JP6302121B1 - Cleaning sheet - Google Patents

Abstract

[PROBLEMS] To prevent bacteria and fungi from being sterilized and to inactivate viruses, as well as to reduce the sterilization effect when a base sheet is impregnated with a drug, and to prevent uneven distribution of the base sheet. Provide a cleaning sheet with excellent antifungal properties. The cleaning sheet of the present invention is a cleaning sheet in which an aqueous disinfectant is impregnated into a base sheet capable of holding a liquid, and the aqueous disinfectant is a fourth component as component (A). Class A ammonium salt type surfactant, at least one selected from inorganic electrolytes, organic acids and organic acid salts as component (B), aminocarboxylic acid type chelating agent as component (C), and water as component (D) The pH of the aqueous disinfectant impregnated in the base sheet is 4.8 or more and 8.0 or less, and the base sheet is selected from regenerated fiber, synthetic fiber, and natural fiber. It contains at least one kind. [Selection figure] None

Description

  The present invention is not only sterilizing against bacteria and fungi, virus inactivating effect, but also when the base sheet is impregnated with a sterilizing agent, there is little influence of the uneven distribution of chemicals and sterilizing components on the base sheet, The present invention relates to a cleaning sheet having excellent antifungal properties to a substrate sheet.

  The so-called wet sheet (cleaning sheet), in which a nonwoven fabric is impregnated with an aqueous solution containing a disinfectant, is simple and easy to use, and can be disposable. It is used for environmental improvement in factories, kitchens, and medical facilities.

  Patent Document 1 discloses an antibacterial composition containing ε-polylysine and / or a salt thereof, an electrolyte having pH buffering capacity, and an amino acid, and an antibacterial sheet-like article using the same.

  Patent Document 2 discloses a wiping sheet impregnated with a cleaning agent containing water, a bactericidal preservative, a water-soluble humectant, and, if necessary, a solubilizing agent.

  Patent Document 3 discloses a cleaning water impregnated with an aqueous impregnation liquid in which an aqueous impregnation liquid contains a silicone or oily fragrance that forms a peelable silicone film, and a part or all of the silicone or oily fragrance is contained as an aqueous emulsion. A dissolvable wet sheet is disclosed.

  Further, as a disinfectant impregnated in the cleaning sheet, one containing a quaternary ammonium salt type surfactant is known, and Patent Document 4 discloses a mixture of polyaminopropyl biguanide and quaternary ammonium salt. A water-soluble composition for impregnating a fiber sheet having a pH of 3.5 to 4.5, comprising sodium benzoate, citric acid, disodium ethylenediaminetetraacetate, a nonionic surfactant and water is disclosed.

JP 2004-67586 A JP 2006-230612 A JP 2011-30793 A JP 2013-151447 A

  However, in the cleaning sheets described in Patent Documents 1 to 3, the drug is unevenly distributed on the base sheet, and the base sheet cannot be said to have sufficient antifungal properties. When the drug is unevenly distributed on the base sheet, a concentration gradient is generated in the base sheet, and mold is generated in the base sheet portion having a low drug concentration.

  On the other hand, the disinfectant containing a quaternary ammonium salt as described in Patent Document 4 has an excellent disinfecting effect, but the composition having a pH of 3.5 to 4.5 has a sufficient antifungal property. It cannot be said that when it is impregnated in a base sheet such as a nonwoven fabric, it is strongly adsorbed by the fibers of the base sheet and the effective amount of the disinfectant component is reduced. There was a possibility that the sustainability of the sterilization effect would be reduced. If the base sheet is made of recycled fibers, particularly fibers containing rayon, the base sheet becomes hydrophilic, so that the amount of water-containing disinfectant can be increased. Since the adsorptive property of the active ingredient of the disinfectant is higher than other fibers, the amount of active ingredient in the disinfectant impregnated in the base sheet and the decrease in pH are significant, so that the base sheet is impregnated. Even if the amount of the agent is increased, it is difficult to sufficiently improve the sterilization effect and its sustainability, and it is also difficult to improve the antifungal property of the base sheet.

  Therefore, the problem to be solved by the present invention is not only sterilization against bacteria and fungi, virus inactivation effect, but also has prevention of uneven distribution of the drug on the base sheet and anti-mold of the base sheet, An object of the present invention is to provide a cleaning sheet that does not have a risk of reducing the sterilization effect when impregnated into a base sheet.

  In order to solve the above-mentioned problems, the present inventors have intensively studied. As a result, (A) a quaternary ammonium salt, (B) an inorganic electrolyte, an organic acid, an organic acid salt, and (C) an aminocarboxylic acid. A base sheet is impregnated with a type chelating agent and (D) an aqueous disinfectant containing water, and the pH of the aqueous disinfectant impregnated in the base sheet is 4.8 or more and 8.0 or less. It has been found that the cleaning sheet can solve the problems of the conventional cleaning sheet, and the present invention has been completed.

That is, the present invention
(1) In the cleaning sheet impregnated with an aqueous disinfectant with respect to a base sheet capable of holding a liquid, the aqueous disinfectant has 6 to 18 carbon atoms of the alkyl group as the component (A). A quaternary ammonium salt type surfactant selected from dialkyldimethylammonium salts of the above, alkyldimethylbenzylammonium salts having an alkyl group having 6 to 18 carbon atoms, sodium dihydrogen phosphate as the component (B) , phosphoric acid At least one selected from potassium dihydrogen, disodium hydrogen phosphate, dipotassium hydrogen phosphate, potassium chloride, acetic acid or a salt thereof, gluconic acid or a salt thereof, malic acid or a salt thereof, ethylenediamine tetra Acetic acid (EDTA), nitrilotriacetic acid (NTA), methylglycine diacetic acid (MGDA), glutamic acid diacetic acid (GLDA) Or an aminocarboxylic acid-type chelating agent selected from these alkali metal salts and ammonium salts, and the aqueous disinfectant impregnated in the base sheet, containing water as the component (D), has a pH of 4. 8 or more and 8.0 or less,
The cleaning sheet, wherein the base sheet contains at least one selected from recycled fiber, synthetic fiber, and natural fiber,
(2) The component (A) is at least selected from octyldecyldimethylammonium chloride, dioctyldimethylammonium chloride, didecyldimethylammonium chloride, and alkyldimethylbenzylammonium chloride (mixture of alkyl group having 12 to 16 carbon atoms). The cleaning sheet according to (1), which is one type ,
(3) The component (B) is a combination of at least one of sodium dihydrogen phosphate and potassium dihydrogen phosphate and at least one of disodium hydrogen phosphate and dipotassium hydrogen phosphate, a combination of acetic acid and its salt A cleaning sheet according to any one of the above (1) or (2), which is at least one combination selected from a combination of malic acid and a salt thereof, and a combination of gluconic acid and a salt thereof ,
(4) Any of the above (1) to (3), wherein the aqueous disinfectant has a mass ratio (A) / (B) of the component (A) to the component (B) of 0.005 or more and 20 or less. A cleaning sheet.
(5) Any of (1) to (4) above, wherein the aqueous disinfectant contains at least one selected from an anionic surfactant, a nonionic surfactant and an amphoteric surfactant as the component (E) Cleaning sheet,
(6) The cleaning sheet according to any one of (1) to (5) above, wherein the base sheet contains regenerated fibers,
(7) The cleaning agent according to any one of (1) to (6), wherein the aqueous disinfectant impregnated in the base sheet is 150 parts by mass or more and 350 parts by mass or less per 100 parts by mass of the base sheet. Sheet.
(8) Any of (1) to (7) above, wherein the component (A) in the aqueous disinfectant impregnated in the base sheet is 0.00045% by mass or more and 20% by mass or less. A cleaning sheet,
(9) The cleaning sheet according to any one of (1) to (8) above, wherein the aqueous disinfectant impregnated in the base sheet has a virus inactivating effect,
(10) The cleaning sheet according to any one of (1) to (9), which is a cleaning sheet for sterilization, mold prevention, and virus inactivation,
Is a summary.

  The cleaning sheet of the present invention has excellent sterilizing properties against bacteria, molds and the like, has an inactivating effect on viruses, and has a sterilizing effect when a base sheet is impregnated with a sterilizing agent. There is little fall of this, and it has effects, such as prevention of the medicine uneven distribution to a base material sheet, and mold-proof property of a base material sheet.

  In the aqueous disinfectant impregnated in the cleaning sheet of the present invention, the quaternary ammonium salt type surfactant as the component (A) includes dialkyl dimethyl ammonium salt, alkyl trimethyl ammonium salt, alkyl dimethyl ethyl ammonium salt, dialkyl. Examples include ethylmethylammonium salt, dialkylmonomethylhydroxyammonium salt, alkyldimethylhydroxyethylammonium salt, alkylbenzyldimethylammonium salt, alkyldipolyoxyethylenemethylammonium salt, alkylpyridinium salt, and benzethonium salt. Here, examples of the alkyl group include alkyl groups having 6 to 18 carbon atoms, preferably linear alkyl groups having 6 to 18 carbon atoms. Specific examples include hexyl, octyl, decyl, dodecyl, tetradecyl, hexadecyl, heptadecyl and octadecyl, more preferably octyl and decyl. As salts, chlorine ions, bromine ions, alkyl sulfate ester ions having 1 or 2 carbon atoms, fatty acid ions having 1 to 12 carbon atoms, 1 to 3 or less alkyl groups having 1 to 3 carbon atoms are substituted. Benzenesulfonic acid ions which may be used are preferred. (A) A component can be used 1 type or in combination of 2 or more types. Among them, alkyldimethylbenzylammonium chloride, didecyldimethylammonium adipate, decyltrimethylammonium chloride, didecyldimethylammonium chloride, dioctyldimethylammonium chloride, octyldecyl dichloride are used in terms of sterilization, fungicidal properties and virus inactivating effect. Decylammonium chloride, alkyldimethylethylbenzylammonium chloride, and benzethonium chloride are preferable. Particularly, alkyldimethylbenzylammonium chloride having 12 to 16 carbon atoms, didecyldimethylammonium chloride, dioctyldimethylammonium chloride, octyldecyldidecylammonium salt, alkyldimethylethyl Benzyl ammonium chloride, benzethonium chloride Ride is preferred. Specific examples of the quaternary ammonium salt type surfactant of component (A) include didecyldimethylammonium chloride, didecyldimethylammonium adipate, didecyldimethylammonium gluconate, didecyldimethylammonium propionate, Didecyldimethylammonium salts such as decyldimethylammonium methosulfate, Dioctyldimethylammonium salts such as dioctyldimethylammonium chloride, Octyldecyldimethylammonium salts such as octyldecyldimethylammonium chloride, Alkyldimethylbenzylammonium chloride, Hexadecyltrimethylammonium chloride, Di Decyl monomethyl hydroxyethyl ammonium chloride, didecyl monomethyl hydroxye Ruammonium adipate, didecylmonomethylhydroxyethylammonium gluconate, didecylmonomethylhydroxyethylammonium sulfonate, 1,4-bis (3,3 ′-(1-decylpyridinium) methyloxy) butanedibromide, N, N′— Hexamethylenebis (4-carbamoyl-1-decylpyridinium bromide), alkyldimethylhydroxyethylammonium chloride, alkyltrimethylammonium chloride, alkyldimethylethylammonium ethyl sulfate, cetylpyridinium chloride, alkyldimethylethylbenzylammonium chloride, decylisononyldimethylammonium Chloride, didecylmethyl polyoxyethylene ammonium propionate, Benzethonium chloride and the like and the like.

  Examples of the inorganic electrolyte of the component (B) in the aqueous disinfectant include carbonic acid, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium sesquicarbonate, potassium sesquicarbonate, sodium percarbonate, potassium percarbonate, sodium sulfate, Potassium sulfate, sodium chloride, potassium chloride, boric acid, sodium borate, potassium borate, phosphoric acid, sodium phosphate, potassium phosphate, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, phosphorus Examples include dipotassium oxyhydrogen. Organic acids or organic acid salts include formic acid or a salt thereof, acetic acid or a salt thereof, citric acid or a salt thereof, malic acid or a salt thereof, lactic acid or a salt thereof, oxalic acid or a salt thereof, propionic acid or a salt thereof, tartaric acid or The salt, fumaric acid or its salt, maleic acid or its salt, gluconic acid or its salt, adipic acid or its salt, itaconic acid or its salt, etc. are mentioned. (B) A component can be used 1 type or in combination of 2 or more types. Among them, acetic acid or its salt, citric acid or its salt, malic acid or its salt, lactic acid or its salt, oxalic acid or its salt, propionic acid or its salt, tartaric acid or its salt, fumaric acid or its salt, maleic acid Or a salt thereof, gluconic acid or a salt thereof, adipic acid or a salt thereof, itaconic acid or a salt thereof, phosphoric acid or a salt thereof, sodium dihydrogen phosphate, potassium dihydrogen phosphate, disodium hydrogen phosphate, dihydrogen phosphate Use of potassium is preferable because it improves mold resistance, and is a combination of acetic acid and its salt, a combination of citric acid and its salt, a combination of malic acid and its salt, a combination of gluconic acid and its salt, sodium dihydrogen phosphate or At least one kind of potassium dihydrogen phosphate and a small amount of disodium hydrogen phosphate or dipotassium hydrogen phosphate The combination of a kind also are more preferred. In particular, when a combination of at least one of sodium dihydrogen phosphate or potassium dihydrogen phosphate and at least one of disodium hydrogen phosphate or dipotassium hydrogen phosphate is used, the antifungal property is further improved, and the base material Since the effect which can prevent the chemical | medical agent uneven distribution of a sheet | seat is acquired, it is preferable. As the component (B), a combination of (Ba) at least one kind of sodium dihydrogen phosphate or potassium dihydrogen phosphate and (Bb) at least one kind of disodium hydrogen phosphate or dipotassium hydrogen phosphate is used. When used, the mass ratio (Ba) / (BB) of the component (Ba) and the component (BB) is preferably 0.01 or more and 15 or less, more preferably 0.03 or more and 10 or less. Preferably, 0.1 or more and 6 or less are particularly preferable, and 0.2 or more and 3 or less are most preferable.

  As the component (C), an aminocarboxylic acid type chelating agent is used. For example, ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), methylglycine diacetic acid (MGDA), hydroxyethylenediaminetriacetic acid (HEDTA), diethylenetriamino Pentaacetic acid (DTPA), triethylenetetraamine hexaacetic acid (TTHA), hydroxyethyliminodiacetic acid (HIDA), dihydroxyethylglycine (DHEG), glutamic acid diacetic acid (GLDA), aspartic acid diacetic acid (ASDA), β-alanine Examples thereof include diacetic acid (ADA), serine diacetic acid (SDA), and alkali metal salts and ammonium salts thereof. These may be used alone or in combination of two or more. Aminocarboxylic acid type chelating agents are ethylenediaminetetraacetic acid (EDTA), nitrilotriacetic acid (NTA), methylglycine diacetic acid (MGDA), glutamic acid diacetic acid (in terms of detergency and prevention of drug uneven distribution on the base sheet. GLDA) and their sodium and potassium salts are more preferred. The proportion in these aqueous disinfectants is preferably 0.001 to 10% by mass, more preferably 0.005 to 3% by mass, 0.01 to 1% by mass. The following is more preferable.

  The water of the component (D) in the aqueous disinfectant is not particularly limited, and examples thereof include tap water, well water, ion exchange water, and soft water. (D) A component can be used 1 type or in combination of 2 or more types. Of these, ion-exchanged water or soft water is preferable from the viewpoints of sterilization and mold prevention.

  In the cleaning sheet of the present invention, the aqueous sterilizing agent is impregnated in a base material sheet capable of retaining a liquid, but the aqueous sterilizing agent impregnated in the base material sheet has a pH of 4.8. As mentioned above, it is 8.0 or less, Preferably pH is 6.0 or more and 8.0 or less. If the pH of the aqueous disinfectant impregnated in the base sheet is less than 4.8, the corrosion resistance of the material to be cleaned, the skin irritation, and the mold resistance of the cleaning sheet may be lowered. If it exceeds 0, the corrosion resistance of the material to be cleaned, skin irritation, and the mold resistance of the cleaning sheet may be reduced. The aqueous disinfectant impregnated in the cleaning sheet of the present invention is selected from inorganic electrolytes, organic acids, and organic acid salts as component (B) together with quaternary ammonium salt type surfactant as component (A). In addition, by containing at least one aminocarboxylic acid type chelating agent as the component (C) and water as the component (D), the active component is adsorbed on the fibers of the substrate sheet when impregnated into the substrate sheet. There is no risk that the amount of the quaternary ammonium salt type surfactant is reduced or the antifungal property of the sterilizing sheet is lowered, and even if the base sheet contains rayon, it is an active ingredient (A ) There is no possibility that the amount of the quaternary ammonium salt type surfactant as a component is lowered.

  In the aqueous disinfectant impregnated in the base sheet, the component (A) is preferably 0.0001% by mass or more and 20% by mass or less, and 0.05% by mass or more and 10% by mass or less. Is more preferable, and it is further more preferable that it is 0.1 mass% or more and 4 mass% or less. If the component (A) is less than 0.0001% by mass, the cleaning property, sterilization and virus inactivating effect may be reduced, and if it exceeds 20% by mass, irritation to the skin may be increased. The aqueous disinfectant for impregnating the base sheet is preferably such that the mass ratio (A) / (B) of the component (A) and the component (B) is 0.005 or more and 20 or less, It is more preferably 0.01 or more and 10 or less, and particularly preferably 0.1 or more and 5 or less. If the mass ratio (A) / (B) between the component (A) and the component (B) is less than 0.005, there is a possibility that the anti-mold property and virus inactivation effect of the wet wipe may be reduced. There is a possibility that the preventive property is lowered. The pH of the aqueous sanitizer impregnated in the base sheet, the concentration of the component (B), and the mass ratio (A) / (B) of the component (A) to the component (B) are based on the aqueous sanitizer. It is a value measured by sampling the aqueous disinfectant impregnated in the base material sheet after 24 hours or more after impregnating the sheet.

  Examples of the base sheet in the cleaning sheet of the present invention include recycled fibers, synthetic fibers, natural fibers, and nonwoven fabrics, woven fabrics, and net cloths made of mixed fibers thereof. Examples of the regenerated fiber include rayon, polynosic, cupra, lyocell, and acetate. Rayon is preferable from the viewpoint of drug resistance of the nonwoven fabric and uneven distribution of the drug. When the regenerated fiber is used for the base sheet, the base sheet becomes hydrophilic and the amount of impregnation with the aqueous disinfectant can be improved. The proportion of recycled fibers in the base sheet is preferably 10% or more, and more preferably 50% or more. The amount of the aqueous sanitizer to be impregnated into the sheet base material is usually 20 to 120 parts by mass per 100 parts by mass of the fibers constituting the sheet base material, but when the base sheet contains regenerated fibers, the base material The amount of the aqueous disinfectant impregnated into the sheet can be increased. The use of inorganic fibers such as glass fibers is not preferable because it reduces the feeling of use, wears the material to be cleaned, and unevenly distributes chemicals. The cleaning sheet of the present invention is preferably impregnated with 150 to 350 parts by mass of an aqueous disinfectant per 100 parts by mass of the base sheet, and is impregnated with 200 to 330 parts by mass. More preferably.

  The aqueous sanitizing agent used in the cleaning sheet of the present invention is further washed with one or more surfactants of an anionic surfactant, nonionic surfactant, and amphoteric surfactant as component (E). And the permeability of the aqueous disinfectant to the base sheet, particularly the base sheet made of synthetic fibers, can be improved. Examples of the anionic surfactant include higher fatty acid salts, higher alcohol sulfate esters, sulfurized olefin salts, higher alkyl sulfonates, α-olefin sulfonates, sulfated fatty acid salts, sulfonated fatty acid salts, and phosphate ester salts. , Fatty acid ester sulfate ester salt, glyceride sulfate ester salt, fatty acid ester sulfonate salt, α-sulfo fatty acid methyl ester salt, polyoxyalkylene alkyl ether sulfate ester salt, polyoxyalkylene alkyl phenyl ether sulfate ester salt, polyoxyalkylene Alkyl ether carboxylate, acylated peptide, sulfate ester salt of fatty acid alkanolamide or its alkylene oxide adduct, sulfosuccinate ester, alkylbenzene sulfonate, alkyl naphthalene sulfonate Salt, alkylbenzimidazole sulfonate, polyoxyalkylene sulfosuccinate, N-acyl-N-methyltaurine salt, N-acyl glutamic acid or salt thereof, acyloxyethane sulfonate, alkoxyethane sulfonate, N-acyl -Β-alanine or salt thereof, N-acyl-N-carboxyethyltaurine or salt thereof, N-acyl-N-carboxymethylglycine or salt thereof, acyl lactate, N-acyl sarcosine salt, and alkyl or alkenylaminocarboxy Examples thereof include methyl sulfate and lower fatty acid salts of higher alkylamines. These anionic surfactants may be used alone or in combination of two or more. Examples of nonionic surfactants include polyoxyalkylene alkyl ethers, polyoxyalkylene fatty acid esters, block copolymers of polyoxyethylene and polyoxypropylene, and polyoxyalkylene styrenated phenyl ethers. These nonionic surfactants may be used alone or in combination of two or more. Amphoteric surfactants include alkylamine oxide, alkylbetaine, alkylamidopropylbetaine, 2-alkyl-N-carboxymethylimidazolinium betaine, 2-alkyl-N-carboxyethylimidazolinium betaine, alkylaminoethylglycine, Alkyldi (aminoethyl) glycine, glycine n- (3-aminopropyl) C10-16 derivative, alkylpolyaminoethylglycine, alkyl β-alanine, alkylaminopropionic acid and / or salt thereof, and alkylamidodimethylhydroxypropylsulfobetaine Can be mentioned. These amphoteric surfactants may be used alone or in combination of two or more. The proportion of these aqueous disinfectants is preferably 0.01% by mass or more and 5% by mass or less, more preferably 0.05% by mass or more and 2% by mass or less.

  The aqueous disinfectant used for the cleaning sheet of the present invention may further contain components that are usually used in the art. Examples of such a component include a solvent as the component (F), a pH adjuster, a fragrance, and a pigment as the component (G). The proportion of these aqueous disinfectants is preferably 0.001% by mass or more and 10% by mass or less, more preferably 0.01% by mass or more and 5% by mass or less.

  Examples of the solvent for the component (F) include organic solvents such as methanol, ethanol, 1-propanol, 2-propanol, acetone, hexane, acetonitrile, and toluene, ethylene glycol, propylene glycol, glycerin, sorbitol, hexylene glycol, Examples include ethylene glycol monobutyl ether, dipropylene glycol dimethyl ether, diethylene glycol monoethyl ether, diethylene glycol monobutyl ether, propylene glycol monomethyl ether, propylene glycol monobutyl ether, propylene glycol monoethyl ether, and propylene glycol dimethyl ether. Of these, propylene glycol, glycerin, and sorbitol are preferred from the viewpoint of synergistic effects of sterilization, fungicidal properties, and virus inactivating effect. These may be used alone or in combination of two or more. The solvent is preferably blended in an aqueous disinfectant in an amount of 0.001% by mass or more and 5% by mass or less, and 0.01% by mass or more and 3% by mass or less in terms of improving liquid stability in a solution state. It is more preferable.

  Examples of the pH adjuster for the component (G) include inorganic acids such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid and boric acid, citric acid, malic acid, oxalic acid, malonic acid, succinic acid, glutaric acid, maleic acid, Examples thereof include organic acids such as fumaric acid, tartaric acid, gluconic acid, aspartic acid, formic acid, acetic acid, and lactic acid. These may be used alone or in combination of two or more. When the base sheet containing rayon is impregnated with an aqueous disinfectant, in order to adjust the pH of the aqueous disinfectant impregnated in the base sheet to 4.8 or more and 8.0 or less, It is preferable to adjust the pH of the aqueous disinfectant to 4.8 or more and 10.5 or less. As component (B) contained in the aqueous disinfectant, (Ba) at least one kind of sodium dihydrogen phosphate or potassium dihydrogen phosphate, and (Bb) disodium hydrogen phosphate or hydrogen phosphate When used in combination with at least one kind of dipotassium, even in the case of a base sheet containing rayon, there is no substantial change in the pH of the aqueous disinfectant before and after impregnation of the base sheet.

  As the fragrance, conventionally known fragrances can be used without particular limitation. For example, natural fragrances extracted from natural products such as peppermint oil, synthetic fragrances synthesized such as limonene, and two or more known fragrances are appropriately used. A fragrance obtained by mixing at a ratio of As the fragrance component, those conventionally contained in various fragrances and natural products having fragrance can be used without particular limitation. Examples of the natural fragrance include anise oil, basil oil, bergamot oil, cedar. Oil, clove oil, coriander oil, eucalyptus oil, fennel oil, galvanum oil, geranium oil, jasmine absolute, lavandin oil, lavender oil, lemongrass oil, lemon oil, lavender spike oil, neroli oil, oak moss absolute, patchouli oil, pe Tigren oil, pine oil, rose oil, rosemary oil, clary sage oil, sandalwood oil, thyme oil, tonka absolute, tuberose absolute, vetiver oil, ylang ylang oil, peppermint oil, camphor oil, mellow oil, perilla oil, spearmint Oil, star anise oil, la Mu oil, okotia oil, turpentine oil, nutmeg oil, citronella oil, bored rose oil, cananga oil, cardamom oil, cassia oil, orange oil, mandarin oil, tangerine oil, bay oil, Jerome oil, hiba oil, coconut oil, grapefruit oil , Yuzu oil and the like.

  Synthetic fragrances include hydrocarbons (α-pinene, limonene, camphene, p-cymene, fenchen, osimene, guaien, etc.), alcohols (linalol, geraniol, citronellol, nerol, menthol, borneol, benzyl alcohol, anis alcohol) , Nerolidol, eugenol, α-phenylethyl alcohol, β-phenylethyl alcohol, rosinol, ambrinol, myrcenol, tetrahydrolinalol, terpineol, cedrol, 1-octanol, 3-octanol, 9-decenol, 10-undecenol, dihydrocarbene All, prenol, ethyl linalool, 3-heptanol, benzyl eugenol, 2-ethylhexanol, 3-hexenol, 2,4-dimethyl-3-cyclohex Sen-1-methanol, 4-isopropylcyclohexanol, P-isopropylcyclohexenemethanol, 1-nonanol, 2-nonanol, P-isopropylcyclohexanol, 2-methyl-3-buten-2-ol, 2-hexenol, 1- Nonen-3-ol, 3-methyl-1-pentanol, 2,6-dimethyl-heptanol and 3,4,5,6,6-pentamethyl-2-heptanol, etc.), aldehydes (n-butyraldehyde, isobutyraldehyde) , Hexyl aldehyde, heptyl aldehyde, n-nonyl aldehyde, nonadienal, citral, citronellal, benzaldehyde, cinnamic aldehyde, heliotropin, vanillin, tripral, 2-dodecenal, 2,5,6-trimethyl-4-heptana , Trimethylundecenal, 2-decenal, p-tolylaldehyde, acetaldehyde diethyl acetal, n-octanal, n-decanal, p-isopropylphenylacetaldehyde, octanal dimethyl acetal, n-nonanal, undecanal, 10-undecenal, Phenylpropionaldehyde, 3-hexenal, 2-undecenal and p-methylhydratropaldehyde), ketones (methyl amyl ketone, methyl nonyl ketone, diacetyl, acetyl propionyl, acetyl butyryl, carvone, menthone, camphor, acetophenone, p-methylacetophenone, ionone, dihydrocarbon and 2-undecanone, etc.), lactones or oxides (amylbutyrolactone, methylphenylglycid) Ethyl, γ-nonyllactone, coumarin, cineol, jasmine lactone, methyl r-decalactone, 2,2,6-trimethyl-6-vinyltetrahydropyran and 5-isoproperol-2-methyl-2-vinyltetrahydrofuran), ethers (1,8-cineole, rose oxide, cedrol methyl ether (cedlum bar), p-cresyl methyl ether, isoamylphenyl ethyl ether, 4-phenyl-2,4,6-trimethyl-1,3-dioxane, anethole, etc. Can be mentioned. Esters (methyl formate, isopropyl formate, linalyl formate, ethyl acetate, octyl acetate, menthyl acetate, benzyl acetate, cinnamyl acetate, butyl propionate, isoamyl acetate, isopropyl isobutyrate, granyl isovalerate, caproic acid Allyl, butyl heptylate, octyl caprylate, methyl heptine carboxylate, ethyl perahagonate, methyl octynecarboxylate, isoacyl caprate, methyl laurate, ethyl myristate, ethyl benzoate, benzyl benzoate, methyl phenylacetate, phenyl Butyl acetate, methyl cinnamate, cinnamyl cinnamate, methyl salicylate, ethyl anisate, methyl anthranilate, ethyl pyruvate, ethyl α-butyl butyrate, decyl acetate Bigisan propyl etc.) and the like.

Examples of the dye include natural dyes, synthetic dyes, and mixtures of two or more thereof. Specific examples of natural pigments include, for example, red cabbage pigment (purple red), red radish pigment (red orange to red purple), purple potato pigment (purple red), beet red (red), alkane pigment ( Red to reddish purple), cochineal dye (yellow orange to purple), lac dye (red orange to purple), safflower red dye (red), red mushroom (yellow orange to reddish purple), gardenia red dye (red), red beetle dye (Red), red pepper pigment (yellow to red-orange), annatto pigment (yellow to red-orange), gardenia yellow (yellow), safflower yellow (yellow), turmeric (yellow), marigold pigment (yellow), caramel Dye (dark brown to black), Kouliang dye (red brown to dark brown), onion dye (brown), sheanut dye (brown), pecannut dye (brown), chicory dye (red brown to brown), cacao dye (red) ~ Brown), chlorophyll (green), gardenia blue pigment (blue), and the like spirulina pigment (blue).
Specific examples of the synthetic pigment include, for example, Red No. 1, Red No. 2, Red No. 3, Red No. 4, Red No. 5, Red No. 101, Red No. 102, Red No. 103, Red No. 104, Red No. 105, Red No. 106, Orange No. 1, Orange No. 2, Yellow No. 1, Yellow No. 2, Yellow No. 3, Yellow No. 4, Yellow No. 5, Green No. 1, Green No. 2, Green No. 3, Green No. 1 , Blue No. 2, Purple No. 1, edible mixed dyes, and the like.

  The cleaning sheet of the present invention is excellent in sterilization, mold prevention, and virus inactivation effects against bacteria, molds, and viruses. Therefore, a wide range of areas where contamination and contamination of bacteria, molds and viruses are problematic, mainly in the medical field, It is useful for sterilization, mold prevention, and virus inactivation in the food service industry, food, brewing, and agriculture. In particular, it can be suitably used for sterilization, mold prevention, and virus inactivation of hard surfaces in the medical field.

  The cleaning sheet of the present invention can be applied in various applications, and is suitable for, for example, surface disinfection, device disinfection, or disinfecting / antifungal / virus inactivating agents around toilets and beds. The cleaning sheet of the present invention can be formed in a form in which a plurality of sheets are laminated, a long sheet wound in a roll shape, or in a folded form. It can be used as a cleaning sheet for activation.

  EXAMPLES Hereinafter, although an Example and a comparative example demonstrate this invention concretely, this invention is not limited by these. Each component used for blending in Examples and Comparative Examples is shown below. Note that EO is an abbreviation for ethylene oxide and PO is an abbreviation for propylene oxide, and the subsequent numbers represent the average added moles of EO and PO, respectively. Moreover, the numerical value of the mixing | blending of each component in the Example in a table | surface and a comparative example represents the mass% of a pure part. The “remainder” indicating the water content indicates a blending amount adjusted so that the total amount of the aqueous disinfectant as the final preparation is 100% by mass. The “appropriate amount” indicating the content of the pH adjuster indicates an amount blended for adjusting the pH (25 ° C.) of the aqueous disinfectant impregnated in the base sheet to the pH shown in the table. As the pH adjuster, 2M-sodium hydroxide or 2M-hydrochloric acid was used to adjust the pH (25 ° C.) of the squeezed solution after immersion in the sheet to the value shown in the table.

(A) Component A-1: Octyldecyldimethylammonium chloride A-2: Dioctyldimethylammonium chloride A-3: Didecyldimethylammonium chloride A-4: Alkyldimethylammonium chloride (wherein the alkyl group has 8 or more carbon atoms, 16 The following mixture)
A-5: Alkyldimethylbenzylammonium chloride (wherein the alkyl group is a mixture of 12 to 16 carbon atoms)
A-6: Benzethonium chloride (A ′) component [Comparative component of component (A)]
A′-1: N-alkyl trimethylenediamine oleate (however, the alkyl group is a mixture having 14 to 18 carbon atoms)
A′-2: alkylamine acetate (wherein the alkyl group is a mixture having 8 to 18 carbon atoms)

(B) Component B-1: Acetic acid B-2: Citric acid B-3: Gluconic acid B-4: Malic acid B-5: Sodium dihydrogen phosphate B-6: Disodium hydrogen phosphate B-7: Phosphorus Potassium dihydrogen acid B-8: Dipotassium hydrogen phosphate B-9: Potassium chloride B-10: Sodium sulfate (B ′) component [Comparative component of component (B)]
B′-1: Sodium polyacrylate (weight average molecular weight: 4,500)

(C) Component C-1: Ethylenediaminetetraacetic acid / disodium salt (EDTA-2Na)
C-2: Ethylenediaminetetraacetic acid dipotassium salt (EDTA-2K)
C-3: Ethylenediaminetetraacetic acid tetrasodium salt (EDTA-4Na)
C-4: Methylglycine diacetic acid trisodium salt (MGDA-3Na)
C-5: N, N′-dicarboxymethylglutamic acid tetrasodium salt (GLDA-4Na)
C-6: nitrilotriacetic acid trisodium salt (NTA-3Na)

(D) Component D-1: Ion exchange water

(E) Component E-1: Polyoxyethylene alkyl ether (wherein EO is 6.5 mol, the alkyl group has 9 to 11 carbon atoms)
E-2: Polyoxyalkylene lauryl ether (however, EO is 38 mol, PO is 2 mol)
E-3: Octyldimethylamine oxide E-4: Polyoxyethylene lauryl ether phosphate E-5: Dodecylaminoethylaminoethylglycine

Other components Solvent F-1: Ethanol F-2: Normal propyl alcohol F-3: Isopropyl alcohol F-4: Propylene glycol F-5: Butyl glycol F-6: Glycerin F-7: Sorbitol pH adjuster G-1: Sodium hydroxide G-2: Hydrochloric acid

Examples 1 to 100, Comparative Examples 1 to 10
An aqueous disinfectant was prepared based on the formulations shown in Tables 1 to 10. The nonwoven fabric base material sheet containing the regenerated fiber shown in the table was impregnated with each aqueous disinfectant for 24 hours so that the impregnation amount shown in the table per 100 parts by mass of the base material sheet was used as a cleaning sheet. Using a vise, the cleaning sheet is tightened with a force of 10 N · cm for 10 minutes, the pH of the squeezed solution (hereinafter referred to as squeezed liquid), the effective (A) component amount, and the sterilizing property of the cleaning sheet , Fungicide, anti-adsorption, virus inactivation, chemical resistance to non-woven fabric of aqueous disinfectant, feeling of use of cleaning sheet, wear of material to be cleaned, corrosiveness of material to be cleaned, skin irritation, prevention Properties such as moldability and uneven distribution of chemicals in the cleaning sheet were evaluated. The results are shown in Tables 1 to 10.

pH measurement method <calibration of pH meter>
Connect a pH measurement composite electrode (made by HORIBA; glass sliding sleeve type) to a pH meter (made by HORIBA; pH / ion meter F-23) and turn on the power. A saturated potassium chloride aqueous solution (3.33 mol / L) was used as the pH electrode internal solution. Next, pH 4.01 standard solution (phthalate standard solution), pH 6.86 standard solution (neutral phosphate standard solution), and pH 9.18 standard solution (borate standard solution) are filled in a 100 mL beaker. And immersed in a constant temperature bath at 25 ° C. for 30 minutes. The pH measurement electrode was immersed in a standard solution adjusted to a constant temperature for 3 minutes, and calibration operations were performed in the order of pH 6.86, pH 9.18, and pH 4.01.
<PH measurement>
The pH measurement electrode was immersed for 3 minutes in 100 mL of a squeezed solution adjusted to a constant temperature of 25 ° C. in a thermostatic chamber, and the pH was measured.

Effective (A) component amount (cationic surfactant amount) measuring method Take 8 mL of the extract in a beaker, 1 mL of 0.25 M sodium acetate buffer pH 5.7, 6 × 10 ⁻⁴ M chromium in the extract. Azurol S solution (1 mL) was sequentially added, and the mixture was titrated with an aqueous 2.0 mol / L sodium lauryl sulfate solution while stirring with a magnetic stirrer to determine the amount of component (A) in the extract. The end point of the titration was visually determined that the color of the solution changed from purple to orange.

* 1: Bactericidal test method:
The test strain is cultured in SCD bouillon medium for bacteria, and in GP liquid medium for fungi, and the number of bacteria is adjusted to 2.0 × 10 ⁸ CFU / mL or more and 9.0 × 10 ⁸ CFU / mL or less. To obtain a bacterial solution. Add 0.1 mL of each test bacterial solution to 10 mL of the extract and let it contact at 25 ° C. for 15 minutes, then add a sterile neutralizing solution (SCDLP medium for bacteria, GPLP liquid medium for molds) Stir. ^{Bacterial, Pseudomonas aeruginosa NBRC13736 (10 8 CFU} / mL ^{level), Staphylococcus aureus NBRC13276 (10 8} CFU / mL ^{level), Escherichia coli ATCC11229 (10 8} CFU / mL ^{level), Alcaligenes faecalis NBRC14479 (10 8} CFU / mL level) , Serratia marcescens NBRC12648 the (10 ⁸ CFU / mL level), as ^{fungi, Aspergillus niger NBRC105649 (10 8 CFU} / mL ^{level), Trichophyton mentagrophytes ATCC9533 (10 8} CFU / mL level), Candida Albic ns ATCC11651 and (10 ⁸ CFU / mL level) was used.
1 mL of this was mixed-cultured on a SCD agar medium for bacteria and PDA medium for fungi, the number of viable bacteria was confirmed, and evaluated according to the following criteria.
Evaluation criteria:
1 point: Decrease in the number of bacteria with a log reduction of 5 or more in the test bacteria 2 points: Decrease in the number of bacteria in the test bacteria with a reduction of 4 or more but less than 5 Decrease in the number of bacteria: 4 points: As the number of bacteria whose log reduction of the test bacteria was less than 3, the reduction in the number of bacteria was evaluated by the score for each of the above bacterial species.
For bacteria, the average value of five types of bacteria for the number of bacteria reduction was determined, and sterilization was evaluated according to the following criteria.
A: The average value is 1.0 point or more and less than 1.5 point.
A: The average value is 1.5 points or more and less than 2.5 points.
Δ: The average value is 2.5 points or more and less than 3.5 points.
X: The average value is 3.5 or more.
About mold | fungi, the average value about three types of mold | fungi was calculated | required and the sterilization property was evaluated on the following references | standards.
A: The average value is 1.0 point or more and less than 1.5 point.
A: The average value is 1.5 points or more and less than 2.5 points.
Δ: The average value is 2.5 points or more and less than 3.5 points.
X: The average value is 3.5 or more.
Δ, ○, and ◎ were determined to be practical for both sterilization against bacteria and fungi.

* 2: Adsorption prevention test The amount of active ingredient was measured for the squeezed liquid, and compared with the measured value of the solution before impregnation, the degree of adsorption of the components in the solution to the nonwoven fabric was evaluated. The active ingredient amount (cationic surfactant amount) measurement method was performed by measuring the active ingredients before and after the impregnation and evaluating them according to the following criteria.
Evaluation criteria:
A: Effective component amount is 80% or more and 100% or less before impregnation O: Effective component amount is 60% or more and less than 80% before impregnation Δ: Active component amount is 40% or more and less than 60% before impregnation ×: The amount of active ingredient was determined to be less than 40% before impregnation, and Δ, ○, and ◎ were determined to be practical.

* 3: Evaluation test method for drug resistance of nonwoven fabric:
Ten nonwoven fabrics (200 mm × 250 mm) made of various materials shown in Table 1 to Table 10 were used, impregnated in 200 mL of each test aqueous disinfectant and stored at 40 ° C. for 1 week, and then the appearance change of the nonwoven fabric was visually observed. Observed.
Evaluation criteria:
○: No discoloration or deterioration has occurred.
(Triangle | delta): The deep discoloration and strong degradation have generate | occur | produced partially.
X: Dark discoloration or strong deterioration occurs as a whole.
And Δ and ○ were determined to be practical.

* 4: Evaluation test method for feeling of use:
Ten nonwoven fabrics (200 mm × 250 mm) made of various materials shown in Table 1 to Table 10 were used, impregnated in 200 mL of each test aqueous disinfectant, and after confirming that the chemical solution was sufficiently spread, the chemical solution was infiltrated. Take out one piece of non-woven fabric, wipe the surface of a clean stainless steel approximately 30 cm square, wipe it up and down 5 times, left and right 5 times, and use it by a sensory test from the viewpoint of foaming, sticky wateriness, stiff feeling, dampness, etc. It was confirmed. Panelists were randomly selected and n = 10 for each sample. Statistical analysis was performed to analyze the evaluation results, and the items with the highest evaluation were adopted as the evaluation results.
Evaluation criteria:
○: There is no foaming, stickiness, wateriness, and a feeling of firmness.
Δ: Slight bubbling, stickiness, wateriness, stiff feeling, or no moderate dampness.
X: Foaming, stickiness, wateriness, and a feeling of firmness are very strong, or there is almost no dampness and a feeling of use is bad.
And Δ and ○ were determined to be practical.

* 5: Evaluation test method for wear of materials to be cleaned:
Ten nonwoven fabrics (200 mm × 250 mm) made of various materials shown in Table 1 to Table 10 were used, impregnated in 200 mL of each test aqueous disinfectant, and after confirming that the chemical solution was sufficiently spread, the chemical solution was infiltrated. One piece of nonwoven fabric was taken out, and a clean stainless steel surface was wiped 5 times up and down and 5 times on the left and right sides over about 30 cm. Thereafter, the scratches generated on the stainless steel surface were visually observed.
Evaluation criteria:
○: No scratches are seen.
Δ: Deep scratches are partially observed.
X: Deep scratches are seen as a whole.
And Δ and ○ were determined to be practical.

* 6: Evaluation test method for the corrosivity of the material to be cleaned:
15 types of resin and metal panels (vinyl chloride / ABS / polypropylene / polyethylene / acrylic / polycarbonate / silicon) cut to a size of 3 cm × 5 cm with respect to various wet cloth squeezed liquids shown in Tables 1 to 10・ Teflon (registered trademark) ・ Brass ・ Soft iron ・ Aluminum ・ Zinc nickel ・ Aluminum ・ Copper ・ Stainless steel) Soaked a total of 30 pieces each and stored at 25 ℃ for 48 hours, then rinsed each panel with ion exchange water for 24 hours After drying at room temperature, the degree of corrosion was evaluated visually.
Evaluation criteria:
A: No discoloration, deterioration, cracks, etc. are seen on all panels.
○: Discoloration, deterioration, cracks, etc. are seen in less than 20% of the panels.
Δ: Discoloration, deterioration, cracks, etc. are observed in 20% or more and less than 30% of the panels.
X: Discoloration, deterioration, cracks, etc. are seen in 30% or more of panels.
And Δ, ○, and ◎ were determined to be practical.

* 7: Test for skin irritation Take out one wet wipe shown in Table 1 to Table 10, cut into 1cm square, and apply it to the inside of an adult elbow randomly selected using adhesive tape. Immediately after peeling after a lapse of time, the skin condition was visually confirmed to evaluate skin irritation.
Evaluation criteria:
A: Erythema and edema are not seen at all.
◯: Almost no erythema or edema is observed.
Δ: Slightly red erythema and mild edema are observed.
X: Strong redness erythema and severe edema are observed.

* 8: Evaluation test method for mold resistance of wet wipes:
Nonwoven fabrics (200 mm x 250 mm x 300 sheets) made of various materials shown in Table 1 to Table 10 are placed in a 3 L polypropylene bag, impregnated with 2 L of each test aqueous disinfectant, and stored at room temperature for 24 hours. After that, the nonwoven fabric was cut into half lengths and taken out from the outside to the center at three regular intervals, cut out with scissors to fit in the petri dish, and then black mold fungus (Aspergillus niger NBRC105649 (10 ⁸ CFU / The sample was affixed to a petri dish coated with mL level)) and cultured at 25 ° C. for 4 days, and the degree of mold generation on the nonwoven fabric field was visually observed.
Evaluation criteria:
A: The occurrence of mold is completely suppressed.
○: Almost no occurrence of mold.
Δ: Part of mold is observed, but it is generally suppressed.
X: Mold is generated as a whole.
And Δ, ○, and ◎ were determined to be practical.

* 9: Evaluation test method for uneven distribution of chemicals in base sheet:
Nonwoven fabrics (200 mm x 250 mm x 300 sheets) made of various materials shown in Table 1 to Table 10 are placed in a 3 L polypropylene bag, impregnated with 2 L of each test aqueous disinfectant, and stored at room temperature for 24 hours. After that, it was cut into half length, and it was visually observed whether the chemical solution had penetrated to the central part.
Evaluation criteria:
A: The chemical solution is soaked evenly throughout.
○: The drug solution is almost completely infiltrated.
(Triangle | delta): There is a part which is not soaked in part.
X: There are parts that are not soaked everywhere.
And Δ, ○, and ◎ were determined to be practical.

* 10: Virus inactivation test method:
0.9 mL of the squeezed solution and 0.1 mL of virus solution adjusted to 10 ⁸ TCID ₅₀ / mL were added to the test tube, mixed with a mixer, and allowed to act at 25 ° C. for 10 minutes. After the action, 0.1 mL was sampled and added to 9.9 mL of action stop solution (a cell growth solution containing 2% sodium thiosulfate, 0.2% lecithin and 1.5% polysorbate 80) and diluted 100 times, The action of the aqueous disinfectant (extracted liquid) on the virus was stopped. This was used for measurement of infectious titer as a stock solution for measuring virus infectious titer. Similarly, a test using phosphate buffered saline (hereinafter sometimes abbreviated as PBS) in place of the squeezed solution was performed as a control. Phosphate buffered saline is composed of 8g sodium chloride, 0.2g potassium chloride, 1.44g disodium hydrogen phosphate, 0.24g potassium dihydrogen phosphate, mixed with 4 kinds of salt and made up to 900mL with ultrapure water. After dissolution, the pH is adjusted to 7.4 with hydrochloric acid. Sterilize by autoclaving after measuring up to 1L. As the virus, feline calicivirus, mouse norovirus, hepatitis B virus, hepatitis C virus, adenovirus, AIDS virus, influenza virus were used.
Dilbeco's modified Eagle's Medium (DMEM) supplemented with 5% of the stock solution for infectivity titration and 50 μL of diluted virus solution and fetal bovine serum (FBS) after 10-fold serial dilution of the stock solution for virus infectivity titer measurement with PBS The cells suspended in (1) were seeded in a 96-well plate. Thereafter, the cells were cultured in a carbon dioxide incubator at 37 ° C. and 5% CO ₂ for 4 days. After culturing, the presence or absence of CPE (cytopathic effect) due to virus growth was observed under an inverted microscope, and the virus infectivity titer (TCID ₅₀ / mL) was determined using the Reed-Muench method and evaluated according to the following criteria.
Evaluation criteria:
1 point: Log reduction of virus infection titre is 5 or more 2 points: Log reduction of virus infection titre is 4 or more, less than 5 3 points: Log reduction of virus infection titre is 3 or more, less than 4 4 points : Log reduction of virus infectivity titer was reduced by less than 3, the virus infectivity titre of each of the above viruses was evaluated by a score to obtain an average value, and the virus inactivation effect was evaluated by the following criteria.
A: The average value is 1.0 point or more and less than 1.5 point.
A: The average value is 1.5 points or more and less than 2.5 points.
Δ: The average value is 2.5 points or more and less than 3.5 points.
X: The average value is 3.5 or more.
And Δ, ○, and ◎ were determined to be practical.

* 11: Antibacterial sustainability test A 20 mm x 20 mm stainless steel plate is prepared, wiped up and down 5 times with the various wet cloths shown in Tables 1 to 10 and left and right for 5 hours in an incubator set at 25 ° C (1 (Time, 12 hours, 24 hours, 72 hours) An untreated stainless steel plate was also prepared as a control. Each test panel that was allowed to stand for a predetermined time was placed in a sterilized plastic bottle, and 0.2 mL of each bacterial solution prepared in the sterilization test was inoculated and applied evenly over the entire panel surface. Each test panel was naturally dried at 25 ° C. for 2 hours, 20 mL of SCDLP medium for bacteria and 20 mL of GPLP liquid medium for fungi were added, put into a stomacher bag, and the bacteria were washed out by hand 60 times. The washed test solution was cultured on bacteria using an SCD agar medium, and on mold using a PDA medium, and the number of bacteria (cfu / mL) was determined and evaluated according to the following criteria compared with the control.
Evaluation criteria:
1 point: The common logarithm of the number of bacteria is 3 or more smaller than the control until the standing time is 72 hours.
2 points: The common logarithm of the number of bacteria is 3 or more smaller than the control until the standing time is 24 hours.
3 points: The common logarithm of the number of bacteria is 3 or more smaller than the control until the standing time is 12 hours.
4 points: The common logarithm of the number of bacteria is 3 or more smaller than the control until the standing time is 1 hour.
The antibacterial persistence was evaluated by a score.
About bacteria, the average value with respect to five types of antimicrobial persistence bacteria was calculated | required, and the antimicrobial persistence effect was evaluated with the following references | standards.
A: The average value is 1.0 point or more and less than 1.5 point.
A: The average value is 1.5 points or more and less than 2.5 points.
Δ: The average value is 2.5 points or more and less than 3.5 points.
X: The average value is 3.5 or more.
Moreover, about mold | fungi, the average value with respect to three types of antimicrobial persistence mold was calculated | required, and the following reference | standard evaluated.
A: The average value is 1.0 point or more and less than 1.5 point.
A: The average value is 1.5 points or more and less than 2.5 points.
Δ: The average value is 2.5 points or more and less than 3.5 points.
X: The average value is 3.5 or more.
For both the antibacterial persistence against bacteria and the antibacterial persistence against mold, Δ, ○, and ◎ were judged as practical.

* 12: Stainless steel plate of 20mm x 20mm antiviral sustainability test is prepared, wiped up and down 5 times with the various wet cloths shown in Table 1 to Table 10 and left and right for 5 hours in an incubator set at 25 ° C ( (1 hour, 12 hours, 24 hours, 72 hours) An untreated stainless steel plate was also prepared as a control. Each test panel that was allowed to stand for a predetermined time was placed in a sterilized plastic bottle, and 0.2 mL of virus solution (feline calicivirus, mouse norovirus, adenovirus, influenza virus) was inoculated and applied evenly over the entire panel surface. Each test panel was air-dried at 25 ° C. for 2 hours, 20 mL of SCDLP medium was added, put into a stomacher bag, and the itch virus was washed out 60 times by hand. After preparing the diluted test solution in a cell culture medium using a 10-fold dilution method, host cells corresponding to each virus (feline calicivirus: Crandekk-Reese feline kidney cell, mouse norovirus: Mouse monocyte / macrophage) cell line RAW264, adenovirus: Hela cell, influenza virus: Madin-Darby canine kidney cell).
The presence or absence of virus infection was observed after a certain period of time, and the virus infection titer (TCID ₅₀ / mL) was determined and evaluated according to the following criteria compared with the control.
Evaluation criteria:
1 point: The common logarithm of the virus infectivity value is 3 or more smaller than that of the control until the standing time is 72 hours.
2 points: The common logarithm of the virus infectivity titer is 3 or more smaller than the control until the standing time is 24 hours.
3 points: The common logarithm of the virus infectivity titer is 3 or more smaller than the control until the standing time is 12 hours.
4 points: The common logarithm of the virus infectivity value is 3 or more smaller than the control until the standing time is 1 hour.
As above, the antiviral persistence was evaluated by a score, the average value of antiviral persistence for each virus was determined, and the antiviral persistence effect was evaluated according to the following criteria.
A: The average value is 1.0 point or more and less than 1.5 point.
A: The average value is 1.5 points or more and less than 2.5 points.
Δ: The average value is 2.5 points or more and less than 3.5 points.
X: The average value is 3.5 or more.
And Δ, ○, and ◎ were determined to be practical.

* 13: Detergency test method:
The mass of a test piece was prepared by adhering and drying pseudo-fouling mixed with beef tallow: soybean oil: chloroform 1: 1: 5 on a stainless steel plate (15 × 50 mm) whose mass was measured. This test piece was fixed to a flat surface, 50 g of various wet cloths shown in Tables 1 to 10 were taken out, placed in a folded state twice, placed on the test piece, and a weight of 300 g was placed thereon. In this state, the wet cloth was turned up and down 5 times at intervals of once per second. Thereafter, the test piece was rinsed with ion-exchanged water, allowed to dry naturally, and then the mass was measured. The cleaning rate was calculated from the following formula based on the change in mass of the test piece before and after wiping, and was shown on the following scale.
(Equation 1)
Cleaning rate = (S−T) / (S−U) × 100
S: Mass of test piece before wiping T: Mass of test piece after wiping U: Mass evaluation criteria of stainless steel plate:
○: Cleaning rate of 70% or more and 100% or less Δ: Cleaning rate of 30% or more and less than 70% ×: Cleaning rate of less than 30%, and Δ and ○ were determined to be practical.

Claims (10)

In a cleaning sheet in which an aqueous disinfectant is impregnated with respect to a substrate sheet capable of holding a liquid, the aqueous disinfectant is a dialkyldimethyl having an alkyl group having 6 to 18 carbon atoms as component (A). Ammonium salt, quaternary ammonium salt type surfactant selected from alkyldimethylbenzylammonium salt having alkyl group having 6 to 18 carbon atoms , (B) sodium dihydrogen phosphate, potassium dihydrogen phosphate as component (B) , Disodium hydrogen phosphate, dipotassium hydrogen phosphate, potassium chloride, acetic acid or salt thereof, gluconic acid or salt thereof, malic acid or salt thereof , (C) ethylenediaminetetraacetic acid (EDTA ) as component ), Nitrilotriacetic acid (NTA), methylglycine diacetic acid (MGDA), glutamic acid diacetic acid (GLDA), Et alkali metal salts of amino carboxylic acid type chelating agent selected from ammonium salts, (D) contain water as a component, pH of the aqueous disinfectant impregnated in the substrate sheet 4.8 or higher , 8.0 or less,
The cleaning sheet, wherein the base sheet contains at least one selected from recycled fibers, synthetic fibers, and natural fibers. The component (A) is at least one selected from octyldecyldimethylammonium chloride, dioctyldimethylammonium chloride, didecyldimethylammonium chloride, and alkyldimethylbenzylammonium chloride (a mixture of alkyl groups having 12 to 16 carbon atoms). the cleaning sheet of a claim 1, wherein. (B) Component is a combination of at least one of sodium dihydrogen phosphate and potassium dihydrogen phosphate and at least one of disodium hydrogen phosphate and dipotassium hydrogen phosphate, a combination of acetic acid and its salt, malic acid The cleaning sheet according to claim 1, wherein the cleaning sheet is at least one combination selected from a combination of gluconic acid and a salt thereof . The cleaning agent according to any one of claims 1 to 3, wherein the aqueous disinfectant has a mass ratio (A) / (B) of the component (A) to the component (B) of 0.005 or more and 20 or less. Sheet.   The cleaning sheet according to any one of claims 1 to 4, wherein the aqueous disinfectant contains at least one selected from an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant as the component (E). .   The cleaning sheet according to claim 1, wherein the base sheet contains recycled fibers.   The cleaning sheet according to any one of claims 1 to 6, wherein the aqueous disinfectant impregnated in the base sheet is 150 parts by weight or more and 350 parts by weight or less per 100 parts by weight of the base sheet.   The component (A) in the aqueous disinfectant impregnated in the base sheet is 0.00045% by mass or more and 20% by mass or less, for cleaning according to any one of claims 1 to 7 Sheet.   The cleaning sheet according to any one of claims 1 to 8, wherein the aqueous disinfectant impregnated in the base sheet has a virus inactivating effect.   The cleaning sheet according to any one of claims 1 to 9, which is a cleaning sheet for sterilization, mold prevention, and virus inactivation.