA-N perillyl alcohol Chemical compound CC(=C)C1CCC(CO)=CC1 NDTYTMIUWGWIMO-UHFFFAOYSA-N 0.000 claims description 6
• 230000036470 plasma concentration Effects 0.000 claims description 6
• 230000035945 sensitivity Effects 0.000 claims description 6
• 150000003431 steroids Chemical class 0.000 claims description 6
• 230000002195 synergetic effect Effects 0.000 claims description 6
• 108090000994 Catalytic RNA Proteins 0.000 claims description 5
• 102000053642 Catalytic RNA Human genes 0.000 claims description 5
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
• 101000852815 Homo sapiens Insulin receptor Proteins 0.000 claims description 5
• 239000004440 Isodecyl alcohol Substances 0.000 claims description 5
• XNSAINXGIQZQOO-UHFFFAOYSA-N L-pyroglutamyl-L-histidyl-L-proline amide Natural products NC(=O)C1CCCN1C(=O)C(NC(=O)C1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-UHFFFAOYSA-N 0.000 claims description 5
• 239000005517 L01XE01 - Imatinib Substances 0.000 claims description 5
• 239000005536 L01XE08 - Nilotinib Substances 0.000 claims description 5
• 108700005126 Ornithine decarboxylases Proteins 0.000 claims description 5
• 102000052812 Ornithine decarboxylases Human genes 0.000 claims description 5
• 239000000627 Thyrotropin-Releasing Hormone Substances 0.000 claims description 5
• 102100023132 Transcription factor Jun Human genes 0.000 claims description 5
• 108010092464 Urate Oxidase Proteins 0.000 claims description 5
• 239000000654 additive Substances 0.000 claims description 5
• 150000001413 amino acids Chemical class 0.000 claims description 5
• 239000005557 antagonist Substances 0.000 claims description 5
• 230000001754 anti-pyretic effect Effects 0.000 claims description 5
• 230000000259 anti-tumor effect Effects 0.000 claims description 5
• 239000002221 antipyretic Substances 0.000 claims description 5
• 230000001472 cytotoxic effect Effects 0.000 claims description 5
• 238000005516 engineering process Methods 0.000 claims description 5
• 239000002532 enzyme inhibitor Substances 0.000 claims description 5
• 230000002068 genetic effect Effects 0.000 claims description 5
• 229940088597 hormone Drugs 0.000 claims description 5
• 239000005556 hormone Substances 0.000 claims description 5
• 102000047882 human INSR Human genes 0.000 claims description 5
• 210000005036 nerve Anatomy 0.000 claims description 5
• 208000004235 neutropenia Diseases 0.000 claims description 5
• HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 claims description 5
• 229960001346 nilotinib Drugs 0.000 claims description 5
• 230000037361 pathway Effects 0.000 claims description 5
• 108010056274 polo-like kinase 1 Proteins 0.000 claims description 5
• 229920000747 poly(lactic acid) Polymers 0.000 claims description 5
• 239000004626 polylactic acid Substances 0.000 claims description 5
• 239000003755 preservative agent Substances 0.000 claims description 5
• XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims description 5
• 229960003581 pyridoxal Drugs 0.000 claims description 5
• 235000008164 pyridoxal Nutrition 0.000 claims description 5
• 239000011674 pyridoxal Substances 0.000 claims description 5
• 102000027426 receptor tyrosine kinases Human genes 0.000 claims description 5
• 108091008598 receptor tyrosine kinases Proteins 0.000 claims description 5
• 108091092562 ribozyme Proteins 0.000 claims description 5
• 239000006188 syrup Substances 0.000 claims description 5
• 235000020357 syrup Nutrition 0.000 claims description 5
• 238000012360 testing method Methods 0.000 claims description 5
• 229940034199 thyrotropin-releasing hormone Drugs 0.000 claims description 5
• BNZPFJBUHRBLNB-UHFFFAOYSA-N 1-oxido-1,2,4-benzotriazin-1-ium Chemical compound C1=CC=C2[N+]([O-])=NC=NC2=C1 BNZPFJBUHRBLNB-UHFFFAOYSA-N 0.000 claims description 4
• HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims description 4
• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 claims description 4
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
• GMTUGPYJRUMVTC-UHFFFAOYSA-N Daidzin Natural products OC(COc1ccc2C(=O)C(=COc2c1)c3ccc(O)cc3)C(O)C(O)C(O)C=O GMTUGPYJRUMVTC-UHFFFAOYSA-N 0.000 claims description 4
• KYQZWONCHDNPDP-UHFFFAOYSA-N Daidzoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-UHFFFAOYSA-N 0.000 claims description 4
• ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims description 4
• 108010032035 Desmoglein 3 Proteins 0.000 claims description 4
• 102000007577 Desmoglein 3 Human genes 0.000 claims description 4
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 4
• 108010029961 Filgrastim Proteins 0.000 claims description 4
• 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 claims description 4
• PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 4
• 239000002067 L01XE06 - Dasatinib Substances 0.000 claims description 4
• 229930195725 Mannitol Natural products 0.000 claims description 4
• 102000016397 Methyltransferase Human genes 0.000 claims description 4
• 108060004795 Methyltransferase Proteins 0.000 claims description 4
• 102000029749 Microtubule Human genes 0.000 claims description 4
• 108091022875 Microtubule Proteins 0.000 claims description 4
• 101150111783 NTRK1 gene Proteins 0.000 claims description 4
• 101150056950 Ntrk2 gene Proteins 0.000 claims description 4
• BUQLXKSONWUQAC-UHFFFAOYSA-N Parthenolide Natural products CC1C2OC(=O)C(=C)C2CCC(=C/CCC1(C)O)C BUQLXKSONWUQAC-UHFFFAOYSA-N 0.000 claims description 4
• 108090000315 Protein Kinase C Proteins 0.000 claims description 4
• 102000003923 Protein Kinase C Human genes 0.000 claims description 4
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims description 4
• 239000002262 Schiff base Substances 0.000 claims description 4
• 150000004753 Schiff bases Chemical class 0.000 claims description 4
• 206010070834 Sensitisation Diseases 0.000 claims description 4
• DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 claims description 4
• 229940123237 Taxane Drugs 0.000 claims description 4
• 108010017842 Telomerase Proteins 0.000 claims description 4
• 102000040945 Transcription factor Human genes 0.000 claims description 4
• 108091023040 Transcription factor Proteins 0.000 claims description 4
• 102000004243 Tubulin Human genes 0.000 claims description 4
• 108090000704 Tubulin Proteins 0.000 claims description 4
• LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims description 4
• TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims description 4
• 239000012190 activator Substances 0.000 claims description 4
• 239000000556 agonist Substances 0.000 claims description 4
• 229940024606 amino acid Drugs 0.000 claims description 4
• 235000001014 amino acid Nutrition 0.000 claims description 4
• 230000001142 anti-diarrhea Effects 0.000 claims description 4
• 230000003474 anti-emetic effect Effects 0.000 claims description 4
• 239000002111 antiemetic agent Substances 0.000 claims description 4
• 239000004599 antimicrobial Substances 0.000 claims description 4
• 230000003078 antioxidant effect Effects 0.000 claims description 4
• 239000003886 aromatase inhibitor Substances 0.000 claims description 4
• 229920013641 bioerodible polymer Polymers 0.000 claims description 4
• 230000008512 biological response Effects 0.000 claims description 4
• 229960002685 biotin Drugs 0.000 claims description 4
• 239000011616 biotin Substances 0.000 claims description 4
• 229930003827 cannabinoid Natural products 0.000 claims description 4
• 239000003557 cannabinoid Substances 0.000 claims description 4
• 239000013078 crystal Substances 0.000 claims description 4
• 239000002875 cyclin dependent kinase inhibitor Substances 0.000 claims description 4
• 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 claims description 4
• 239000002254 cytotoxic agent Substances 0.000 claims description 4
• 231100000599 cytotoxic agent Toxicity 0.000 claims description 4
• 229960002448 dasatinib Drugs 0.000 claims description 4
• 230000007423 decrease Effects 0.000 claims description 4
• 238000002405 diagnostic procedure Methods 0.000 claims description 4
• 238000012631 diagnostic technique Methods 0.000 claims description 4
• 239000000539 dimer Substances 0.000 claims description 4
• 239000000890 drug combination Substances 0.000 claims description 4
• 230000002496 gastric effect Effects 0.000 claims description 4
• 231100000414 gastrointestinal toxicity Toxicity 0.000 claims description 4
• 230000009368 gene silencing by RNA Effects 0.000 claims description 4
• 229910052736 halogen Chemical group 0.000 claims description 4
• 150000002367 halogens Chemical group 0.000 claims description 4
• 150000002402 hexoses Chemical class 0.000 claims description 4
• 230000002209 hydrophobic effect Effects 0.000 claims description 4
• KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 claims description 4
• 229960002411 imatinib Drugs 0.000 claims description 4
• 208000015181 infectious disease Diseases 0.000 claims description 4
• 238000001361 intraarterial administration Methods 0.000 claims description 4
• 238000007913 intrathecal administration Methods 0.000 claims description 4
• CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 claims description 4
• 235000008696 isoflavones Nutrition 0.000 claims description 4
• 239000000594 mannitol Substances 0.000 claims description 4
• 235000010355 mannitol Nutrition 0.000 claims description 4
• 239000004005 microsphere Substances 0.000 claims description 4
• MXWHMTNPTTVWDM-NXOFHUPFSA-N mitoguazone Chemical compound NC(N)=N\N=C(/C)\C=N\N=C(N)N MXWHMTNPTTVWDM-NXOFHUPFSA-N 0.000 claims description 4
• 239000002159 nanocrystal Substances 0.000 claims description 4
• 238000004806 packaging method and process Methods 0.000 claims description 4
• 229940069510 parthenolide Drugs 0.000 claims description 4
• UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims description 4
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 4
• 229920000768 polyamine Polymers 0.000 claims description 4
• 239000003528 protein farnesyltransferase inhibitor Substances 0.000 claims description 4
• 230000009257 reactivity Effects 0.000 claims description 4
• 230000009467 reduction Effects 0.000 claims description 4
• 239000003590 rho kinase inhibitor Substances 0.000 claims description 4
• 230000008313 sensitization Effects 0.000 claims description 4
• 239000000829 suppository Substances 0.000 claims description 4
• 150000003573 thiols Chemical class 0.000 claims description 4
• 206010043554 thrombocytopenia Diseases 0.000 claims description 4
• 229940116269 uric acid Drugs 0.000 claims description 4
• 210000002700 urine Anatomy 0.000 claims description 4
• SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 3
• QNOCRUSVMMAKSC-CCEZHUSRSA-N (3e)-1-methyl-3-(2-oxo-1h-indol-3-ylidene)indol-2-one Chemical compound C12=CC=CC=C2N(C)C(=O)\C1=C\1C2=CC=CC=C2NC/1=O QNOCRUSVMMAKSC-CCEZHUSRSA-N 0.000 claims description 3
• MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims description 3
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 3
• IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical compound C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 claims description 3
• OQLZINXFSUDMHM-UHFFFAOYSA-N Acetamidine Chemical compound CC(N)=N OQLZINXFSUDMHM-UHFFFAOYSA-N 0.000 claims description 3
• 102100022718 Atypical chemokine receptor 2 Human genes 0.000 claims description 3
• 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 claims description 3
• 108091007065 BIRCs Proteins 0.000 claims description 3
• 229940122035 Bcl-XL inhibitor Drugs 0.000 claims description 3
• 229940123711 Bcl2 inhibitor Drugs 0.000 claims description 3
• OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 claims description 3
• BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 3
• 102000014914 Carrier Proteins Human genes 0.000 claims description 3
• 102000052052 Casein Kinase II Human genes 0.000 claims description 3
• 108010010919 Casein Kinase II Proteins 0.000 claims description 3
• 101000749287 Clitocybe nebularis Clitocypin Proteins 0.000 claims description 3
• 101000767029 Clitocybe nebularis Clitocypin-1 Proteins 0.000 claims description 3
• 239000004971 Cross linker Substances 0.000 claims description 3
• 101710095468 Cyclase Proteins 0.000 claims description 3
• 102000008130 Cyclic AMP-Dependent Protein Kinases Human genes 0.000 claims description 3
• 108010049894 Cyclic AMP-Dependent Protein Kinases Proteins 0.000 claims description 3
• 229940094664 Cysteine protease inhibitor Drugs 0.000 claims description 3
• 208000003311 Cytochrome P-450 Enzyme Inhibitors Diseases 0.000 claims description 3
• 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 claims description 3
• 102000012199 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 claims description 3
• 102100037024 E3 ubiquitin-protein ligase XIAP Human genes 0.000 claims description 3
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 claims description 3
• 102000005720 Glutathione transferase Human genes 0.000 claims description 3
• 108010070675 Glutathione transferase Proteins 0.000 claims description 3
• 101710113864 Heat shock protein 90 Proteins 0.000 claims description 3
• 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 claims description 3
• 108010033040 Histones Proteins 0.000 claims description 3
• 101000600756 Homo sapiens 3-phosphoinositide-dependent protein kinase 1 Proteins 0.000 claims description 3
• 101000678892 Homo sapiens Atypical chemokine receptor 2 Proteins 0.000 claims description 3
• 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 claims description 3
• 101000716070 Homo sapiens C-C chemokine receptor type 9 Proteins 0.000 claims description 3
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 claims description 3
• 101000785063 Homo sapiens Serine-protein kinase ATM Proteins 0.000 claims description 3
• 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 claims description 3
• 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 claims description 3
• 101001117146 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Proteins 0.000 claims description 3
• 108060003951 Immunoglobulin Proteins 0.000 claims description 3
• 102100024319 Intestinal-type alkaline phosphatase Human genes 0.000 claims description 3
• 241000713321 Intracisternal A-particles Species 0.000 claims description 3
• 102000042838 JAK family Human genes 0.000 claims description 3
• 108091082332 JAK family Proteins 0.000 claims description 3
• 229940121730 Janus kinase 2 inhibitor Drugs 0.000 claims description 3
• 102000001291 MAP Kinase Kinase Kinase Human genes 0.000 claims description 3
• 108060006687 MAP kinase kinase kinase Proteins 0.000 claims description 3
• 229940122661 MET tyrosine kinase inhibitor Drugs 0.000 claims description 3
• 102000002151 Microfilament Proteins Human genes 0.000 claims description 3
• 108010040897 Microfilament Proteins Proteins 0.000 claims description 3
• 241001529936 Murinae Species 0.000 claims description 3
• 108020005497 Nuclear hormone receptor Proteins 0.000 claims description 3
• 102000015636 Oligopeptides Human genes 0.000 claims description 3
• 108010038807 Oligopeptides Proteins 0.000 claims description 3
• 108091007960 PI3Ks Proteins 0.000 claims description 3
• 229930012538 Paclitaxel Natural products 0.000 claims description 3
• 101710176384 Peptide 1 Proteins 0.000 claims description 3
• 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 claims description 3
• 229940123932 Phosphodiesterase 4 inhibitor Drugs 0.000 claims description 3
• 229920000954 Polyglycolide Polymers 0.000 claims description 3
• 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 claims description 3
• 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 claims description 3
• 108020005115 Pyruvate Kinase Proteins 0.000 claims description 3
• 102000013009 Pyruvate Kinase Human genes 0.000 claims description 3
• ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims description 3
• 229940123690 Raf kinase inhibitor Drugs 0.000 claims description 3
• 108091005682 Receptor kinases Proteins 0.000 claims description 3
• HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims description 3
• 101150099493 STAT3 gene Proteins 0.000 claims description 3
• 102100020824 Serine-protein kinase ATM Human genes 0.000 claims description 3
• 102100031081 Serine/threonine-protein kinase Chk1 Human genes 0.000 claims description 3
• 229940122924 Src inhibitor Drugs 0.000 claims description 3
• GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 claims description 3
• 102100029519 Tripartite motif-containing protein 29 Human genes 0.000 claims description 3
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 3
• 229930003316 Vitamin D Natural products 0.000 claims description 3
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 3
• 229930003427 Vitamin E Natural products 0.000 claims description 3
• 108700031544 X-Linked Inhibitor of Apoptosis Proteins 0.000 claims description 3
• PXXFHZSZZJJSHO-UHFFFAOYSA-N [Bi].CC(=O)C=O Chemical compound [Bi].CC(=O)C=O PXXFHZSZZJJSHO-UHFFFAOYSA-N 0.000 claims description 3
• 229960004308 acetylcysteine Drugs 0.000 claims description 3
• 238000001467 acupuncture Methods 0.000 claims description 3
• 239000002580 adenosine A3 receptor antagonist Substances 0.000 claims description 3
• 230000001780 adrenocortical effect Effects 0.000 claims description 3
• 150000001298 alcohols Chemical class 0.000 claims description 3
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 3
• 230000001387 anti-histamine Effects 0.000 claims description 3
• 229940125683 antiemetic agent Drugs 0.000 claims description 3
• 239000000739 antihistaminic agent Substances 0.000 claims description 3
• 239000005441 aurora Substances 0.000 claims description 3
• 239000002585 base Substances 0.000 claims description 3
• 229940049706 benzodiazepine Drugs 0.000 claims description 3
• 108091008324 binding proteins Proteins 0.000 claims description 3
• 229940126600 bulk drug product Drugs 0.000 claims description 3
• 230000000711 cancerogenic effect Effects 0.000 claims description 3
• DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical group NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 claims description 3
• 231100000315 carcinogenic Toxicity 0.000 claims description 3
• CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims description 3
• 229960001380 cimetidine Drugs 0.000 claims description 3
• 238000003776 cleavage reaction Methods 0.000 claims description 3
• 239000006184 cosolvent Substances 0.000 claims description 3
• 229940111134 coxibs Drugs 0.000 claims description 3
• 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims description 3
• 150000001944 cysteine derivatives Chemical class 0.000 claims description 3
• 231100000433 cytotoxic Toxicity 0.000 claims description 3
• KYQZWONCHDNPDP-QNDFHXLGSA-N daidzein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 KYQZWONCHDNPDP-QNDFHXLGSA-N 0.000 claims description 3
• 239000003599 detergent Substances 0.000 claims description 3
• 239000012990 dithiocarbamate Substances 0.000 claims description 3
• 239000002329 esterase inhibitor Substances 0.000 claims description 3
• 210000002950 fibroblast Anatomy 0.000 claims description 3
• 238000011049 filling Methods 0.000 claims description 3
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
• 229940093181 glucose injection Drugs 0.000 claims description 3
• 125000003827 glycol group Chemical group 0.000 claims description 3
• 229910001385 heavy metal Inorganic materials 0.000 claims description 3
• 235000008216 herbs Nutrition 0.000 claims description 3
• FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 3
• HYFHYPWGAURHIV-UHFFFAOYSA-N homoharringtonine Natural products C1=C2CCN3CCCC43C=C(OC)C(OC(=O)C(O)(CCCC(C)(C)O)CC(=O)OC)C4C2=CC2=C1OCO2 HYFHYPWGAURHIV-UHFFFAOYSA-N 0.000 claims description 3
• 229920001477 hydrophilic polymer Polymers 0.000 claims description 3
• 230000000147 hypnotic effect Effects 0.000 claims description 3
• 102000018358 immunoglobulin Human genes 0.000 claims description 3
• 238000007912 intraperitoneal administration Methods 0.000 claims description 3
• GOMNOOKGLZYEJT-UHFFFAOYSA-N isoflavone Chemical compound C=1OC2=CC=CC=C2C(=O)C=1C1=CC=CC=C1 GOMNOOKGLZYEJT-UHFFFAOYSA-N 0.000 claims description 3
• 229960003350 isoniazid Drugs 0.000 claims description 3
• QRXWMOHMRWLFEY-UHFFFAOYSA-N isoniazide Chemical compound NNC(=O)C1=CC=NC=C1 QRXWMOHMRWLFEY-UHFFFAOYSA-N 0.000 claims description 3
• MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims description 3
• AXESYCSCGBQJBL-SZPBEECKSA-N largazole Chemical compound O=C([C@@]1(C)N=C2SC1)N[C@@H](C(C)C)C(=O)O[C@H](/C=C/CCSC(=O)CCCCCCC)CC(=O)NCC1=NC2=CS1 AXESYCSCGBQJBL-SZPBEECKSA-N 0.000 claims description 3
• 108010039490 largazole Proteins 0.000 claims description 3
• 230000000670 limiting effect Effects 0.000 claims description 3
• 150000002632 lipids Chemical class 0.000 claims description 3
• 229940124302 mTOR inhibitor Drugs 0.000 claims description 3
• 150000002678 macrocyclic compounds Chemical class 0.000 claims description 3
• 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 claims description 3
• 210000004688 microtubule Anatomy 0.000 claims description 3
• 229960003539 mitoguazone Drugs 0.000 claims description 3
• SUXGLLRPXXXJER-LICLKQGHSA-N myrsinoic acid A Chemical compound CC(C)=CCC\C(C)=C\CC1=CC(C(O)=O)=CC(CC=C(C)C)=C1O SUXGLLRPXXXJER-LICLKQGHSA-N 0.000 claims description 3
• SUXGLLRPXXXJER-UHFFFAOYSA-N myrsinoic acid A Natural products CC(C)=CCCC(C)=CCC1=CC(C(O)=O)=CC(CC=C(C)C)=C1O SUXGLLRPXXXJER-UHFFFAOYSA-N 0.000 claims description 3
• 239000002105 nanoparticle Substances 0.000 claims description 3
• 229940029345 neupogen Drugs 0.000 claims description 3
• 230000007935 neutral effect Effects 0.000 claims description 3
• 229960002715 nicotine Drugs 0.000 claims description 3
• SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 3
• 108020004017 nuclear receptors Proteins 0.000 claims description 3
• 230000025308 nuclear transport Effects 0.000 claims description 3
• 235000016709 nutrition Nutrition 0.000 claims description 3
• 229960002230 omacetaxine mepesuccinate Drugs 0.000 claims description 3
• HYFHYPWGAURHIV-JFIAXGOJSA-N omacetaxine mepesuccinate Chemical compound C1=C2CCN3CCC[C@]43C=C(OC)[C@@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)[C@H]4C2=CC2=C1OCO2 HYFHYPWGAURHIV-JFIAXGOJSA-N 0.000 claims description 3
• 239000006186 oral dosage form Substances 0.000 claims description 3
• 229960001592 paclitaxel Drugs 0.000 claims description 3
• KTEXNACQROZXEV-PVLRGYAZSA-N parthenolide Chemical compound C1CC(/C)=C/CC[C@@]2(C)O[C@@H]2[C@H]2OC(=O)C(=C)[C@@H]21 KTEXNACQROZXEV-PVLRGYAZSA-N 0.000 claims description 3
• 230000036961 partial effect Effects 0.000 claims description 3
• 229960003243 phenformin Drugs 0.000 claims description 3
• ICFJFFQQTFMIBG-UHFFFAOYSA-N phenformin Chemical compound NC(=N)NC(=N)NCCC1=CC=CC=C1 ICFJFFQQTFMIBG-UHFFFAOYSA-N 0.000 claims description 3
• 239000008363 phosphate buffer Substances 0.000 claims description 3
• 102000051624 phosphatidylethanolamine binding protein Human genes 0.000 claims description 3
• 108700021017 phosphatidylethanolamine binding protein Proteins 0.000 claims description 3
• 239000002587 phosphodiesterase IV inhibitor Substances 0.000 claims description 3
• 239000003504 photosensitizing agent Substances 0.000 claims description 3
• 239000004633 polyglycolic acid Substances 0.000 claims description 3
• 235000005875 quercetin Nutrition 0.000 claims description 3
• 229960001285 quercetin Drugs 0.000 claims description 3
• 239000000718 radiation-protective agent Substances 0.000 claims description 3
• 239000002534 radiation-sensitizing agent Substances 0.000 claims description 3
• 230000002285 radioactive effect Effects 0.000 claims description 3
• 229940044601 receptor agonist Drugs 0.000 claims description 3
• 239000000018 receptor agonist Substances 0.000 claims description 3
• 239000013557 residual solvent Substances 0.000 claims description 3
• 239000011347 resin Substances 0.000 claims description 3
• 229920005989 resin Polymers 0.000 claims description 3
• 230000007017 scission Effects 0.000 claims description 3
• 229940075439 smac mimetic Drugs 0.000 claims description 3
• 235000010267 sodium hydrogen sulphite Nutrition 0.000 claims description 3
• 239000002732 sphingomyelin phosphodiesterase inhibitor Substances 0.000 claims description 3
• 150000005846 sugar alcohols Chemical class 0.000 claims description 3
• 231100000617 superantigen Toxicity 0.000 claims description 3
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims description 3
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 3
• IQFYYKKMVGJFEH-CSMHCCOUSA-N telbivudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1O[C@@H](CO)[C@H](O)C1 IQFYYKKMVGJFEH-CSMHCCOUSA-N 0.000 claims description 3
• 238000011200 topical administration Methods 0.000 claims description 3
• 229940100611 topical cream Drugs 0.000 claims description 3
• 239000013603 viral vector Substances 0.000 claims description 3
• 235000019155 vitamin A Nutrition 0.000 claims description 3
• 239000011719 vitamin A Substances 0.000 claims description 3
• 235000019166 vitamin D Nutrition 0.000 claims description 3
• 239000011710 vitamin D Substances 0.000 claims description 3
• 150000003710 vitamin D derivatives Chemical class 0.000 claims description 3
• 235000019165 vitamin E Nutrition 0.000 claims description 3
• 239000011709 vitamin E Substances 0.000 claims description 3
• 229940046009 vitamin E Drugs 0.000 claims description 3
• 229940045997 vitamin a Drugs 0.000 claims description 3
• 229940046008 vitamin d Drugs 0.000 claims description 3
• SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims description 2
• UPALIKSFLSVKIS-UHFFFAOYSA-N 5-amino-2-[2-(dimethylamino)ethyl]benzo[de]isoquinoline-1,3-dione Chemical compound NC1=CC(C(N(CCN(C)C)C2=O)=O)=C3C2=CC=CC3=C1 UPALIKSFLSVKIS-UHFFFAOYSA-N 0.000 claims description 2
• 229940121683 Acetylcholine receptor antagonist Drugs 0.000 claims description 2
• 229930024421 Adenine Natural products 0.000 claims description 2
• GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 2
• 229940123786 Adenosine A3 receptor antagonist Drugs 0.000 claims description 2
• 102000005758 Adenosylmethionine decarboxylase Human genes 0.000 claims description 2
• 108010070753 Adenosylmethionine decarboxylase Proteins 0.000 claims description 2
• 229940122815 Aromatase inhibitor Drugs 0.000 claims description 2
• 229940126074 CDK kinase inhibitor Drugs 0.000 claims description 2
• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims description 2
• GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims description 2
• 229940122360 Casein kinase 2 inhibitor Drugs 0.000 claims description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 2
• 102100031065 Choline kinase alpha Human genes 0.000 claims description 2
• 229940121737 Choline kinase inhibitor Drugs 0.000 claims description 2
• 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 claims description 2
• QSJXEFYPDANLFS-UHFFFAOYSA-N Diacetyl Chemical group CC(=O)C(C)=O QSJXEFYPDANLFS-UHFFFAOYSA-N 0.000 claims description 2
• 229940117937 Dihydrofolate reductase inhibitor Drugs 0.000 claims description 2
• 244000133098 Echinacea angustifolia Species 0.000 claims description 2
• 102100022623 Hepatocyte growth factor receptor Human genes 0.000 claims description 2
• 101710184069 Hepatocyte growth factor receptor Proteins 0.000 claims description 2
• 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 claims description 2
• 101150038517 JUN gene Proteins 0.000 claims description 2
• 101000686985 Mouse mammary tumor virus (strain C3H) Protein PR73 Proteins 0.000 claims description 2
• 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims description 2
• 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims description 2
• 101710163270 Nuclease Proteins 0.000 claims description 2
• 108010049358 Oncogene Protein p65(gag-jun) Proteins 0.000 claims description 2
• 229940122016 Pim kinase inhibitor Drugs 0.000 claims description 2
• 108091008611 Protein Kinase B Proteins 0.000 claims description 2
• 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 claims description 2
• 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 claims description 2
• 108010061312 Sphingomyelin Phosphodiesterase Proteins 0.000 claims description 2
• 229940122171 Sphingomyelinase inhibitor Drugs 0.000 claims description 2
• 102000014384 Type C Phospholipases Human genes 0.000 claims description 2
• 108010079194 Type C Phospholipases Proteins 0.000 claims description 2
• 102000010126 acid sphingomyelin phosphodiesterase activity proteins Human genes 0.000 claims description 2
• 229960000643 adenine Drugs 0.000 claims description 2
• 230000029936 alkylation Effects 0.000 claims description 2
• 238000005804 alkylation reaction Methods 0.000 claims description 2
• BVCZEBOGSOYJJT-UHFFFAOYSA-N ammonium carbamate Chemical compound [NH4+].NC([O-])=O BVCZEBOGSOYJJT-UHFFFAOYSA-N 0.000 claims description 2
• 229960004701 amonafide Drugs 0.000 claims description 2
• 239000002220 antihypertensive agent Substances 0.000 claims description 2
• 229940046844 aromatase inhibitors Drugs 0.000 claims description 2
• 210000000601 blood cell Anatomy 0.000 claims description 2
• 229960004117 capecitabine Drugs 0.000 claims description 2
• 238000000576 coating method Methods 0.000 claims description 2
• 239000000599 controlled substance Substances 0.000 claims description 2
• 239000003246 corticosteroid Substances 0.000 claims description 2
• 235000007240 daidzein Nutrition 0.000 claims description 2
• 239000003166 dihydrofolate reductase inhibitor Substances 0.000 claims description 2
• 235000014134 echinacea Nutrition 0.000 claims description 2
• 230000002708 enhancing effect Effects 0.000 claims description 2
• 238000010195 expression analysis Methods 0.000 claims description 2
• 239000000945 filler Substances 0.000 claims description 2
• 239000008103 glucose Substances 0.000 claims description 2
• 229940121372 histone deacetylase inhibitor Drugs 0.000 claims description 2
• 239000003276 histone deacetylase inhibitor Substances 0.000 claims description 2
• 229940090044 injection Drugs 0.000 claims description 2
• 238000002347 injection Methods 0.000 claims description 2
• 239000007924 injection Substances 0.000 claims description 2
• 108700025907 jun Genes Proteins 0.000 claims description 2
• 239000003226 mitogen Substances 0.000 claims description 2
• MOZRQQTUYAYCQT-FQEVSTJZSA-N n-[[(3s)-3-amino-1-(5-ethyl-7h-pyrrolo[2,3-d]pyrimidin-4-yl)pyrrolidin-3-yl]methyl]-2,4-difluorobenzamide Chemical compound C([C@]1(CCN(C1)C=1N=CN=C2NC=C(C=12)CC)N)NC(=O)C1=CC=C(F)C=C1F MOZRQQTUYAYCQT-FQEVSTJZSA-N 0.000 claims description 2
• 210000004498 neuroglial cell Anatomy 0.000 claims description 2
• 239000000825 pharmaceutical preparation Substances 0.000 claims description 2
• 229910052697 platinum Inorganic materials 0.000 claims description 2
• 229940076372 protein antagonist Drugs 0.000 claims description 2
• 125000004076 pyridyl group Chemical group 0.000 claims description 2
• 108091006084 receptor activators Proteins 0.000 claims description 2
• 229940044551 receptor antagonist Drugs 0.000 claims description 2
• 239000002464 receptor antagonist Substances 0.000 claims description 2
• 102000034285 signal transducing proteins Human genes 0.000 claims description 2
• 108091006024 signal transducing proteins Proteins 0.000 claims description 2
• 229940079827 sodium hydrogen sulfite Drugs 0.000 claims description 2
• 241000894007 species Species 0.000 claims description 2
• 239000004066 vascular targeting agent Substances 0.000 claims description 2
• 210000005166 vasculature Anatomy 0.000 claims description 2
• 230000024883 vasodilation Effects 0.000 claims description 2
• 108010090804 Streptavidin Proteins 0.000 claims 6
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 claims 4
• 102400000336 Thyrotropin-releasing hormone Human genes 0.000 claims 4
• 101800004623 Thyrotropin-releasing hormone Proteins 0.000 claims 4
• 239000003153 chemical reaction reagent Substances 0.000 claims 4
• 230000003308 immunostimulating effect Effects 0.000 claims 4
• BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 3
• 229960001438 immunostimulant agent Drugs 0.000 claims 3
• 239000003022 immunostimulating agent Substances 0.000 claims 3
• CLUQWSRYSHBBDD-DYXFYOPSSA-N (4s)-4-[(2-amino-4-methylsulfanylbutanoyl)amino]-5-[[(2s)-1-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-(1h-indol-3-yl)ethyl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]amino]- Chemical class C([C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)C(N)CCSC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)C1=CN=CN1 CLUQWSRYSHBBDD-DYXFYOPSSA-N 0.000 claims 2
• 101710186708 Agglutinin Proteins 0.000 claims 2
• 229940122280 Cytochrome P450 inhibitor Drugs 0.000 claims 2
• 108010016626 Dipeptides Proteins 0.000 claims 2
• 102000009025 Endorphins Human genes 0.000 claims 2
• 108010049140 Endorphins Proteins 0.000 claims 2
• 229940122601 Esterase inhibitor Drugs 0.000 claims 2
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims 2
• 239000004378 Glycyrrhizin Substances 0.000 claims 2
• 101710146024 Horcolin Proteins 0.000 claims 2
• 108090000723 Insulin-Like Growth Factor I Chemical group 0.000 claims 2
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
• 108090001117 Insulin-Like Growth Factor II Chemical group 0.000 claims 2
• 102000048143 Insulin-Like Growth Factor II Human genes 0.000 claims 2
• 102000006992 Interferon-alpha Human genes 0.000 claims 2
• 108010047761 Interferon-alpha Proteins 0.000 claims 2
• 101710189395 Lectin Proteins 0.000 claims 2
• 101710179758 Mannose-specific lectin Proteins 0.000 claims 2
• 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims 2
• 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims 2
• XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 claims 2
• 229940122907 Phosphatase inhibitor Drugs 0.000 claims 2
• 108010057464 Prolactin Proteins 0.000 claims 2
• 102000003946 Prolactin Human genes 0.000 claims 2
• 102000005157 Somatostatin Human genes 0.000 claims 2
• 108010056088 Somatostatin Proteins 0.000 claims 2
• GXBMIBRIOWHPDT-UHFFFAOYSA-N Vasopressin Natural products N1C(=O)C(CC=2C=C(O)C=CC=2)NC(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C1CC1=CC=CC=C1 GXBMIBRIOWHPDT-UHFFFAOYSA-N 0.000 claims 2
• 108010004977 Vasopressins Proteins 0.000 claims 2
• 102000002852 Vasopressins Human genes 0.000 claims 2
• 239000000910 agglutinin Substances 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 229940125716 antipyretic agent Drugs 0.000 claims 2
• KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical compound C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 claims 2
• 210000002421 cell wall Anatomy 0.000 claims 2
• UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 claims 2
• 230000012202 endocytosis Effects 0.000 claims 2
• HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 claims 2
• LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims 2
• 229960004949 glycyrrhizic acid Drugs 0.000 claims 2
• UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims 2
• 235000019410 glycyrrhizin Nutrition 0.000 claims 2
• LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims 2
• 229960003151 mercaptamine Drugs 0.000 claims 2
• 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 239000008177 pharmaceutical agent Substances 0.000 claims 2
• 229940097325 prolactin Drugs 0.000 claims 2
• 108020001580 protein domains Proteins 0.000 claims 2
• 239000000932 sedative agent Substances 0.000 claims 2
• 230000001624 sedative effect Effects 0.000 claims 2
• NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 2
• 229960000553 somatostatin Drugs 0.000 claims 2
• 229940042129 topical gel Drugs 0.000 claims 2
• 229960003726 vasopressin Drugs 0.000 claims 2
• SPFMQWBKVUQXJV-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;hydrate Chemical compound O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O SPFMQWBKVUQXJV-BTVCFUMJSA-N 0.000 claims 1
• VEEGZPWAAPPXRB-BJMVGYQFSA-N (3e)-3-(1h-imidazol-5-ylmethylidene)-1h-indol-2-one Chemical compound O=C1NC2=CC=CC=C2\C1=C/C1=CN=CN1 VEEGZPWAAPPXRB-BJMVGYQFSA-N 0.000 claims 1
• 239000005541 ACE inhibitor Substances 0.000 claims 1
• 101150038313 AHI1 gene Proteins 0.000 claims 1
• 229940097396 Aminopeptidase inhibitor Drugs 0.000 claims 1
• 102000006501 Angiopoietin-like Proteins Human genes 0.000 claims 1
• 108010019425 Angiopoietin-like Proteins Proteins 0.000 claims 1
• 229940088872 Apoptosis inhibitor Drugs 0.000 claims 1
• 229940125814 BTK kinase inhibitor Drugs 0.000 claims 1
• 229940122361 Bisphosphonate Drugs 0.000 claims 1
• 229940043709 CaM kinase II inhibitor Drugs 0.000 claims 1
• 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 claims 1
• 229940122739 Calcineurin inhibitor Drugs 0.000 claims 1
• 101710192106 Calcineurin-binding protein cabin-1 Proteins 0.000 claims 1
• 102100024123 Calcineurin-binding protein cabin-1 Human genes 0.000 claims 1
• 108010076667 Caspases Proteins 0.000 claims 1
• 102000011727 Caspases Human genes 0.000 claims 1
• 108091006146 Channels Proteins 0.000 claims 1
• 102000005927 Cysteine Proteases Human genes 0.000 claims 1
• 108010005843 Cysteine Proteases Proteins 0.000 claims 1
• 102000053602 DNA Human genes 0.000 claims 1
• 230000033616 DNA repair Effects 0.000 claims 1
• 229940123736 Decarboxylase inhibitor Drugs 0.000 claims 1
• 229940124226 Farnesyltransferase inhibitor Drugs 0.000 claims 1
• 102400000932 Gonadoliberin-1 Human genes 0.000 claims 1
• 102000004457 Granulocyte-Macrophage Colony-Stimulating Factor Human genes 0.000 claims 1
• 101500026183 Homo sapiens Gonadoliberin-1 Proteins 0.000 claims 1
• 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 claims 1
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
• VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 claims 1
• 208000037147 Hypercalcaemia Diseases 0.000 claims 1
• 108010055717 JNK Mitogen-Activated Protein Kinases Proteins 0.000 claims 1
• JPIJQSOTBSSVTP-STHAYSLISA-N L-threonic acid Chemical compound OC[C@H](O)[C@@H](O)C(O)=O JPIJQSOTBSSVTP-STHAYSLISA-N 0.000 claims 1
• 229940122696 MAP kinase inhibitor Drugs 0.000 claims 1
• 229940083338 MDM2 inhibitor Drugs 0.000 claims 1
• 239000012819 MDM2-Inhibitor Substances 0.000 claims 1
• 229940124647 MEK inhibitor Drugs 0.000 claims 1
• 229940124761 MMP inhibitor Drugs 0.000 claims 1
• 101710181812 Methionine aminopeptidase Proteins 0.000 claims 1
• 102100023482 Mitogen-activated protein kinase 14 Human genes 0.000 claims 1
• 101100335081 Mus musculus Flt3 gene Proteins 0.000 claims 1
• 108010021466 Mutant Proteins Proteins 0.000 claims 1
• 102000008300 Mutant Proteins Human genes 0.000 claims 1
• 108010052419 NF-KappaB Inhibitor alpha Proteins 0.000 claims 1
• 102100039337 NF-kappa-B inhibitor alpha Human genes 0.000 claims 1
• 108010032605 Nerve Growth Factor Receptors Proteins 0.000 claims 1
• 102000007399 Nuclear hormone receptor Human genes 0.000 claims 1
• 240000007594 Oryza sativa Species 0.000 claims 1
• 235000007164 Oryza sativa Nutrition 0.000 claims 1
• 229940121708 Oxygenase inhibitor Drugs 0.000 claims 1
• 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 claims 1
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 claims 1
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 claims 1
• 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 1
• 229940079156 Proteasome inhibitor Drugs 0.000 claims 1
• 229940116193 Protein phosphatase inhibitor Drugs 0.000 claims 1
• 102100033479 RAF proto-oncogene serine/threonine-protein kinase Human genes 0.000 claims 1
• 101710141955 RAF proto-oncogene serine/threonine-protein kinase Proteins 0.000 claims 1
• 102000014128 RANK Ligand Human genes 0.000 claims 1
• 108010025832 RANK Ligand Proteins 0.000 claims 1
• 102000009572 RNA Polymerase II Human genes 0.000 claims 1
• 108010009460 RNA Polymerase II Proteins 0.000 claims 1
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
• 229940123934 Reductase inhibitor Drugs 0.000 claims 1
• 206010039710 Scleroderma Diseases 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 229940121742 Serine/threonine kinase inhibitor Drugs 0.000 claims 1
• 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 claims 1
• 229940121856 Somatostatin receptor antagonist Drugs 0.000 claims 1
• 229940100514 Syk tyrosine kinase inhibitor Drugs 0.000 claims 1
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 1
• 108010014401 TWEAK Receptor Proteins 0.000 claims 1
• 229940123582 Telomerase inhibitor Drugs 0.000 claims 1
• 102100028786 Tumor necrosis factor receptor superfamily member 12A Human genes 0.000 claims 1
• 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims 1
• 229940076850 Tyrosine phosphatase inhibitor Drugs 0.000 claims 1
• 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 claims 1
• 101710112791 Tyrosine-protein kinase JAK2 Proteins 0.000 claims 1
• 102100025387 Tyrosine-protein kinase JAK3 Human genes 0.000 claims 1
• 101710112792 Tyrosine-protein kinase JAK3 Proteins 0.000 claims 1
• 229940123429 VEGFR tyrosine kinase inhibitor Drugs 0.000 claims 1
• 102000016549 Vascular Endothelial Growth Factor Receptor-2 Human genes 0.000 claims 1
• 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 claims 1
• 102100024148 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Human genes 0.000 claims 1
• 150000007513 acids Chemical class 0.000 claims 1
• 239000003121 adenosine kinase inhibitor Substances 0.000 claims 1
• 150000001412 amines Chemical class 0.000 claims 1
• 239000002269 analeptic agent Substances 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
• 230000002491 angiogenic effect Effects 0.000 claims 1
• 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
• 230000002280 anti-androgenic effect Effects 0.000 claims 1
• 229940046836 anti-estrogen Drugs 0.000 claims 1
• 230000001833 anti-estrogenic effect Effects 0.000 claims 1
• 239000000051 antiandrogen Substances 0.000 claims 1
• 229940030600 antihypertensive agent Drugs 0.000 claims 1
• 239000000158 apoptosis inhibitor Substances 0.000 claims 1
• 239000003719 aurora kinase inhibitor Substances 0.000 claims 1
• 150000003836 berberines Chemical group 0.000 claims 1
• 150000004663 bisphosphonates Chemical class 0.000 claims 1
• 108010046616 cdc25 Phosphatases Proteins 0.000 claims 1
• 102000007588 cdc25 Phosphatases Human genes 0.000 claims 1
• 230000024245 cell differentiation Effects 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 239000000084 colloidal system Substances 0.000 claims 1
• 229960001334 corticosteroids Drugs 0.000 claims 1
• 239000003954 decarboxylase inhibitor Substances 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 230000018044 dehydration Effects 0.000 claims 1
• 238000006297 dehydration reaction Methods 0.000 claims 1
• 230000000779 depleting effect Effects 0.000 claims 1
• UXGNZZKBCMGWAZ-UHFFFAOYSA-N dimethylformamide dmf Chemical compound CN(C)C=O.CN(C)C=O UXGNZZKBCMGWAZ-UHFFFAOYSA-N 0.000 claims 1
• 229940126534 drug product Drugs 0.000 claims 1
• 230000008482 dysregulation Effects 0.000 claims 1
• 230000002124 endocrine Effects 0.000 claims 1
• 229940125532 enzyme inhibitor Drugs 0.000 claims 1
• 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 1
• 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 1
• 239000000328 estrogen antagonist Substances 0.000 claims 1
• 238000000556 factor analysis Methods 0.000 claims 1
• 229930182830 galactose Natural products 0.000 claims 1
• XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 1
• 229960001442 gonadorelin Drugs 0.000 claims 1
• 239000003481 heat shock protein 90 inhibitor Substances 0.000 claims 1
• 229960001330 hydroxycarbamide Drugs 0.000 claims 1
• 208000030915 hypercalcemia disease Diseases 0.000 claims 1
• 108010042209 insulin receptor tyrosine kinase Proteins 0.000 claims 1
• 239000000138 intercalating agent Substances 0.000 claims 1
• CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical compound C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims 1
• 230000011987 methylation Effects 0.000 claims 1
• 238000007069 methylation reaction Methods 0.000 claims 1
• 229940101578 microlipid Drugs 0.000 claims 1
• YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 1
• 239000003650 oxygenase inhibitor Substances 0.000 claims 1
• 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 claims 1
• AZQWKYJCGOJGHM-UHFFFAOYSA-N para-benzoquinone Natural products O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 claims 1
• 125000000810 parthenolide group Chemical group 0.000 claims 1
• 239000002935 phosphatidylinositol 3 kinase inhibitor Substances 0.000 claims 1
• 229940043441 phosphoinositide 3-kinase inhibitor Drugs 0.000 claims 1
• 239000003934 phosphoprotein phosphatase inhibitor Substances 0.000 claims 1
• 239000003207 proteasome inhibitor Substances 0.000 claims 1
• 239000003801 protein tyrosine phosphatase 1B inhibitor Substances 0.000 claims 1
• 239000002994 raw material Substances 0.000 claims 1
• 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 1
• 235000009566 rice Nutrition 0.000 claims 1
• 239000002002 slurry Substances 0.000 claims 1
• 108010087686 src-Family Kinases Proteins 0.000 claims 1
• 102000009076 src-Family Kinases Human genes 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1
• 239000003277 telomerase inhibitor Substances 0.000 claims 1
• 229940022036 threonate Drugs 0.000 claims 1
• 230000003424 uricosuric effect Effects 0.000 claims 1
• 239000008215 water for injection Substances 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 description 43
• 125000003118 aryl group Chemical group 0.000 description 42
• 125000005842 heteroatom Chemical group 0.000 description 20
• 208000029824 high grade glioma Diseases 0.000 description 20
• 201000011614 malignant glioma Diseases 0.000 description 20
• VXFJYXUZANRPDJ-WTNASJBWSA-N Trandopril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@H]2CCCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 VXFJYXUZANRPDJ-WTNASJBWSA-N 0.000 description 17
• 229910052717 sulfur Inorganic materials 0.000 description 17
• 125000003342 alkenyl group Chemical group 0.000 description 16
• 125000000304 alkynyl group Chemical group 0.000 description 16
• 125000001072 heteroaryl group Chemical group 0.000 description 16
• 125000000623 heterocyclic group Chemical group 0.000 description 14
• 229910052757 nitrogen Inorganic materials 0.000 description 14
• 229910052760 oxygen Inorganic materials 0.000 description 14
• 125000000753 cycloalkyl group Chemical group 0.000 description 13
• 125000003710 aryl alkyl group Chemical group 0.000 description 11
• 125000004429 atom Chemical group 0.000 description 11
• 125000004122 cyclic group Chemical group 0.000 description 10
• 125000004404 heteroalkyl group Chemical group 0.000 description 10
• 239000012071 phase Substances 0.000 description 9
• YTFVRYKNXDADBI-UHFFFAOYSA-N 3,4,5-trimethoxycinnamic acid Chemical compound COC1=CC(C=CC(O)=O)=CC(OC)=C1OC YTFVRYKNXDADBI-UHFFFAOYSA-N 0.000 description 8
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
• 230000008901 benefit Effects 0.000 description 8
• 230000004044 response Effects 0.000 description 8
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 7
• 125000003545 alkoxy group Chemical group 0.000 description 7
• 239000000562 conjugate Substances 0.000 description 7
• 125000004446 heteroarylalkyl group Chemical group 0.000 description 7
• 229920006395 saturated elastomer Polymers 0.000 description 7
• 125000002837 carbocyclic group Chemical group 0.000 description 6
• 238000011161 development Methods 0.000 description 6
• 230000018109 developmental process Effects 0.000 description 6
• 230000001973 epigenetic effect Effects 0.000 description 6
• 125000001183 hydrocarbyl group Chemical group 0.000 description 6
• 231100000682 maximum tolerated dose Toxicity 0.000 description 6
• 238000002483 medication Methods 0.000 description 6
• 125000002950 monocyclic group Chemical group 0.000 description 6
• 210000001519 tissue Anatomy 0.000 description 6
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 5
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 5
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 5
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 5
• 238000003556 assay Methods 0.000 description 5
• 125000004432 carbon atom Chemical group C* 0.000 description 5
• 125000002704 decyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 5
• VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 description 5
• 230000000144 pharmacologic effect Effects 0.000 description 5
• DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 5
• 229960003081 probenecid Drugs 0.000 description 5
• 238000011160 research Methods 0.000 description 5
• 238000012216 screening Methods 0.000 description 5
• 239000012453 solvate Substances 0.000 description 5
• LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 4
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 4
• RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 4
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 4
• 208000026310 Breast neoplasm Diseases 0.000 description 4
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 4
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
• GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 4
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
• IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
• 230000009471 action Effects 0.000 description 4
• 239000013543 active substance Substances 0.000 description 4
• 230000000996 additive effect Effects 0.000 description 4
• 125000002947 alkylene group Chemical group 0.000 description 4
• 208000007502 anemia Diseases 0.000 description 4
• 230000003110 anti-inflammatory effect Effects 0.000 description 4
• 230000001640 apoptogenic effect Effects 0.000 description 4
• 229960002707 bendamustine Drugs 0.000 description 4
• YTKUWDBFDASYHO-UHFFFAOYSA-N bendamustine Chemical compound ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 YTKUWDBFDASYHO-UHFFFAOYSA-N 0.000 description 4
• 229960004217 benzyl alcohol Drugs 0.000 description 4
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 4
• 229910052794 bromium Inorganic materials 0.000 description 4
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 4
• 230000008859 change Effects 0.000 description 4
• 238000012790 confirmation Methods 0.000 description 4
• 230000006378 damage Effects 0.000 description 4
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 4
• 238000011156 evaluation Methods 0.000 description 4
• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 description 4
• OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 4
• 238000000338 in vitro Methods 0.000 description 4
• 238000001727 in vivo Methods 0.000 description 4
• 239000011630 iodine Substances 0.000 description 4
• 229910052740 iodine Inorganic materials 0.000 description 4
• 239000011777 magnesium Substances 0.000 description 4
• 238000005259 measurement Methods 0.000 description 4
• VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 4
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
• 102000004196 processed proteins & peptides Human genes 0.000 description 4
• BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 4
• WVYADZUPLLSGPU-UHFFFAOYSA-N salsalate Chemical compound OC(=O)C1=CC=CC=C1OC(=O)C1=CC=CC=C1O WVYADZUPLLSGPU-UHFFFAOYSA-N 0.000 description 4
• MSTNYGQPCMXVAQ-RYUDHWBXSA-N (6S)-5,6,7,8-tetrahydrofolic acid Chemical compound C([C@H]1CNC=2N=C(NC(=O)C=2N1)N)NC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-RYUDHWBXSA-N 0.000 description 3
• ZHSKUOZOLHMKEA-UHFFFAOYSA-N 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)C1=CC=C2N(C)C(CCCC(O)=O)=NC2=C1 ZHSKUOZOLHMKEA-UHFFFAOYSA-N 0.000 description 3
• 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 3
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
• 102100021906 Cyclin-O Human genes 0.000 description 3
• HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 3
• 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 description 3
• 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 description 3
• 102100038104 Glycogen synthase kinase-3 beta Human genes 0.000 description 3
• 101000897441 Homo sapiens Cyclin-O Proteins 0.000 description 3
• 206010020850 Hyperthyroidism Diseases 0.000 description 3
• 206010021143 Hypoxia Diseases 0.000 description 3
• 102000035195 Peptidases Human genes 0.000 description 3
• 108091005804 Peptidases Proteins 0.000 description 3
• 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 description 3
• 239000004365 Protease Substances 0.000 description 3
• PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 3
• 108090000958 Thiopurine S-methyltransferases Proteins 0.000 description 3
• 108010022394 Threonine synthase Proteins 0.000 description 3
• 239000000365 Topoisomerase I Inhibitor Substances 0.000 description 3
• 229940122954 Transcription factor inhibitor Drugs 0.000 description 3
• 102000007537 Type II DNA Topoisomerases Human genes 0.000 description 3
• 108010046308 Type II DNA Topoisomerases Proteins 0.000 description 3
• 125000002252 acyl group Chemical group 0.000 description 3
• HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 3
• 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 description 3
• 229940126587 biotherapeutics Drugs 0.000 description 3
• 210000001772 blood platelet Anatomy 0.000 description 3
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
• 230000001413 cellular effect Effects 0.000 description 3
• 239000013043 chemical agent Substances 0.000 description 3
• 239000000460 chlorine Substances 0.000 description 3
• 229910052801 chlorine Inorganic materials 0.000 description 3
• 125000004093 cyano group Chemical group *C#N 0.000 description 3
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 description 3
• 230000004069 differentiation Effects 0.000 description 3
• 239000000499 gel Substances 0.000 description 3
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 3
• 239000003292 glue Substances 0.000 description 3
• 235000011187 glycerol Nutrition 0.000 description 3
• 125000004415 heterocyclylalkyl group Chemical group 0.000 description 3
• 230000001146 hypoxic effect Effects 0.000 description 3
• 239000000367 immunologic factor Substances 0.000 description 3
• 239000007943 implant Substances 0.000 description 3
• CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 3
• 210000000265 leukocyte Anatomy 0.000 description 3
• 125000004433 nitrogen atom Chemical group N* 0.000 description 3
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 3
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 3
• 102000039446 nucleic acids Human genes 0.000 description 3
• 108020004707 nucleic acids Proteins 0.000 description 3
• 150000007523 nucleic acids Chemical class 0.000 description 3
• 238000009522 phase III clinical trial Methods 0.000 description 3
• 230000002265 prevention Effects 0.000 description 3
• 230000008569 process Effects 0.000 description 3
• 150000003180 prostaglandins Chemical class 0.000 description 3
• 150000003254 radicals Chemical class 0.000 description 3
• 238000006722 reduction reaction Methods 0.000 description 3
• 239000011593 sulfur Substances 0.000 description 3
• 239000005460 tetrahydrofolate Substances 0.000 description 3
• 230000001131 transforming effect Effects 0.000 description 3
• 125000004953 trihalomethyl group Chemical group 0.000 description 3
• 230000003827 upregulation Effects 0.000 description 3
• 229960005486 vaccine Drugs 0.000 description 3
• 230000003442 weekly effect Effects 0.000 description 3
• OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 description 2
• FELGMEQIXOGIFQ-CYBMUJFWSA-N (3r)-9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1h-carbazol-4-one Chemical compound CC1=NC=CN1C[C@@H]1C(=O)C(C=2C(=CC=CC=2)N2C)=C2CC1 FELGMEQIXOGIFQ-CYBMUJFWSA-N 0.000 description 2
• JYEUMXHLPRZUAT-UHFFFAOYSA-N 1,2,3-triazine Chemical compound C1=CN=NN=C1 JYEUMXHLPRZUAT-UHFFFAOYSA-N 0.000 description 2
• WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 description 2
• JIEKMACRVQTPRC-UHFFFAOYSA-N 2-[4-(4-chlorophenyl)-2-phenyl-5-thiazolyl]acetic acid Chemical compound OC(=O)CC=1SC(C=2C=CC=CC=2)=NC=1C1=CC=C(Cl)C=C1 JIEKMACRVQTPRC-UHFFFAOYSA-N 0.000 description 2
• 102100037263 3-phosphoinositide-dependent protein kinase 1 Human genes 0.000 description 2
• MHJBZVSGOZTKRH-IZHYLOQSSA-N 4-Hydroxy-N-desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=C(O)C=C1 MHJBZVSGOZTKRH-IZHYLOQSSA-N 0.000 description 2
• LSGNKLDHMQVTEK-UHFFFAOYSA-N 4-[5-(4-phenyl-8-propan-2-ylquinolin-2-yl)-1h-pyrrol-2-yl]benzoic acid Chemical compound N1=C2C(C(C)C)=CC=CC2=C(C=2C=CC=CC=2)C=C1C(N1)=CC=C1C1=CC=C(C(O)=O)C=C1 LSGNKLDHMQVTEK-UHFFFAOYSA-N 0.000 description 2
• VVIAGPKUTFNRDU-UHFFFAOYSA-N 6S-folinic acid Natural products C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-UHFFFAOYSA-N 0.000 description 2
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 2
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
• 241000271566 Aves Species 0.000 description 2
• DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
• 102000015735 Beta-catenin Human genes 0.000 description 2
• 108060000903 Beta-catenin Proteins 0.000 description 2
• AOCCBINRVIKJHY-UHFFFAOYSA-N Carmofur Chemical compound CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O AOCCBINRVIKJHY-UHFFFAOYSA-N 0.000 description 2
• 206010009944 Colon cancer Diseases 0.000 description 2
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 2
• XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
• LVZWSLJZHVFIQJ-UHFFFAOYSA-N Cyclopropane Chemical compound C1CC1 LVZWSLJZHVFIQJ-UHFFFAOYSA-N 0.000 description 2
• 230000006820 DNA synthesis Effects 0.000 description 2
• 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 description 2
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
• 238000002965 ELISA Methods 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical class NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
• GIMBKDZNMKTZMG-UHFFFAOYSA-N Isopropylpyrazine Chemical compound CC(C)C1=CN=CC=N1 GIMBKDZNMKTZMG-UHFFFAOYSA-N 0.000 description 2
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• AIJULSRZWUXGPQ-UHFFFAOYSA-N Methylglyoxal Chemical compound CC(=O)C=O AIJULSRZWUXGPQ-UHFFFAOYSA-N 0.000 description 2
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 2
• OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
• XUYPXLNMDZIRQH-LURJTMIESA-N N-acetyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC(C)=O XUYPXLNMDZIRQH-LURJTMIESA-N 0.000 description 2
• UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
• CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 2
• MITFXPHMIHQXPI-UHFFFAOYSA-N Oraflex Chemical compound N=1C2=CC(C(C(O)=O)C)=CC=C2OC=1C1=CC=C(Cl)C=C1 MITFXPHMIHQXPI-UHFFFAOYSA-N 0.000 description 2
• 102000038030 PI3Ks Human genes 0.000 description 2
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
• 206010036790 Productive cough Diseases 0.000 description 2
• 206010060862 Prostate cancer Diseases 0.000 description 2
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 102000004377 Thiopurine S-methyltransferases Human genes 0.000 description 2
• 102000003911 Thyrotropin Receptors Human genes 0.000 description 2
• 108090000253 Thyrotropin Receptors Proteins 0.000 description 2
• 101710183280 Topoisomerase Proteins 0.000 description 2
• 239000000317 Topoisomerase II Inhibitor Substances 0.000 description 2
• 229940116731 Uricosuric agent Drugs 0.000 description 2
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 2
• DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 2
• 229960001138 acetylsalicylic acid Drugs 0.000 description 2
• 230000002378 acidificating effect Effects 0.000 description 2
• 230000033115 angiogenesis Effects 0.000 description 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
• 229960001671 azapropazone Drugs 0.000 description 2
• WOIIIUDZSOLAIW-NSHDSACASA-N azapropazone Chemical compound C1=C(C)C=C2N3C(=O)[C@H](CC=C)C(=O)N3C(N(C)C)=NC2=C1 WOIIIUDZSOLAIW-NSHDSACASA-N 0.000 description 2
• 108700000707 bcl-2-Associated X Proteins 0.000 description 2
• 102000055102 bcl-2-Associated X Human genes 0.000 description 2
• 229960001215 bendamustine hydrochloride Drugs 0.000 description 2
• 230000009286 beneficial effect Effects 0.000 description 2
• UHOVQNZJYSORNB-UHFFFAOYSA-N benzene Substances C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 2
• CNBGNNVCVSKAQZ-UHFFFAOYSA-N benzydamine Chemical compound C12=CC=CC=C2C(OCCCN(C)C)=NN1CC1=CC=CC=C1 CNBGNNVCVSKAQZ-UHFFFAOYSA-N 0.000 description 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
• MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
• IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
• 229960002537 betamethasone Drugs 0.000 description 2
• UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 description 2
• 239000003124 biologic agent Substances 0.000 description 2
• 230000004071 biological effect Effects 0.000 description 2
• 230000000903 blocking effect Effects 0.000 description 2
• 239000011203 carbon fibre reinforced carbon Substances 0.000 description 2
• 229960003261 carmofur Drugs 0.000 description 2
• 230000003034 chemosensitisation Effects 0.000 description 2
• 229960001231 choline Drugs 0.000 description 2
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
• LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 description 2
• 238000001514 detection method Methods 0.000 description 2
• 229960003957 dexamethasone Drugs 0.000 description 2
• 238000003745 diagnosis Methods 0.000 description 2
• HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 description 2
• 229960000616 diflunisal Drugs 0.000 description 2
• 102000004419 dihydrofolate reductase Human genes 0.000 description 2
• DMBHHRLKUKUOEG-UHFFFAOYSA-N diphenylamine Chemical compound C=1C=CC=CC=1NC1=CC=CC=C1 DMBHHRLKUKUOEG-UHFFFAOYSA-N 0.000 description 2
• 238000009826 distribution Methods 0.000 description 2
• 239000002934 diuretic Substances 0.000 description 2
• 229940030606 diuretics Drugs 0.000 description 2
• FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 description 2
• 229960001253 domperidone Drugs 0.000 description 2
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 2
• 229960004679 doxorubicin Drugs 0.000 description 2
• YJGVMLPVUAXIQN-UHFFFAOYSA-N epipodophyllotoxin Natural products COC1=C(OC)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YJGVMLPVUAXIQN-UHFFFAOYSA-N 0.000 description 2
• 229940082789 erbitux Drugs 0.000 description 2
• MNJVRJDLRVPLFE-UHFFFAOYSA-N etoricoxib Chemical compound C1=NC(C)=CC=C1C1=NC=C(Cl)C=C1C1=CC=C(S(C)(=O)=O)C=C1 MNJVRJDLRVPLFE-UHFFFAOYSA-N 0.000 description 2
• 229960004945 etoricoxib Drugs 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 229960002679 fentiazac Drugs 0.000 description 2
• QXNWVJOHUAQHLM-AZUAARDMSA-N ferruginol Chemical compound CC([C@@H]1CC2)(C)CCC[C@]1(C)C1=C2C=C(C(C)C)C(O)=C1 QXNWVJOHUAQHLM-AZUAARDMSA-N 0.000 description 2
• HOJWCCXHGGCJQV-YLJYHZDGSA-N ferruginol Natural products CC(C)c1ccc2c(CC[C@@H]3C(C)(C)CCC[C@]23C)c1O HOJWCCXHGGCJQV-YLJYHZDGSA-N 0.000 description 2
• ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 2
• 229960000961 floxuridine Drugs 0.000 description 2
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 2
• 235000019152 folic acid Nutrition 0.000 description 2
• 239000011724 folic acid Substances 0.000 description 2
• 229960000304 folic acid Drugs 0.000 description 2
• VVIAGPKUTFNRDU-ABLWVSNPSA-N folinic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C=O)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 VVIAGPKUTFNRDU-ABLWVSNPSA-N 0.000 description 2
• 235000008191 folinic acid Nutrition 0.000 description 2
• 239000011672 folinic acid Substances 0.000 description 2
• 229960003692 gamma aminobutyric acid Drugs 0.000 description 2
• 229960005277 gemcitabine Drugs 0.000 description 2
• OZBAVEKZGSOMOJ-MIUGBVLSSA-N glycitin Chemical compound COC1=CC(C(C(C=2C=CC(O)=CC=2)=CO2)=O)=C2C=C1O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O OZBAVEKZGSOMOJ-MIUGBVLSSA-N 0.000 description 2
• 210000003714 granulocyte Anatomy 0.000 description 2
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
• LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
• 230000003463 hyperproliferative effect Effects 0.000 description 2
• 230000036737 immune function Effects 0.000 description 2
• 230000028993 immune response Effects 0.000 description 2
• 238000003018 immunoassay Methods 0.000 description 2
• 239000002955 immunomodulating agent Substances 0.000 description 2
• 229940121354 immunomodulator Drugs 0.000 description 2
• 230000002401 inhibitory effect Effects 0.000 description 2
• 150000002500 ions Chemical class 0.000 description 2
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 2
• 229960004768 irinotecan Drugs 0.000 description 2
• ATHLLZUXVPNPAW-UHFFFAOYSA-N lamellarin d Chemical compound C1=C(O)C(OC)=CC(C2=C3C4=CC(OC)=C(O)C=C4C=CN3C3=C2C=2C=C(OC)C(O)=CC=2OC3=O)=C1 ATHLLZUXVPNPAW-UHFFFAOYSA-N 0.000 description 2
• 229960001691 leucovorin Drugs 0.000 description 2
• 229940127021 low-dose drug Drugs 0.000 description 2
• 201000005202 lung cancer Diseases 0.000 description 2
• 208000020816 lung neoplasm Diseases 0.000 description 2
• 238000004519 manufacturing process Methods 0.000 description 2
• 239000000463 material Substances 0.000 description 2
• 239000012528 membrane Substances 0.000 description 2
• 230000001394 metastastic effect Effects 0.000 description 2
• 206010061289 metastatic neoplasm Diseases 0.000 description 2
• 229930182817 methionine Natural products 0.000 description 2
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 2
• 230000000116 mitigating effect Effects 0.000 description 2
• 238000007837 multiplex assay Methods 0.000 description 2
• 229960002009 naproxen Drugs 0.000 description 2
• CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 2
• 210000000440 neutrophil Anatomy 0.000 description 2
• 102000006255 nuclear receptors Human genes 0.000 description 2
• 238000011275 oncology therapy Methods 0.000 description 2
• 229960005343 ondansetron Drugs 0.000 description 2
• 210000004789 organ system Anatomy 0.000 description 2
• 125000002971 oxazolyl group Chemical group 0.000 description 2
• 239000001301 oxygen Substances 0.000 description 2
• 229960005489 paracetamol Drugs 0.000 description 2
• 229960004662 parecoxib Drugs 0.000 description 2
• TZRHLKRLEZJVIJ-UHFFFAOYSA-N parecoxib Chemical compound C1=CC(S(=O)(=O)NC(=O)CC)=CC=C1C1=C(C)ON=C1C1=CC=CC=C1 TZRHLKRLEZJVIJ-UHFFFAOYSA-N 0.000 description 2
• 229960005079 pemetrexed Drugs 0.000 description 2
• WBXPDJSOTKVWSJ-ZDUSSCGKSA-N pemetrexed Chemical compound C=1NC=2NC(N)=NC(=O)C=2C=1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 WBXPDJSOTKVWSJ-ZDUSSCGKSA-N 0.000 description 2
• RDOWQLZANAYVLL-UHFFFAOYSA-N phenanthridine Chemical compound C1=CC=C2C3=CC=CC=C3C=NC2=C1 RDOWQLZANAYVLL-UHFFFAOYSA-N 0.000 description 2
• DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 2
• 230000026731 phosphorylation Effects 0.000 description 2
• 238000006366 phosphorylation reaction Methods 0.000 description 2
• 229960001237 podophyllotoxin Drugs 0.000 description 2
• YJGVMLPVUAXIQN-XVVDYKMHSA-N podophyllotoxin Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-XVVDYKMHSA-N 0.000 description 2
• YVCVYCSAAZQOJI-UHFFFAOYSA-N podophyllotoxin Natural products COC1=C(O)C(OC)=CC(C2C3=CC=4OCOC=4C=C3C(O)C3C2C(OC3)=O)=C1 YVCVYCSAAZQOJI-UHFFFAOYSA-N 0.000 description 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
• GPTFURBXHJWNHR-UHFFFAOYSA-N protopine Chemical compound C1=C2C(=O)CC3=CC=C4OCOC4=C3CN(C)CCC2=CC2=C1OCO2 GPTFURBXHJWNHR-UHFFFAOYSA-N 0.000 description 2
• LOUPRKONTZGTKE-LHHVKLHASA-N quinidine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@H]2[C@@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-LHHVKLHASA-N 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 125000006413 ring segment Chemical group 0.000 description 2
• 229960000953 salsalate Drugs 0.000 description 2
• 229930195734 saturated hydrocarbon Natural products 0.000 description 2
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 2
• 238000009097 single-agent therapy Methods 0.000 description 2
• 150000003384 small molecules Chemical class 0.000 description 2
• 208000024794 sputum Diseases 0.000 description 2
• 210000003802 sputum Anatomy 0.000 description 2
• 125000000547 substituted alkyl group Chemical group 0.000 description 2
• 238000006467 substitution reaction Methods 0.000 description 2
• 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 2
• NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 2
• 229960001278 teniposide Drugs 0.000 description 2
• 229960002871 tenoxicam Drugs 0.000 description 2
• WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 description 2
• 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 2
• 125000003396 thiol group Chemical group [H]S* 0.000 description 2
• 229940104230 thymidine Drugs 0.000 description 2
• 229950002376 tirapazamine Drugs 0.000 description 2
• ORYDPOVDJJZGHQ-UHFFFAOYSA-N tirapazamine Chemical compound C1=CC=CC2=[N+]([O-])C(N)=N[N+]([O-])=C21 ORYDPOVDJJZGHQ-UHFFFAOYSA-N 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 2
• 229960000303 topotecan Drugs 0.000 description 2
• 238000013518 transcription Methods 0.000 description 2
• 230000035897 transcription Effects 0.000 description 2
• 239000003383 uricosuric agent Substances 0.000 description 2
• 239000002525 vasculotropin inhibitor Substances 0.000 description 2
• 229960003048 vinblastine Drugs 0.000 description 2
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 2
• SMLNREUXXJESLR-BYPYZUCNSA-N (2r)-2-(ethylamino)-3-sulfanylpropanoic acid Chemical compound CCN[C@@H](CS)C(O)=O SMLNREUXXJESLR-BYPYZUCNSA-N 0.000 description 1
• RJMIEHBSYVWVIN-LLVKDONJSA-N (2r)-2-[4-(3-oxo-1h-isoindol-2-yl)phenyl]propanoic acid Chemical compound C1=CC([C@H](C(O)=O)C)=CC=C1N1C(=O)C2=CC=CC=C2C1 RJMIEHBSYVWVIN-LLVKDONJSA-N 0.000 description 1
• RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 description 1
• GUHPRPJDBZHYCJ-SECBINFHSA-N (2s)-2-(5-benzoylthiophen-2-yl)propanoic acid Chemical compound S1C([C@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CC=C1 GUHPRPJDBZHYCJ-SECBINFHSA-N 0.000 description 1
• ZZKNRXZVGOYGJT-VKHMYHEASA-N (2s)-2-[(2-phosphonoacetyl)amino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)CP(O)(O)=O ZZKNRXZVGOYGJT-VKHMYHEASA-N 0.000 description 1
• MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
• IEJSCSAMMLUINT-NRFANRHFSA-N (2s)-2-[[4-[(2,7-dimethyl-4-oxo-1h-quinazolin-6-yl)methyl-prop-2-ynylamino]-2-fluorobenzoyl]amino]-4-(2h-tetrazol-5-yl)butanoic acid Chemical compound C([C@H](NC(=O)C1=CC=C(C=C1F)N(CC#C)CC=1C=C2C(=O)N=C(NC2=CC=1C)C)C(O)=O)CC=1N=NNN=1 IEJSCSAMMLUINT-NRFANRHFSA-N 0.000 description 1
• ZUQBAQVRAURMCL-CVRLYYSRSA-N (2s)-2-[[4-[2-(2-amino-4-oxo-5,6,7,8-tetrahydro-1h-pyrido[2,3-d]pyrimidin-6-yl)ethyl]benzoyl]amino]pentanedioic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2CC1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZUQBAQVRAURMCL-CVRLYYSRSA-N 0.000 description 1
• ZUQBAQVRAURMCL-DOMZBBRYSA-N (2s)-2-[[4-[2-[(6r)-2-amino-4-oxo-5,6,7,8-tetrahydro-1h-pyrido[2,3-d]pyrimidin-6-yl]ethyl]benzoyl]amino]pentanedioic acid Chemical compound C([C@@H]1CC=2C(=O)N=C(NC=2NC1)N)CC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZUQBAQVRAURMCL-DOMZBBRYSA-N 0.000 description 1
• QXOPTIPQEVJERB-JQWIXIFHSA-N (2s)-2-[[5-[2-[(6s)-2-amino-4-oxo-5,6,7,8-tetrahydro-1h-pyrido[2,3-d]pyrimidin-6-yl]ethyl]-4-methylthiophene-2-carbonyl]amino]pentanedioic acid Chemical compound C1=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)SC(CC[C@H]2CC=3C(=O)N=C(N)NC=3NC2)=C1C QXOPTIPQEVJERB-JQWIXIFHSA-N 0.000 description 1
• XYRIRLDHOQSNLW-UHFFFAOYSA-N (3-oxo-1h-2-benzofuran-1-yl) 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate Chemical compound CC1=C(CC(=O)OC2C3=CC=CC=C3C(=O)O2)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 XYRIRLDHOQSNLW-UHFFFAOYSA-N 0.000 description 1
• WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
• DIWRORZWFLOCLC-HNNXBMFYSA-N (3s)-7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one Chemical compound N([C@H](C(NC1=CC=C(Cl)C=C11)=O)O)=C1C1=CC=CC=C1Cl DIWRORZWFLOCLC-HNNXBMFYSA-N 0.000 description 1
• IEFNEZUQHDYNRM-UHFFFAOYSA-L (4-azanidyl-2-methylbutyl)azanide;cyclobutane-1,1-dicarboxylate;platinum(4+) Chemical compound [Pt+4].[NH-]CC(C)CC[NH-].[O-]C(=O)C1(C([O-])=O)CCC1 IEFNEZUQHDYNRM-UHFFFAOYSA-L 0.000 description 1
• WRRSFOZOETZUPG-FFHNEAJVSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;hydrate Chemical compound O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC WRRSFOZOETZUPG-FFHNEAJVSA-N 0.000 description 1
• AKTXOQVMWSFEBQ-LCYFTJDESA-N (5z)-2-amino-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-1,3-thiazol-4-one Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(\C=C/2C(N=C(N)S\2)=O)=C1 AKTXOQVMWSFEBQ-LCYFTJDESA-N 0.000 description 1
• FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 description 1
• 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 1
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 1
• UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 1
• 229930182837 (R)-adrenaline Natural products 0.000 description 1
• PAEZRCINULFAGO-OAQYLSRUSA-N (R)-homocamptothecin Chemical compound CC[C@@]1(O)CC(=O)OCC(C2=O)=C1C=C1N2CC2=CC3=CC=CC=C3N=C21 PAEZRCINULFAGO-OAQYLSRUSA-N 0.000 description 1
• SYTBZMRGLBWNTM-JTQLQIEISA-N (S)-flurbiprofen Chemical compound FC1=CC([C@@H](C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-JTQLQIEISA-N 0.000 description 1
• ZGNLFUXWZJGETL-YUSKDDKASA-N (Z)-[(2S)-2-amino-2-carboxyethyl]-hydroxyimino-oxidoazanium Chemical compound N[C@@H](C\[N+]([O-])=N\O)C(O)=O ZGNLFUXWZJGETL-YUSKDDKASA-N 0.000 description 1
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
• ZTXDHEQQZVFGPK-UHFFFAOYSA-N 1,2,4-tris(oxiran-2-ylmethyl)-1,2,4-triazolidine-3,5-dione Chemical compound C1OC1CN1C(=O)N(CC2OC2)C(=O)N1CC1CO1 ZTXDHEQQZVFGPK-UHFFFAOYSA-N 0.000 description 1
• DIIIISSCIXVANO-UHFFFAOYSA-N 1,2-Dimethylhydrazine Chemical compound CNNC DIIIISSCIXVANO-UHFFFAOYSA-N 0.000 description 1
• QUKGLNCXGVWCJX-UHFFFAOYSA-N 1,3,4-thiadiazol-2-amine Chemical compound NC1=NN=CS1 QUKGLNCXGVWCJX-UHFFFAOYSA-N 0.000 description 1
• UNOIJXLSRIRQIV-UHFFFAOYSA-N 1,4-dioxido-2H-1,2,4-benzotriazine-1,4-diium-3-one Chemical compound C1=CC=CC2=[N+]([O-])C(O)=N[N+]([O-])=C21 UNOIJXLSRIRQIV-UHFFFAOYSA-N 0.000 description 1
• HJTAZXHBEBIQQX-UHFFFAOYSA-N 1,5-bis(chloromethyl)naphthalene Chemical compound C1=CC=C2C(CCl)=CC=CC2=C1CCl HJTAZXHBEBIQQX-UHFFFAOYSA-N 0.000 description 1
• OUPZKGBUJRBPGC-HLTSFMKQSA-N 1,5-bis[[(2r)-oxiran-2-yl]methyl]-3-[[(2s)-oxiran-2-yl]methyl]-1,3,5-triazinane-2,4,6-trione Chemical compound O=C1N(C[C@H]2OC2)C(=O)N(C[C@H]2OC2)C(=O)N1C[C@H]1CO1 OUPZKGBUJRBPGC-HLTSFMKQSA-N 0.000 description 1
• GPCYHDGTRHTWJZ-UHFFFAOYSA-N 1-(1-oxido-4-oxo-1,2,4-benzotriazin-4-ium-3-yl)ethanol Chemical compound C1=CC=CC2=[N+]([O-])C(C(O)C)=N[N+]([O-])=C21 GPCYHDGTRHTWJZ-UHFFFAOYSA-N 0.000 description 1
• KHWIRCOLWPNBJP-UHFFFAOYSA-N 1-(2-chloroethyl)-3-(2,6-dioxopiperidin-3-yl)-1-nitrosourea Chemical compound ClCCN(N=O)C(=O)NC1CCC(=O)NC1=O KHWIRCOLWPNBJP-UHFFFAOYSA-N 0.000 description 1
• YJZJEQBSODVMTH-UHFFFAOYSA-N 1-(2-chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea Chemical compound OCCNC(=O)N(N=O)CCCl YJZJEQBSODVMTH-UHFFFAOYSA-N 0.000 description 1
• BQIFCAGMUAMYDV-DHBOJHSNSA-N 1-(2-chloroethyl)-3-[(2r,6s)-2,6-dihydroxycyclohexyl]-1-nitrosourea Chemical compound O[C@H]1CCC[C@@H](O)C1NC(=O)N(CCCl)N=O BQIFCAGMUAMYDV-DHBOJHSNSA-N 0.000 description 1
• RCLLNBVPCJDIPX-UHFFFAOYSA-N 1-(2-chloroethyl)-3-[2-(dimethylsulfamoyl)ethyl]-1-nitrosourea Chemical compound CN(C)S(=O)(=O)CCNC(=O)N(N=O)CCCl RCLLNBVPCJDIPX-UHFFFAOYSA-N 0.000 description 1
• ZHXUEUKVDMWSKV-UHFFFAOYSA-N 1-(3,5-ditert-butyl-4-hydroxyphenyl)hex-5-yn-1-one Chemical compound CC(C)(C)C1=CC(C(=O)CCCC#C)=CC(C(C)(C)C)=C1O ZHXUEUKVDMWSKV-UHFFFAOYSA-N 0.000 description 1
• GTLQQCMKADHZLK-UHFFFAOYSA-N 1-oxido-1,2,4-benzotriazin-4-ium 4-oxide Chemical compound C1=CC=C2N([O-])N=C[N+](=O)C2=C1 GTLQQCMKADHZLK-UHFFFAOYSA-N 0.000 description 1
• RYAKEFJXIZLFNQ-UHFFFAOYSA-N 1-oxido-7-(trifluoromethyl)-1,2,4-benzotriazin-1-ium-3-amine Chemical compound C1=C(C(F)(F)F)C=CC2=NC(N)=N[N+]([O-])=C21 RYAKEFJXIZLFNQ-UHFFFAOYSA-N 0.000 description 1
• FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
• AVRPFRMDMNDIDH-UHFFFAOYSA-N 1h-quinazolin-2-one Chemical compound C1=CC=CC2=NC(O)=NC=C21 AVRPFRMDMNDIDH-UHFFFAOYSA-N 0.000 description 1
• OOMDVERDMZLRFX-UHFFFAOYSA-N 2,2-bis(aminomethyl)propane-1,3-diol;cyclobutane-1,1-dicarboxylic acid;platinum Chemical compound [Pt].NCC(CN)(CO)CO.OC(=O)C1(C(O)=O)CCC1 OOMDVERDMZLRFX-UHFFFAOYSA-N 0.000 description 1
• KLIVRBFRQSOGQI-UHFFFAOYSA-N 2-(11-oxo-6h-benzo[c][1]benzothiepin-3-yl)acetic acid Chemical compound S1CC2=CC=CC=C2C(=O)C2=CC=C(CC(=O)O)C=C12 KLIVRBFRQSOGQI-UHFFFAOYSA-N 0.000 description 1
• MYQXHLQMZLTSDB-UHFFFAOYSA-N 2-(2-ethyl-2,3-dihydro-1-benzofuran-5-yl)acetic acid Chemical compound OC(=O)CC1=CC=C2OC(CC)CC2=C1 MYQXHLQMZLTSDB-UHFFFAOYSA-N 0.000 description 1
• MQIMZDXIAHJKQP-UHFFFAOYSA-N 2-(3-fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol Chemical compound N=1C2=CC(O)=CC(C=C)=C2OC=1C1=CC=C(O)C(F)=C1 MQIMZDXIAHJKQP-UHFFFAOYSA-N 0.000 description 1
• LAINPTZBIXYTIZ-UHFFFAOYSA-N 2-(3-hydroxy-2,4,5,7-tetraiodo-6-oxo-9-xanthenyl)benzoic acid Chemical compound OC(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C(O)=C(I)C=C21 LAINPTZBIXYTIZ-UHFFFAOYSA-N 0.000 description 1
• BUUODSZYUAZDIF-AOMKIAJQSA-N 2-[(1s,4r)-4-benzyl-1-ethyl-4,9-dihydro-3h-pyrano[3,4-b]indol-1-yl]acetic acid Chemical compound C([C@H]1CO[C@](C2=C1C1=CC=CC=C1N2)(CC(O)=O)CC)C1=CC=CC=C1 BUUODSZYUAZDIF-AOMKIAJQSA-N 0.000 description 1
• VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 description 1
• VEVMYTDOWUQLGI-UHFFFAOYSA-N 2-[(tert-butylamino)methyl]-4-[(7-chloroquinolin-4-yl)amino]-5,6,7,8-tetrahydronaphthalen-1-ol Chemical compound C1CCCC2=C(O)C(CNC(C)(C)C)=CC(NC=3C4=CC=C(Cl)C=C4N=CC=3)=C21 VEVMYTDOWUQLGI-UHFFFAOYSA-N 0.000 description 1
• APBSKHYXXKHJFK-UHFFFAOYSA-N 2-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]acetic acid Chemical compound OC(=O)CC1=CSC(C=2C=CC(Cl)=CC=2)=N1 APBSKHYXXKHJFK-UHFFFAOYSA-N 0.000 description 1
• NEBBBTQIVQBKPT-UHFFFAOYSA-N 2-[2-[4-[(4-chlorophenyl)-phenylmethyl]piperazin-1-yl]ethoxy]ethyl 2-(3-benzoylphenyl)propanoate Chemical compound C=1C=CC(C(=O)C=2C=CC=CC=2)=CC=1C(C)C(=O)OCCOCCN(CC1)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 NEBBBTQIVQBKPT-UHFFFAOYSA-N 0.000 description 1
• HGLRIYIVJRXBQM-UHFFFAOYSA-N 2-[2-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxyethyl]-1,3-thiazinane-4-carboxylic acid Chemical compound ClCCN(CCCl)P(=O)(N)OCCC1NC(C(O)=O)CCS1 HGLRIYIVJRXBQM-UHFFFAOYSA-N 0.000 description 1
• ANMLJLFWUCQGKZ-UHFFFAOYSA-N 2-[3-(trifluoromethyl)anilino]-3-pyridinecarboxylic acid (3-oxo-1H-isobenzofuran-1-yl) ester Chemical compound FC(F)(F)C1=CC=CC(NC=2C(=CC=CN=2)C(=O)OC2C3=CC=CC=C3C(=O)O2)=C1 ANMLJLFWUCQGKZ-UHFFFAOYSA-N 0.000 description 1
• XILVEPYQJIOVNB-UHFFFAOYSA-N 2-[3-(trifluoromethyl)anilino]benzoic acid 2-(2-hydroxyethoxy)ethyl ester Chemical compound OCCOCCOC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 XILVEPYQJIOVNB-UHFFFAOYSA-N 0.000 description 1
• YYPDYJQOBSZWHX-UHFFFAOYSA-N 2-[4-(1-carboxyethyl)anilino]benzoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1NC1=CC=CC=C1C(O)=O YYPDYJQOBSZWHX-UHFFFAOYSA-N 0.000 description 1
• AELILMBZWCGOSB-UHFFFAOYSA-N 2-[4-(2,6-dichloroanilino)thiophen-3-yl]acetic acid Chemical compound OC(=O)CC1=CSC=C1NC1=C(Cl)C=CC=C1Cl AELILMBZWCGOSB-UHFFFAOYSA-N 0.000 description 1
• JFGXBHHLHQAGRR-UHFFFAOYSA-N 2-[4-(3-chlorophenyl)piperazin-1-yl]ethyl 2-[4-(2-methylpropyl)phenyl]propanoate Chemical compound C1=CC(CC(C)C)=CC=C1C(C)C(=O)OCCN1CCN(C=2C=C(Cl)C=CC=2)CC1 JFGXBHHLHQAGRR-UHFFFAOYSA-N 0.000 description 1
• TYCOFFBAZNSQOJ-UHFFFAOYSA-N 2-[4-(3-fluorophenyl)phenyl]propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC(F)=C1 TYCOFFBAZNSQOJ-UHFFFAOYSA-N 0.000 description 1
• YAMFWQIVVMITPG-UHFFFAOYSA-N 2-[4-(4-chlorophenyl)-1-(4-fluorophenyl)pyrazol-3-yl]acetic acid Chemical compound OC(=O)CC1=NN(C=2C=CC(F)=CC=2)C=C1C1=CC=C(Cl)C=C1 YAMFWQIVVMITPG-UHFFFAOYSA-N 0.000 description 1
• IQPPOXSMSDPZKU-JQIJEIRASA-N 2-[4-[(3e)-3-hydroxyiminocyclohexyl]phenyl]propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1CC(=N/O)/CCC1 IQPPOXSMSDPZKU-JQIJEIRASA-N 0.000 description 1
• AUZUGWXLBGZUPP-GXDHUFHOSA-N 2-[4-[(e)-(2-oxocyclohexylidene)methyl]phenyl]propanoic acid Chemical compound C1=CC(C(C(O)=O)C)=CC=C1\C=C/1C(=O)CCCC\1 AUZUGWXLBGZUPP-GXDHUFHOSA-N 0.000 description 1
• PBUUPFTVAPUWDE-UGZDLDLSSA-N 2-[[(2S,4S)-2-[bis(2-chloroethyl)amino]-2-oxo-1,3,2lambda5-oxazaphosphinan-4-yl]sulfanyl]ethanesulfonic acid Chemical compound OS(=O)(=O)CCS[C@H]1CCO[P@](=O)(N(CCCl)CCCl)N1 PBUUPFTVAPUWDE-UGZDLDLSSA-N 0.000 description 1
• ODUOJXZPIYUATO-UHFFFAOYSA-N 2-[[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]amino]acetic acid (phenylmethyl) ester Chemical compound C=1C=CC=CC=1COC(=O)CNC(=O)C(CSC(=O)C)CC1=CC=CC=C1 ODUOJXZPIYUATO-UHFFFAOYSA-N 0.000 description 1
• WGDADRBTCPGSDG-UHFFFAOYSA-N 2-[[4,5-bis(4-chlorophenyl)-1,3-oxazol-2-yl]sulfanyl]propanoic acid Chemical compound O1C(SC(C)C(O)=O)=NC(C=2C=CC(Cl)=CC=2)=C1C1=CC=C(Cl)C=C1 WGDADRBTCPGSDG-UHFFFAOYSA-N 0.000 description 1
• RMWVZGDJPAKBDE-UHFFFAOYSA-N 2-acetyloxy-4-(trifluoromethyl)benzoic acid Chemical compound CC(=O)OC1=CC(C(F)(F)F)=CC=C1C(O)=O RMWVZGDJPAKBDE-UHFFFAOYSA-N 0.000 description 1
• XKSAJZSJKURQRX-UHFFFAOYSA-N 2-acetyloxy-5-(4-fluorophenyl)benzoic acid Chemical compound C1=C(C(O)=O)C(OC(=O)C)=CC=C1C1=CC=C(F)C=C1 XKSAJZSJKURQRX-UHFFFAOYSA-N 0.000 description 1
• POPPVIRYGJQIOF-UHFFFAOYSA-N 2-acetyloxyethyl(trimethyl)azanium;3-(1-methylpyrrolidin-2-yl)pyridine Chemical compound CC(=O)OCC[N+](C)(C)C.CN1CCCC1C1=CC=CN=C1 POPPVIRYGJQIOF-UHFFFAOYSA-N 0.000 description 1
• MSWZFWKMSRAUBD-GASJEMHNSA-N 2-amino-2-deoxy-D-galactopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@H](O)[C@@H]1O MSWZFWKMSRAUBD-GASJEMHNSA-N 0.000 description 1
• VOXBZHOHGGBLCQ-UHFFFAOYSA-N 2-amino-3,7-dihydropurine-6-thione;hydrate Chemical compound O.N1C(N)=NC(=S)C2=C1N=CN2.N1C(N)=NC(=S)C2=C1N=CN2 VOXBZHOHGGBLCQ-UHFFFAOYSA-N 0.000 description 1
• OCLZPNCLRLDXJC-NTSWFWBYSA-N 2-amino-9-[(2r,5s)-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound C1=2NC(N)=NC(=O)C=2N=CN1[C@H]1CC[C@@H](CO)O1 OCLZPNCLRLDXJC-NTSWFWBYSA-N 0.000 description 1
• DLMJOWMKJXYGRB-UHFFFAOYSA-N 2-amino-n-phenyl-5-pyridin-3-ylpyridine-3-carboxamide Chemical compound NC1=NC=C(C=2C=NC=CC=2)C=C1C(=O)NC1=CC=CC=C1 DLMJOWMKJXYGRB-UHFFFAOYSA-N 0.000 description 1
• NADDOZUGAJXMGT-UHFFFAOYSA-Q 2-diphenylphosphaniumylethyl(diphenyl)phosphanium gold(1+) chloride Chemical compound Cl[Au].C(C[PH+](c1ccccc1)c1ccccc1)[PH+](c1ccccc1)c1ccccc1.C(C[PH+](c1ccccc1)c1ccccc1)[PH+](c1ccccc1)c1ccccc1 NADDOZUGAJXMGT-UHFFFAOYSA-Q 0.000 description 1
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
• DQOYUDHAZMAVLD-UHFFFAOYSA-N 2-pyrrolidin-1-ylethyl 2-[[7-(trifluoromethyl)quinolin-4-yl]amino]benzoate Chemical compound C=1C=NC2=CC(C(F)(F)F)=CC=C2C=1NC1=CC=CC=C1C(=O)OCCN1CCCC1 DQOYUDHAZMAVLD-UHFFFAOYSA-N 0.000 description 1
• XUSKJHCMMWAAHV-SANMLTNESA-N 220913-32-6 Chemical compound C1=C(O)C=C2C([Si](C)(C)C(C)(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 XUSKJHCMMWAAHV-SANMLTNESA-N 0.000 description 1
• YWPMKTWUFVOFPL-UHFFFAOYSA-N 3,4-dihydro-2h-isoquinolin-1-one Chemical class C1=CC=C2C(=O)NCCC2=C1 YWPMKTWUFVOFPL-UHFFFAOYSA-N 0.000 description 1
• NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
• UKVFKRGLLNSVNJ-UHFFFAOYSA-L 3,5-dichloro-4-[1,2-diamino-2-(2,6-dichloro-4-hydroxyphenyl)ethyl]phenol;platinum(2+);sulfate;dihydrate Chemical compound O.O.[Pt+2].[O-]S([O-])(=O)=O.ClC=1C=C(O)C=C(Cl)C=1C(N)C(N)C1=C(Cl)C=C(O)C=C1Cl UKVFKRGLLNSVNJ-UHFFFAOYSA-L 0.000 description 1
• HDBQZGJWHMCXIL-UHFFFAOYSA-N 3,7-dihydropurine-2-thione Chemical compound SC1=NC=C2NC=NC2=N1 HDBQZGJWHMCXIL-UHFFFAOYSA-N 0.000 description 1
• IOSAAWHGJUZBOG-UHFFFAOYSA-N 3-(6-amino-9h-purin-9-yl)nonan-2-ol Chemical compound N1=CN=C2N(C(C(C)O)CCCCCC)C=NC2=C1N IOSAAWHGJUZBOG-UHFFFAOYSA-N 0.000 description 1
• PWMYMKOUNYTVQN-UHFFFAOYSA-N 3-(8,8-diethyl-2-aza-8-germaspiro[4.5]decan-2-yl)-n,n-dimethylpropan-1-amine Chemical compound C1C[Ge](CC)(CC)CCC11CN(CCCN(C)C)CC1 PWMYMKOUNYTVQN-UHFFFAOYSA-N 0.000 description 1
• QNKJFXARIMSDBR-UHFFFAOYSA-N 3-[2-[bis(2-chloroethyl)amino]ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione Chemical compound O=C1N(CCN(CCCl)CCCl)C(=O)NC11CCCCC1 QNKJFXARIMSDBR-UHFFFAOYSA-N 0.000 description 1
• YLJRTDTWWRXOFG-UHFFFAOYSA-N 3-[5-(4-chlorophenyl)furan-2-yl]-3-hydroxypropanoic acid Chemical compound O1C(C(CC(O)=O)O)=CC=C1C1=CC=C(Cl)C=C1 YLJRTDTWWRXOFG-UHFFFAOYSA-N 0.000 description 1
• GSCPDZHWVNUUFI-UHFFFAOYSA-N 3-aminobenzamide Chemical compound NC(=O)C1=CC=CC(N)=C1 GSCPDZHWVNUUFI-UHFFFAOYSA-N 0.000 description 1
• OSIJKHBADJESAA-UHFFFAOYSA-N 3-decyl-1,4-dioxido-1,2,4-benzotriazine-1,4-diium Chemical compound C(CCCCCCCCC)C=1N=[N+](C2=C([N+]=1[O-])C=CC=C2)[O-] OSIJKHBADJESAA-UHFFFAOYSA-N 0.000 description 1
• AANFHDFOMFRLLR-UHFFFAOYSA-N 3-fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)acetyl]amino]benzoic acid Chemical compound C=1C=C2C(C)(C)CCC(C)(C)C2=CC=1C(O)C(=O)NC1=CC=C(C(O)=O)C=C1F AANFHDFOMFRLLR-UHFFFAOYSA-N 0.000 description 1
• OVEUEJFUJDFKBK-UHFFFAOYSA-N 3-propyl-1,2,4-benzotriazine Chemical compound C1=CC=CC2=NC(CCC)=NN=C21 OVEUEJFUJDFKBK-UHFFFAOYSA-N 0.000 description 1
• AXMZZGKKZDJGAZ-UHFFFAOYSA-N 4-(4-methylphenyl)-3-(4-methylsulfonylphenyl)-1-propyl-2h-pyrrol-5-one Chemical compound O=C1N(CCC)CC(C=2C=CC(=CC=2)S(C)(=O)=O)=C1C1=CC=C(C)C=C1 AXMZZGKKZDJGAZ-UHFFFAOYSA-N 0.000 description 1
• JTVBXQAYBIJXRP-SNVBAGLBSA-N 4-[(1R)-1-aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide Chemical compound C1=CC([C@H](N)C)=CC=C1C(=O)NC1=CC=NC2=C1C=CN2 JTVBXQAYBIJXRP-SNVBAGLBSA-N 0.000 description 1
• LLSFXOUAPAZFIV-SNVBAGLBSA-N 4-[(1r)-1-aminoethyl]-n-pyridin-4-ylbenzamide Chemical compound C1=CC([C@H](N)C)=CC=C1C(=O)NC1=CC=NC=C1 LLSFXOUAPAZFIV-SNVBAGLBSA-N 0.000 description 1
• WFWMIUSHSIJAKH-DBRKOABJSA-N 4-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-oxido-1,2,4-triazin-1-ium-3-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)N=[N+]([O-])C=C1 WFWMIUSHSIJAKH-DBRKOABJSA-N 0.000 description 1
• FIKVYIRIUOFLLR-UHFFFAOYSA-N 4-[4-(2,4-difluorophenyl)phenyl]-2-methyl-4-oxobutanoic acid Chemical compound C1=CC(C(=O)CC(C)C(O)=O)=CC=C1C1=CC=C(F)C=C1F FIKVYIRIUOFLLR-UHFFFAOYSA-N 0.000 description 1
• GRVCTHTXJDYIHB-UHFFFAOYSA-N 4-cyano-5,5-bis(4-methoxyphenyl)pent-4-enoic acid Chemical compound C1=CC(OC)=CC=C1C(=C(CCC(O)=O)C#N)C1=CC=C(OC)C=C1 GRVCTHTXJDYIHB-UHFFFAOYSA-N 0.000 description 1
• OGAYSXXAHVIFFB-UHFFFAOYSA-N 4-ethyl-2-phenylpyrimidine Chemical compound CCC1=CC=NC(C=2C=CC=CC=2)=N1 OGAYSXXAHVIFFB-UHFFFAOYSA-N 0.000 description 1
• SYCHUQUJURZQMO-UHFFFAOYSA-N 4-hydroxy-2-methyl-1,1-dioxo-n-(1,3-thiazol-2-yl)-1$l^{6},2-benzothiazine-3-carboxamide Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=CS1 SYCHUQUJURZQMO-UHFFFAOYSA-N 0.000 description 1
• CQVHWLHWUZRTQC-UHFFFAOYSA-N 4-nitrooxybutyl 2-[2-(2,6-dichloroanilino)phenyl]acetate Chemical compound [O-][N+](=O)OCCCCOC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl CQVHWLHWUZRTQC-UHFFFAOYSA-N 0.000 description 1
• QTNCSPZZZRNTPF-UHFFFAOYSA-N 5-(1-ethylsulfonyl-3,6-dihydro-2h-pyridin-4-yl)-3-(5-phenyl-1,3,4-oxadiazol-2-yl)pyridin-2-amine Chemical compound C1N(S(=O)(=O)CC)CCC(C=2C=C(C(N)=NC=2)C=2OC(=NN=2)C=2C=CC=CC=2)=C1 QTNCSPZZZRNTPF-UHFFFAOYSA-N 0.000 description 1
• ILMMRHUILQOQGP-UHFFFAOYSA-N 5-[(3,5-ditert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidin-4-one Chemical compound CC(C)(C)C1=C(O)C(C(C)(C)C)=CC(CC2C(NCS2)=O)=C1 ILMMRHUILQOQGP-UHFFFAOYSA-N 0.000 description 1
• XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 description 1
• XMTKXTUIUKKGIL-UHFFFAOYSA-N 5-benzoyl-6-hydroxy-2,3-dihydro-1h-indene-1-carboxylic acid Chemical compound OC=1C=C2C(C(=O)O)CCC2=CC=1C(=O)C1=CC=CC=C1 XMTKXTUIUKKGIL-UHFFFAOYSA-N 0.000 description 1
• 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 description 1
• 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 description 1
• VJXSSYDSOJBUAV-UHFFFAOYSA-N 6-(2,5-dimethoxy-benzyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine Chemical compound COC1=CC=C(OC)C(CC=2C(=C3C(N)=NC(N)=NC3=NC=2)C)=C1 VJXSSYDSOJBUAV-UHFFFAOYSA-N 0.000 description 1
• WYWHKKSPHMUBEB-UHFFFAOYSA-N 6-Mercaptoguanine Natural products N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 1
• LJIRBXZDQGQUOO-KVTDHHQDSA-N 6-amino-3-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,4-dihydro-1,3,5-triazin-2-one Chemical compound C1NC(N)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 LJIRBXZDQGQUOO-KVTDHHQDSA-N 0.000 description 1
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 1
• ZAIRUODZMPTJLF-UHFFFAOYSA-N 7-acetamido-1,2,3-trimethoxy-6,7-dihydro-5h-dibenzo[5,3-b:1',2'-e][7]annulene-9-carboxylic acid Chemical compound C1CC(NC(C)=O)C2=CC(C(O)=O)=CC=C2C2=C1C=C(OC)C(OC)=C2OC ZAIRUODZMPTJLF-UHFFFAOYSA-N 0.000 description 1
• MBACVIQPEDNKOQ-UHFFFAOYSA-N 7-chloro-1,4-dioxido-2H-1,2,4-benzotriazine-1,4-diium-3-one Chemical compound C1=C(Cl)C=CC2=[N+]([O-])C(O)=N[N+]([O-])=C21 MBACVIQPEDNKOQ-UHFFFAOYSA-N 0.000 description 1
• BYSYOJSPRQFNOM-UHFFFAOYSA-N 7-nitro-1-oxido-1,2,4-benzotriazin-4-ium 4-oxide Chemical compound [O-][N+]1=CN=[N+]([O-])C2=CC([N+](=O)[O-])=CC=C21 BYSYOJSPRQFNOM-UHFFFAOYSA-N 0.000 description 1
• PWJFNRJRHXWEPT-UHFFFAOYSA-N ADP ribose Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OCC(O)C(O)C(O)C=O)C(O)C1O PWJFNRJRHXWEPT-UHFFFAOYSA-N 0.000 description 1
• PBZVIYIWLYRXNM-ZGRMKTROSA-N Acanthifolicin Chemical compound O([C@@]12[C@@H]3S[C@]3(C)C[C@H](O2)[C@H](C)/C=C/[C@H]2CC[C@@]3(CC[C@H]4O[C@@H](C([C@@H](O)[C@@H]4O3)=C)C(O)C[C@H](C)[C@@H]3[C@@H](CC[C@@]4(OCCCC4)O3)C)O2)[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]1O PBZVIYIWLYRXNM-ZGRMKTROSA-N 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 102100031786 Adiponectin Human genes 0.000 description 1
• 108010076365 Adiponectin Proteins 0.000 description 1
• 239000000275 Adrenocorticotropic Hormone Substances 0.000 description 1
• QMGUSPDJTPDFSF-UHFFFAOYSA-N Aldophosphamide Chemical class ClCCN(CCCl)P(=O)(N)OCCC=O QMGUSPDJTPDFSF-UHFFFAOYSA-N 0.000 description 1
• 102100033402 Angiopoietin-4 Human genes 0.000 description 1
• 108010064733 Angiotensins Proteins 0.000 description 1
• 102000015427 Angiotensins Human genes 0.000 description 1
• NVHRBQOZEMFKLD-CUYJMHBOSA-N BGC 945 Chemical compound C#CCN([C@@H]1C=2C=C3C(=O)N=C(NC3=CC=2CC1)CO)C1=CC=C(C(=O)N[C@@H](CCC(=O)N[C@H](CCC(O)=O)C(O)=O)C(O)=O)C=C1 NVHRBQOZEMFKLD-CUYJMHBOSA-N 0.000 description 1
• 108700000712 BH3 Interacting Domain Death Agonist Proteins 0.000 description 1
• 102000055105 BH3 Interacting Domain Death Agonist Human genes 0.000 description 1
• 241000894006 Bacteria Species 0.000 description 1
• KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• DFOCUWZXJBAUSQ-UHFFFAOYSA-N Berbamine Natural products O1C(C(=CC=2)O)=CC=2CC(C=23)N(C)CCC3=CC(OC)=C(OC)C=2OC(=CC=23)C(OC)=CC=2CCN(C)C3CC2=CC=C1C=C2 DFOCUWZXJBAUSQ-UHFFFAOYSA-N 0.000 description 1
• 229940123208 Biguanide Drugs 0.000 description 1
• XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 1
• MNIPYSSQXLZQLJ-UHFFFAOYSA-N Biofenac Chemical compound OC(=O)COC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl MNIPYSSQXLZQLJ-UHFFFAOYSA-N 0.000 description 1
• LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 108050001736 Bradykinin receptor Proteins 0.000 description 1
• DTTCBRVHIWNGFY-UHFFFAOYSA-N C1CCCC1.C(C(=O)O)(=O)O Chemical compound C1CCCC1.C(C(=O)O)(=O)O DTTCBRVHIWNGFY-UHFFFAOYSA-N 0.000 description 1
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 description 1
• FVLVBPDQNARYJU-XAHDHGMMSA-N C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O Chemical compound C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O FVLVBPDQNARYJU-XAHDHGMMSA-N 0.000 description 1
• 229940127291 Calcium channel antagonist Drugs 0.000 description 1
• 102000018208 Cannabinoid Receptor Human genes 0.000 description 1
• 108050007331 Cannabinoid receptor Proteins 0.000 description 1
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
• 206010048610 Cardiotoxicity Diseases 0.000 description 1
• 108010089448 Cholecystokinin B Receptor Proteins 0.000 description 1
• 108010018888 Choline kinase Proteins 0.000 description 1
• 108010009685 Cholinergic Receptors Proteins 0.000 description 1
• 235000001258 Cinchona calisaya Nutrition 0.000 description 1
• OIRAEJWYWSAQNG-UHFFFAOYSA-N Clidanac Chemical compound ClC=1C=C2C(C(=O)O)CCC2=CC=1C1CCCCC1 OIRAEJWYWSAQNG-UHFFFAOYSA-N 0.000 description 1
• PRGILOMAMBLWNG-HNNXBMFYSA-N Colchiceine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(O)=CC=C1C1=C2C=C(OC)C(OC)=C1OC PRGILOMAMBLWNG-HNNXBMFYSA-N 0.000 description 1
• 102400000739 Corticotropin Human genes 0.000 description 1
• 101800000414 Corticotropin Proteins 0.000 description 1
• MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
• MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
• XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
• 102000002427 Cyclin B Human genes 0.000 description 1
• 108010068150 Cyclin B Proteins 0.000 description 1
• 108010025454 Cyclin-Dependent Kinase 5 Proteins 0.000 description 1
• 102100032857 Cyclin-dependent kinase 1 Human genes 0.000 description 1
• 101710106279 Cyclin-dependent kinase 1 Proteins 0.000 description 1
• 102100026805 Cyclin-dependent-like kinase 5 Human genes 0.000 description 1
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
• 108010036949 Cyclosporine Proteins 0.000 description 1
• 108090000323 DNA Topoisomerases Proteins 0.000 description 1
• 102000003915 DNA Topoisomerases Human genes 0.000 description 1
• 230000000970 DNA cross-linking effect Effects 0.000 description 1
• 230000007067 DNA methylation Effects 0.000 description 1
• 238000000018 DNA microarray Methods 0.000 description 1
• 239000012626 DNA minor groove binder Substances 0.000 description 1
• 238000001712 DNA sequencing Methods 0.000 description 1
• 231100001074 DNA strand break Toxicity 0.000 description 1
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 1
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 1
• 229940122964 Deacetylase inhibitor Drugs 0.000 description 1
• GZDFHIJNHHMENY-UHFFFAOYSA-N Dimethyl dicarbonate Chemical compound COC(=O)OC(=O)OC GZDFHIJNHHMENY-UHFFFAOYSA-N 0.000 description 1
• LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
• 206010061818 Disease progression Diseases 0.000 description 1
• 102000015554 Dopamine receptor Human genes 0.000 description 1
• 108050004812 Dopamine receptor Proteins 0.000 description 1
• CYQFCXCEBYINGO-DLBZAZTESA-N Dronabinol Natural products C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@H]21 CYQFCXCEBYINGO-DLBZAZTESA-N 0.000 description 1
• 108010024212 E-Selectin Proteins 0.000 description 1
• 102100023471 E-selectin Human genes 0.000 description 1
• 101150016325 EPHA3 gene Proteins 0.000 description 1
• 101150029707 ERBB2 gene Proteins 0.000 description 1
• 102000010180 Endothelin receptor Human genes 0.000 description 1
• 108050001739 Endothelin receptor Proteins 0.000 description 1
• 108010092408 Eosinophil Peroxidase Proteins 0.000 description 1
• 102100028471 Eosinophil peroxidase Human genes 0.000 description 1
• 102100030324 Ephrin type-A receptor 3 Human genes 0.000 description 1
• RHAXSHUQNIEUEY-UHFFFAOYSA-N Epirizole Chemical compound COC1=CC(C)=NN1C1=NC(C)=CC(OC)=N1 RHAXSHUQNIEUEY-UHFFFAOYSA-N 0.000 description 1
• 108010041356 Estrogen Receptor beta Proteins 0.000 description 1
• 102100029951 Estrogen receptor beta Human genes 0.000 description 1
• OKTVKHFLUVLUIH-UHFFFAOYSA-N FC1=C(C(=C(C(=C1F)F)F)F)C(=CC1=CC=C(C=CC(=O)O)C=C1)C Chemical compound FC1=C(C(=C(C(=C1F)F)F)F)C(=CC1=CC=C(C=CC(=O)O)C=C1)C OKTVKHFLUVLUIH-UHFFFAOYSA-N 0.000 description 1
• 102000008175 FSH Receptors Human genes 0.000 description 1
• 108010060374 FSH Receptors Proteins 0.000 description 1
• RBBWCVQDXDFISW-UHFFFAOYSA-N Feprazone Chemical compound O=C1C(CC=C(C)C)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 RBBWCVQDXDFISW-UHFFFAOYSA-N 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 206010016654 Fibrosis Diseases 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• PLDUPXSUYLZYBN-UHFFFAOYSA-N Fluphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(C(F)(F)F)=CC=C2SC2=CC=CC=C21 PLDUPXSUYLZYBN-UHFFFAOYSA-N 0.000 description 1
• 108091006027 G proteins Proteins 0.000 description 1
• 230000037057 G1 phase arrest Effects 0.000 description 1
• 230000037059 G2/M phase arrest Effects 0.000 description 1
• 102000030782 GTP binding Human genes 0.000 description 1
• 108091000058 GTP-Binding Proteins 0.000 description 1
• 102000011392 Galanin receptor Human genes 0.000 description 1
• 108050001605 Galanin receptor Proteins 0.000 description 1
• 102000052874 Gastrin receptors Human genes 0.000 description 1
• 206010051066 Gastrointestinal stromal tumour Diseases 0.000 description 1
• 206010059024 Gastrointestinal toxicity Diseases 0.000 description 1
• 241000237858 Gastropoda Species 0.000 description 1
• ZCOLJUOHXJRHDI-FZHKGVQDSA-N Genistein 7-O-glucoside Natural products O([C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)c1cc(O)c2C(=O)C(c3ccc(O)cc3)=COc2c1 ZCOLJUOHXJRHDI-FZHKGVQDSA-N 0.000 description 1
• CJPNHKPXZYYCME-UHFFFAOYSA-N Genistin Natural products OCC1OC(Oc2ccc(O)c3OC(=CC(=O)c23)c4ccc(O)cc4)C(O)C(O)C1O CJPNHKPXZYYCME-UHFFFAOYSA-N 0.000 description 1
• 108010027915 Glutamate Receptors Proteins 0.000 description 1
• 102000018899 Glutamate Receptors Human genes 0.000 description 1
• XJTZHGNBKZYODI-UHFFFAOYSA-N Glycitin Natural products OCC1OC(Oc2ccc3OC=C(C(=O)c3c2CO)c4ccc(O)cc4)C(O)C(O)C1O XJTZHGNBKZYODI-UHFFFAOYSA-N 0.000 description 1
• 102000001895 Gonadotropin Receptors Human genes 0.000 description 1
• 108010040490 Gonadotropin Receptors Proteins 0.000 description 1
• 102000001398 Granzyme Human genes 0.000 description 1
• 108060005986 Granzyme Proteins 0.000 description 1
• 241000288105 Grus Species 0.000 description 1
• 102000006947 Histones Human genes 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 1
• 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 description 1
• 101000799388 Homo sapiens Thiopurine S-methyltransferase Proteins 0.000 description 1
• 101000891649 Homo sapiens Transcription elongation factor A protein-like 1 Proteins 0.000 description 1
• 206010062904 Hormone-refractory prostate cancer Diseases 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
• STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
• OBYGAPWKTPDTAS-OCAPTIKFSA-N ICRF-193 Chemical compound N1([C@H](C)[C@H](C)N2CC(=O)NC(=O)C2)CC(=O)NC(=O)C1 OBYGAPWKTPDTAS-OCAPTIKFSA-N 0.000 description 1
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
• HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
• 102100022338 Integrin alpha-M Human genes 0.000 description 1
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
• 229940118465 Isomerase inhibitor Drugs 0.000 description 1
• PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
• UETNIIAIRMUTSM-UHFFFAOYSA-N Jacareubin Natural products CC1(C)OC2=CC3Oc4c(O)c(O)ccc4C(=O)C3C(=C2C=C1)O UETNIIAIRMUTSM-UHFFFAOYSA-N 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• MLFKVJCWGUZWNV-UHFFFAOYSA-N L-alanosine Natural products OC(=O)C(N)CN(O)N=O MLFKVJCWGUZWNV-UHFFFAOYSA-N 0.000 description 1
• 102000008238 LHRH Receptors Human genes 0.000 description 1
• 108010021290 LHRH Receptors Proteins 0.000 description 1
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
• SBDNJUWAMKYJOX-UHFFFAOYSA-N Meclofenamic Acid Chemical compound CC1=CC=C(Cl)C(NC=2C(=CC=CC=2)C(O)=O)=C1Cl SBDNJUWAMKYJOX-UHFFFAOYSA-N 0.000 description 1
• ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 description 1
• 102100037510 Metallothionein-1E Human genes 0.000 description 1
• 241001465754 Metazoa Species 0.000 description 1
• FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 description 1
• DJEIHHYCDCTAAH-UHFFFAOYSA-N Mofezolac (TN) Chemical compound C1=CC(OC)=CC=C1C1=NOC(CC(O)=O)=C1C1=CC=C(OC)C=C1 DJEIHHYCDCTAAH-UHFFFAOYSA-N 0.000 description 1
• 101100325747 Mus musculus Bak1 gene Proteins 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
• 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 1
• QJMCKEPOKRERLN-UHFFFAOYSA-N N-3,4-tridhydroxybenzamide Chemical compound ONC(=O)C1=CC=C(O)C(O)=C1 QJMCKEPOKRERLN-UHFFFAOYSA-N 0.000 description 1
• STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
• 125000003047 N-acetyl group Chemical group 0.000 description 1
• 229910002651 NO3 Inorganic materials 0.000 description 1
• BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 description 1
• 108050002826 Neuropeptide Y Receptor Proteins 0.000 description 1
• 102000012301 Neuropeptide Y receptor Human genes 0.000 description 1
• 206010029350 Neurotoxicity Diseases 0.000 description 1
• JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 description 1
• 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 description 1
• 229960005556 ONX-0801 Drugs 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 108700020796 Oncogene Proteins 0.000 description 1
• 102000003840 Opioid Receptors Human genes 0.000 description 1
• 108090000137 Opioid Receptors Proteins 0.000 description 1
• 206010033128 Ovarian cancer Diseases 0.000 description 1
• 206010061535 Ovarian neoplasm Diseases 0.000 description 1
• 102000004316 Oxidoreductases Human genes 0.000 description 1
• 108090000854 Oxidoreductases Proteins 0.000 description 1
• 102100028139 Oxytocin receptor Human genes 0.000 description 1
• 108090000876 Oxytocin receptors Proteins 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• YCUNGEJJOMKCGZ-UHFFFAOYSA-N Pallidiflorin Natural products C1=CC(OC)=CC=C1C1=COC2=CC=CC(O)=C2C1=O YCUNGEJJOMKCGZ-UHFFFAOYSA-N 0.000 description 1
• 108010058828 Parathyroid Hormone Receptors Proteins 0.000 description 1
• 102000006461 Parathyroid Hormone Receptors Human genes 0.000 description 1
• 102000003728 Peroxisome Proliferator-Activated Receptors Human genes 0.000 description 1
• 108090000029 Peroxisome Proliferator-Activated Receptors Proteins 0.000 description 1
• RGCVKNLCSQQDEP-UHFFFAOYSA-N Perphenazine Chemical compound C1CN(CCO)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 RGCVKNLCSQQDEP-UHFFFAOYSA-N 0.000 description 1
• ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
• 108700023400 Platelet-activating factor receptors Proteins 0.000 description 1
• 108030005449 Polo kinases Proteins 0.000 description 1
• 108091026813 Poly(ADPribose) Proteins 0.000 description 1
• 229920002685 Polyoxyl 35CastorOil Polymers 0.000 description 1
• TVQZAMVBTVNYLA-UHFFFAOYSA-N Pranoprofen Chemical compound C1=CC=C2CC3=CC(C(C(O)=O)C)=CC=C3OC2=N1 TVQZAMVBTVNYLA-UHFFFAOYSA-N 0.000 description 1
• HFVNWDWLWUCIHC-GUPDPFMOSA-N Prednimustine Chemical compound O=C([C@@]1(O)CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)[C@@H](O)C[C@@]21C)COC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 HFVNWDWLWUCIHC-GUPDPFMOSA-N 0.000 description 1
• 108010009736 Protein Hydrolysates Proteins 0.000 description 1
• 229940123573 Protein synthesis inhibitor Drugs 0.000 description 1
• 102000052575 Proto-Oncogene Human genes 0.000 description 1
• 108700020978 Proto-Oncogene Proteins 0.000 description 1
• 102000013535 Proto-Oncogene Proteins c-bcl-2 Human genes 0.000 description 1
• 108010090931 Proto-Oncogene Proteins c-bcl-2 Proteins 0.000 description 1
• 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 1
• 102000007568 Proto-Oncogene Proteins c-fos Human genes 0.000 description 1
• 108010087776 Proto-Oncogene Proteins c-myb Proteins 0.000 description 1
• 102000009096 Proto-Oncogene Proteins c-myb Human genes 0.000 description 1
• 108010087705 Proto-Oncogene Proteins c-myc Proteins 0.000 description 1
• 102000009092 Proto-Oncogene Proteins c-myc Human genes 0.000 description 1
• LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Natural products C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 description 1
• 230000006819 RNA synthesis Effects 0.000 description 1
• AHHFEZNOXOZZQA-ZEBDFXRSSA-N Ranimustine Chemical compound CO[C@H]1O[C@H](CNC(=O)N(CCCl)N=O)[C@@H](O)[C@H](O)[C@H]1O AHHFEZNOXOZZQA-ZEBDFXRSSA-N 0.000 description 1
• 229940127361 Receptor Tyrosine Kinase Inhibitors Drugs 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 102000016983 Releasing hormones receptors Human genes 0.000 description 1
• 108070000025 Releasing hormones receptors Proteins 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• 108091006299 SLC2A2 Proteins 0.000 description 1
• SKZKKFZAGNVIMN-UHFFFAOYSA-N Salicilamide Chemical compound NC(=O)C1=CC=CC=C1O SKZKKFZAGNVIMN-UHFFFAOYSA-N 0.000 description 1
• NGFMICBWJRZIBI-JZRPKSSGSA-N Salicin Natural products O([C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O1)c1c(CO)cccc1 NGFMICBWJRZIBI-JZRPKSSGSA-N 0.000 description 1
• 206010039897 Sedation Diseases 0.000 description 1
• 201000001880 Sexual dysfunction Diseases 0.000 description 1
• ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 1
• 108050001286 Somatostatin Receptor Proteins 0.000 description 1
• 102000011096 Somatostatin receptor Human genes 0.000 description 1
• 241001330502 Stephania Species 0.000 description 1
• 239000005864 Sulphur Substances 0.000 description 1
• 230000005867 T cell response Effects 0.000 description 1
• CYQFCXCEBYINGO-UHFFFAOYSA-N THC Natural products C1=C(C)CCC2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3C21 CYQFCXCEBYINGO-UHFFFAOYSA-N 0.000 description 1
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
• 102100034162 Thiopurine S-methyltransferase Human genes 0.000 description 1
• 102000005497 Thymidylate Synthase Human genes 0.000 description 1
• 229940127327 Thymidylate Synthetase Inhibitors Drugs 0.000 description 1
• IVTVGDXNLFLDRM-HNNXBMFYSA-N Tomudex Chemical compound C=1C=C2NC(C)=NC(=O)C2=CC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)S1 IVTVGDXNLFLDRM-HNNXBMFYSA-N 0.000 description 1
• 206010044221 Toxic encephalopathy Diseases 0.000 description 1
• LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
• 108050005223 Transcription factor Jun Proteins 0.000 description 1
• 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
• DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 description 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
• 108010000134 Vascular Cell Adhesion Molecule-1 Proteins 0.000 description 1
• 102100023543 Vascular cell adhesion protein 1 Human genes 0.000 description 1
• 102000004136 Vasopressin Receptors Human genes 0.000 description 1
• 108090000643 Vasopressin Receptors Proteins 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• WREGKURFCTUGRC-POYBYMJQSA-N Zalcitabine Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](CO)CC1 WREGKURFCTUGRC-POYBYMJQSA-N 0.000 description 1
• MUXFZBHBYYYLTH-UHFFFAOYSA-N Zaltoprofen Chemical compound O=C1CC2=CC(C(C(O)=O)C)=CC=C2SC2=CC=CC=C21 MUXFZBHBYYYLTH-UHFFFAOYSA-N 0.000 description 1
• LJBKHHZPVCABCX-ZYUZMQFOSA-N [(2r,3r,4r,5r)-2,5-dihydroxy-3,4-dimethoxy-6-methylsulfonyloxyhexyl] methanesulfonate Chemical compound CS(=O)(=O)OC[C@@H](O)[C@@H](OC)[C@H](OC)[C@H](O)COS(C)(=O)=O LJBKHHZPVCABCX-ZYUZMQFOSA-N 0.000 description 1
• DJUWKQJNJVMFIU-IHAUNJBESA-N [(2r,3r,4s,5r)-3,4,5-triacetyloxy-6-[bis(2-chloroethyl)amino]oxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@H]1OC(N(CCCl)CCCl)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H]1OC(C)=O DJUWKQJNJVMFIU-IHAUNJBESA-N 0.000 description 1
• IFJUINDAXYAPTO-UUBSBJJBSA-N [(8r,9s,13s,14s,17s)-17-[2-[4-[4-[bis(2-chloroethyl)amino]phenyl]butanoyloxy]acetyl]oxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-yl] benzoate Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4OC(=O)COC(=O)CCCC=1C=CC(=CC=1)N(CCCl)CCCl)C)CC2=CC=3OC(=O)C1=CC=CC=C1 IFJUINDAXYAPTO-UUBSBJJBSA-N 0.000 description 1
• PWJFNRJRHXWEPT-AOOZFPJJSA-N [[(2r,3s,4r,5r)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2r,3r,4r)-2,3,4-trihydroxy-5-oxopentyl] hydrogen phosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)[C@@H](O)[C@H]1O PWJFNRJRHXWEPT-AOOZFPJJSA-N 0.000 description 1
• MHVFYGIQJNFWGQ-UHFFFAOYSA-N [[4,6-bis[hydroxymethyl(methyl)amino]-1,3,5-triazin-2-yl]-methylamino]methanol Chemical compound OCN(C)C1=NC(N(C)CO)=NC(N(C)CO)=N1 MHVFYGIQJNFWGQ-UHFFFAOYSA-N 0.000 description 1
• 230000002159 abnormal effect Effects 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• 229960004420 aceclofenac Drugs 0.000 description 1
• 102000034337 acetylcholine receptors Human genes 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 description 1
• 229960003205 adefovir dipivoxil Drugs 0.000 description 1
• 208000009956 adenocarcinoma Diseases 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 229950005033 alanosine Drugs 0.000 description 1
• 229960005142 alclofenac Drugs 0.000 description 1
• ARHWPKZXBHOEEE-UHFFFAOYSA-N alclofenac Chemical compound OC(=O)CC1=CC=C(OCC=C)C(Cl)=C1 ARHWPKZXBHOEEE-UHFFFAOYSA-N 0.000 description 1
• 229930013930 alkaloid Natural products 0.000 description 1
• 150000003797 alkaloid derivatives Chemical class 0.000 description 1
• 150000001336 alkenes Chemical class 0.000 description 1
• 125000005090 alkenylcarbonyl group Chemical group 0.000 description 1
• 125000005092 alkenyloxycarbonyl group Chemical group 0.000 description 1
• 125000005137 alkenylsulfonyl group Chemical group 0.000 description 1
• 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
• 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
• 125000005276 alkyl hydrazino group Chemical group 0.000 description 1
• 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
• 125000005087 alkynylcarbonyl group Chemical group 0.000 description 1
• 125000005225 alkynyloxycarbonyl group Chemical group 0.000 description 1
• 125000005139 alkynylsulfonyl group Chemical group 0.000 description 1
• OFCNXPDARWKPPY-UHFFFAOYSA-N allopurinol Chemical compound OC1=NC=NC2=C1C=NN2 OFCNXPDARWKPPY-UHFFFAOYSA-N 0.000 description 1
• 229960003459 allopurinol Drugs 0.000 description 1
• 229960004663 alminoprofen Drugs 0.000 description 1
• FPHLBGOJWPEVME-UHFFFAOYSA-N alminoprofen Chemical compound OC(=O)C(C)C1=CC=C(NCC(C)=C)C=C1 FPHLBGOJWPEVME-UHFFFAOYSA-N 0.000 description 1
• NGFMICBWJRZIBI-UHFFFAOYSA-N alpha-salicin Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UHFFFAOYSA-N 0.000 description 1
• 229960000473 altretamine Drugs 0.000 description 1
• SOYCMDCMZDHQFP-UHFFFAOYSA-N amfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=CC=C1 SOYCMDCMZDHQFP-UHFFFAOYSA-N 0.000 description 1
• 229950008930 amfenac Drugs 0.000 description 1
• 150000001408 amides Chemical class 0.000 description 1
• 150000003862 amino acid derivatives Chemical class 0.000 description 1
• 229920000469 amphiphilic block copolymer Polymers 0.000 description 1
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
• 229960000723 ampicillin Drugs 0.000 description 1
• LSNWBKACGXCGAJ-UHFFFAOYSA-N ampiroxicam Chemical compound CN1S(=O)(=O)C2=CC=CC=C2C(OC(C)OC(=O)OCC)=C1C(=O)NC1=CC=CC=N1 LSNWBKACGXCGAJ-UHFFFAOYSA-N 0.000 description 1
• 229950011249 ampiroxicam Drugs 0.000 description 1
• 229960001220 amsacrine Drugs 0.000 description 1
• XCPGHVQEEXUHNC-UHFFFAOYSA-N amsacrine Chemical compound COC1=CC(NS(C)(=O)=O)=CC=C1NC1=C(C=CC=C2)C2=NC2=CC=CC=C12 XCPGHVQEEXUHNC-UHFFFAOYSA-N 0.000 description 1
• 229950001003 anaxirone Drugs 0.000 description 1
• 108010069801 angiopoietin 4 Proteins 0.000 description 1
• 230000003288 anthiarrhythmic effect Effects 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000003266 anti-allergic effect Effects 0.000 description 1
• 230000001772 anti-angiogenic effect Effects 0.000 description 1
• 230000002456 anti-arthritic effect Effects 0.000 description 1
• 230000001093 anti-cancer Effects 0.000 description 1
• 230000002253 anti-ischaemic effect Effects 0.000 description 1
• 230000003471 anti-radiation Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 238000009175 antibody therapy Methods 0.000 description 1
• 239000000935 antidepressant agent Substances 0.000 description 1
• 229940005513 antidepressants Drugs 0.000 description 1
• 229940127088 antihypertensive drug Drugs 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
• PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 1
• 125000005140 aralkylsulfonyl group Chemical group 0.000 description 1
• 229950003523 araprofen Drugs 0.000 description 1
• GOLCXWYRSKYTSP-UHFFFAOYSA-N arsenic trioxide Inorganic materials O1[As]2O[As]1O2 GOLCXWYRSKYTSP-UHFFFAOYSA-N 0.000 description 1
• 125000005161 aryl oxy carbonyl group Chemical group 0.000 description 1
• 125000004391 aryl sulfonyl group Chemical group 0.000 description 1
• 125000004104 aryloxy group Chemical group 0.000 description 1
• GIXWDMTZECRIJT-UHFFFAOYSA-N aurintricarboxylic acid Chemical compound C1=CC(=O)C(C(=O)O)=CC1=C(C=1C=C(C(O)=CC=1)C(O)=O)C1=CC=C(O)C(C(O)=O)=C1 GIXWDMTZECRIJT-UHFFFAOYSA-N 0.000 description 1
• 229940120638 avastin Drugs 0.000 description 1
• KLNFSAOEKUDMFA-UHFFFAOYSA-N azanide;2-hydroxyacetic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OCC(O)=O KLNFSAOEKUDMFA-UHFFFAOYSA-N 0.000 description 1
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 1
• 229960002170 azathioprine Drugs 0.000 description 1
• LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 description 1
• 210000003651 basophil Anatomy 0.000 description 1
• 229950001858 batimastat Drugs 0.000 description 1
• XFILPEOLDIKJHX-QYZOEREBSA-N batimastat Chemical compound C([C@@H](C(=O)NC)NC(=O)[C@H](CC(C)C)[C@H](CSC=1SC=CC=1)C(=O)NO)C1=CC=CC=C1 XFILPEOLDIKJHX-QYZOEREBSA-N 0.000 description 1
• 102000055574 bcl-2 Homologous Antagonist-Killer Human genes 0.000 description 1
• 108700039689 bcl-2 Homologous Antagonist-Killer Proteins 0.000 description 1
• 229950000210 beclometasone dipropionate Drugs 0.000 description 1
• LNHWXBUNXOXMRL-VWLOTQADSA-N belotecan Chemical compound C1=CC=C2C(CCNC(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 LNHWXBUNXOXMRL-VWLOTQADSA-N 0.000 description 1
• 229950011276 belotecan Drugs 0.000 description 1
• 229960005149 bendazac Drugs 0.000 description 1
• BYFMCKSPFYVMOU-UHFFFAOYSA-N bendazac Chemical compound C12=CC=CC=C2C(OCC(=O)O)=NN1CC1=CC=CC=C1 BYFMCKSPFYVMOU-UHFFFAOYSA-N 0.000 description 1
• 229960005430 benoxaprofen Drugs 0.000 description 1
• PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical group NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 description 1
• 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 1
• 150000001557 benzodiazepines Chemical class 0.000 description 1
• 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 1
• 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 1
• 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 description 1
• KMGARVOVYXNAOF-UHFFFAOYSA-N benzpiperylone Chemical compound C1CN(C)CCC1N1C(=O)C(CC=2C=CC=CC=2)=C(C=2C=CC=CC=2)N1 KMGARVOVYXNAOF-UHFFFAOYSA-N 0.000 description 1
• 229950007647 benzpiperylone Drugs 0.000 description 1
• 229960000333 benzydamine Drugs 0.000 description 1
• 102000012740 beta Adrenergic Receptors Human genes 0.000 description 1
• 108010079452 beta Adrenergic Receptors Proteins 0.000 description 1
• SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
• DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 description 1
• 230000001588 bifunctional effect Effects 0.000 description 1
• 230000003115 biocidal effect Effects 0.000 description 1
• 229920002988 biodegradable polymer Polymers 0.000 description 1
• 239000004621 biodegradable polymer Substances 0.000 description 1
• 238000012925 biological evaluation Methods 0.000 description 1
• 230000008236 biological pathway Effects 0.000 description 1
• 230000005540 biological transmission Effects 0.000 description 1
• 238000001574 biopsy Methods 0.000 description 1
• 238000007413 biotinylation Methods 0.000 description 1
• 230000006287 biotinylation Effects 0.000 description 1
• QRZAKQDHEVVFRX-UHFFFAOYSA-N biphenyl-4-ylacetic acid Chemical compound C1=CC(CC(=O)O)=CC=C1C1=CC=CC=C1 QRZAKQDHEVVFRX-UHFFFAOYSA-N 0.000 description 1
• OTBHHUPVCYLGQO-UHFFFAOYSA-N bis(3-aminopropyl)amine Chemical compound NCCCNCCCN OTBHHUPVCYLGQO-UHFFFAOYSA-N 0.000 description 1
• 238000004820 blood count Methods 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• 210000002798 bone marrow cell Anatomy 0.000 description 1
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 1
• 229960001467 bortezomib Drugs 0.000 description 1
• 210000004556 brain Anatomy 0.000 description 1
• 210000000481 breast Anatomy 0.000 description 1
• PZOHOALJQOFNTB-UHFFFAOYSA-M brequinar sodium Chemical compound [Na+].N1=C2C=CC(F)=CC2=C(C([O-])=O)C(C)=C1C(C=C1)=CC=C1C1=CC=CC=C1F PZOHOALJQOFNTB-UHFFFAOYSA-M 0.000 description 1
• 229960003655 bromfenac Drugs 0.000 description 1
• ZBPLOVFIXSTCRZ-UHFFFAOYSA-N bromfenac Chemical compound NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1 ZBPLOVFIXSTCRZ-UHFFFAOYSA-N 0.000 description 1
• 229950005608 bucloxic acid Drugs 0.000 description 1
• IJTPQQVCKPZIMV-UHFFFAOYSA-N bucloxic acid Chemical compound ClC1=CC(C(=O)CCC(=O)O)=CC=C1C1CCCCC1 IJTPQQVCKPZIMV-UHFFFAOYSA-N 0.000 description 1
• 229950002361 budotitane Drugs 0.000 description 1
• 229960003354 bumadizone Drugs 0.000 description 1
• FLWFHHFTIRLFPV-UHFFFAOYSA-N bumadizone Chemical compound C=1C=CC=CC=1N(C(=O)C(C(O)=O)CCCC)NC1=CC=CC=C1 FLWFHHFTIRLFPV-UHFFFAOYSA-N 0.000 description 1
• UULSXYSSHHRCQK-UHFFFAOYSA-N butibufen Chemical compound CCC(C(O)=O)C1=CC=C(CC(C)C)C=C1 UULSXYSSHHRCQK-UHFFFAOYSA-N 0.000 description 1
• 229960002973 butibufen Drugs 0.000 description 1
• 239000000480 calcium channel blocker Substances 0.000 description 1
• 230000005907 cancer growth Effects 0.000 description 1
• 229940065144 cannabinoids Drugs 0.000 description 1
• 125000004452 carbocyclyl group Chemical group 0.000 description 1
• 229960004562 carboplatin Drugs 0.000 description 1
• 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
• 231100000259 cardiotoxicity Toxicity 0.000 description 1
• 229960005243 carmustine Drugs 0.000 description 1
• 229960003184 carprofen Drugs 0.000 description 1
• IVUMCTKHWDRRMH-UHFFFAOYSA-N carprofen Chemical compound C1=CC(Cl)=C[C]2C3=CC=C(C(C(O)=O)C)C=C3N=C21 IVUMCTKHWDRRMH-UHFFFAOYSA-N 0.000 description 1
• 229960000590 celecoxib Drugs 0.000 description 1
• RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 1
• 230000022131 cell cycle Effects 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 238000002659 cell therapy Methods 0.000 description 1
• UKTAZPQNNNJVKR-KJGYPYNMSA-N chembl2368925 Chemical compound C1=CC=C2C(C(O[C@@H]3C[C@@H]4C[C@H]5C[C@@H](N4CC5=O)C3)=O)=CNC2=C1 UKTAZPQNNNJVKR-KJGYPYNMSA-N 0.000 description 1
• 150000005829 chemical entities Chemical class 0.000 description 1
• 230000002113 chemopreventative effect Effects 0.000 description 1
• 239000006114 chemosensitizer Substances 0.000 description 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
• 229960004630 chlorambucil Drugs 0.000 description 1
• 239000012320 chlorinating reagent Substances 0.000 description 1
• 125000001309 chloro group Chemical group Cl* 0.000 description 1
• ZPEIMTDSQAKGNT-UHFFFAOYSA-N chlorpromazine Chemical compound C1=C(Cl)C=C2N(CCCN(C)C)C3=CC=CC=C3SC2=C1 ZPEIMTDSQAKGNT-UHFFFAOYSA-N 0.000 description 1
• 229960001076 chlorpromazine Drugs 0.000 description 1
• 229960001265 ciclosporin Drugs 0.000 description 1
• 229950010851 cimicoxib Drugs 0.000 description 1
• KYXDNECMRLFQMZ-UHFFFAOYSA-N cimicoxib Chemical compound C1=C(F)C(OC)=CC=C1C1=C(Cl)N=CN1C1=CC=C(S(N)(=O)=O)C=C1 KYXDNECMRLFQMZ-UHFFFAOYSA-N 0.000 description 1
• 229950011171 cinmetacin Drugs 0.000 description 1
• NKPPORKKCMYYTO-DHZHZOJOSA-N cinmetacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)\C=C\C1=CC=CC=C1 NKPPORKKCMYYTO-DHZHZOJOSA-N 0.000 description 1
• GPUVGQIASQNZET-CCEZHUSRSA-N cinnoxicam Chemical compound C=1C=CC=CC=1/C=C/C(=O)OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 GPUVGQIASQNZET-CCEZHUSRSA-N 0.000 description 1
• 229950001983 cinnoxicam Drugs 0.000 description 1
• 230000007882 cirrhosis Effects 0.000 description 1
• 208000019425 cirrhosis of liver Diseases 0.000 description 1
• 229950010886 clidanac Drugs 0.000 description 1
• 229940121657 clinical drug Drugs 0.000 description 1
• 229960003140 clofezone Drugs 0.000 description 1
• CLOMYZFHNHFSIQ-UHFFFAOYSA-N clonixin Chemical compound CC1=C(Cl)C=CC=C1NC1=NC=CC=C1C(O)=O CLOMYZFHNHFSIQ-UHFFFAOYSA-N 0.000 description 1
• 229960001209 clonixin Drugs 0.000 description 1
• SJCRQMUYEQHNTC-UHFFFAOYSA-N clopirac Chemical compound CC1=CC(CC(O)=O)=C(C)N1C1=CC=C(Cl)C=C1 SJCRQMUYEQHNTC-UHFFFAOYSA-N 0.000 description 1
• 229950009185 clopirac Drugs 0.000 description 1
• 230000006690 co-activation Effects 0.000 description 1
• 230000003081 coactivator Effects 0.000 description 1
• 230000015271 coagulation Effects 0.000 description 1
• 238000005345 coagulation Methods 0.000 description 1
• 229960004126 codeine Drugs 0.000 description 1
• OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Natural products C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 1
• PRGILOMAMBLWNG-UHFFFAOYSA-N colchicceine Natural products C1CC(NC(C)=O)C2=CC(=O)C(O)=CC=C2C2=C1C=C(OC)C(OC)=C2OC PRGILOMAMBLWNG-UHFFFAOYSA-N 0.000 description 1
• 230000001332 colony forming effect Effects 0.000 description 1
• 238000002648 combination therapy Methods 0.000 description 1
• 238000002967 competitive immunoassay Methods 0.000 description 1
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
• 229960000258 corticotropin Drugs 0.000 description 1
• 229960004544 cortisone Drugs 0.000 description 1
• POADTFBBIXOWFJ-VWLOTQADSA-N cositecan Chemical compound C1=CC=C2C(CC[Si](C)(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 POADTFBBIXOWFJ-VWLOTQADSA-N 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• UVKZSORBKUEBAZ-UHFFFAOYSA-N cyclizine Chemical compound C1CN(C)CCN1C(C=1C=CC=CC=1)C1=CC=CC=C1 UVKZSORBKUEBAZ-UHFFFAOYSA-N 0.000 description 1
• 229960003564 cyclizine Drugs 0.000 description 1
• 125000006254 cycloalkyl carbonyl group Chemical group 0.000 description 1
• BVQPGVHVDXIPJF-UHFFFAOYSA-L cyclohexane-1,2-diamine;hydron;2-[(2-phosphonatoacetyl)amino]butanedioate;platinum(2+) Chemical compound [H+].[H+].[Pt+2].NC1CCCCC1N.[O-]C(=O)CC(C([O-])=O)NC(=O)CP([O-])([O-])=O BVQPGVHVDXIPJF-UHFFFAOYSA-L 0.000 description 1
• 229960004397 cyclophosphamide Drugs 0.000 description 1
• 229930182912 cyclosporin Natural products 0.000 description 1
• 102000003675 cytokine receptors Human genes 0.000 description 1
• 108010057085 cytokine receptors Proteins 0.000 description 1
• 239000000824 cytostatic agent Substances 0.000 description 1
• 230000001085 cytostatic effect Effects 0.000 description 1
• 239000002619 cytotoxin Substances 0.000 description 1
• 229950000393 darbufelone Drugs 0.000 description 1
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 1
• 229960000975 daunorubicin Drugs 0.000 description 1
• 230000034994 death Effects 0.000 description 1
• 238000003066 decision tree Methods 0.000 description 1
• 229940073499 decyl glucoside Drugs 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• WAZQAZKAZLXFMK-UHFFFAOYSA-N deracoxib Chemical compound C1=C(F)C(OC)=CC=C1C1=CC(C(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 WAZQAZKAZLXFMK-UHFFFAOYSA-N 0.000 description 1
• 229960003314 deracoxib Drugs 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 125000004985 dialkyl amino alkyl group Chemical group 0.000 description 1
• BEZLHIODJLUHQU-UHFFFAOYSA-N diaminomethylideneazanium phthalate Chemical compound NC(N)=N.NC(N)=N.OC(=O)C1=CC=CC=C1C(O)=O BEZLHIODJLUHQU-UHFFFAOYSA-N 0.000 description 1
• DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
• 229960001259 diclofenac Drugs 0.000 description 1
• UFIVBRCCIRTJTN-UHFFFAOYSA-N difenoxin Chemical compound C1CC(C(=O)O)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 UFIVBRCCIRTJTN-UHFFFAOYSA-N 0.000 description 1
• 229960005493 difenoxin Drugs 0.000 description 1
• 150000004683 dihydrates Chemical class 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• MZDOIJOUFRQXHC-UHFFFAOYSA-N dimenhydrinate Chemical compound O=C1N(C)C(=O)N(C)C2=NC(Cl)=N[C]21.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 MZDOIJOUFRQXHC-UHFFFAOYSA-N 0.000 description 1
• 229960004993 dimenhydrinate Drugs 0.000 description 1
• 235000010300 dimethyl dicarbonate Nutrition 0.000 description 1
• ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
• 229960000520 diphenhydramine Drugs 0.000 description 1
• HYPPXZBJBPSRLK-UHFFFAOYSA-N diphenoxylate Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(C#N)(C=1C=CC=CC=1)C1=CC=CC=C1 HYPPXZBJBPSRLK-UHFFFAOYSA-N 0.000 description 1
• 229960004192 diphenoxylate Drugs 0.000 description 1
• 229940035422 diphenylamine Drugs 0.000 description 1
• 230000005750 disease progression Effects 0.000 description 1
• 238000004090 dissolution Methods 0.000 description 1
• 230000001882 diuretic effect Effects 0.000 description 1
• 229960003413 dolasetron Drugs 0.000 description 1
• 229960003638 dopamine Drugs 0.000 description 1
• 231100000673 dose–response relationship Toxicity 0.000 description 1
• 238000004980 dosimetry Methods 0.000 description 1
• 230000002222 downregulating effect Effects 0.000 description 1
• 229960004242 dronabinol Drugs 0.000 description 1
• 229960001850 droxicam Drugs 0.000 description 1
• OEHFRZLKGRKFAS-UHFFFAOYSA-N droxicam Chemical compound C12=CC=CC=C2S(=O)(=O)N(C)C(C2=O)=C1OC(=O)N2C1=CC=CC=N1 OEHFRZLKGRKFAS-UHFFFAOYSA-N 0.000 description 1
• 230000008406 drug-drug interaction Effects 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• FSIRXIHZBIXHKT-MHTVFEQDSA-N edatrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CC(CC)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FSIRXIHZBIXHKT-MHTVFEQDSA-N 0.000 description 1
• 230000000441 effect on granulocytes Effects 0.000 description 1
• 235000013601 eggs Nutrition 0.000 description 1
• 229950003860 elmustine Drugs 0.000 description 1
• 229950009219 eltenac Drugs 0.000 description 1
• 210000005168 endometrial cell Anatomy 0.000 description 1
• 210000002889 endothelial cell Anatomy 0.000 description 1
• HLNLBEFKHHCAMV-UHFFFAOYSA-N enfenamic acid Chemical compound OC(=O)C1=CC=CC=C1NCCC1=CC=CC=C1 HLNLBEFKHHCAMV-UHFFFAOYSA-N 0.000 description 1
• 229950010996 enfenamic acid Drugs 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 150000002085 enols Chemical class 0.000 description 1
• 210000003979 eosinophil Anatomy 0.000 description 1
• 230000006718 epigenetic regulation Effects 0.000 description 1
• 229960005139 epinephrine Drugs 0.000 description 1
• 229950003801 epirizole Drugs 0.000 description 1
• 210000003743 erythrocyte Anatomy 0.000 description 1
• 229950006887 esflurbiprofen Drugs 0.000 description 1
• 125000004185 ester group Chemical group 0.000 description 1
• 229960001766 estramustine phosphate sodium Drugs 0.000 description 1
• IIUMCNJTGSMNRO-VVSKJQCTSA-L estramustine sodium phosphate Chemical compound [Na+].[Na+].ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)OP([O-])([O-])=O)[C@@H]4[C@@H]3CCC2=C1 IIUMCNJTGSMNRO-VVSKJQCTSA-L 0.000 description 1
• AVOLMBLBETYQHX-UHFFFAOYSA-N etacrynic acid Chemical compound CCC(=C)C(=O)C1=CC=C(OCC(O)=O)C(Cl)=C1Cl AVOLMBLBETYQHX-UHFFFAOYSA-N 0.000 description 1
• 229960003199 etacrynic acid Drugs 0.000 description 1
• HYSIJEPDMLSIQJ-UHFFFAOYSA-N ethanolate;1-phenylbutane-1,3-dione;titanium(4+) Chemical compound [Ti+4].CC[O-].CC[O-].CC(=O)[CH-]C(=O)C1=CC=CC=C1.CC(=O)[CH-]C(=O)C1=CC=CC=C1 HYSIJEPDMLSIQJ-UHFFFAOYSA-N 0.000 description 1
• SBNKFTQSBPKMBZ-UHFFFAOYSA-N ethenzamide Chemical compound CCOC1=CC=CC=C1C(N)=O SBNKFTQSBPKMBZ-UHFFFAOYSA-N 0.000 description 1
• 229960000514 ethenzamide Drugs 0.000 description 1
• 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 description 1
• GLFJQXMGTAJTGY-AVBZIYQWSA-N ethyl (2s,5s)-5-[[(2s)-2-amino-3-(4-fluorophenyl)propanoyl]amino]-6-[3-[bis(2-chloroethyl)amino]phenyl]-2-(2-methylsulfanylethyl)-4-oxohexanoate;hydrochloride Chemical compound Cl.C([C@@H](C(=O)C[C@@H](CCSC)C(=O)OCC)NC(=O)[C@@H](N)CC=1C=CC(F)=CC=1)C1=CC=CC(N(CCCl)CCCl)=C1 GLFJQXMGTAJTGY-AVBZIYQWSA-N 0.000 description 1
• 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
• 229960005293 etodolac Drugs 0.000 description 1
• XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 description 1
• 229960001493 etofenamate Drugs 0.000 description 1
• ZVYVPGLRVWUPMP-FYSMJZIKSA-N exatecan Chemical compound C1C[C@H](N)C2=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC3=CC(F)=C(C)C1=C32 ZVYVPGLRVWUPMP-FYSMJZIKSA-N 0.000 description 1
• 229950009429 exatecan Drugs 0.000 description 1
• NMUSYJAQQFHJEW-ARQDHWQXSA-N fazarabine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-ARQDHWQXSA-N 0.000 description 1
• 229950005096 fazarabine Drugs 0.000 description 1
• 229960000192 felbinac Drugs 0.000 description 1
• ZPAKPRAICRBAOD-UHFFFAOYSA-N fenbufen Chemical compound C1=CC(C(=O)CCC(=O)O)=CC=C1C1=CC=CC=C1 ZPAKPRAICRBAOD-UHFFFAOYSA-N 0.000 description 1
• 229960001395 fenbufen Drugs 0.000 description 1
• IDKAXRLETRCXKS-UHFFFAOYSA-N fenclofenac Chemical compound OC(=O)CC1=CC=CC=C1OC1=CC=C(Cl)C=C1Cl IDKAXRLETRCXKS-UHFFFAOYSA-N 0.000 description 1
• 229950006236 fenclofenac Drugs 0.000 description 1
• 229950011481 fenclozic acid Drugs 0.000 description 1
• HAWWPSYXSLJRBO-UHFFFAOYSA-N fendosal Chemical compound C1=C(O)C(C(=O)O)=CC(N2C(=CC=3C4=CC=CC=C4CCC=32)C=2C=CC=CC=2)=C1 HAWWPSYXSLJRBO-UHFFFAOYSA-N 0.000 description 1
• 229950005416 fendosal Drugs 0.000 description 1
• 229960001419 fenoprofen Drugs 0.000 description 1
• 229960000489 feprazone Drugs 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• KFSXLIJSXOJBCB-HZMBPMFUSA-N filenadol Chemical compound N1([C@@H]([C@@H](O)C)C=2C=C3OCOC3=CC=2)CCOCC1 KFSXLIJSXOJBCB-HZMBPMFUSA-N 0.000 description 1
• 229950003056 filenadol Drugs 0.000 description 1
• 229960004177 filgrastim Drugs 0.000 description 1
• 229950002994 florifenine Drugs 0.000 description 1
• 229950005722 flosulide Drugs 0.000 description 1
• 229960000390 fludarabine Drugs 0.000 description 1
• 229960005304 fludarabine phosphate Drugs 0.000 description 1
• LPEPZBJOKDYZAD-UHFFFAOYSA-N flufenamic acid Chemical compound OC(=O)C1=CC=CC=C1NC1=CC=CC(C(F)(F)F)=C1 LPEPZBJOKDYZAD-UHFFFAOYSA-N 0.000 description 1
• 229960004369 flufenamic acid Drugs 0.000 description 1
• 229950007979 flufenisal Drugs 0.000 description 1
• NOOCSNJCXJYGPE-UHFFFAOYSA-N flunixin Chemical compound C1=CC=C(C(F)(F)F)C(C)=C1NC1=NC=CC=C1C(O)=O NOOCSNJCXJYGPE-UHFFFAOYSA-N 0.000 description 1
• 229960000588 flunixin Drugs 0.000 description 1
• 229960001321 flunoxaprofen Drugs 0.000 description 1
• ARPYQKTVRGFPIS-VIFPVBQESA-N flunoxaprofen Chemical compound N=1C2=CC([C@@H](C(O)=O)C)=CC=C2OC=1C1=CC=C(F)C=C1 ARPYQKTVRGFPIS-VIFPVBQESA-N 0.000 description 1
• 229960001347 fluocinolone acetonide Drugs 0.000 description 1
• FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 125000001153 fluoro group Chemical group F* 0.000 description 1
• 229960002690 fluphenazine Drugs 0.000 description 1
• 229950001284 fluprofen Drugs 0.000 description 1
• ZWOUXWWGKJBAHQ-UHFFFAOYSA-N fluproquazone Chemical compound N=1C(=O)N(C(C)C)C2=CC(C)=CC=C2C=1C1=CC=C(F)C=C1 ZWOUXWWGKJBAHQ-UHFFFAOYSA-N 0.000 description 1
• 229950004250 fluproquazone Drugs 0.000 description 1
• 229960002390 flurbiprofen Drugs 0.000 description 1
• SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
• YAKWPXVTIGTRJH-UHFFFAOYSA-N fotemustine Chemical compound CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O YAKWPXVTIGTRJH-UHFFFAOYSA-N 0.000 description 1
• 229960004783 fotemustine Drugs 0.000 description 1
• 229950010931 furofenac Drugs 0.000 description 1
• 125000002541 furyl group Chemical group 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 201000011243 gastrointestinal stromal tumor Diseases 0.000 description 1
• 230000002178 gastroprotective effect Effects 0.000 description 1
• UIVFUQKYVFCEKJ-OPTOVBNMSA-N gimatecan Chemical compound C1=CC=C2C(\C=N\OC(C)(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UIVFUQKYVFCEKJ-OPTOVBNMSA-N 0.000 description 1
• 210000001703 glandular epithelial cell Anatomy 0.000 description 1
• 229940080856 gleevec Drugs 0.000 description 1
• 229940084910 gliadel Drugs 0.000 description 1
• DXYUAIFZCFRPTH-UHFFFAOYSA-N glycitein Chemical compound C1=C(O)C(OC)=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 DXYUAIFZCFRPTH-UHFFFAOYSA-N 0.000 description 1
• NNUVCMKMNCKPKN-UHFFFAOYSA-N glycitein Natural products COc1c(O)ccc2OC=C(C(=O)c12)c3ccc(O)cc3 NNUVCMKMNCKPKN-UHFFFAOYSA-N 0.000 description 1
• 235000008466 glycitein Nutrition 0.000 description 1
• 108010074717 glycosaminoglycan receptor Proteins 0.000 description 1
• 229930182470 glycoside Natural products 0.000 description 1
• 150000002338 glycosides Chemical class 0.000 description 1
• 125000003147 glycosyl group Chemical group 0.000 description 1
• MFWNKCLOYSRHCJ-BTTYYORXSA-N granisetron Chemical compound C1=CC=C2C(C(=O)N[C@H]3C[C@H]4CCC[C@@H](C3)N4C)=NN(C)C2=C1 MFWNKCLOYSRHCJ-BTTYYORXSA-N 0.000 description 1
• 229960003727 granisetron Drugs 0.000 description 1
• 231100000226 haematotoxicity Toxicity 0.000 description 1
• 230000003394 haemopoietic effect Effects 0.000 description 1
• 125000000262 haloalkenyl group Chemical group 0.000 description 1
• 125000004438 haloalkoxy group Chemical group 0.000 description 1
• 125000001188 haloalkyl group Chemical group 0.000 description 1
• 125000000232 haloalkynyl group Chemical group 0.000 description 1
• 125000003106 haloaryl group Chemical group 0.000 description 1
• 125000005216 haloheteroaryl group Chemical group 0.000 description 1
• 229960003878 haloperidol Drugs 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 230000003862 health status Effects 0.000 description 1
• 208000014617 hemorrhoid Diseases 0.000 description 1
• 230000002440 hepatic effect Effects 0.000 description 1
• 230000002443 hepatoprotective effect Effects 0.000 description 1
• 229940022353 herceptin Drugs 0.000 description 1
• 102000034345 heterotrimeric G proteins Human genes 0.000 description 1
• 108091006093 heterotrimeric G proteins Proteins 0.000 description 1
• 150000004687 hexahydrates Chemical class 0.000 description 1
• UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 description 1
• 150000004677 hydrates Chemical class 0.000 description 1
• OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 1
• 229960000890 hydrocortisone Drugs 0.000 description 1
• 239000000017 hydrogel Substances 0.000 description 1
• 125000005020 hydroxyalkenyl group Chemical group 0.000 description 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 description 1
• 125000005016 hydroxyalkynyl group Chemical group 0.000 description 1
• 125000005027 hydroxyaryl group Chemical group 0.000 description 1
• ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 description 1
• 229960000930 hydroxyzine Drugs 0.000 description 1
• 229950009183 ibufenac Drugs 0.000 description 1
• CYWFCPPBTWOZSF-UHFFFAOYSA-N ibufenac Chemical compound CC(C)CC1=CC=C(CC(O)=O)C=C1 CYWFCPPBTWOZSF-UHFFFAOYSA-N 0.000 description 1
• 229960001680 ibuprofen Drugs 0.000 description 1
• 229960001101 ifosfamide Drugs 0.000 description 1
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 1
• YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
• 125000002883 imidazolyl group Chemical group 0.000 description 1
• 238000003119 immunoblot Methods 0.000 description 1
• 229960000593 imrecoxib Drugs 0.000 description 1
• 230000002779 inactivation Effects 0.000 description 1
• 229960000905 indomethacin Drugs 0.000 description 1
• 229960004187 indoprofen Drugs 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 238000007917 intracranial administration Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 230000002601 intratumoral effect Effects 0.000 description 1
• 230000005865 ionizing radiation Effects 0.000 description 1
• 229950010897 iproplatin Drugs 0.000 description 1
• 150000002515 isoflavone derivatives Chemical class 0.000 description 1
• PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical compound C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 description 1
• 239000003394 isomerase inhibitor Substances 0.000 description 1
• 238000006317 isomerization reaction Methods 0.000 description 1
• VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical class C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 description 1
• 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 description 1
• YYUAYBYLJSNDCX-UHFFFAOYSA-N isoxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC=1C=C(C)ON=1 YYUAYBYLJSNDCX-UHFFFAOYSA-N 0.000 description 1
• 229950002252 isoxicam Drugs 0.000 description 1
• 229960004130 itraconazole Drugs 0.000 description 1
• 150000002576 ketones Chemical class 0.000 description 1
• DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
• 229960000991 ketoprofen Drugs 0.000 description 1
• 229960004752 ketorolac Drugs 0.000 description 1
• OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 238000012125 lateral flow test Methods 0.000 description 1
• 102000003835 leukotriene receptors Human genes 0.000 description 1
• 108090000146 leukotriene receptors Proteins 0.000 description 1
• UAWXGRJVZSAUSZ-UHFFFAOYSA-N licofelone Chemical compound OC(=O)CC=1N2CC(C)(C)CC2=C(C=2C=CC=CC=2)C=1C1=CC=C(Cl)C=C1 UAWXGRJVZSAUSZ-UHFFFAOYSA-N 0.000 description 1
• 229950003488 licofelone Drugs 0.000 description 1
• 229950001311 lobuprofen Drugs 0.000 description 1
• 229960002247 lomustine Drugs 0.000 description 1
• 229960003768 lonazolac Drugs 0.000 description 1
• XVUQHFRQHBLHQD-UHFFFAOYSA-N lonazolac Chemical compound OC(=O)CC1=CN(C=2C=CC=CC=2)N=C1C1=CC=C(Cl)C=C1 XVUQHFRQHBLHQD-UHFFFAOYSA-N 0.000 description 1
• 229960001571 loperamide Drugs 0.000 description 1
• RDOIQAHITMMDAJ-UHFFFAOYSA-N loperamide Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)N(C)C)CCN(CC1)CCC1(O)C1=CC=C(Cl)C=C1 RDOIQAHITMMDAJ-UHFFFAOYSA-N 0.000 description 1
• 229960004391 lorazepam Drugs 0.000 description 1
• 229960002373 loxoprofen Drugs 0.000 description 1
• BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 description 1
• 229960000994 lumiracoxib Drugs 0.000 description 1
• KHPKQFYUPIUARC-UHFFFAOYSA-N lumiracoxib Chemical compound OC(=O)CC1=CC(C)=CC=C1NC1=C(F)C=CC=C1Cl KHPKQFYUPIUARC-UHFFFAOYSA-N 0.000 description 1
• 208000022766 lymph node neoplasm Diseases 0.000 description 1
• 210000000207 lymphocyte subset Anatomy 0.000 description 1
• 229950001846 mabuprofen Drugs 0.000 description 1
• JVGUNCHERKJFCM-UHFFFAOYSA-N mabuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(=O)NCCO)C=C1 JVGUNCHERKJFCM-UHFFFAOYSA-N 0.000 description 1
• 229950000547 mafosfamide Drugs 0.000 description 1
• 229910052749 magnesium Inorganic materials 0.000 description 1
• 238000002595 magnetic resonance imaging Methods 0.000 description 1
• 229950008959 marimastat Drugs 0.000 description 1
• OCSMOTCMPXTDND-OUAUKWLOSA-N marimastat Chemical compound CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO OCSMOTCMPXTDND-OUAUKWLOSA-N 0.000 description 1
• 239000003550 marker Substances 0.000 description 1
• 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 description 1
• 239000003771 matrix metalloproteinase inhibitor Substances 0.000 description 1
• 229960003803 meclofenamic acid Drugs 0.000 description 1
• 229960003464 mefenamic acid Drugs 0.000 description 1
• HYYBABOKPJLUIN-UHFFFAOYSA-N mefenamic acid Chemical compound CC1=CC=CC(NC=2C(=CC=CC=2)C(O)=O)=C1C HYYBABOKPJLUIN-UHFFFAOYSA-N 0.000 description 1
• 229960001929 meloxicam Drugs 0.000 description 1
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
• 229960001924 melphalan Drugs 0.000 description 1
• 230000037323 metabolic rate Effects 0.000 description 1
• 229960004584 methylprednisolone Drugs 0.000 description 1
• TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 1
• 229960004503 metoclopramide Drugs 0.000 description 1
• 229950006616 miroprofen Drugs 0.000 description 1
• OJGQFYYLKNCIJD-UHFFFAOYSA-N miroprofen Chemical compound C1=CC(C(C(O)=O)C)=CC=C1C1=CN(C=CC=C2)C2=N1 OJGQFYYLKNCIJD-UHFFFAOYSA-N 0.000 description 1
• CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 1
• 229950010913 mitolactol Drugs 0.000 description 1
• VFKZTMPDYBFSTM-GUCUJZIJSA-N mitolactol Chemical compound BrC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CBr VFKZTMPDYBFSTM-GUCUJZIJSA-N 0.000 description 1
• 229960004857 mitomycin Drugs 0.000 description 1
• 230000011278 mitosis Effects 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 229960005285 mofebutazone Drugs 0.000 description 1
• REOJLIXKJWXUGB-UHFFFAOYSA-N mofebutazone Chemical compound O=C1C(CCCC)C(=O)NN1C1=CC=CC=C1 REOJLIXKJWXUGB-UHFFFAOYSA-N 0.000 description 1
• 229960000429 mofezolac Drugs 0.000 description 1
• 210000001616 monocyte Anatomy 0.000 description 1
• 150000004682 monohydrates Chemical class 0.000 description 1
• OOGNFQMTGRZRAB-UHFFFAOYSA-N morazone Chemical compound CC1C(C=2C=CC=CC=2)OCCN1CC(C1=O)=C(C)N(C)N1C1=CC=CC=C1 OOGNFQMTGRZRAB-UHFFFAOYSA-N 0.000 description 1
• 229960004610 morazone Drugs 0.000 description 1
• 108700021654 myb Genes Proteins 0.000 description 1
• 208000025113 myeloid leukemia Diseases 0.000 description 1
• 230000003039 myelosuppressive effect Effects 0.000 description 1
• OGULUONTZZYGMQ-UHFFFAOYSA-N n-[(6-methoxypyridin-3-yl)methyl]-5-(7h-pyrrolo[2,3-d]pyrimidin-5-ylmethyl)pyrimidin-2-amine Chemical compound C1=NC(OC)=CC=C1CNC(N=C1)=NC=C1CC1=CNC2=NC=NC=C12 OGULUONTZZYGMQ-UHFFFAOYSA-N 0.000 description 1
• MDYALASTPGGXQH-INIZCTEOSA-N n-[(7s)-1,2,3,9-tetramethoxy-10-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound C1=C(OC)C(=O)C=CC2=C1[C@@H](NC(C)=O)CCC1=C2C(OC)=C(OC)C(OC)=C1 MDYALASTPGGXQH-INIZCTEOSA-N 0.000 description 1
• CMEGANPVAXDBPL-INIZCTEOSA-N n-[(7s)-1,2,3-trimethoxy-10-methylsulfanyl-9-oxo-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(SC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC CMEGANPVAXDBPL-INIZCTEOSA-N 0.000 description 1
• CENZECKWJXZRDO-CQPGNPNMSA-N n-[(7s)-10-amino-1,2-dimethoxy-9-oxo-3-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6,7-dihydro-5h-benzo[a]heptalen-7-yl]acetamide Chemical compound C1([C@@H](NC(C)=O)CCC2=C3)=CC(=O)C(N)=CC=C1C2=C(OC)C(OC)=C3O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O CENZECKWJXZRDO-CQPGNPNMSA-N 0.000 description 1
• XEFNBUBDJCJOGM-OUJCMCIWSA-N n-[1-[(2r,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]hexadecanamide Chemical compound O=C1N=C(NC(=O)CCCCCCCCCCCCCCC)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 XEFNBUBDJCJOGM-OUJCMCIWSA-N 0.000 description 1
• ZAPRLADYRFPQSH-UHFFFAOYSA-N n-[4-[(2-methyl-4-oxo-1,3-benzodioxin-2-yl)oxy]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1OC1(C)OC2=CC=CC=C2C(=O)O1 ZAPRLADYRFPQSH-UHFFFAOYSA-N 0.000 description 1
• BLSOATWWAGIRGE-UHFFFAOYSA-N n-[5-[[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]carbamoyl]-1-methylpyrrol-3-yl]-4-[[4-[bis(2-chloroethyl)amino]benzoyl]amino]-1-methylpyrrole-2-carboxamide;hydrochloride Chemical compound Cl.C1=C(C(=O)NCCC(N)=N)N(C)C=C1NC(=O)C1=CC(NC(=O)C=2N(C=C(NC(=O)C=3C=CC(=CC=3)N(CCCl)CCCl)C=2)C)=CN1C BLSOATWWAGIRGE-UHFFFAOYSA-N 0.000 description 1
• CXJONBHNIJFARE-UHFFFAOYSA-N n-[6-(2,4-difluorophenoxy)-1-oxo-2,3-dihydroinden-5-yl]methanesulfonamide Chemical compound CS(=O)(=O)NC1=CC=2CCC(=O)C=2C=C1OC1=CC=C(F)C=C1F CXJONBHNIJFARE-UHFFFAOYSA-N 0.000 description 1
• 229960004270 nabumetone Drugs 0.000 description 1
• 229940075566 naphthalene Drugs 0.000 description 1
• 229940091170 naphthoquine Drugs 0.000 description 1
• 125000001624 naphthyl group Chemical group 0.000 description 1
• 229960003759 naproxcinod Drugs 0.000 description 1
• AKFJWRDCWYYTIG-ZDUSSCGKSA-N naproxcinod Chemical compound C1=C([C@H](C)C(=O)OCCCCO[N+]([O-])=O)C=CC2=CC(OC)=CC=C21 AKFJWRDCWYYTIG-ZDUSSCGKSA-N 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 239000008239 natural water Substances 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 231100000228 neurotoxicity Toxicity 0.000 description 1
• 230000007135 neurotoxicity Effects 0.000 description 1
• 230000000508 neurotrophic effect Effects 0.000 description 1
• 229960000916 niflumic acid Drugs 0.000 description 1
• 229960000965 nimesulide Drugs 0.000 description 1
• HYWYRSMBCFDLJT-UHFFFAOYSA-N nimesulide Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1=CC=CC=C1 HYWYRSMBCFDLJT-UHFFFAOYSA-N 0.000 description 1
• 229960001420 nimustine Drugs 0.000 description 1
• VFEDRRNHLBGPNN-UHFFFAOYSA-N nimustine Chemical compound CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 VFEDRRNHLBGPNN-UHFFFAOYSA-N 0.000 description 1
• KPMKNHGAPDCYLP-UHFFFAOYSA-N nimustine hydrochloride Chemical compound Cl.CC1=NC=C(CNC(=O)N(CCCl)N=O)C(N)=N1 KPMKNHGAPDCYLP-UHFFFAOYSA-N 0.000 description 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
• DLWSRGHNJVLJAH-UHFFFAOYSA-N nitroflurbiprofen Chemical compound FC1=CC(C(C(=O)OCCCCO[N+]([O-])=O)C)=CC=C1C1=CC=CC=C1 DLWSRGHNJVLJAH-UHFFFAOYSA-N 0.000 description 1
• CMUOJBJRZUHRMU-UHFFFAOYSA-N nitrourea Chemical compound NC(=O)N[N+]([O-])=O CMUOJBJRZUHRMU-UHFFFAOYSA-N 0.000 description 1
• XHWRWCSCBDLOLM-UHFFFAOYSA-N nolatrexed Chemical compound CC1=CC=C2NC(N)=NC(=O)C2=C1SC1=CC=NC=C1 XHWRWCSCBDLOLM-UHFFFAOYSA-N 0.000 description 1
• 229950000891 nolatrexed Drugs 0.000 description 1
• 239000002777 nucleoside Substances 0.000 description 1
• 150000003833 nucleoside derivatives Chemical class 0.000 description 1
• QQBDLJCYGRGAKP-FOCLMDBBSA-N olsalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=C(C(O)=CC=2)C(O)=O)=C1 QQBDLJCYGRGAKP-FOCLMDBBSA-N 0.000 description 1
• 229960004110 olsalazine Drugs 0.000 description 1
• 229950003655 orpanoxin Drugs 0.000 description 1
• 150000002905 orthoesters Chemical class 0.000 description 1
• 229940045681 other alkylating agent in atc Drugs 0.000 description 1
• 230000001151 other effect Effects 0.000 description 1
• 229960005113 oxaceprol Drugs 0.000 description 1
• 229960001756 oxaliplatin Drugs 0.000 description 1
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 1
• 229960002739 oxaprozin Drugs 0.000 description 1
• OFPXSFXSNFPTHF-UHFFFAOYSA-N oxaprozin Chemical compound O1C(CCC(=O)O)=NC(C=2C=CC=CC=2)=C1C1=CC=CC=C1 OFPXSFXSNFPTHF-UHFFFAOYSA-N 0.000 description 1
• 150000004843 oxaziridines Chemical class 0.000 description 1
• 150000002923 oximes Chemical class 0.000 description 1
• 229950001435 oxindanac Drugs 0.000 description 1
• QUANRIQJNFHVEU-UHFFFAOYSA-N oxirane;propane-1,2,3-triol Chemical compound C1CO1.OCC(O)CO QUANRIQJNFHVEU-UHFFFAOYSA-N 0.000 description 1
• 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 description 1
• 125000004430 oxygen atom Chemical group O* 0.000 description 1
• 229960000649 oxyphenbutazone Drugs 0.000 description 1
• CNDQSXOVEQXJOE-UHFFFAOYSA-N oxyphenbutazone hydrate Chemical compound O.O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 CNDQSXOVEQXJOE-UHFFFAOYSA-N 0.000 description 1
• 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
• 230000000242 pagocytic effect Effects 0.000 description 1
• CPZBLNMUGSZIPR-NVXWUHKLSA-N palonosetron Chemical compound C1N(CC2)CCC2[C@@H]1N1C(=O)C(C=CC=C2CCC3)=C2[C@H]3C1 CPZBLNMUGSZIPR-NVXWUHKLSA-N 0.000 description 1
• 229960002131 palonosetron Drugs 0.000 description 1
• 229950006536 pamicogrel Drugs 0.000 description 1
• ISCHOARKJADAKJ-UHFFFAOYSA-N pamicogrel Chemical compound CCOC(=O)CN1C=CC=C1C1=NC(C=2C=CC(OC)=CC=2)=C(C=2C=CC(OC)=CC=2)S1 ISCHOARKJADAKJ-UHFFFAOYSA-N 0.000 description 1
• 229950003399 parcetasal Drugs 0.000 description 1
• DXHYQIJBUNRPJT-UHFFFAOYSA-N parsalmide Chemical compound CCCCNC(=O)C1=CC(N)=CC=C1OCC#C DXHYQIJBUNRPJT-UHFFFAOYSA-N 0.000 description 1
• 229950001060 parsalmide Drugs 0.000 description 1
• 229950010552 pelubiprofen Drugs 0.000 description 1
• 229950005386 pemedolac Drugs 0.000 description 1
• 229960002340 pentostatin Drugs 0.000 description 1
• FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 description 1
• 230000000737 periodic effect Effects 0.000 description 1
• 229960000762 perphenazine Drugs 0.000 description 1
• 229940127557 pharmaceutical product Drugs 0.000 description 1
• 230000002974 pharmacogenomic effect Effects 0.000 description 1
• 238000009520 phase I clinical trial Methods 0.000 description 1
• 238000009521 phase II clinical trial Methods 0.000 description 1
• IZJDOKYDEWTZSO-UHFFFAOYSA-N phenethyl isothiocyanate Chemical compound S=C=NCCC1=CC=CC=C1 IZJDOKYDEWTZSO-UHFFFAOYSA-N 0.000 description 1
• 239000002530 phenolic antioxidant Substances 0.000 description 1
• 150000002989 phenols Chemical class 0.000 description 1
• 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
• 229960002895 phenylbutazone Drugs 0.000 description 1
• VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 229910052698 phosphorus Inorganic materials 0.000 description 1
• 238000001126 phototherapy Methods 0.000 description 1
• CYJAWBVQRMVFEO-UHFFFAOYSA-N piperazine-2,6-dione Chemical compound O=C1CNCC(=O)N1 CYJAWBVQRMVFEO-UHFFFAOYSA-N 0.000 description 1
• 229950007914 pirazolac Drugs 0.000 description 1
• 229950001030 piritrexim Drugs 0.000 description 1
• 229960002702 piroxicam Drugs 0.000 description 1
• QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
• PIDSZXPFGCURGN-UHFFFAOYSA-N pirprofen Chemical compound ClC1=CC(C(C(O)=O)C)=CC=C1N1CC=CC1 PIDSZXPFGCURGN-UHFFFAOYSA-N 0.000 description 1
• 229960000851 pirprofen Drugs 0.000 description 1
• 102000030769 platelet activating factor receptor Human genes 0.000 description 1
• 229960003171 plicamycin Drugs 0.000 description 1
• 229920001610 polycaprolactone Polymers 0.000 description 1
• 229920002721 polycyanoacrylate Polymers 0.000 description 1
• 239000008389 polyethoxylated castor oil Substances 0.000 description 1
• 238000006116 polymerization reaction Methods 0.000 description 1
• 102000054765 polymorphisms of proteins Human genes 0.000 description 1
• 102000040430 polynucleotide Human genes 0.000 description 1
• 108091033319 polynucleotide Proteins 0.000 description 1
• 239000002157 polynucleotide Substances 0.000 description 1
• 229920006324 polyoxymethylene Polymers 0.000 description 1
• 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 description 1
• 229960003101 pranoprofen Drugs 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 229960004694 prednimustine Drugs 0.000 description 1
• 229960004618 prednisone Drugs 0.000 description 1
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 229960003111 prochlorperazine Drugs 0.000 description 1
• WIKYUJGCLQQFNW-UHFFFAOYSA-N prochlorperazine Chemical compound C1CN(C)CCN1CCCN1C2=CC(Cl)=CC=C2SC2=CC=CC=C21 WIKYUJGCLQQFNW-UHFFFAOYSA-N 0.000 description 1
• 108090000468 progesterone receptors Proteins 0.000 description 1
• 102000003998 progesterone receptors Human genes 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• 229960003910 promethazine Drugs 0.000 description 1
• 230000001737 promoting effect Effects 0.000 description 1
• 230000000069 prophylactic effect Effects 0.000 description 1
• 239000003223 protective agent Substances 0.000 description 1
• 229940121649 protein inhibitor Drugs 0.000 description 1
• 239000012268 protein inhibitor Substances 0.000 description 1
• 239000000007 protein synthesis inhibitor Substances 0.000 description 1
• 229940034080 provenge Drugs 0.000 description 1
• 125000003373 pyrazinyl group Chemical group 0.000 description 1
• 125000003226 pyrazolyl group Chemical group 0.000 description 1
• 150000003222 pyridines Chemical class 0.000 description 1
• 125000005344 pyridylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 1
• 125000000714 pyrimidinyl group Chemical group 0.000 description 1
• 125000000168 pyrrolyl group Chemical group 0.000 description 1
• 229960001404 quinidine Drugs 0.000 description 1
• 229960000948 quinine Drugs 0.000 description 1
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
• 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 description 1
• YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
• 229960002281 racecadotril Drugs 0.000 description 1
• 108700040249 racecadotril Proteins 0.000 description 1
• 238000011127 radiochemotherapy Methods 0.000 description 1
• 238000003127 radioimmunoassay Methods 0.000 description 1
• 229960004432 raltitrexed Drugs 0.000 description 1
• NTHPAPBPFQJABD-LLVKDONJSA-N ramosetron Chemical compound C12=CC=CC=C2N(C)C=C1C(=O)[C@H]1CC(NC=N2)=C2CC1 NTHPAPBPFQJABD-LLVKDONJSA-N 0.000 description 1
• 229950001588 ramosetron Drugs 0.000 description 1
• 229960002185 ranimustine Drugs 0.000 description 1
• 239000003642 reactive oxygen metabolite Substances 0.000 description 1
• 238000012827 research and development Methods 0.000 description 1
• 235000021283 resveratrol Nutrition 0.000 description 1
• 229940016667 resveratrol Drugs 0.000 description 1
• 238000012552 review Methods 0.000 description 1
• 229960004641 rituximab Drugs 0.000 description 1
• RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
• 229960000371 rofecoxib Drugs 0.000 description 1
• 102200082402 rs751610198 Human genes 0.000 description 1
• NGFMICBWJRZIBI-UJPOAAIJSA-N salicin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC=CC=C1CO NGFMICBWJRZIBI-UJPOAAIJSA-N 0.000 description 1
• 229940120668 salicin Drugs 0.000 description 1
• 229960000581 salicylamide Drugs 0.000 description 1
• 229950007628 satigrel Drugs 0.000 description 1
• 229960002646 scopolamine Drugs 0.000 description 1
• LACQPOBCQQPVIT-SEYKEWMNSA-N scopolamine hydrobromide trihydrate Chemical compound O.O.O.Br.C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 LACQPOBCQQPVIT-SEYKEWMNSA-N 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 230000028327 secretion Effects 0.000 description 1
• 230000036280 sedation Effects 0.000 description 1
• 229960003440 semustine Drugs 0.000 description 1
• 230000001953 sensory effect Effects 0.000 description 1
• 238000000926 separation method Methods 0.000 description 1
• 231100000872 sexual dysfunction Toxicity 0.000 description 1
• 230000001568 sexual effect Effects 0.000 description 1
• 230000019491 signal transduction Effects 0.000 description 1
• 230000008054 signal transmission Effects 0.000 description 1
• 102000035025 signaling receptors Human genes 0.000 description 1
• 108091005475 signaling receptors Proteins 0.000 description 1
• 229960004025 sodium salicylate Drugs 0.000 description 1
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 description 1
• 230000000392 somatic effect Effects 0.000 description 1
• 229950006315 spirogermanium Drugs 0.000 description 1
• 229950006050 spiromustine Drugs 0.000 description 1
• 239000003270 steroid hormone Substances 0.000 description 1
• 239000002294 steroidal antiinflammatory agent Substances 0.000 description 1
• 230000003637 steroidlike Effects 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 125000005346 substituted cycloalkyl group Chemical group 0.000 description 1
• 229950005175 sudoxicam Drugs 0.000 description 1
• 235000000346 sugar Nutrition 0.000 description 1
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical compound [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
• NCEXYHBECQHGNR-QZQOTICOSA-N sulfasalazine Chemical compound C1=C(O)C(C(=O)O)=CC(\N=N\C=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-QZQOTICOSA-N 0.000 description 1
• 229960001940 sulfasalazine Drugs 0.000 description 1
• NCEXYHBECQHGNR-UHFFFAOYSA-N sulfasalazine Natural products C1=C(O)C(C(=O)O)=CC(N=NC=2C=CC(=CC=2)S(=O)(=O)NC=2N=CC=CC=2)=C1 NCEXYHBECQHGNR-UHFFFAOYSA-N 0.000 description 1
• 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 description 1
• MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
• 229960000894 sulindac Drugs 0.000 description 1
• 230000009469 supplementation Effects 0.000 description 1
• 229960004492 suprofen Drugs 0.000 description 1
• 229960005314 suramin Drugs 0.000 description 1
• FIAFUQMPZJWCLV-UHFFFAOYSA-H suramin(6-) Chemical compound [O-]S(=O)(=O)C1=CC(S([O-])(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)C)C=CC=3)C)=CC=C(S([O-])(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-H 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 239000003826 tablet Substances 0.000 description 1
• 108010021891 tallimustine Proteins 0.000 description 1
• 229950005100 talmetacin Drugs 0.000 description 1
• 229960005262 talniflumate Drugs 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• 229950010168 tauromustine Drugs 0.000 description 1
• 229950009722 tazofelone Drugs 0.000 description 1
• 229950003441 tebufelone Drugs 0.000 description 1
• 229940061353 temodar Drugs 0.000 description 1
• 229960003676 tenidap Drugs 0.000 description 1
• LXIKEPCNDFVJKC-QXMHVHEDSA-N tenidap Chemical compound C12=CC(Cl)=CC=C2N(C(=O)N)C(=O)\C1=C(/O)C1=CC=CS1 LXIKEPCNDFVJKC-QXMHVHEDSA-N 0.000 description 1
• VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
• 229960004693 tenofovir disoproxil fumarate Drugs 0.000 description 1
• XYKWNRUXCOIMFZ-UHFFFAOYSA-N tepoxalin Chemical compound C1=CC(OC)=CC=C1N1C(C=2C=CC(Cl)=CC=2)=CC(CCC(=O)N(C)O)=N1 XYKWNRUXCOIMFZ-UHFFFAOYSA-N 0.000 description 1
• 229950009638 tepoxalin Drugs 0.000 description 1
• 229950008703 teroxirone Drugs 0.000 description 1
• IFLREYGFSNHWGE-UHFFFAOYSA-N tetracene Chemical compound C1=CC=CC2=CC3=CC4=CC=CC=C4C=C3C=C21 IFLREYGFSNHWGE-UHFFFAOYSA-N 0.000 description 1
• 125000005247 tetrazinyl group Chemical group N1=NN=NC(=C1)* 0.000 description 1
• 125000003831 tetrazolyl group Chemical group 0.000 description 1
• 238000000015 thermotherapy Methods 0.000 description 1
• 125000000335 thiazolyl group Chemical group 0.000 description 1
• 125000001544 thienyl group Chemical group 0.000 description 1
• 229960004869 thiethylperazine Drugs 0.000 description 1
• XCTYLCDETUVOIP-UHFFFAOYSA-N thiethylperazine Chemical compound C12=CC(SCC)=CC=C2SC2=CC=CC=C2N1CCCN1CCN(C)CC1 XCTYLCDETUVOIP-UHFFFAOYSA-N 0.000 description 1
• DHCDFWKWKRSZHF-UHFFFAOYSA-L thiosulfate(2-) Chemical compound [O-]S([S-])(=O)=O DHCDFWKWKRSZHF-UHFFFAOYSA-L 0.000 description 1
• 229960001312 tiaprofenic acid Drugs 0.000 description 1
• HTJXMOGUGMSZOG-UHFFFAOYSA-N tiaramide Chemical compound C1CN(CCO)CCN1C(=O)CN1C(=O)SC2=CC=C(Cl)C=C21 HTJXMOGUGMSZOG-UHFFFAOYSA-N 0.000 description 1
• 229950010302 tiaramide Drugs 0.000 description 1
• 229960003723 tiazofurine Drugs 0.000 description 1
• FVRDYQYEVDDKCR-DBRKOABJSA-N tiazofurine Chemical compound NC(=O)C1=CSC([C@H]2[C@@H]([C@H](O)[C@@H](CO)O2)O)=N1 FVRDYQYEVDDKCR-DBRKOABJSA-N 0.000 description 1
• MIMJSJSRRDZIPW-UHFFFAOYSA-N tilmacoxib Chemical compound C=1C=C(S(N)(=O)=O)C(F)=CC=1C=1OC(C)=NC=1C1CCCCC1 MIMJSJSRRDZIPW-UHFFFAOYSA-N 0.000 description 1
• 229950001953 tilmacoxib Drugs 0.000 description 1
• PFENFDGYVLAFBR-UHFFFAOYSA-N tinoridine Chemical compound C1CC=2C(C(=O)OCC)=C(N)SC=2CN1CC1=CC=CC=C1 PFENFDGYVLAFBR-UHFFFAOYSA-N 0.000 description 1
• 229950010298 tinoridine Drugs 0.000 description 1
• 229960003087 tioguanine Drugs 0.000 description 1
• 229950002345 tiopinac Drugs 0.000 description 1
• 229950006150 tioxaprofen Drugs 0.000 description 1
• YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
• 229960002905 tolfenamic acid Drugs 0.000 description 1
• 229960001017 tolmetin Drugs 0.000 description 1
• UPSPUYADGBWSHF-UHFFFAOYSA-N tolmetin Chemical compound C1=CC(C)=CC=C1C(=O)C1=CC=C(CC(O)=O)N1C UPSPUYADGBWSHF-UHFFFAOYSA-N 0.000 description 1
• 231100000041 toxicology testing Toxicity 0.000 description 1
• 239000003053 toxin Substances 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 229940066958 treanda Drugs 0.000 description 1
• 229960005294 triamcinolone Drugs 0.000 description 1
• GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
• 125000004306 triazinyl group Chemical group 0.000 description 1
• 125000001425 triazolyl group Chemical group 0.000 description 1
• 229960002268 triflusal Drugs 0.000 description 1
• 150000004684 trihydrates Chemical class 0.000 description 1
• 229960001099 trimetrexate Drugs 0.000 description 1
• NOYPYLRCIDNJJB-UHFFFAOYSA-N trimetrexate Chemical compound COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 NOYPYLRCIDNJJB-UHFFFAOYSA-N 0.000 description 1
• KYLIMUJRJDIPPF-UHFFFAOYSA-N trisalicylate Chemical compound O=C1OC2=CC=CC=C2C(=O)OC2=CC=CC=C2C(=O)OC2=CC=CC=C12 KYLIMUJRJDIPPF-UHFFFAOYSA-N 0.000 description 1
• 229950002470 tropesin Drugs 0.000 description 1
• UCCJWNPWWPJKGL-UHFFFAOYSA-N tropesin Chemical compound CC1=C(CC(=O)OCC(C(O)=O)C=2C=CC=CC=2)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 UCCJWNPWWPJKGL-UHFFFAOYSA-N 0.000 description 1
• 230000005747 tumor angiogenesis Effects 0.000 description 1
• DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
• 229940045145 uridine Drugs 0.000 description 1
• 201000005112 urinary bladder cancer Diseases 0.000 description 1
• 229940096998 ursolic acid Drugs 0.000 description 1
• PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
• 229960002004 valdecoxib Drugs 0.000 description 1
• LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
• 108700026220 vif Genes Proteins 0.000 description 1
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
• 229960004528 vincristine Drugs 0.000 description 1
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
• UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
• 229960004355 vindesine Drugs 0.000 description 1
• GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
• 229960002066 vinorelbine Drugs 0.000 description 1
• 229940088594 vitamin Drugs 0.000 description 1
• 229930003231 vitamin Natural products 0.000 description 1
• 235000013343 vitamin Nutrition 0.000 description 1
• 239000011782 vitamin Substances 0.000 description 1
• 108010069784 vitespin Proteins 0.000 description 1
• 235000012431 wafers Nutrition 0.000 description 1
• 239000002023 wood Substances 0.000 description 1
• 229950000707 ximoprofen Drugs 0.000 description 1
• 235000020138 yakult Nutrition 0.000 description 1
• 229960000523 zalcitabine Drugs 0.000 description 1
• 229950004227 zaltoprofen Drugs 0.000 description 1
• ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1
• 229960003414 zomepirac Drugs 0.000 description 1