TW201410245A - 治療用調合物及治療方法 - Google Patents
治療用調合物及治療方法 Download PDFInfo
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- TW201410245A TW201410245A TW102120341A TW102120341A TW201410245A TW 201410245 A TW201410245 A TW 201410245A TW 102120341 A TW102120341 A TW 102120341A TW 102120341 A TW102120341 A TW 102120341A TW 201410245 A TW201410245 A TW 201410245A
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Landscapes
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| WO2015164419A1 (en) * | 2014-04-22 | 2015-10-29 | Acucela Inc. | Pupillometric assessment of retinal pharmacodynamics and responses therefrom |
| MX2017008737A (es) | 2014-12-30 | 2018-01-25 | Cell Cure Neurosciences Ltd | Poblaciones de celulas rpe y metodos para generar las mismas. |
| US20200243170A1 (en) * | 2017-10-17 | 2020-07-30 | Apeliotus Technologies, Inc. | Functional biomarkers for statin therapy in age-related macular degeneration (amd) |
| SG11202005795TA (en) * | 2017-12-29 | 2020-07-29 | Cell Cure Neurosciences Ltd | Retinal pigment epithelium cell compositions |
| CN112007031A (zh) * | 2019-05-30 | 2020-12-01 | 杏国新药股份有限公司 | 眼用制剂 |
| US12109211B2 (en) | 2021-12-29 | 2024-10-08 | Endo Operations Limited | Hydralazine compositions and methods |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4055645A (en) | 1976-02-13 | 1977-10-25 | Merck & Co., Inc. | Novel anti-hypertensive compositions |
| FI873429L (fi) | 1986-08-18 | 1988-02-19 | Houston Biotechnology | Oftalmologiska kompositioner foer behandling av nervdegenerationer. |
| US4865599A (en) | 1986-08-18 | 1989-09-12 | Houston Biotechnology, Inc. | Ophthalmic compositions for treating nerve degeneration |
| CA1319099C (en) * | 1987-01-23 | 1993-06-15 | James A. Nathanson | Atriopeptins, guanylate cyclase activators, and phosphodiesterase inhibitors as treatment for glaucoma, hydrocephalus and cerebral edema (cranial fluid volume dysfunction) |
| US5500230A (en) * | 1987-01-23 | 1996-03-19 | The General Hospital Corporation | Method for treatment of glaucoma with nitrogen containing guanylate cyclase activators |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5252607A (en) | 1992-01-24 | 1993-10-12 | Texas A&M University System | Treatment of low pressure glaucoma and ischemic retinal degeneration |
| US5459133A (en) | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| TW264385B (enExample) | 1993-05-14 | 1995-12-01 | Taiho Pharmaceutical Co Ltd | |
| US5422116A (en) * | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| US5596011A (en) | 1995-04-06 | 1997-01-21 | Repine; Karen M. | Method for the treatment of macular degeneration |
| CN1216469A (zh) | 1996-04-26 | 1999-05-12 | 藤泽药品工业株式会社 | 含有二氢吡啶类化合物的眼组织末梢循环改善剂 |
| US6066675A (en) | 1996-09-13 | 2000-05-23 | The Regents Of The University Of California | Method for treatment of retinal diseases |
| ES2317650T3 (es) | 1996-10-28 | 2009-04-16 | Senju Pharmaceutical Co., Ltd. | Farmacos para mejorar trastornos circulatorios oculares. |
| EP1058546A4 (en) | 1998-03-06 | 2004-07-28 | Univ Texas | COMPILATIONS AND METHODS FOR THE TREATMENT OF MACULA DISEASES |
| US6028099A (en) | 1998-03-13 | 2000-02-22 | John Hopkins University, School Of Medicine | Use of an inhibitor of the protein tyrosine kinase pathway in the treatment of choroidal neovascularization |
| CA2363503C (en) | 1999-03-05 | 2009-03-10 | University Of Iowa Research Foundation | Diagnostics and therapeutics for drusen associated ocular disorders |
| IL137429A0 (en) | 1999-07-28 | 2001-07-24 | Pfizer Prod Inc | Methods and compsitions for treating diseases and conditions of the eye |
| EP1246605A2 (en) | 1999-08-10 | 2002-10-09 | The Board Of Regents, The University Of Texas System | Facilitating the preservation of sight by increasing optic nerve, choroidal and retinal blood flow |
| US6692759B1 (en) | 2000-06-28 | 2004-02-17 | The Regents Of The University Of California | Methods for preparing and using implantable substance delivery devices |
| US20030171375A1 (en) | 2002-02-13 | 2003-09-11 | Brazzell Romulus Kimbro | Method for treating ocular neovascular diseases |
| AU2003287250B9 (en) | 2002-10-30 | 2010-01-28 | Ptc Therapeutics, Inc. | Identifying therapeutic compounds based on their physical-chemical properties |
| JP2004250347A (ja) | 2003-02-18 | 2004-09-09 | Ajinomoto Co Inc | 網膜虚血に基づく疾患の治療および/又は予防剤 |
| US20040214215A1 (en) | 2003-03-07 | 2004-10-28 | Yu Ruey J. | Bioavailability and improved delivery of alkaline pharmaceutical drugs |
| US20050059744A1 (en) | 2003-09-12 | 2005-03-17 | Allergan, Inc. | Methods and compositions for the treatment of pain and other alpha 2 adrenergic-mediated conditions |
| US20080300292A1 (en) | 2004-11-08 | 2008-12-04 | Nitromed, Inc | Nitrosated and Nitrosylated Compounds, Compositions and Methods for the Treatment of Ophthalmic Disorders |
| EP1858863A1 (en) * | 2005-02-28 | 2007-11-28 | Nitromed, Inc. | Cardiovascular compounds comprising nitric oxide enhancing groups, compositions and methods of use |
| US8088773B2 (en) | 2005-05-12 | 2012-01-03 | The Texas A&M University System | Therapeutic compositions and methods |
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| SG11201408230VA (en) | 2015-01-29 |
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| US20160151368A1 (en) | 2016-06-02 |
| US20130331393A1 (en) | 2013-12-12 |
| WO2013188217A1 (en) | 2013-12-19 |
| CN104768533A (zh) | 2015-07-08 |
| US9254287B2 (en) | 2016-02-09 |
| HK1212225A1 (en) | 2016-06-10 |
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