TW201347714A - Aqueous composition for impregnation into fiber sheet - Google Patents

Abstract

To provide an aqueous composition for impregnation into a fiber sheet that has a good anti-microorganism and antiseptic and preservative performance, has excellent storage stability of the impregnated liquid, and is gentle on the skin. An aqueous composition, which is free from a paraben, and includes, as a chemical solution, polyaminopropyl biguanide, which is a cationic biocide, or a mixture of polyaminopropyl biguanide and a quaternary ammonium salt; sodium benzoate; citric acid; disodium ethylenediaminetetraacetate; a non-ionic surfactant; and water, wherein the chemical solution has a pH of 3.5 to 4.5.

Description

Aqueous composition for impregnating into fiberboard

The present invention relates to a chemical solution for impregnating into a fiberboard which is particularly suitable as a pre-wet wipe for infants, a cleaning or pre-wetting wipe for adults and other wipes (sanitary panels).

Conventionally, the aqueous composition of such fiberboard (hereinafter sometimes referred to as "chemical solution") already contains an antibacterial agent and a preservative to prevent contamination and deterioration by microorganisms during use and storage. Preservatives, such as biguanide compounds (such as polyaminopropyl biguanide), quaternary ammonium salts (such as benzalkonium chloride, cetylpyridinium chloride and benzethonium chloride), parabens (such as p-hydroxyl) Methyl benzoate and ethyl p-hydroxybenzoate) and organic acids and salts thereof (such as benzoic acid, sodium benzoate, sorbic acid, potassium sorbate) have been mainly used as antibacterial agents in chemical solutions for fiberboard and preservative.

Preferably, such antibacterial agents and preservatives are less irritating to the human body and have high antibacterial and antiseptic properties. These effects are especially important when used by people with low skin resistance, such as infants and the elderly.

In addition, fiber sheets have recently been stored at temperatures equal to or above room temperature (about 35 to 45 ° C) for warmer temperatures (eg, wipes that pre-wet the baby at a suitable temperature) use. In addition, the properties and structure of the fiber sheets used vary widely. Therefore, the conditions and properties of the fiberboard and the structure have a great influence on the storage stability of the chemical solution containing the antibacterial agent and the preservative in the fiberboard. Therefore, the long-term sustainability of this antibacterial effect can be a problem.

Although chemical solutions for fiberboards containing antibacterial agents and preservatives are required to have high antiseptic effects and low skin irritation, in many cases, these effects are contrary to each other. For example, parabens are often used as preservatives in aqueous compositions for fiberboard. However, since parabens can cause skin troubles such as cracks and rashes, chemical solutions for fiber sheets containing no parabens have recently been disclosed.

Reference list Patent literature

[Patent Document 1] Japanese Patent No. 2643458

[Patent Document 2] JP 2000-191521 A

[Patent Document 3] JP 2004-188085 A

[Patent Document 4] JP 2004-298412 A

[Patent Document 5] JP 2008-295837 A

[Patent Document 6] JP 2003-79530 A

[Patent Document 7] Japanese Patent Application No. 6-48664

The object of the present invention is to provide a chemical solution for impregnating into a fiberboard, which has improved antiseptic effect, excellent chemical solution long-term storage stability and a chemical solution in the form of a non-irritating chemical solution (the main solution of such a chemical solution) Made from water that is irritating to the skin, simpler to prepare, milder to the skin of the consumer, and easier to use, the fiberboard is particularly suitable as a pre-wet wipe for infants, for cleaning or pre-wetting for adults Wipes and other wipes (sanitary plates), the chemical solution does not use parabens, but at the same time maintains a similar level of antibacterial effect.

A chemical solution for impregnating into a fiberboard containing an antibacterial agent and a preservative according to the present invention is prepared to obtain an optimum antimicrobial activity. The chemical solution comprises at least polyaminopropyl biguanide (this is a cationic biocide), a quaternary ammonium salt, a benzoate, citric acid and disodium edetate, the balance being water. The chemical solution of the present invention has high antibacterial effect and excellent long-term storage stability.

Highly water-soluble chemical solutions for the use of potassium sorbate, which is a very safe food additive, as an antifungal fiberboard are often used because they also have antifungal efficacy. However, since such a chemical solution is stored in a high temperature, low pH range, it tends to undergo a large degree of yellowing, which is maintained and stored for a relatively long period of time. The storage stability of the chemical solutions used for fiberboard and fiberboard can have an adverse effect.

However, aqueous compositions for fiberboards using benzoates, which are very safe food additives of the same type as highly water-soluble antifungal agents, do not exhibit yellowing at elevated temperatures and low pH values. Therefore, such chemical solutions have excellent storage stability for fiberboards stored for a relatively long period of time and chemical solutions for such fiberboards.

Although the antimicrobial activity is attributed to polyaminopropyl biguanide and benzoate, the addition of citric acid and disodium edetate can adjust the pH of the chemical solution used in the fiberboard to a predetermined range to prevent adsorption. The base fiberboard acts as a pH leveling agent. Therefore, it has been possible to prepare a chemical solution having an improved antiseptic effect, better long-term storage stability, and a long-lasting effect thereof, as compared with the related art.

The chemical solution for the fiberboard according to the present invention has excellent long-term storage stability because it is formed only from the water-soluble component and does not contain the paraben. Further, since the chemical solution for the fiberboard of the present invention does not need to contain a polyol for dissolving the paraben, it has the advantage that the fiberboard does not feel slippery or sticky when applied to the skin.

The content of the nonionic surfactant used in the chemical solution for the fiberboard according to the present invention is preferably from 0.05 to 0.5% by weight, more preferably from 0.05 to 0.3% by weight, particularly preferably Between 0.1 and 0.25% by weight.

When a nonionic surfactant having an HLB of 17 to 20 is used in the chemical solution for the fiberboard according to the present invention, it is revealed that The advantage of a fiberboard that is less irritating to the skin. The term HLB (hydrophilic-lipophilic balance) represents the value of the balance between the relative strength of the hydrophilic and lipophilic possessed by the surfactant molecule. The HLB value is in the range of 0 to 20. The closer the value is to 0, the higher the lipophilicity, and the closer the value is to 20, the higher the hydrophilicity. Furthermore, by incorporating not more than 1.00% by weight of the chemical solution containing the above-mentioned antibacterial agent and preservative, etc., and setting the water content to 99.00% by weight or more than 99.00% by weight (relative to the total weight) (that is, making the chemistry The solution is mainly produced from water) and exhibits the advantage of reducing and preventing irritation to the skin.

Examples of the nonionic surfactant having an HLB value of from 5 to 16 in addition to the above-mentioned chemical solution for fiberboard include polyoxyethylene hydrogenated castor oil, polyethylene glycol dilaurate, and sorbitan. Monolaurate, polyoxyethylene alkyl ether, and the like. These compounds are optionally used with the following known agents: skin moisturizers such as propylene glycol, butylene glycol, glycerin, sorbitol, hyaluronic acid and soluble collagen; emollients such as ethoxylated lanolin, Ethoxylated glucose, polyoxygenated oil, mineral oil and fatty acid ester; amphoteric surfactant, such as lauryl dimethylaminoacetate betaine, coconut fatty acid guanamine propyl betaine, agent for imparting cooling sensation , emollients, pH adjusters, perfumes, antioxidants, chelating agents, plant extracts, anti-browning agents, anti-inflammatory agents, skin activators, astringents, and the like.

The amount of chemical solution that is impregnated into the fiberboard can be determined in an appropriate manner. It is preferably between 150 and 500% by weight, particularly preferably between 200 and 400% by weight, based on the weight of the base fiberboard. If The impregnation amount is 150% by weight or less, and sometimes sufficient wiping effect may not be obtained, and the fiberboard tends to become dry. If the amount of impregnation is 500% by weight or more than 500% by weight, it may sometimes become difficult to grasp the fiberboard, and the skin may sometimes become too wet.

The chemical solution for the fiberboard according to the present invention may be put into practical use by impregnating the chemical solution into the substrate material. Examples of the base material that can be used include non-woven fabrics and papers formed from natural fibers or synthetic fibers. It is preferred to use a spunlace nonwoven fabric having a high wet strength of a blended hydrophilic fiber such as rayon and pulp and one or more synthetic fibers such as polyester, polyethylene and polypropylene. Although the size of the sheet for the base material is appropriately selected depending on the portion to be used, or the container or package to be placed, the size is usually about 150 x 200 mm.

Advantageous effects of the present invention will now be described in more detail with reference to the following examples.

Chemical solutions having the compositions of Examples 1 to 4 and Comparative Examples 1 to 9 shown in Tables 1 and 2 were prepared. These chemical solutions were stored at 0 ° C for 1 week and at 50 ° C for 4 weeks, and then the storage appearance was observed with the naked eye. The rating of the chemical solution in which the composition was transparently dissolved was indicated as "○", and the composition was transparently dissolved therein, but the rating of the chemical solution containing the slight precipitate was observed to be "Δ", and white was observed therein. The rating of the turbid, yellowing precipitated chemical solution is indicated as "X".

(antimicrobial efficacy test)

The following antimicrobial efficacy tests were performed. When the number of viable microorganisms after the expiration of the longest contact time is 10 ¹ or less than 10 ¹ per ml, the rating of the antimicrobial efficacy is indicated as "○"; the other rating is indicated as "X".

(1) Testing microorganisms

- E. coli NBRC 3972

- Pseudomonas aeruginosa NBRC 13275

- Staphylococcus aureus golden subspecies NBRC 13276

Klebsiella pneumonia (wild species detected from wipes)

Sphinogomonas paucimobilis (wild species detected from wipes)

Acidovorax avenae (wild species detected from wipes)

- Aspergillus niger NBRC 9455

Cladosporium cladosprioides NBRC 6348

Aspergillus niger (wild species detected from wipes)

Penicillium herquei (wild species detected from wipes)

(2) Test medium

NA medium: ordinary agar medium (Eiken Chemical Co., Ltd.)

PDA medium: potato dextrose agar medium (Ryoyan Chemical Co., Ltd.)

SCDLP medium: SCDLP medium (Japan Pharmaceutical Co., Ltd.)

GPLP medium: GPLP medium (Japan Pharmaceutical Co., Ltd.)

SCDLPA medium: SCDLP agar medium (Japan Pharmaceutical Co., Ltd.)

GPLPA medium: GPLP agar medium (Japan Pharmaceutical Co., Ltd.)

(3) Preparation method of infected solution

a) Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Sphingomonas sphaeroides and oat acidophilus

After incubation for 24 hours in NA medium at 35 ° C ± 1 ° C, the cells of the obtained test bacteria were suspended in sterile phosphate buffered saline to prepare a test infected solution, wherein the number of bacteria has been adjusted to about ml per ml. 10 ⁷ to 10 ⁸ .

b) Aspergillus niger, Rhizoctonia solani, Aspergillus niger and Penicillium hamensis

After culturing for 10 days in PDA medium at 27 ° C ± 1 ° C, the spores of the obtained test fungus were suspended in polysorbate 80 / physiological saline to prepare a spore solution, wherein the number of spores was adjusted to about 10 ⁶ per ml. To 10 ⁷ .

(4) Preparation method of sample

Each of the chemical solutions having the compositions of Examples 1 to 4 and Comparative Examples 1 to 9 shown in Tables 1 and 2 was impregnated into the fiberboard, and the resulting impregnated fiberboard was kept at 50 ° C for 4 weeks. After 4 weeks of storage, the fiberboard was wrung out and the unscrewed liquid was collected. 20 ml of this liquid was dispensed into a sterilized container. Sterilized physiological saline was used as a control sample. A 60 g/m ² spunlace nonwoven fabric formed from 60% rayon and 40% polyester was cut into a size of 150 × 200 mm, and then each chemistry was 280 parts by weight (by weight of the base fiberboard) The solution was saturated with the cut woven fabric to make a chemical solution impregnated fiberboard for this evaluation.

(5) Test operation

A 1% by weight (0.2 ml) test microorganism solution was inoculated into the specimen and stored in a 25 ° C incubator. On the bacterial side, 1 ml was collected after 1 minute, 10 minutes, 1 hour, 6 hours, and transferred to 9 ml of SCDLP liquid medium. In terms of fungi, 1 ml was collected after 2 hours, 24 hours, and 48 hours, and transferred to 9 ml of GPLP liquid medium. In terms of bacteria, the bacteria were cultured at 37 ° C for 48 hours according to the SCDLP pour plate method, and in the fungi, the fungus was cultured at 28 ° C for 72 hours according to the GPLP pouring plate method to determine SCDLP and GPLP liquid. The amount of viable microorganisms in the medium solution.

(Antibacterial and antiseptic efficacy test)

According to the following antimicrobial efficacy test, when the difference in the number of living microorganisms at the beginning and end of the test is 3 Log or more, the rating of the result is indicated as "○", while the rating of other results is indicated as "X".

(1) Test microorganism: as described above.

(2) Test medium: as described above.

(3) Preparation method of microbial solution: as described above.

(4) Preparation method of sample

Each of the chemical solutions having the compositions of Examples 1 to 4 and Comparative Examples 1 to 9 shown in Tables 1 and 2 was impregnated into the fiberboard, and the impregnated fiberboard was kept at 50 ° C for 4 weeks. After storage for 4 weeks, the fiberboard was cut into squares having a side length of about 5 cm and three of the squares were laminated to each other to make a specimen. Further, a base fiber sheet not impregnated with a chemical solution was cut into squares having a side length of about 5 cm and three of the squares were laminated to each other. The stacked layer was saturated with a predetermined amount of sterilized pure water, and then autoclaved (121 ° C, 15 minutes) to prepare a control sample.

(5) Test operation

The specimen was placed in a sterilized Petri dish, 0.1 ml of the microbial solution was added dropwise thereto, and then the petri dish was covered with a lid. In terms of bacteria, the bacteria were stored in a 37 ° C ± 1 ° C incubator for 7 days, and then 10 ml of phosphate buffered saline sample was added. The resulting mixture was mixed for 1 minute and then extracted. According to the SCDLP pouring plate method, the bacteria were cultured at 37 ° C for 48 hours to determine the number of viable bacteria in the extraction solution. In terms of fungi, the fungus was stored for 7 days and then 10 ml of phosphate buffered saline sample was added. The resulting mixture was mixed for 1 minute and then extracted. The number of viable spores in the extraction solution was determined by culturing for 4 days at 28 ° C according to the GPLP pouring plate method.

It can be seen from Table 1 that Examples 1 to 4 have higher antimicrobial efficacy, higher antibacterial and preservative efficacy and better storage stability than Comparative Examples 1 to 9.

Claims (6)

An aqueous composition for impregnating into a fiberboard comprising 0.01 to 0.1% by weight of polyaminopropyl biguanide or a mixture of polyaminopropyl biguanide and a quaternary ammonium salt, 0.15 to 0.6% by weight of sodium benzoate, 0.05 To 0.50% by weight of citric acid, 0.01 to 0.20% by weight of disodium ethylenediaminetetraacetate and 0.05 to 0.5% by weight of a nonionic surfactant, and the water reaches 100%, wherein the pH of the aqueous composition It is from 3.5 to 4.5. The aqueous composition of claim 1, wherein the nonionic surfactant of the aqueous composition has an HLB of from 17 to 20. The aqueous composition of claim 1, wherein the aqueous composition contains 99.0% by weight or more than 99.0% by weight of water. The aqueous composition of any one of claims 1 to 3, wherein the aqueous composition does not contain a paraben. The aqueous composition of any one of claims 1 to 3, wherein the aqueous composition comprises a skin moisturizer, an emollient, a surfactant, or a mixture of the components. The aqueous composition according to any one of claims 1 to 3, wherein the amount of the aqueous composition impregnated into the fiberboard is between 150 and 500% by weight based on the weight of the fiberboard.