TW201443064A - 經雜芳基取代之六氫哌喃並［３，４－ｄ］［１，３］噻□－２－胺化合物 - Google Patents

經雜芳基取代之六氫哌喃並［３，４－ｄ］［１，３］噻□－２－胺化合物 Download PDF

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Publication number
TW201443064A
TW201443064A TW103104416A TW103104416A TW201443064A TW 201443064 A TW201443064 A TW 201443064A TW 103104416 A TW103104416 A TW 103104416A TW 103104416 A TW103104416 A TW 103104416A TW 201443064 A TW201443064 A TW 201443064A
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Taiwan
Prior art keywords
difluorophenyl
compound
tautomer
hexahydropyrano
methyl
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TW103104416A
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English (en)
Chinese (zh)
Inventor
Michael Aaron Brodney
Christopher Ryan Butler
Elizabeth Mary Beck
Jennifer Elizabeth Davoren
Erik Alphie Lachapelle
Brian T O'neill
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Pfizer
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Publication of TW201443064A publication Critical patent/TW201443064A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
TW103104416A 2013-02-13 2014-02-11 經雜芳基取代之六氫哌喃並［３，４－ｄ］［１，３］噻□－２－胺化合物 TW201443064A (zh)

Applications Claiming Priority (1)

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US201361764185P 2013-02-13 2013-02-13

Publications (1)

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TW201443064A true TW201443064A (zh) 2014-11-16

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TW103104416A TW201443064A (zh) 2013-02-13 2014-02-11 經雜芳基取代之六氫哌喃並［３，４－ｄ］［１，３］噻□－２－胺化合物

Country Status (8)

Country Link
US (3) US8865706B2 (OSRAM)
EP (1) EP2956458B1 (OSRAM)
JP (1) JP2016507551A (OSRAM)
AR (1) AR094762A1 (OSRAM)
CA (1) CA2897678A1 (OSRAM)
TW (1) TW201443064A (OSRAM)
UY (1) UY35320A (OSRAM)
WO (1) WO2014125394A1 (OSRAM)

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US20210393621A1 (en) 2018-10-26 2021-12-23 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN115272385B (zh) * 2021-04-30 2025-05-16 中国医学科学院基础医学研究所 基于自动生成标签的脑出血和周围水肿的协同交叉分割系统
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Publication number Publication date
US20140364426A1 (en) 2014-12-11
US9045499B2 (en) 2015-06-02
WO2014125394A1 (en) 2014-08-21
EP2956458B1 (en) 2017-08-09
EP2956458A1 (en) 2015-12-23
UY35320A (es) 2014-09-30
CA2897678A1 (en) 2014-08-21
US8865706B2 (en) 2014-10-21
US20150224110A1 (en) 2015-08-13
US20140228356A1 (en) 2014-08-14
JP2016507551A (ja) 2016-03-10
US9192612B2 (en) 2015-11-24
AR094762A1 (es) 2015-08-26

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