TW201416089A - Skin care composition - Google Patents

Skin care composition Download PDF

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TW201416089A
TW201416089A TW101138420A TW101138420A TW201416089A TW 201416089 A TW201416089 A TW 201416089A TW 101138420 A TW101138420 A TW 101138420A TW 101138420 A TW101138420 A TW 101138420A TW 201416089 A TW201416089 A TW 201416089A
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skin
vitamin
hyaluronic acid
skin care
care composition
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TW101138420A
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Pin-Chi Chiu
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Ginza Suzurando Cosmetic Co Ltd
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Abstract

A skin care composition comprises a medium that is qualified in a cosmetic filed. In the medium, vitamin B3 with additive content of 0.1% to 5%, vitamin B5 with additive content of 0.1% to 5%, and middle molecule hyaluronic acid with additive content of 0.001% to 1% are added, in which molecular weight of the middle molecule hyaluronic acid is ranged from 50,000 to 500,000. With these three major parts, including vitamin B3, vitamin B5 and middle molecule hyaluronic acid, to be added in the medium that is qualified in the cosmetic filed, viz. to compose a particular skin maintenance care content compound, skin-beautifying effects such as bright white, anti acne, repair, moisture retention and acne scar lighting for users can be obtained.

Description

皮膚保養組合物 Skin care composition

本發明係有關一種皮膚保養組合物,特別指一種結合維他命B3、維他命原B5及中分子玻尿酸的多重美容成分功效,帶來美膚效果,調理健康膚質的皮膚保養組合物。 The present invention relates to a skin care composition, in particular to a skin care composition which combines the effects of multiple beauty ingredients of vitamin B3, provitamin B5 and medium molecular hyaluronic acid to provide a skin-beautifying effect and to regulate healthy skin.

肌膚主要係由表皮與真皮層所組成,真皮層係提供表皮支持與血液供應之功能,另外,真皮層亦提供了維持肌膚的彈性及其外觀的重要性。大部分的真皮層係由細胞及細胞外基質(Extracellular Matrix,ECM)所組成,而細胞外基質的組成主要決定於成纖維母細胞(Fibroblasts)。成纖維母細胞會生成多種成分,例如膠原蛋白、玻尿酸、彈力蛋白(Elastin)及蛋白醣質,隨著年齡增長以及太陽紫外線曝曬及環境的污染下,真皮層的支持物會變少變性且被破壞,此種情形會導致皮膚下垂及皺紋。 The skin is mainly composed of the epidermis and the dermis. The dermis provides epidermal support and blood supply. In addition, the dermis also provides the importance of maintaining the elasticity and appearance of the skin. Most of the dermis is composed of cells and extracellular matrix (ECM), and the composition of the extracellular matrix is mainly determined by fibroblasts. Fibroblasts produce a variety of components, such as collagen, hyaluronic acid, elastin and protein saccharide. With age and sun exposure and environmental pollution, the dermis support will become less degraded and Destruction, which can cause sagging and wrinkles in the skin.

市面上的皮膚保養品很多,其中現有皮膚保養品最常見的主要的天然成份為:維他命B3(Niacinamide也稱為Nicotinamide)對於皮膚功能方面扮演著重要角色,在體內有相當多的酵素生化反應也需要維他命B3的幫忙。 There are many skin care products on the market. Among them, the most common natural ingredients of existing skin care products are: Vitamin B3 (Niacinamide, also known as Nicotinamide) plays an important role in skin function, and there are quite a lot of enzyme biochemical reactions in the body. Need the help of vitamin B3.

維他命原B5又稱泛醇(D-Panthenol),維他命B5是輔酶A(Co-enzyme A)的組成部分,與丙酮酸、α-酮戊二酸和脂肪酸的代謝相關,缺乏維他命B5時會有皮膚角質化異常,導致脫皮的症狀產生,另外當腎上腺 製造類固醇(Steroids)及皮質酮時也需要維他命B5。維他命B5存在於肝臟、大豆、啤酒酵母及全榖食品中,被證實有皮膚消炎的功效,幫助皮膚正常角質化,可促進傷口癒合和皮膚組織的修復,同時可維持頭髮中的水分,避免頭髮乾燥分裂。 Vitamin B5 is also known as D-Panthenol. Vitamin B5 is a component of Co-enzyme A. It is related to the metabolism of pyruvate, α-ketoglutarate and fatty acids. When vitamin B is lacking, it will be Abnormal skin keratinization, leading to symptoms of peeling, in addition to the adrenal gland Vitamin B5 is also required for the manufacture of steroids (Steroids) and corticosterone. Vitamin B5 is found in liver, soy, brewer's yeast and whole glutinous foods. It has been proven to have anti-inflammatory effects on the skin, help the skin to normalize keratinization, promote wound healing and repair of skin tissue, while maintaining moisture in the hair and avoiding hair. Dry and split.

玻尿酸(透明質酸)大量存在於人體的結締組織及真皮層中,是一種透明的膠狀物質,當中吸滿了水分,可說是皮膚的保濕因子。玻尿酸稱為Hyaluronic acid(Hyaluronan),早期的玻尿酸產品常由動物(如:雞冠)身上萃取,隨著科技的進步,現在玻尿酸多由生技方式生成。在品質提升之下,漸漸發展出中分子玻尿酸的應用,以往百萬分子量大分子玻尿酸主要以滋潤、保濕為主要效果,但滲透性不佳。中分子玻尿酸,則具有滲透快、效能高及抗老目的的功效。 Hyaluronic acid (hyaluronic acid) is abundant in the connective tissue and dermis layer of the human body. It is a transparent gelatinous substance, which is filled with water and can be said to be a moisturizing factor of the skin. Hyaluronic acid is called Hyaluronic acid (Hyaluronan). Early hyaluronic acid products are often extracted from animals (such as: cockscomb). With the advancement of technology, hyaluronic acid is now produced by biotechnology. Under the improvement of quality, the application of molecular hyaluronic acid has gradually developed. In the past, the molecular weight macromolecular hyaluronic acid mainly used moisturizing and moisturizing as the main effect, but the permeability was not good. The medium molecular hyaluronic acid has the effects of fast penetration, high efficacy and anti-aging purpose.

前述成份各有各的功能與優點,但是,市面上現有臉部保養商品只有添加單一或兩種成分製成,也因為如果要達成前述三種成分各有的多重生理功能,結合這三種成分的優點,就必需組合成特殊的肌膚養護成分複方。 Each of the aforementioned components has its own functions and advantages. However, the existing face care products on the market are only made by adding a single or two components, and because the multiple physiological functions of the above three components are to be achieved, the advantages of combining the three components are combined. It is necessary to combine into a special skin care ingredient combination.

於是,為解決上述缺失,本發明之目的係在提供一種皮膚保養組合物,在皮膚保養組合物內利用維他命B3、維他命B5及中分子玻尿酸等三大成分,以絕妙的含量比例添加於保養組合物,提供使用者亮白、抗痘、修復、保濕、淡疤等美膚作用。 Therefore, in order to solve the above-mentioned deficiency, the object of the present invention is to provide a skin care composition which utilizes three major components, such as vitamin B3, vitamin B5 and medium molecular hyaluronic acid, in a skin care composition, and is added to the maintenance combination in a wonderful proportion. It provides users with brightening, anti-acne, repair, moisturizing, and phlegm.

為達上述之目的,本發明揭露一種皮膚保養組合物,其包括:一化粧品界合格之媒液,且添加:(I)維 他命B3添加含量:0.1%至5%;(Ⅱ)維他命原B5添加含量:0.1%至5%;及(Ⅲ)中分子玻尿酸添加含量:0.001%至1%,該中分子玻尿酸的分子量係5萬到50萬。 In order to achieve the above object, the present invention discloses a skin care composition comprising: a cosmetic medium qualified for the cosmetics industry, and adding: (I) dimension He added B3 added content: 0.1% to 5%; (II) Vitamin B5 added content: 0.1% to 5%; and (III) Molecular hyaluronic acid added content: 0.001% to 1%, the molecular weight of the molecular hyaluronic acid 50,000 to 500,000.

其中,該媒液係下列之一者:一化妝水、一軟膏、一乳霜、及其結合物;且該媒液係可使用於一皮膚上或是藥學上可接受的載體,該載體係選自下列者:一織布貼片、一非織布貼片、一微脂粒傳送工具、及其結合物。 Wherein, the vehicle is one of the following: a lotion, an ointment, a cream, and a combination thereof; and the vehicle can be applied to a skin or a pharmaceutically acceptable carrier, the carrier Selected from the group consisting of a woven patch, a non-woven patch, a viscous transfer tool, and combinations thereof.

本案的優點在於,將維他命B3、維他命B5及中分子玻尿酸等三大成分添入化粧品界合格之媒液,組合成特殊的肌膚養護成分複方,提供使用者亮白、抗痘、修復、保濕、淡疤等美膚作用。該些添加物成分單純、溫和,均為人體所需之營養素,此三種成分也是身體代謝中所需,利用身體原有的成分加強肌膚功能,為未來肌膚保養趨勢。 The advantage of this case is that vitamin B3, vitamin B5 and medium molecular hyaluronic acid are added to the qualified media of the cosmetics industry, and combined into a special skin care ingredient compound to provide users with whitening, acne resistance, repair and moisturizing. Light skin and other skin effects. These additives are simple and mild, and are all nutrients required by the human body. These three ingredients are also needed in the body's metabolism, and use the original ingredients of the body to strengthen the skin function and maintain the trend of future skin care.

茲有關本發明之詳細內容及技術說明,現以做進一步說明。 The details and technical description of the present invention are now further described.

本案係一種皮膚保養組合物,其包括:一化粧品界合格之媒液,且在該媒液中添加:(I)維他命B3添加含量:0.1%至5%;(Ⅱ)維他命原B5添加含量:0.1%至5%;及(Ⅲ)中分子玻尿酸添加含量:0.001%至1%。 The present invention relates to a skin care composition comprising: a qualified media for cosmetics, and added to the vehicle: (I) vitamin B3 added content: 0.1% to 5%; (II) vitamin B5 added content: 0.1% to 5%; and (III) molecular hyaluronic acid added content: 0.001% to 1%.

維他命B3(Vitamin B3)又稱為菸鹼醯胺(Niacinamide)。在人體多項代謝的過程裡,菸鹼醯胺擔任輔脢的任務,其中最重要的則是參與醣代謝,在體內有相當多的酵素生化反應也需要維他命B3的幫忙。雖然說在營養學上維他命B3的效果已早被確認,但在 皮膚保養的功效上,近年來才被廣泛研究及討論。 Vitamin B3 is also known as Niacinamide. In the process of multiple metabolism of the human body, nicotine amide is the task of auxiliary sputum. The most important thing is to participate in sugar metabolism. There are quite a lot of enzyme biochemical reactions in the body, which also needs the help of vitamin B3. Although the effect of vitamin B3 on nutrition has long been confirmed, The efficacy of skin care has only been extensively studied and discussed in recent years.

目前已知維他命B3對於皮膚保養的的功效如下:抑制紫外線造成皮膚免疫下降及癌化;抑制光老化肌膚真皮中膠原蛋白的破壞;對於青春痘有抗發炎效果;抑制黑色素麥拉寧小體傳輸而具有淡斑功效;增加表皮細胞間脂質生成及加強表皮障壁功能;加強表皮保濕能力改善乾性肌膚狀態;減緩酒糟症狀;降低皮脂線分泌;改善皮膚蠟黃、細紋、泛紅、色斑等老化現象。 At present, the effects of vitamin B3 on skin care are as follows: inhibition of ultraviolet light causes skin immunity and canceration; inhibition of collagen damage in photo-aging skin; anti-inflammatory effect on acne; inhibition of melanin melanin transmission It has the effect of light spotting; it increases the lipid production between epidermal cells and strengthens the epidermal barrier function; strengthens the skin moisturizing ability to improve the dry skin condition; slows the symptoms of distiller's grains; reduces the secretion of sebum lines; improves the skin sallow, fine lines, redness, pigmentation and other aging phenomenon.

綜合已知的維他命B3功效,維他命B3可當作抗老成份來應用,加上他本身穩定性及溫和度不錯,而且刺激性低、副作用也相當少見,幾乎所有膚質都可以使用。所以近年來有很多抗痘及美白品甚至保濕品其中都會添加維他命B3,目前在保養品中所使用的濃度大約為1~5%左右。近年來在酵母菌和線蟲的研究上發現,維他命B3及其相關輔酶菸醯胺腺嘌呤二核酸(NAD/NADH-nicotinamide adenine dinucleotide)對於細胞內的長壽基因(Sirtuin)會有調控的作用。由於長壽基因與細胞應付環境壓力及增強細胞修復活性有關,而且可能對於延長細胞的壽命有正向幫忙。 Combining the known effects of vitamin B3, vitamin B3 can be used as an anti-aging ingredient, plus its own stability and mildness, and low irritation and side effects are rare. Almost all skin types can be used. Therefore, in recent years, there are many anti-acne and whitening products and even moisturizers, which will add vitamin B3. The concentration currently used in skin care products is about 1~5%. In recent years, studies on yeasts and nematodes have found that vitamin B3 and its related coenzyme, NAD/NADH-nicotinamide adenine dinucleotide, have a regulatory effect on intracellular longevity genes (Sirtuins). Because longevity genes are involved in cell stress and cell repair activity, and may be positive for extending cell life.

維他命原B5又稱泛醇(Panthenol),維他命B5是輔酶A(Co-enzyme A)的組成部分,與丙酮酸、α-酮戊二酸和脂肪酸的代謝相關。缺乏維他命B5時會有皮膚角質化異常,導致脫皮的症狀產生,另外當腎上腺製造類固醇(Steroids)及皮質酮時也需要維他命B5,和合成膽固醇有關。維他命原B5存在於肝臟、大豆、啤酒酵母及全榖食品中,被證實有皮膚消炎的功效,幫助皮膚正常角質 化,可促進傷口癒合和皮膚組織的修復,同時可維持頭髮中的水分,避免頭髮乾燥分裂。 Provitamin B5, also known as panthenol (Panthenol), is part of Co-enzyme A and is involved in the metabolism of pyruvate, alpha-ketoglutarate and fatty acids. In the absence of vitamin B5, there is abnormal skin keratinization, which leads to the symptoms of peeling. In addition, when the adrenal glands produce steroids (Steroids) and corticosterone, vitamin B5 is also required, which is related to synthetic cholesterol. Provitamin B5 is found in liver, soy, brewer's yeast and whole glutinous foods. It has been proven to have anti-inflammatory effects on the skin, helping the skin to have normal keratin. It can promote wound healing and skin tissue repair, while maintaining moisture in the hair and avoiding dry and split hair.

泛醇是泛酸的同效物,是一種穩定又具有生物活性的B群維生素,泛醇存在L-泛醇和D-泛醇兩種同分異構體,DL-泛醇(消旋泛醇)生理活性只有D-泛醇(右旋泛醇)的一半,故保養品的使用上多採用D-泛醇。泛酸是輔酶A的組成部分,人體缺乏泛酸時皮膚角化異常,導致脫皮。泛醇被人體吸收後轉化為泛酸發揮生理作用。D-泛醇外觀為無色透明粘性液體,易溶於水、乙醇、甲醇和丙二醇,在氯仿和醚中可溶,在甘油中有微溶性,不溶於植物油、礦物油和脂肪。對熱較穩定,pH值為4~7時穩定(最適宜pH值為6.0),熔點範圍64.5℃~68.5℃。 Ubiquinol is a homologue of pantothenic acid, a stable and biologically active B group of vitamins. Ubiquinol exists in two isomers of L-panthenol and D-panthenol, DL-panthenol (racemic panthenol) The physiological activity is only half of that of D-panthenol (d-panthenol), so D-panthenol is often used in the use of skin care products. Pantothenic acid is a component of coenzyme A. When the body is deficient in pantothenic acid, skin keratinization is abnormal, leading to peeling. Ubiquinol is absorbed by the body and converted into pantothenic acid to exert physiological effects. D-panthenol has a colorless transparent viscous liquid, is easily soluble in water, ethanol, methanol and propylene glycol, is soluble in chloroform and ether, is slightly soluble in glycerin, and is insoluble in vegetable oil, mineral oil and fat. It is stable to heat, stable at pH 4~7 (the most suitable pH is 6.0), and the melting point ranges from 64.5°C to 68.5°C.

維他命原B5是化妝品中最常用的維他命,維他命原B5係不黏膩的保濕成分,具強效吸水效果,且與肌膚皮脂膜相近,易於吸收滲透及浸潤肌膚表面的角質層,使肌膚柔軟,有效預防肌膚粗燥現象,達到肌膚保溼與組織修復的功效。雖然D及L兩種結構的泛醇(Panthenol)皆具有保溼特性,但僅有D-panthenol具生物活性作用。 Vitamin B5 is the most commonly used vitamin in cosmetics. Vitamin B5 is a non-stick moisturizing ingredient. It has a strong water-absorbing effect and is similar to the skin sebum film. It is easy to absorb the cuticle which penetrates and infiltrates the skin surface, making the skin soft. Effectively prevent skin dryness and achieve skin moisturizing and tissue repair. Although both D and L pentanols have moisturizing properties, only D-panthenol has biological activity.

玻尿酸一種酸性多醣體,中文譯名很多,諸如玻璃質酸、透明質酸、生化醣醛酸都是。以前取得來源,大多是由雞冠或動物眼球所得,現在主要藉由醱酵生技技術,由微生物與葡萄醣液作用生成而純化所成。分子量皆可高達百萬分子量以上。 Hyaluronic acid is an acidic polysaccharide with many Chinese translations, such as hyaluronic acid, hyaluronic acid, and biochemical uronic acid. Previously, the source was mostly obtained from the cockscomb or the eyeball of the animal. Now it is mainly purified by the action of microorganisms and glucose solution by the fermentation technology. The molecular weight can be up to a million molecular weight or more.

玻尿酸是一種透明的膠狀體,在人體內的含量會隨 著年齡增加慢慢減少。大部份存在結締組織、眼球和細胞間空隙,在組織間有緩衝與潤滑的作用,當中吸滿了水分,可說是皮膚的保濕因子。由於玻尿酸在組織間隙亦具填充作用,故近年來,廣泛使用於整型手術,藉以填補凹洞疤痕、撐起鬆垮皮膚;又其原本為體內一部份,安全性高,運用在美容保養方面,一下子就成為熱門素材。 Hyaluronic acid is a transparent gel that will be present in the human body. The increase in age is slowly decreasing. Most of them have connective tissue, eyeballs and intercellular spaces. They have a buffering and lubricating effect between tissues. They are filled with water and can be said to be the skin's moisturizing factor. Because hyaluronic acid also has a filling effect in the interstitial space, it has been widely used in modern surgery in recent years to fill the pit scars and support the loose skin. It is originally part of the body and has high safety. It is used in beauty care. In fact, it has become a hot material at once.

玻尿酸是一種酸性多醣體,主要存在於真皮層中,是人體皮膚主要的保濕因子。但隨著年齡的增加而逐步流失,二十五歲之前,玻尿酸的含量很高,三十歲的肌膚,玻尿酸含量只有嬰兒期的65%,到了六十歲更掉到只有25%,玻尿酸流失後的肌膚會使真皮層的含水量降低,漸漸失去彈性與光澤,同時對陽光、環境的傷害,肌膚自我修護力也下降,進一步造成老化皺紋。 Hyaluronic acid is an acidic polysaccharide mainly found in the dermis and is the main moisturizing factor of human skin. However, with the increase of age, it gradually loses. Before the age of 25, the content of hyaluronic acid is very high. In the 30-year-old skin, the hyaluronic acid content is only 65% of the infancy, and it is only 25% when it is 60 years old. The hyaluronic acid is lost. After the skin will reduce the water content of the dermis layer, gradually lose the elasticity and luster, while the damage to the sun, the environment, the skin's self-repairing power also decreased, further causing aging wrinkles.

玻尿酸的分子大小會影響到實際的護膚效果,如果是百萬分子量以上的玻尿酸,主要是當作高分子吸水保濕劑所以是當作保濕的目的使用。如果是分子量5萬到幾十萬的中分子玻尿酸(最佳為分子量5萬到50萬),目前發現會跟皮膚的受體結合對老化肌膚有回春的效果;而分子量幾千到5萬間的低分子玻尿酸,目前發現會誘發免疫發炎反應及血管增生,對於皮膚傷口癒合有幫忙。所以可以看出來不同分子量的玻尿酸對於皮膚的功效是不同的。 The molecular size of hyaluronic acid will affect the actual skin care effect. If it is a molecular weight of more than one million molecular weight hyaluronic acid, it is mainly used as a polymer water humectant, so it is used for moisturizing purposes. If it is a molecular weight 50,000-100,000 molecular weight hyaluronic acid (optimally molecular weight 50,000 to 500,000), it has been found to combine with skin receptors to rejuvenate aging skin; and the molecular weight is between tens and 50,000. The low molecular weight hyaluronic acid is currently found to induce immune inflammatory reactions and vascular proliferation, which is helpful for skin wound healing. Therefore, it can be seen that the hyaluronic acid of different molecular weights has different effects on the skin.

實施上,該媒液係下列之一者:一化妝水、一軟膏、一乳霜、及其結合物;所以本案皮膚保養組合物係可經由下列形式之組合物:肌膚的化妝水、乳液、凝膠、泡沫劑、乳膏劑、糊狀物、乳狀液、噴霧劑、調理劑、化 妝品、唇膏、指甲油、刮鬍後之泡沫劑,或是為了在肌膚或是其他角質結構上打算留下一些美感、預防性或其他好處之類似的形式。可以手指或使用工具或裝置,如該媒液係可使用於一皮膚上或是藥學上可接受的載體,該載體係選自下列者:一織布貼片、一非織布貼片、一微脂粒傳送工具、及其結合物,(例如面膜、墊、棉花球、筆狀塗抹器、噴霧器及其類似物)應用此組成物。 In practice, the vehicle is one of the following: a lotion, an ointment, a cream, and a combination thereof; therefore, the skin care composition of the present invention can be a combination of the following forms: lotion, lotion, Gel, foaming agent, cream, paste, emulsion, spray, conditioner, chemical Cosmetics, lipsticks, nail varnishes, foaming agents after shaving, or similar forms intended to leave some aesthetic, preventive or other benefits on the skin or other keratinous structures. The carrier can be applied to a skin or a pharmaceutically acceptable carrier by finger or using a tool or device, the carrier being selected from the group consisting of: a woven patch, a non-woven patch, a The viscous delivery tool, and combinations thereof, such as masks, pads, cotton balls, pen applicators, nebulizers, and the like, are applied to the composition.

惟以上所述者,僅為本發明之較佳實施例而已,當不能以此限定本發明實施之範圍,即大凡依本發明申請專利範圍及發明說明內容所作之簡單的等效變化與修飾,皆仍屬本發明專利涵蓋之範圍內。 The above is only the preferred embodiment of the present invention, and the scope of the invention is not limited thereto, that is, the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are All remain within the scope of the invention patent.

Claims (5)

一種皮膚保養組合物,其包括:一化粧品界合格之媒液,且添加:(I)維他命B3添加含量:0.1%至5%;(Ⅱ)維他命原B5添加含量:0.1%至5%;及(Ⅲ)中分子玻尿酸添加含量:0.001%至1%。 A skin care composition comprising: a cosmetic medium qualified for the cosmetics industry, and adding: (I) vitamin B3 added content: 0.1% to 5%; (II) vitamin B5 added content: 0.1% to 5%; (III) Content of molecular hyaluronic acid added: 0.001% to 1%. 如申請專利範圍第1項所述之皮膚保養組合物,其中,該媒液係下列之一者:一化妝水、一軟膏、一乳霜、及其結合物。 The skin care composition according to claim 1, wherein the vehicle is one of the following: a lotion, an ointment, a cream, and a combination thereof. 如申請專利範圍第2項所述之皮膚保養組合物,其中,該媒液係可使用於皮膚上可接受的一載體。 The skin care composition of claim 2, wherein the vehicle is for use in a skin-acceptable carrier. 如申請專利範圍第3項所述之皮膚保養組合物,其中,該載體係選自下列者:一織布貼片、一非織布貼片、一微脂粒導入工具、及其結合物。 The skin care composition of claim 3, wherein the carrier is selected from the group consisting of a woven patch, a non-woven patch, a vesicle introduction tool, and combinations thereof. 如申請專利範圍第1項所述之皮膚保養組合物,其中,該中分子玻尿酸的分子量係5萬到50萬。 The skin care composition according to claim 1, wherein the molecular weight hyaluronic acid has a molecular weight of 50,000 to 500,000.
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