JP6549299B1 - Liquid disinfectant composition and disinfecting method - Google Patents
Liquid disinfectant composition and disinfecting method Download PDFInfo
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- JP6549299B1 JP6549299B1 JP2018178635A JP2018178635A JP6549299B1 JP 6549299 B1 JP6549299 B1 JP 6549299B1 JP 2018178635 A JP2018178635 A JP 2018178635A JP 2018178635 A JP2018178635 A JP 2018178635A JP 6549299 B1 JP6549299 B1 JP 6549299B1
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- acid
- disinfectant composition
- mass
- liquid disinfectant
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- 239000000203 mixture Substances 0.000 title claims abstract description 102
- 239000000645 desinfectant Substances 0.000 title claims abstract description 96
- 239000007788 liquid Substances 0.000 title claims abstract description 84
- 230000000249 desinfective effect Effects 0.000 title claims abstract description 22
- 238000000034 method Methods 0.000 title claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 42
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 35
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 239000003093 cationic surfactant Substances 0.000 claims abstract description 19
- 239000002280 amphoteric surfactant Substances 0.000 claims abstract description 10
- 239000002738 chelating agent Substances 0.000 claims abstract description 8
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 8
- 125000004432 carbon atom Chemical group C* 0.000 claims description 27
- 230000001954 sterilising effect Effects 0.000 claims description 24
- 238000004659 sterilization and disinfection Methods 0.000 claims description 21
- 239000006260 foam Substances 0.000 claims description 10
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 6
- CIEZZGWIJBXOTE-UHFFFAOYSA-N 2-[bis(carboxymethyl)amino]propanoic acid Chemical compound OC(=O)C(C)N(CC(O)=O)CC(O)=O CIEZZGWIJBXOTE-UHFFFAOYSA-N 0.000 claims description 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 5
- WDJHALXBUFZDSR-UHFFFAOYSA-N acetoacetic acid Chemical compound CC(=O)CC(O)=O WDJHALXBUFZDSR-UHFFFAOYSA-N 0.000 claims description 5
- 239000004220 glutamic acid Substances 0.000 claims description 5
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 4
- RUSUZAGBORAKPY-UHFFFAOYSA-N acetic acid;n'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O.NCCNCCNCCN RUSUZAGBORAKPY-UHFFFAOYSA-N 0.000 claims description 4
- 235000013922 glutamic acid Nutrition 0.000 claims description 4
- MGFYIUFZLHCRTH-UHFFFAOYSA-N nitrilotriacetic acid Chemical compound OC(=O)CN(CC(O)=O)CC(O)=O MGFYIUFZLHCRTH-UHFFFAOYSA-N 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 229940100484 5-chloro-2-methyl-4-isothiazolin-3-one Drugs 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 3
- UEFCKYIRXORTFI-UHFFFAOYSA-N 1,2-thiazolidin-3-one Chemical compound O=C1CCSN1 UEFCKYIRXORTFI-UHFFFAOYSA-N 0.000 claims description 2
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- -1 alkyl dimethyl benzyl ammonium Chemical compound 0.000 description 40
- 238000012360 testing method Methods 0.000 description 36
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- 241000196324 Embryophyta Species 0.000 description 17
- 230000000694 effects Effects 0.000 description 15
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- LJINSKIHVMGTDJ-UHFFFAOYSA-N 2-(2,2-diaminoethylamino)acetic acid Chemical compound NC(N)CNCC(O)=O LJINSKIHVMGTDJ-UHFFFAOYSA-N 0.000 description 10
- 230000000844 anti-bacterial effect Effects 0.000 description 10
- 238000007865 diluting Methods 0.000 description 10
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- 238000005260 corrosion Methods 0.000 description 9
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- 230000008029 eradication Effects 0.000 description 9
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- 239000008272 agar Substances 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 239000003599 detergent Substances 0.000 description 7
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
- 239000004471 Glycine Substances 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 6
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 125000005210 alkyl ammonium group Chemical group 0.000 description 6
- 239000000460 chlorine Substances 0.000 description 6
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- 238000010998 test method Methods 0.000 description 6
- 239000012085 test solution Substances 0.000 description 6
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 description 5
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
- 239000012153 distilled water Substances 0.000 description 5
- 230000008030 elimination Effects 0.000 description 5
- 238000003379 elimination reaction Methods 0.000 description 5
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- 238000002360 preparation method Methods 0.000 description 5
- 229910052708 sodium Inorganic materials 0.000 description 5
- 239000011734 sodium Substances 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 3
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 3
- UYWHIOXLXHJJDP-UHFFFAOYSA-N C(CCCCCCC)C(NCC(N)N)(C(=O)O)CCCCCCCC Chemical compound C(CCCCCCC)C(NCC(N)N)(C(=O)O)CCCCCCCC UYWHIOXLXHJJDP-UHFFFAOYSA-N 0.000 description 3
- JMHWNJGXUIJPKG-UHFFFAOYSA-N CC(=O)O[SiH](CC=C)OC(C)=O Chemical compound CC(=O)O[SiH](CC=C)OC(C)=O JMHWNJGXUIJPKG-UHFFFAOYSA-N 0.000 description 3
- JGFDZZLUDWMUQH-UHFFFAOYSA-N Didecyldimethylammonium Chemical compound CCCCCCCCCC[N+](C)(C)CCCCCCCCCC JGFDZZLUDWMUQH-UHFFFAOYSA-N 0.000 description 3
- RUPBZQFQVRMKDG-UHFFFAOYSA-M Didecyldimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCC[N+](C)(C)CCCCCCCCCC RUPBZQFQVRMKDG-UHFFFAOYSA-M 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- 108010039918 Polylysine Proteins 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000607715 Serratia marcescens Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
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- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
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- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 2
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- CSNIZNHTOVFARY-UHFFFAOYSA-N 1,2-benzothiazole Chemical compound C1=CC=C2C=NSC2=C1 CSNIZNHTOVFARY-UHFFFAOYSA-N 0.000 description 1
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- GKQHIYSTBXDYNQ-UHFFFAOYSA-M 1-dodecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+]1=CC=CC=C1 GKQHIYSTBXDYNQ-UHFFFAOYSA-M 0.000 description 1
- GQEZCXVZFLOKMC-UHFFFAOYSA-N 1-hexadecene Chemical group CCCCCCCCCCCCCCC=C GQEZCXVZFLOKMC-UHFFFAOYSA-N 0.000 description 1
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- HFDVRLIODXPAHB-UHFFFAOYSA-N 1-tetradecene Chemical group CCCCCCCCCCCCC=C HFDVRLIODXPAHB-UHFFFAOYSA-N 0.000 description 1
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- SHHOXQWCXVHCLT-UHFFFAOYSA-N 2-(2,2-diaminoethylamino)acetic acid;hydrochloride Chemical compound Cl.NC(N)CNCC(O)=O SHHOXQWCXVHCLT-UHFFFAOYSA-N 0.000 description 1
- PIINGYXNCHTJTF-UHFFFAOYSA-N 2-(2-azaniumylethylamino)acetate Chemical compound NCCNCC(O)=O PIINGYXNCHTJTF-UHFFFAOYSA-N 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
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- 229940079842 sodium cumenesulfonate Drugs 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 229940048842 sodium xylenesulfonate Drugs 0.000 description 1
- XKKTVIWAHIWFAN-UHFFFAOYSA-M sodium;2-[2-[2-(dodecylamino)ethylamino]ethylamino]acetate Chemical compound [Na+].CCCCCCCCCCCCNCCNCCNCC([O-])=O XKKTVIWAHIWFAN-UHFFFAOYSA-M 0.000 description 1
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 description 1
- KVCGISUBCHHTDD-UHFFFAOYSA-M sodium;4-methylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1 KVCGISUBCHHTDD-UHFFFAOYSA-M 0.000 description 1
- QEKATQBVVAZOAY-UHFFFAOYSA-M sodium;4-propan-2-ylbenzenesulfonate Chemical compound [Na+].CC(C)C1=CC=C(S([O-])(=O)=O)C=C1 QEKATQBVVAZOAY-UHFFFAOYSA-M 0.000 description 1
- 235000014214 soft drink Nutrition 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 235000013555 soy sauce Nutrition 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical compound C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
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- Apparatus For Disinfection Or Sterilisation (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
【課題】本発明は、一般細菌のみならず、芽胞形成菌の芽胞や、陽イオン界面活性剤抵抗性菌に対して、除菌力を有する除菌剤組成物を提供することを目的とする。【解決手段】上記目的を達成するため、本発明は、（Ａ）成分として下記一般式（１）で表される両性界面活性剤又はその塩、（Ｂ）成分として陽イオン界面活性剤、（Ｃ）成分としてキレート剤、（Ｄ）成分として水を含有し、２５℃におけるｐＨが７．５〜１３である、液体除菌剤組成物を提供する：【化１】（式中、Ｒ１は炭素数６〜１８のアルキル基、Ｒ２は水素原子又は炭素数６〜１８のアルキル基；ｍは１〜４の整数、ｎは０〜２の整数である。）【選択図】なしAn object of the present invention is to provide a disinfectant composition having a disinfecting power against not only general bacteria but also spores of spore-forming bacteria and cationic surfactant-resistant bacteria. . In order to achieve the above object, the present invention provides an amphoteric surfactant represented by the following general formula (1) or a salt thereof as component (A), a cationic surfactant as component (B), Provided is a liquid disinfectant composition containing a chelating agent as component C) and water as component (D) and having a pH of 7.5 to 13 at 25 ° C: wherein R1 is (C6-18 alkyl group, R2 is a hydrogen atom or a C6-18 alkyl group; m is an integer of 1-4, n is an integer of 0-2)
Description
本発明は、液体除菌剤組成物及び除菌方法に関する。具体的に、本発明は、芽胞形成菌の芽胞に対する除菌性に優れ、軽金属に対する腐食性が低く、かつ保存安定性に優れた液体除菌剤組成物及び当該液体除菌組成物を用いた除菌方法に関する。 The present invention relates to a liquid disinfectant composition and a disinfecting method. Specifically, the present invention is a liquid disinfectant composition excellent in the ability to eliminate spores of spores forming bacteria, low in corrosion resistance to light metals, and excellent in storage stability, and the liquid eradication composition It relates to the sterilization method.
食中毒のリスク軽減や、食品工場、厨房施設の衛生環境を良好に保つため、除菌剤が使用されている。食品工場、厨房施設の除菌には、第四級アンモニウム塩を主成分とした除菌洗浄剤が一般的に使用されている。また、芽胞形成菌（以下、芽胞菌とも言う）の除菌を目的とした場合や高度な除菌力が必要な場合、次亜塩素酸ナトリウム等に代表される塩素系酸化剤を主成分とした除菌洗浄剤組成物が用いられる。 A disinfectant is used to reduce the risk of food poisoning and to maintain a good sanitation environment for food factories and kitchen facilities. For sterilization in food factories and kitchen facilities, sterilization cleaners based on quaternary ammonium salts are generally used. In addition, if the purpose is to eradicate spore-forming bacteria (hereinafter referred to as spore bacteria) or if high eradication ability is required, chlorine-based oxidizing agents represented by sodium hypochlorite etc. The disinfected detergent composition is used.
しかしながら、第四級アンモニウム塩を主成分とした除菌洗浄剤は、芽胞菌に対する除菌力がほとんど無いため、芽胞菌の除菌はできない。また、第四級アンモニウム塩には陽イオン界面活性剤抵抗生菌の出現が問題となる場合がある。塩素系酸化剤を含む除菌洗浄剤は、芽胞菌に対する一定の除菌効果が認められるが、軽金属に対する腐食性が大きく、使用可能な設備が限定されてしまう。芽胞菌は、薬剤耐性が高いため、残存した芽胞菌が食品に混入し、食品腐敗及び食中毒を引き起こす問題がある。 However, since the disinfectant cleaner mainly composed of quaternary ammonium salt has almost no disinfecting ability against spores, it can not disinfect spores. In addition, the appearance of cationic surfactant resistant bacteria may be problematic for quaternary ammonium salts. A disinfectant cleaner containing a chlorine-based oxidizing agent has a certain eradication effect on spore bacteria, but is highly corrosive to light metals, which limits the equipment that can be used. Since spores are highly resistant to drugs, the remaining spores contaminate the food, causing problems of food spoilage and food poisoning.
従来の除菌洗浄剤としては、特許文献１にはジ長鎖アルキルジ短鎖アルキルアンモニウム塩と両性界面活性剤からなる殺菌洗浄剤組成物が記載されている。引用文献２にはラウリルジメチルベンジルアンモニウムを８０重量％以上含有するアルキルジメチルベンジルアンモニウム、両性界面活性剤、非イオン界面活性剤からなる殺菌洗浄剤組成物が記載されている。引用文献３にはチアゾリン系防腐剤、陽イオン界面活性剤、両性界面活性剤を配合し、ｐＨが５．０〜９．０である除菌剤組成物が記載されている。 As a conventional disinfecting detergent, Patent Document 1 describes a bactericidal detergent composition comprising a di-long chain alkyl di short chain alkyl ammonium salt and an amphoteric surfactant. Reference 2 describes a bactericidal detergent composition comprising alkyl dimethyl benzyl ammonium containing 80% by weight or more of lauryl dimethyl benzyl ammonium, an amphoteric surfactant, and a nonionic surfactant. Reference 3 describes a disinfectant composition which contains a thiazoline preservative, a cationic surfactant and an amphoteric surfactant and has a pH of 5.0 to 9.0.
しかしながら、特許文献１および特許文献２に記載の殺菌洗浄剤組成物は、大腸菌、黄色ブドウ球菌、緑膿菌等に除菌効果を示すが、薬剤耐性の高い芽胞菌や、陽イオン界面活性剤抵抗性菌に対する除菌効果がほとんど無い。特許文献３に記載の除菌剤組成物も、芽胞菌には効果が無く、陽イオン界面活性剤抵抗性菌に除菌性を示すが、長時間（数日）接触させる必要がある。 However, although the bactericidal detergent compositions described in Patent Document 1 and Patent Document 2 show a bactericidal effect against E. coli, Staphylococcus aureus, Pseudomonas aeruginosa etc., they have high drug resistance, spore bacteria, cationic surfactants, etc. There is almost no eradication effect on resistant bacteria. The disinfectant composition described in Patent Document 3 also has no effect on spore bacteria and exhibits disinfectability to cationic surfactant-resistant bacteria, but it needs to be in contact for a long time (several days).
従って、本発明の目的は、一般細菌のみならず、芽胞形成菌の芽胞や、陽イオン界面活性剤抵抗性菌に対して、除菌力を有する除菌剤組成物を提供することにある。 Therefore, an object of the present invention is to provide a disinfectant composition having a disinfecting ability against not only general bacteria but also spores of spore forming bacteria and cationic surfactant-resistant bacteria.
上記課題を解決するために、本発明者らは鋭意検討した結果、（Ａ）成分として一般式（１）で表される両性界面活性剤又はその塩、（Ｂ）成分として陽イオン界面活性剤、（Ｃ）成分としてキレート剤、（Ｄ）成分として水を含有し、２５℃におけるｐＨが７．５〜１３である液体除菌剤組成物が従来の除菌剤組成物が有していた課題を解決できることを見出し、本発明を完成するに至った。 In order to solve the above problems, the present inventors have intensively studied and as a result, the amphoteric surfactant represented by the general formula (1) as the component (A) or a salt thereof, and the cationic surfactant as the component (B) The conventional disinfectant composition had a liquid disinfectant composition containing a chelating agent as component (C) and water as component (D) and having a pH of 7.5 to 13 at 25 ° C. It has been found that the problems can be solved, and the present invention has been completed.
即ち本発明は、
（１）（Ａ）成分として下記一般式（１）で表される両性界面活性剤又はその塩、（Ｂ）成分として陽イオン界面活性剤、（Ｃ）成分としてキレート剤、（Ｄ）成分として水を含有し、２５℃におけるｐＨが７．５〜１３である、液体除菌剤組成物、
That is, the present invention
(1) Amphoteric surfactant or its salt represented by the following general formula (1) as component (A), cationic surfactant as component (B), chelating agent as component (C), component (D) A liquid disinfectant composition comprising water and having a pH of 7.5 to 13 at 25 ° C.
（式中、Ｒ１は炭素数６〜１８のアルキル基、Ｒ２は水素原子又は炭素数６〜１８のアルキル基；ｍは１〜４の整数、ｎは０〜２の整数である。）
（２）（Ａ）成分と（Ｃ）成分の質量比（Ａ）／（Ｃ）が０．００５〜２０である、（１）の液体除菌剤組成物、
（３）（Ｃ）成分が、エチレンジアミン四酢酸、ニトリロ三酢酸、ジエチレントリアミノ五酢酸、トリエチレンテトラアミン六酢酸、グルタミン酸二酢酸、メチルグリシン二酢酸、及びこれらの塩からなる群から選択される１種又は２種以上である、（１）又は（２）の液体除菌剤組成物、
（４）さらに、（Ｅ）成分として、アルキル基の炭素数８〜１６であるアルキルジメチルアミンオキサイドの１種又は２種以上を含有する、（１）〜（３）に記載の液体除菌剤組成物、
（５）さらに（Ｆ）成分として、５−クロロ−２−メチル−４−イソチアゾリン−３−オン、２−メチル−４−イソチアリゾン−３−オン、イソチアゾリン−３−オン及び１，２−ベンズイソチアゾリン−３−オンからなる群から選択される１種又は２種以上を含む、（１）〜（４）のいずれかの液体除菌剤組成物、
（６）（１）〜（５）のいずれかの液体除菌剤組成物を含む除菌液に被除菌体を浸漬する工程、及び、浸漬後に被除菌体から除菌液を除去する工程を含む、除菌方法、及び、
（７）（１）〜（５）のいずれかの液体除菌剤組成物を含む除菌液を起泡させて、比重０．０５〜０．９ｇ／立方センチメートルの泡または泡と液の混合物として被除菌体の表面に吹付ける工程と、被除菌体に吹き付けた後静置するか、又は擦り洗いする工程と、水ですすぐ工程とを含む、除菌方法である。
(Wherein, R 1 is an alkyl group having 6 to 18 carbon atoms, R 2 is a hydrogen atom or an alkyl group having 6 to 18 carbon atoms; m is an integer of 1 to 4 and n is an integer of 0 to 2)
(2) The liquid disinfectant composition according to (1), wherein the mass ratio (A) / (C) of the component (A) to the component (C) is 0.005 to 20,
(3) The component (C) is selected from the group consisting of ethylenediaminetetraacetic acid, nitrilotriacetic acid, diethylenetriaminopentaacetic acid, triethylenetetraamine hexaacetic acid, glutamic acid diacetic acid, methylglycine diacetic acid, and salts thereof (1) or (2) liquid disinfectant composition which is a species or two or more species;
(4) The liquid disinfectant according to (1) to (3), which further contains, as the component (E), one or two or more types of alkyldimethylamine oxide having 8 to 16 carbon atoms of alkyl group. Composition,
(5) Furthermore, as the (F) component, 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothializone-3-one, isothiazolin-3-one and 1,2-benzisothiazoline The liquid disinfectant composition according to any one of (1) to (4), which comprises one or more selected from the group consisting of -3-one.
(6) A step of immersing the disinfected body in a disinfecting solution containing the liquid disinfectant composition according to any one of (1) to (5), and removing the disinfecting solution from the disinfected body after immersion A sterilization method including a process, and
(7) A disinfectant containing the liquid disinfectant composition according to any one of (1) to (5) is foamed to give a foam or a mixture of foam and liquid with a specific gravity of 0.05 to 0.9 g / cubic centimeter The sterilization method includes a step of spraying on the surface of the body to be sterilized, a step of standing on the side of the body after being sprayed, or a step of scrubbing, and a step of rinsing with water.
本発明の除菌剤組成物は、芽胞形成菌の芽胞や、真菌、一般細菌、陽イオン界面活性剤抵抗性菌に対して、優れた除菌効果を有する。 The disinfectant composition of the present invention has an excellent disinfectant effect on spores of spore-forming bacteria, fungi, general bacteria, cationic surfactant-resistant bacteria.
本発明は、（Ａ）成分として一般式（１）で表される両性界面活性剤又はその塩、（Ｂ）成分として陽イオン界面活性剤、（Ｃ）成分としてキレート剤、（Ｄ）成分として水を含有し、２５℃におけるｐＨが７．５〜１３である、液体除菌剤組成物である。
以下に、各構成成分について詳細に説明する。
In the present invention, an amphoteric surfactant or a salt thereof represented by the general formula (1) as component (A), a cationic surfactant as component (B), a chelating agent as component (C), and a component (D) It is a liquid disinfectant composition containing water and having a pH of 7.5 to 13 at 25 ° C.
Each component will be described in detail below.
本発明は、（Ａ）成分として、下記一般式（１）で表される両性界面活性剤又はその塩を含む。この（Ａ）成分は、芽胞菌及び陽イオン界面活性剤抵抗性菌の除菌に寄与する。 The present invention includes, as the component (A), an amphoteric surfactant represented by the following general formula (1) or a salt thereof. The component (A) contributes to the elimination of spores and cationic surfactant-resistant bacteria.
（式中、Ｒ１は炭素数６〜１８のアルキル基、Ｒ２は水素原子又は炭素数６〜１８のアルキル基；ｍは１〜４の整数、ｎは０〜２の整数である。） (Wherein, R 1 is an alkyl group having 6 to 18 carbon atoms, R 2 is a hydrogen atom or an alkyl group having 6 to 18 carbon atoms; m is an integer of 1 to 4 and n is an integer of 0 to 2)
一般式（１）のＲ１は、炭素数６〜１８の直鎖又は分枝のあるアルキル基であり、好ましくは炭素数８〜１６の直鎖又は分枝のあるアルキル基であり、より好ましくは炭素数８〜１４の直鎖又は分枝のあるアルキル基である。一般式（１）のＲ２は水素原子又は炭素数６〜１８の直鎖又は分枝のあるアルキル基であり、好ましくは、水素原子又は炭素数８〜１４の直鎖又は分枝のあるアルキル基である。 R 1 in the general formula (1) is a linear or branched alkyl group having 6 to 18 carbon atoms, preferably a linear or branched alkyl group having 8 to 16 carbon atoms, and more preferably Is a linear or branched alkyl group having 8 to 14 carbon atoms. R 2 in the general formula (1) is a hydrogen atom or a linear or branched alkyl group having 6 to 18 carbon atoms, preferably a hydrogen atom or a linear or branched alkyl having 8 to 14 carbon atoms It is a group.
一般式（１）のｍは１〜４の整数であり、好ましくは、ｍは１又は２の整数である。一般式（１）のｎは０、１又は２であり、好ましくは０又は１である。 In the general formula (1), m is an integer of 1 to 4, and preferably m is an integer of 1 or 2. N in the general formula (1) is 0, 1 or 2, preferably 0 or 1.
（Ａ）成分として使用可能な両性界面活性剤として、例えば、ジヘキシルジアミノエチルグリシン、ジヘキシルアミノエチル（ジアミノエチルグリシン）、ジヘキシルジアミノエチル（ジアミノエチルグリシン）、ジオクチルジアミノエチルグリシン、ジオクチルアミノエチル（ジアミノエチルグリシン）、ジオクチルジアミノエチル（ジアミノエチルグリシン）、ジ（２−エチルヘキシル）ジアミノエチルグリシン、ジ（２−エチルヘキシル）アミノエチル（ジアミノエチルグリシン）、ジデシルジアミノエチルグリシン、ジデシルアミノエチル（ジアミノエチルグリシン）、ジデシルジアミノエチル（ジアミノエチルグリシン）、デシルジアミノエチルグリシン、ラウリルジアミノエチルグリシン、オクチルアミノエチルグリシン、オクチルジアミノエチルグリシン、アルキル（Ｃ１２〜１４）ジアミノエチルグリシン、ミリスチルジアミノエチルグリシン及びこれらの塩等が挙げられる。 Examples of amphoteric surfactants usable as the component (A) include dihexyldiaminoethylglycine, dihexylaminoethyl (diaminoethylglycine), dihexyldiaminoethyl (diaminoethylglycine), dioctyldiaminoethylglycine, dioctylaminoethyl (diaminoethyl) Glycine), dioctyldiaminoethyl (diaminoethylglycine), di (2-ethylhexyl) diaminoethylglycine, di (2-ethylhexyl) aminoethyl (diaminoethylglycine), didecyldiaminoethylglycine, didecylaminoethyl (diaminoethylglycine) ), Didecyldiaminoethyl (diaminoethylglycine), decyldiaminoethylglycine, lauryldiaminoethylglycine, octylaminoethylglycine, ocul Distearate aminoethyl glycine, alkyl (C12-14) diamino ethyl glycine, myristyl di-aminoethyl glycine and salts thereof.
本発明の（Ａ）成分として、ジオクチルジアミノエチルグリシン、ジオクチルアミノエチル（ジアミノエチルグリシン）、ジオクチルジアミノエチル（ジアミノエチルグリシン）、オクチルアミノエチルグリシン、オクチルジアミノエチルグリシン、ラウリルジアミノエチルグリシン、アルキル（Ｃ１２〜１４）ジアミノエチルグリシン及びこれらの塩が好ましく、ラウリルジアミノエチルグリシン、アルキル（Ｃ１２〜１４）ジアミノエチルグリシン及びこれらの塩がより好ましい。また、ジオクチルジアミノエチルグリシン、ジオクチルアミノエチル（ジアミノエチルグリシン）、ジオクチルジアミノエチル（ジアミノエチルグリシン）、オクチルアミノエチルグリシン及びオクチルジアミノエチルグリシン及びこれらの塩の混合物も好ましい。 As component (A) of the present invention, dioctyldiaminoethylglycine, dioctylaminoethyl (diaminoethylglycine), dioctyldiaminoethyl (diaminoethylglycine), octylaminoethylglycine, octyldiaminoethylglycine, lauryldiaminoethylglycine, alkyl (C12) -14) Diaminoethyl glycine and salts thereof are preferred, and lauryl diaminoethyl glycine, alkyl (C12-14) diaminoethyl glycine and salts thereof are more preferred. Also preferred are dioctyldiaminoethylglycine, dioctylaminoethyl (diaminoethylglycine), dioctyldiaminoethyl (diaminoethylglycine), octylaminoethylglycine and octyldiaminoethylglycine and mixtures of these salts.
上記の塩として、ナトリウム、カリウム等のアルカリ金属塩、モノエタノールアミン、モノイソプロパノールアミン、トリエタノールアミン等のアルカノールアミン塩、塩酸塩などが挙げられるが、中でも、ナトリウム塩、塩酸塩が好ましい。 Examples of the above salts include alkali metal salts such as sodium and potassium; alkanolamine salts such as monoethanolamine, monoisopropanolamine and triethanolamine; and hydrochlorides. Among these, sodium salts and hydrochlorides are preferable.
上記市販品としては、レボンＳ（三洋化成工業社製）、レボン５０（三洋化成工業社製）、レボンＴ−２（三洋化成工業社製）、パイオニンＣ−１５６（竹本油脂社製）、ニッサンアノンＬＧ−Ｒ（日油社製）などが挙げられる。これらは１種又は２種以上を組み合わせて用いてもよい。 As said commercial item, Levon S (made by Sanyo Chemical Industries, Ltd.), Levon 50 (made by Sanyo Chemical Industries), Levon T-2 (made by Sanyo Chemical Industries), Pyonin C-156 (made by Takemoto Yushi Co., Ltd.), Nissan Anon LG-R (manufactured by NOF Corporation) and the like. These may be used alone or in combination of two or more.
本発明の（Ｂ）成分である陽イオン界面活性剤は、本発明の液体除菌剤組成物へ除菌効果を付与する。
本発明で使用する陽イオン界面活性剤は、本発明の効果を奏するものであれば特に限定されない。具体的に、アルキルアミン又はその塩、アルキルジアミン又はその塩、アルキルトリアミン又はその塩、アルキルピリジニウム塩、グアニジン系陽イオン界面活性剤、第四級アルキルアンモニウムなどが挙げられる。これらの中では、第四級アルキルアンモニウムが好ましい。
The cationic surfactant which is the component (B) of the present invention imparts a sterilizing effect to the liquid disinfectant composition of the present invention.
The cationic surfactant used in the present invention is not particularly limited as long as it exerts the effects of the present invention. Specifically, alkylamines or salts thereof, alkyldiamines or salts thereof, alkyltriamines or salts thereof, alkyl pyridinium salts, guanidine cationic surfactants, quaternary alkyl ammoniums and the like can be mentioned. Of these, quaternary alkyl ammonium is preferred.
前記アルキルアミンとして、ラウリルアミン、ジメチルミリスチルアミン等が挙げられる。前記アルキルジアミンとして、ラウリルエチレンジアミン、ミリスチルエチレンジアミン、パルミチルエチレンジアミン等が挙げられる。前記アルキルトリアミンとして、ラウリルジエチレントリアミン、ミリスチルジエチレントリアミン、パルミチルジエチレントリアミン、ラウリルジプロピレントリアミン等が挙げられる。アルキルピリジニウム塩として、ラウリルピリジニウムクロリド、セチルピリジニウムクロリド等が挙げられる。 Examples of the alkylamine include laurylamine and dimethylmyristylamine. Examples of the alkyl diamine include lauryl ethylene diamine, myristyl ethylene diamine, palmityl ethylene diamine and the like. Examples of the alkyl triamine include lauryl diethylene triamine, myristyl diethylene triamine, palmityl diethylene triamine, lauryl dipropylene triamine and the like. Examples of the alkyl pyridinium salt include lauryl pyridinium chloride, cetyl pyridinium chloride and the like.
グアニジン系陽イオン界面活性剤として、ポリヘキサメチレンビグアナイドハイドロクロライド、ポリヘキサメチレングアニジンホスフェート、ポリヘキサメチレングアニジンクロライド、グルコン酸クロルヘキシジン等が挙げられる。 Examples of guanidine cationic surfactants include polyhexamethylene biguanide hydrochloride, polyhexamethylene guanidine phosphate, polyhexamethylene guanidine chloride and chlorhexidine gluconate.
第四級アルキルアンモニウム塩として、ジアルキルジメチルアンモニウム塩、アルキルジメチルベンジルアンモニウム塩、アルキルトリメチルアンモニウム塩、アルキルジメチルハイドロキシエチルアンモニウム塩、アルキルジメチルエチルアンモニウム塩、アルキルジメチルエチルベンジルアンモニウム塩、ジアルキルエチルメチルアンモニウム塩、ジアルキルモノメチルハイドロキシアンモニウム塩、アルキルジポリオキシエチレンメチルアンモニウム塩、アルキルジポリオキシエチレンメチルアンモニウム塩、ベンゼトニウム塩等が挙げられる。ここで、第四級アルキルアンモニウム塩のアルキル基は、通常、炭素数８〜１８である。 As quaternary alkyl ammonium salts, dialkyl dimethyl ammonium salts, alkyl dimethyl benzyl ammonium salts, alkyl trimethyl ammonium salts, alkyl dimethyl hydroxy ethyl ammonium salts, alkyl dimethyl ethyl ammonium salts, alkyl dimethyl ethyl benzyl ammonium salts, dialkyl ethyl methyl ammonium salts, Examples include dialkyl monomethyl hydroxy ammonium salt, alkyl dipolyoxyethylene methyl ammonium salt, alkyl dipolyoxyethylene methyl ammonium salt, benzethonium salt and the like. Here, the alkyl group of the quaternary alkyl ammonium salt usually has 8 to 18 carbon atoms.
上記の塩として、塩素、臭素、炭素数１又は２のアルキル硫酸エステル、炭素数１以上１２以下の脂肪酸、炭素数が１以上、３以下のアルキル基が１以上３以下で置換されていてもよいベンゼンスルホン酸等が挙げられるが、除菌性の点で塩素もしくは炭素数１又は２のアルキル硫酸エステルが好ましい。 As the above-mentioned salts, chlorine, bromine, alkyl sulfate having 1 or 2 carbon atoms, fatty acid having 1 to 12 carbon atoms, and alkyl having 1 to 3 carbon atoms are substituted by 1 to 3 carbon atoms Good benzenesulfonic acid and the like can be mentioned, but chlorine or alkyl sulfate having 1 or 2 carbon atoms is preferable in view of sterilization.
第四級アルキルアンモニウム塩の具体例として、アルキルジメチルベンジルアンモニウムクロライド、ヘキサデシルトリメチルアンモニウムクロライド、ジデシルジメチルアンモニウムクロライド、ジデシルジメチルアンモニウムアジペート、ジデシルジメチルアンモニウムグルコネート、ジデシルモノメチルハイドロキシエチルアンモニウムクロライド、ジデシルモノメチルハイドロキシエチルアンモニウムアジペート、ジデシルモノメチルハイドロキシエチルアンモニウムグルコネート、ジデシルモノメチルハイドロキシエチルアンモニウムスルホネート、ジデシルジメチルアンモニウムプロピオネート、ジデシルジメチルアンモニウムメトサルフェート、１，４−ビス（３，３’−（１−デシルピリジニウム）メチルオキシ）ブタンジブロマイド、Ｎ，Ｎ’−ヘキサメチレンビス（４−カルバモイル−１−デシルピリジニウムブロマイド）、アルキルジメチルハイドロキシエチルアンモニウムクロライド、アルキルトリメチルアンモニウムクロライド、アルキルジメチルエチルアンモニウムエチルサルフェート、アルキルジメチルエチルベンジルアンモニウムクロライド、デシルイソノニルジメチルアンモニウムクロライド、ジオクチルジメチルアンモニウムクロライド、オクチルデシルジメチルアンモニウムクロライド、ジデシルメチルポリオキシエチレンアンモニウムプロピオネート、ジメチルジ（デシノイルオキシエチル）アンモニウムクロライド、ココアルキルジメチルベンジルアンモニウムクロライド、ベンジルジメチルオキソエチルアンモニウムクロライド及びベンゼトニウムクロライド等が挙げられるが、除菌性の点でジオクチルジメチルアンモニウムクロライド、オクチルデシルジメチルアンモニウムクロライド、ジデシルジメチルアンモニウムクロライド、ジデシルジメチルアンモニウムメトサルフェート、アルキルジメチルベンジルアンモニウムクロライド、アルキルジメチルエチルアンモニウムエチルサルフェート、アルキルジメチルハイドロキシエチルアンモニウムクロライド等が好ましい。 Specific examples of quaternary alkyl ammonium salts include alkyl dimethyl benzyl ammonium chloride, hexadecyl trimethyl ammonium chloride, didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium adipate, didecyl dimethyl ammonium gluconate, didecyl monomethyl hydroxyethyl ammonium chloride, Didecyl monomethyl hydroxyethyl ammonium adipate, didecyl mono methyl hydroxy ethyl ammonium gluconate, didecyl mono methyl hydroxy ethyl ammonium sulfonate, didecyl dimethyl ammonium propionate, didecyl dimethyl ammonium methosulfate, 1,4-bis (3,3 ' -(1-decylpyridinium) methyloxy) butanedi Lomide, N, N'-hexamethylene bis (4-carbamoyl-1-decyl pyridinium bromide), alkyl dimethyl hydroxy ethyl ammonium chloride, alkyl trimethyl ammonium chloride, alkyl dimethyl ethyl ammonium ethyl sulfate, alkyl dimethyl ethyl benzyl ammonium chloride, decyl iso Nonyldimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, octyl decyl dimethyl ammonium chloride, didecyl methyl polyoxyethylene ammonium propionate, dimethyl di (decynoyloxyethyl) ammonium chloride, cocoalkyl dimethyl benzyl ammonium chloride, benzyl dimethyl oxoethyl ammonium chloride as well as Although there may be mentioned nzethonium chloride etc., dioctyldimethyl ammonium chloride, octyl decyl dimethyl ammonium chloride, didecyl dimethyl ammonium chloride, didecyl dimethyl ammonium methosulfate, alkyl dimethyl benzyl ammonium chloride, alkyl dimethyl ethyl ammonium ethylate from the point of bacteria elimination property Sulfate, alkyldimethylhydroxyethyl ammonium chloride and the like are preferable.
本発明の（Ｃ）成分であるキレート剤は芽胞菌の除菌性を向上させる。
本発明の（Ｃ）成分として、エチレンジアミン四酢酸、ヒドロキシエチルイミノ二酢酸、ヒドロキシエチルエチレンジアミン三酢酸、ジエチレントリアミン五酢酸、トリエチレンテトラミン六酢酸、メチルグリシン二酢酸、グルタミン酸二酢酸、イミノジコハク酸、ニトリロ三酢酸、トリポリリン酸、クエン酸、乳酸、リンゴ酸、酒石酸又はそれらの塩等が挙げられる。中でも、芽胞菌の除菌性を向上させる点からエチレンジアミン四酢酸、ジエチレントリアミン五酢酸、トリエチレンテトラミン六酢酸、メチルグリシン二酢酸、グルタミン酸二酢酸、ニトリロ三酢酸又はそれらの塩が好ましい。
The chelating agent which is the component (C) of the present invention improves eradication of spores.
Ethylenediaminetetraacetic acid, hydroxyethyliminodiacetic acid, hydroxyethylethylenediaminetriacetic acid, diethylenetriaminepentaacetic acid, triethylenetetramine hexaacetic acid, methylglycinediacetic acid, glutamic acid diacetic acid, iminodisuccinic acid, nitrilotriacetic acid as the component (C) of the present invention And tripolyphosphoric acid, citric acid, lactic acid, malic acid, tartaric acid or salts thereof. Among them, ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid, triethylenetetramine hexaacetic acid, methylglycinediacetic acid, glutamic acid diacetic acid, nitrilotriacetic acid or salts thereof are preferable from the viewpoint of improving the eradication ability of spore bacteria.
上記キレート剤が塩形態である場合、本発明の（Ｃ）成分はナトリウムやカリウムなどのアルカリ金属との塩、アンモニウム塩、有機アミンとの塩であり得るが、ナトリウム塩、有機アミン塩であることが好ましく、モノエタノールアミン塩、モノイソプロパノールアミン塩であることがより好ましい。アルカノールアミン塩形態のキレート剤は本発明の液体除菌剤組成物の低温安定性を向上させる場合がある。 When the chelating agent is in a salt form, the component (C) of the present invention may be a salt with an alkali metal such as sodium or potassium, an ammonium salt or a salt with an organic amine, but is a sodium salt or an organic amine salt The monoethanolamine salt and the monoisopropanolamine salt are more preferable. Chelating agents in the alkanolamine salt form may improve the low temperature stability of the liquid disinfectant compositions of the present invention.
本発明の液体除菌剤組成物における（Ｄ）成分である水は、水道水、軟水化処理水、純水、ＲＯ水、イオン交換水、蒸留水を用いることができる。経済性の点から、水道水が好ましい。水道水としては、例えば、東京都荒川区の水道水（ｐＨ＝７．６、総アルカリ度（炭酸カルシウム換算として）４０．５ｍｇ／Ｌ、ドイツ硬度２．３°ＤＨ（そのうち、カルシウム硬度１．７°ＤＨ、マグネシウム硬度０．６°ＤＨ）、塩化物イオン２１．９ｍｇ／Ｌ、ナトリウム及びその化合物１５ｍｇ／Ｌ、硝酸態窒素及び亜硝酸態窒素１．２ｍｇ／Ｌ、フッ素及びその化合物０．１ｍｇ／Ｌ、ホウ素及びその化合物０．０４ｍｇ／Ｌ、総トリハロメタン０．０１６ｍｇ／Ｌ、残留塩素０．４ｍｇ／Ｌ、有機物（全有機炭素量）０．７ｍｇ／Ｌ）が挙げられる。水は、液体除菌剤組成物全体が１００質量％となるように配合（必要に応じて後述する（Ｄ）成分〜（Ｆ）成分および任意成分を配合する場合、これらを含めて全体が１００質量％となるように配合）されるものである。 As water which is the component (D) in the liquid disinfectant composition of the present invention, tap water, softened water, pure water, RO water, ion exchanged water, distilled water can be used. From the economic point of view, tap water is preferred. As tap water, for example, tap water in Arakawa-ku, Tokyo (pH = 7.6, total alkalinity (as calcium carbonate conversion) 40.5 mg / L, German hardness 2.3 ° DH (of which calcium hardness 1. 7 ° DH, magnesium hardness 0.6 ° DH), 21.9 mg / L of chloride ion, 15 mg / L of sodium and its compound, 1.2 mg / L of nitrate nitrogen and nitrite nitrogen, fluorine and its compound 0. 2 1 mg / L, boron and its compound 0.04 mg / L, total trihalomethane 0.016 mg / L, residual chlorine 0.4 mg / L, organic substance (total organic carbon content) 0.7 mg / L). The water is blended so that the entire liquid disinfectant composition is 100% by mass (when the components (D) to (F) and optional components described later are blended as necessary, the entire composition including them is 100) It is compounded so that it may become mass%.
本発明の液体除菌剤組成物における（Ａ）成分の濃度は特に限定されない。しかしながら、（Ａ）成分の濃度は、通常、液体除菌剤組成物全量に対して、通常、０．１質量％以上１０質量％以下であり、０．５質量％以上６質量％以下であることが好ましく、１質量％以上４質量％以下がより好ましい。
後述のように、本発明の液体除菌剤組成物は水又はお湯で希釈された除菌液として使用されることがあり、（Ａ）成分が０．１質量％未満であると希釈されたときに極端に濃度が低くなり十分な芽胞菌に対する除菌効果が期待できない場合がある。また、（Ａ）成分が１０質量％より高くなると、本発明の液体除菌剤組成物の貯蔵安定性が悪くなる場合がある。
The concentration of the component (A) in the liquid disinfectant composition of the present invention is not particularly limited. However, the concentration of the component (A) is usually 0.1% by mass or more and 10% by mass or less and 0.5% by mass or more and 6% by mass or less based on the total amount of the liquid disinfectant composition. 1 mass% or more and 4 mass% or less are more preferable.
As described later, the liquid disinfectant composition of the present invention may be used as a disinfectant diluted with water or hot water, and the component (A) is diluted to be less than 0.1% by mass. When the concentration is extremely low, there may be cases where sufficient eradication effect against spores can not be expected. When the component (A) is higher than 10% by mass, the storage stability of the liquid disinfectant composition of the present invention may be deteriorated.
本発明の液体除菌剤組成物における（Ｂ）成分の濃度は特に限定されない。しかしながら、（Ｂ）成分の濃度は、通常、液体除菌剤組成物全量に対して、１質量％以上１５質量％以下であり、３質量％以上１４質量％以下であることが好ましく、５質量％以上１２質量％以下がより好ましい。
（Ｂ）成分が１質量％未満であると本発明の液体除菌剤組成物が希釈されたときに極端に濃度が低くなり十分な除菌効果が期待できない場合がある。また、（Ｂ）成分が１５質量％より高くなると、本発明の液体除菌剤組成物の貯蔵安定性が悪くなる場合がある。
The concentration of the component (B) in the liquid disinfectant composition of the present invention is not particularly limited. However, the concentration of the component (B) is usually 1% by mass or more and 15% by mass or less, preferably 3% by mass or more and 14% by mass or less, with respect to the total amount of the liquid disinfectant composition. % Or more and 12 mass% or less is more preferable.
If the component (B) is less than 1% by mass, the concentration may be extremely lowered when the liquid disinfectant composition of the present invention is diluted, and a sufficient disinfecting effect may not be expected. When the component (B) is higher than 15% by mass, the storage stability of the liquid disinfectant composition of the present invention may be deteriorated.
本発明の液体除菌剤組成物における（Ｃ）成分の濃度は特に限定されない。しかしながら、（Ｃ）成分の濃度は、通常、液体除菌剤組成物全量に対して、０．５質量％以上２０質量％以下であり、３質量％以上１５質量％以下であることが好ましく、６質量％以上１３質量％以下がより好ましい。
（Ｃ）成分が０．５質量％未満であると本発明の液体除菌剤組成物が希釈されたときに極端に濃度が低くなり十分な芽胞菌に対する除菌効果が期待できない場合がある。また、（Ｃ）成分が２０質量％より高くなると、本発明の液体除菌剤組成物のアルミに対する腐食防止性や貯蔵安定性が悪くなる場合がある。
The concentration of the component (C) in the liquid disinfectant composition of the present invention is not particularly limited. However, the concentration of the component (C) is usually 0.5% by mass or more and 20% by mass or less, preferably 3% by mass or more and 15% by mass or less, based on the total amount of the liquid disinfectant composition. 6 mass% or more and 13 mass% or less are more preferable.
When the liquid disinfectant composition of the present invention is diluted when the amount of the component (C) is less than 0.5% by mass, the concentration may be extremely low and a sufficient disinfectant effect on spores may not be expected. In addition, when the component (C) is higher than 20% by mass, the corrosion resistance to aluminum and storage stability of the liquid disinfectant composition of the present invention may be deteriorated.
本発明の液体除菌剤組成物において、（Ａ）成分と（Ｃ）成分の質量比（Ａ）／（Ｃ）が０．００５以上２０以下であることが好ましく、０．０５以上５以下がより好ましく、０．１以上０．９以下が最も好ましい。質量比（Ａ）／（Ｃ）が０．００５以上２０以下であることで、本発明の液体除菌剤組成物の芽胞菌に対する除菌効果を有効に発揮でき、また、貯蔵安定性もより向上する。 In the liquid disinfectant composition of the present invention, the mass ratio (A) / (C) of the component (A) to the component (C) is preferably 0.005 or more and 20 or less, and 0.05 or more and 5 or less More preferably, 0.1 or more and 0.9 or less are the most preferable. When the mass ratio (A) / (C) is 0.005 or more and 20 or less, the bacteria elimination effect of the liquid disinfectant composition of the present invention against spores can be effectively exhibited, and the storage stability is also more than that. improves.
本発明の液体除菌剤組成物において、上記（Ａ）〜（Ｃ）成分以外の残部を（Ｄ）成分とすることができる。 In the liquid disinfectant composition of the present invention, the balance other than the components (A) to (C) can be used as the component (D).
本発明の液体除菌剤組成物は、さらに、（Ｅ）成分として、アルキル基の炭素数８〜１６であるアルキルジメチルアミンオキサイドの１種又は２種以上を含有してもよい。この（Ｅ）成分は、本発明の液体除菌剤組成物の貯蔵安定性に寄与する。
アルキル基の炭素数８〜１６であるアルキルジメチルアミンオキサイドとしては、オクチルジメチルアミンオキサイド、デシルジメチルアミンオキサイド、ラウリルジメチルアミンオキサイド、ミリスチルジメチルアミンオキサイド、セチルジメチルアミンオキサイドが挙げられる。なかでも、アルキル基の炭素数８〜１４であるアルキルジメチルアミンオキサイドが好ましく、アルキル基の炭素数８〜１０であるアルキルジメチルアミンオキサイドがより好ましい
The liquid disinfectant composition of the present invention may further contain, as the component (E), one or more kinds of an alkyldimethylamine oxide having 8 to 16 carbon atoms of an alkyl group. This (E) component contributes to the storage stability of the liquid disinfectant composition of the present invention.
Examples of the alkyldimethylamine oxide having 8 to 16 carbon atoms of alkyl group include octyldimethylamine oxide, decyldimethylamine oxide, lauryldimethylamine oxide, myristyl dimethylamine oxide and cetyldimethylamine oxide. Among them, alkyldimethylamine oxides having 8 to 14 carbon atoms in the alkyl group are preferable, and alkyldimethylamine oxides having 8 to 10 carbon atoms in the alkyl group are more preferable.
本発明の液体除菌剤組成物における（Ｅ）成分の濃度は特に限定されない。しかしながら、（Ｅ）成分の濃度は、通常、液体除菌剤組成物全量に対して、０．１質量％以上１０質量％以下であり、０．３質量％以上７質量％以下であることが好ましく、１質量％以上５質量％以下がより好ましい。
（Ｅ）成分が０．５質量％未満であると本発明の液体除菌剤組成物の貯蔵安定性への効果が十分認められない場合がある。また、（Ｅ）成分が１０質量％より高くなっても、添加量に見合う効果が認められない場合がある。
The concentration of the component (E) in the liquid disinfectant composition of the present invention is not particularly limited. However, the concentration of the component (E) is usually 0.1% by mass or more and 10% by mass or less and 0.3% by mass or more and 7% by mass or less based on the total amount of the liquid disinfectant composition. Preferably, 1% by mass or more and 5% by mass or less is more preferable.
If the component (E) is less than 0.5% by mass, the effect on the storage stability of the liquid disinfectant composition of the present invention may not be sufficiently recognized. Further, even if the amount of the component (E) is higher than 10% by mass, an effect corresponding to the addition amount may not be recognized.
本発明の液体除菌剤組成物は、さらに（Ｆ）成分として、５−クロロ−２−メチル−４−イソチアゾリン−３−オン、２−メチル−４−イソチアリゾン−３−オン、イソチアゾリン−３−オン及び１，２−ベンズイソチアゾリン−３−オンからなる群から選択される１種又は２種以上を含有してもよい。この（Ｆ）成分は陽イオン抵抗性菌への除菌に寄与する。
この中でも、２−メチル−４−イソチアリゾン−３−オン及び１，２−ベンズイソチアゾリン−３−オンが好ましい。
The liquid disinfectant composition of the present invention may further contain 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothializone-3-one, isothiazoline-3- (F) as a component (F). It may contain one or more selected from the group consisting of on and 1,2-benzisothiazolin-3-one. The component (F) contributes to the elimination of cation resistant bacteria.
Among these, 2-methyl-4-isothializone-3-one and 1,2-benzisothiazolin-3-one are preferable.
本発明の液体除菌剤組成物における（Ｆ）成分の濃度は特に限定されない。しかしながら、（Ｆ）成分の濃度は、通常、液体除菌剤組成物全量に対して、０．０１質量％以上４質量％以下であり、０．１質量％以上３質量％以下であることが好ましく、０．４質量％以上２．５質量％以下がより好ましい。
（Ｆ）成分が０．０１質量％未満であると、本発明の液体除菌剤組成物が希釈されたときに極端に濃度が低くなり陽イオン抵抗性菌への除菌効果が十分に認められない場合がある。また、（Ｆ）成分が４質量％より高くなっても、添加量に見合う効果が認められない場合がある。
The concentration of the component (F) in the liquid disinfectant composition of the present invention is not particularly limited. However, the concentration of the component (F) is usually 0.01% by mass or more and 4% by mass or less and 0.1% by mass or more and 3% by mass or less based on the total amount of the liquid disinfectant composition. Preferably, 0.4% by mass or more and 2.5% by mass or less are more preferable.
When the component (F) is less than 0.01% by mass, the concentration is extremely lowered when the liquid disinfectant composition of the present invention is diluted, and the disinfecting effect on cation resistant bacteria is sufficiently recognized. It may not be possible. In addition, even if the component (F) is higher than 4% by mass, an effect corresponding to the addition amount may not be recognized.
本発明の液体除菌剤組成物のｐＨは、使用時において２５℃におけるｐＨが７．５以上１３以下であり、好ましくは８．０〜１２、より好ましくは８．２〜１１である。本発明の液体除菌剤組成物は原液もしくは水又はお湯で希釈して使用できるが、２〜５００倍に希釈した希釈液の２５℃におけるｐＨが７．５以上１３以下であり、好ましくは８．０〜１２、より好ましくは８．２〜１１であると芽胞菌に対する除菌効果が有効に発揮される。本発明の液体除菌剤組成物のｐＨが７．５未満であると、芽胞菌への除菌効果が認められず、１３以上であると被除菌体の金属部分の腐食が生じてしまう。 The liquid disinfectant composition of the present invention has a pH at 25 ° C. of 7.5 or more and 13 or less, preferably 8.0 to 12, and more preferably 8.2 to 11, at the time of use. The liquid disinfectant composition of the present invention can be used after diluting with a stock solution or water or hot water, but the pH of the diluted solution diluted 2 to 500 times at 25 ° C. is 7.5 or more and 13 or less, preferably 8 When it is from 0 to 12, and more preferably from 8.2 to 11, the eradication effect on spores is exhibited effectively. If the pH of the liquid disinfectant composition of the present invention is less than 7.5, the disinfecting effect on spores is not recognized, and if it is 13 or more, corrosion of the metal part of the body to be disinfected occurs. .
本発明の液体除菌剤組成物には、必要に応じて（Ｇ）成分として可溶化剤を配合することができる。可溶化剤を配合すると、組成物の安定性が向上する効果がある。本発明の（Ｇ）成分の可溶化剤として、キシレンスルホン酸、キシレンスルホン酸ナトリウム、キシレンスルホン酸カリウム、トルエンスルホン酸、トルエンスルホン酸ナトリウム、トルエンスルホン酸カリウム、安息香酸、安息香酸ナトリウム、安息香酸カリウム、クメンスルホン酸、クメンスルホン酸ナトリウム、クメンスルホン酸カリウム、エチレングリコール、ジエチレングリコール、トリエチレングリコール、プロピレングリコール、ジプロピレングリコール、トリプロピレングリコール、ヘキシレングリコール、イソプレングリコール、グリセリン、１，３−ブチレングリコール、１，４−ブチレングリコール、ポリプロピレングリコール、ポリエチレングリコール、エタノール、プロパノール、ブタノール等が挙げられるが、好ましくはエチレングリコール、プロピレングリコール、グリセリン、エタノールである。これらは単独でも２種以上を組み合わせてもよい。 In the liquid disinfectant composition of the present invention, a solubilizing agent can be blended as a component (G) as required. The incorporation of a solubilizer has the effect of improving the stability of the composition. As a solubilizing agent of the component (G) of the present invention, xylene sulfonic acid, sodium xylene sulfonate, potassium xylene sulfonate, toluene sulfonic acid, sodium toluene sulfonate, potassium toluene sulfonate, benzoic acid, sodium benzoate, benzoic acid Potassium, cumene sulfonic acid, sodium cumene sulfonate, potassium cumene sulfonate, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, hexylene glycol, isoprene glycol, glycerin, 1,3-butylene Although glycol, 1,4-butylene glycol, polypropylene glycol, polyethylene glycol, ethanol, propanol, butanol and the like can be mentioned, Mashiku ethylene glycol, propylene glycol, glycerol, ethanol. These may be individual or may combine 2 or more types.
本発明の液体除菌剤組成物における（Ｇ）成分の濃度は特に限定されない。しかしながら、（Ｇ）成分の濃度は、通常、液体除菌剤組成物全量に対して、０．０１質量％以上１０質量％以下であり、０．３質量％以上６質量％以下であることが好ましく、０．５質量％以上４質量％以下がより好ましい。
（Ｇ）成分が０．０１質量％未満であると、本発明の液体除菌剤組成物の貯蔵安定性への向上効果が十分に認められない場合がある。また、（Ｇ）成分が１０質量％より高くなっても、添加量に見合う効果が認められない場合がある。
The concentration of the component (G) in the liquid disinfectant composition of the present invention is not particularly limited. However, the concentration of the component (G) is usually 0.01% by mass or more and 10% by mass or less and 0.3% by mass or more and 6% by mass or less based on the total amount of the liquid disinfectant composition. Preferably, 0.5 to 4% by mass is more preferable.
When the amount of the component (G) is less than 0.01% by mass, the improvement effect on the storage stability of the liquid disinfectant composition of the present invention may not be sufficiently recognized. In addition, even if the amount of the component (G) is higher than 10% by mass, an effect corresponding to the addition amount may not be recognized.
本発明の液体除菌剤組成物のｐＨを調整するために必要に応じて、（Ｈ）成分としてｐＨ調整剤を使用することができる。（Ｈ）成分の塩基成分としては、例えば水酸化ナトリウム、水酸化カリウム、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、モノイソプロパノールアミン、ジイソプロパノールアミン、トリイソプロパノールアミン、Ｎ，Ｎ−ジメチルプロパン−1，3−ジアミン等が挙げられ、好ましくは水酸化ナトリウム、水酸化カリウム、モノエタノールアミン、モノイソプロパノールアミンが挙げられる。これらは単独でも２種以上を組み合わせてもよい。また、（Ｈ）成分の酸成分としては、塩酸、酢酸、プロピオン酸、乳酸、リンゴ酸、クエン酸、安息香酸、マロン酸、コハク酸、グルタル酸、アジピン酸、グルコン酸、エチレンジアミン四酢酸、ホスホノブタントリカルボン酸、リン酸などが挙げられるが、好ましくは、塩酸、乳酸、クエン酸である。これらは単独でも２種以上を組み合わせてもよい。 A pH adjuster can be used as the (H) component as needed to adjust the pH of the liquid disinfectant composition of the present invention. Examples of the base component of the component (H) include sodium hydroxide, potassium hydroxide, monoethanolamine, diethanolamine, triethanolamine, monoisopropanolamine, diisopropanolamine, triisopropanolamine, N, N-dimethylpropane-1, 3-diamine etc. are mentioned, Preferably sodium hydroxide, potassium hydroxide, monoethanolamine, monoisopropanolamine is mentioned. These may be individual or may combine 2 or more types. Moreover, as an acid component of (H) component, hydrochloric acid, acetic acid, propionic acid, lactic acid, malic acid, citric acid, benzoic acid, malonic acid, succinic acid, glutaric acid, adipic acid, gluconic acid, ethylenediaminetetraacetic acid, phospho Nobutanetricarboxylic acid, phosphoric acid and the like can be mentioned, with preference given to hydrochloric acid, lactic acid and citric acid. These may be individual or may combine 2 or more types.
本発明の液体除菌剤組成物には、更に必要に応じて上記以外の界面活性剤、分散剤、天然抽出物、他の除菌成分、酵素、染料、消泡剤、起泡剤、防腐剤、香料、腐食抑制剤等を配合することができる。
本発明の液体除菌剤組成物を製造する方法としては、特に制限はなく、各成分を攪拌混合する等の通常の方法で製造することができる。
The liquid disinfectant composition of the present invention may further contain surfactants, dispersants, natural extracts, other disinfectant components, enzymes, dyes, antifoaming agents, foaming agents, preservatives other than those mentioned above as required. Agents, perfumes, corrosion inhibitors, etc. can be blended.
There is no restriction | limiting in particular as a method to manufacture the liquid disinfectant composition of this invention, It can manufacture by the normal method of mixing and stirring each component.
分散剤としては、例えば、ポリアクリル酸、ポリマレイン酸、ポリメタクリル酸、アクリル酸型共重合体、マレイン酸型共重合体、メタクリル酸型共重合体、アクリル酸−スルホン酸型モノマー共重合体等が挙げられる。 As the dispersant, for example, polyacrylic acid, polymaleic acid, polymethacrylic acid, acrylic acid type copolymer, maleic acid type copolymer, methacrylic acid type copolymer, acrylic acid-sulfonic acid type monomer copolymer, etc. Can be mentioned.
天然抽出物としては、例えば、アサ科植物、アカネ科植物、アブラナ科植物、イネ科植物、カキノキ科植物、キク科植物、シソ科植物、ショウガ科植物、ツバキ科植物、ナス科植物、ヒノキ科植物、フトモモ科植物、ブドウ科植物、マメ科植物、ミカン科植物、ユリ科植物等の植物由来の天然抽出物や、リゾチーム、しらこ蛋白抽出物等の動物由来の天然抽出物が挙げられる。 Examples of natural extracts include, for example, plants of the family Asaaceae, plants of the family Racaceae, plants of the family Brassicaceae, plants of the family Poaceae, plants of the family Kakinoki, plants of the family Asteraceae, plants of the family Licophyta, plants of the family Zinnia, plants of the family Solanaceae, cypress Examples include natural extracts derived from plants such as plants, plants of the family Agronomidae, plants of the family Vines, legumes, plants of the family Ritaceae, and plants of the family Lilium and others, and extracts derived from animals such as lysozyme and extracts of shirakko protein.
他の除菌成分としては、次亜塩素酸又はその塩、ジクロロイソシアヌル酸又はその塩等の塩素系漂白剤、ε−ポリリジン、ポリ−γ−グルタミン酸、ナイシン等の微生物由来の抗菌ペプチドが挙げられる。 Other bactericidal components include hypochlorous acid or a salt thereof, chlorine bleach such as dichloroisocyanuric acid or a salt thereof, and antimicrobial peptides derived from microorganisms such as ε-polylysine, poly-γ-glutamic acid, nisin and the like .
本発明の液体除菌剤組成物を用いる除菌方法において、上記の液体除菌剤組成物をそのまま除菌液として用いることもでき、水又はお湯で２〜５００倍に希釈した除菌液を調製して使用することも可能である。ここでの水又はお湯は本発明の液体除菌剤組成物の（Ｄ）成分と同じ水道水、軟水化処理水、純水、ＲＯ水、イオン交換水又は蒸留水を用いることができる。 In the sterilizing method using the liquid sterilizing composition of the present invention, the above liquid sterilizing composition may be used as it is as a sterilizing solution, and the sterilizing solution diluted 2 to 500 times with water or hot water may be used. It is also possible to prepare and use. The water or hot water used here may be tap water, softened water, pure water, RO water, ion-exchanged water or distilled water, which is the same as the component (D) of the liquid disinfectant composition of the present invention.
本発明の液体除菌剤組成物を希釈した除菌液中の（Ａ）成分は、通常、除菌液の全質量に対して、０．０００２５質量％以上０．０５質量％以下であることが好ましく、０．００１２５質量％以上０．０３質量％以下であることがより好ましく、０．００２５質量％以上０．０２質量％以下であることが特に好ましい。
本発明の液体除菌剤組成物を希釈した除菌液中の（Ｂ）成分は、通常、除菌液の全質量に対して、０．００２５質量％以上０．５質量％以下であることが好ましく、０．００７５質量％以上０．０７質量％以下であることがより好ましく、０．０１２５質量％以上０．０６質量％以下であることが特に好ましい。
The component (A) in the disinfecting solution obtained by diluting the liquid disinfectant composition of the present invention is usually 0.00025% by mass or more and 0.05% by mass or less based on the total mass of the disinfecting solution Is preferable, 0.00125 mass% or more and 0.03 mass% or less is more preferable, and 0.0025 mass% or more and 0.02 mass% or less is particularly preferable.
Component (B) in the disinfecting solution obtained by diluting the liquid disinfectant composition of the present invention is usually 0.0025% by mass or more and 0.5% by mass or less based on the total mass of the disinfecting solution Is preferably 0.0075% by mass to 0.07% by mass, and more preferably 0.0125% by mass to 0.06% by mass.
本発明の液体除菌剤組成物を希釈した除菌液中の（Ｃ）成分は、通常、除菌液の全質量に対して、０．００１２５質量％以上０．２５質量％以下であることが好ましく、０．００７５質量％以上０．０７５質量％以下であることがより好ましく、０．０１５質量％以上０．０６５質量％以下であることが特に好ましい。
本発明の液体除菌剤組成物を希釈した除菌液中の（Ｆ）成分は、通常、除菌液の全質量に対して、０．００００２５質量％以上０．０２質量％以下であることが好ましく、０．０００２５質量％以上０．０１５質量％以下であることがより好ましく、０．００１質量％以上０．０１２５質量％以下であることが特に好ましい。
The component (C) in the disinfecting solution obtained by diluting the liquid disinfectant composition of the present invention is usually 0.00125% by mass or more and 0.25% by mass or less based on the total mass of the disinfecting solution Is more preferably 0.0075% by mass to 0.075% by mass, and particularly preferably 0.015% by mass to 0.065% by mass.
The component (F) in the disinfecting solution obtained by diluting the liquid disinfectant composition of the present invention is usually 0.000025% by mass or more and 0.02% by mass or less based on the total mass of the disinfecting solution Is more preferably 0.00025% by mass or more and 0.015% by mass or less, and particularly preferably 0.001% by mass or more and 0.0125% by mass or less.
本発明の液体除菌剤組成物は、芽胞菌を含む菌類・微生物の汚染・混入が問題となる幅広い分野（食品分野、醸造分野、医療分野、農業分野など）での除菌に有用である。例えば、乳製品・乳加工品、大豆製品、大豆加工品、ビール・ワイン・清酒、味噌・醤油などの食品加工工場での容器や製造ラインの除菌、内視鏡等の医療器具の消毒や滅菌、透析ラインの洗浄、野菜及び果物の処理水の病原菌微生物の制御、植物の病気又は損傷及び苗木の腐敗の原因となる種子に取り付いた微生物の制御、食鳥肉の処理場での食鳥肉の表面の病原菌の減少、特に、無菌充填法によるＰＥＴボトル入り清涼飲料の製造での容器包材（ＰＥＴボトル及びキャップ）の除菌、またはそのラインの強化除菌に好適に用いることができる。 The liquid disinfectant composition of the present invention is useful for disinfecting in a wide range of fields (food field, brewing field, medical field, agricultural field etc.) where contamination and contamination of fungi and microorganisms including spores is a problem. . For example, sterilization of containers and production lines in food processing plants such as dairy products, processed milk products, soybean products, processed soybean products, beer, wine, sake, miso and soy sauce, disinfection of medical instruments such as endoscopes, etc. Sterilization, washing of dialysis lines, control of microbes and microbes of treated water of vegetables and fruits, control of microbes attached to seeds that cause plant diseases or damage and rot of seedlings, and poultry at the processing site of poultry meat It can be suitably used for the reduction of germs on the surface of meat, in particular for the sterilization of container packaging materials (PET bottles and caps) in the manufacture of soft drinks containing PET bottles by the aseptic filling method, or for the enhanced sterilization of the line .
本発明の液体除菌剤組成物による除菌方法を行う際の温度は、液体除菌剤組成物を含む除菌液を０℃〜９０℃に調整する。
本発明の除菌方法は、除菌液を被除菌体に発泡洗浄機（スプレーガン）などを用いて噴霧したり、除菌液に被除菌体を浸漬したりする方法を採用することができる。噴霧時間や浸漬時間は、微生物の種類や量、有機汚れあるいは無機汚れの種類や量、除菌液の濃度等によって適宜選択することができる。
The temperature at the time of performing the disinfection method by the liquid disinfectant composition of this invention adjusts the disinfection liquid containing a liquid disinfectant composition to 0 degreeC-90 degreeC.
According to the sterilization method of the present invention, a method of spraying the sterilization liquid onto the body to be sterilized using a foaming cleaner (spray gun) or the like, or immersing the body to be sterilized in the sterilization liquid Can. The spraying time and the immersion time can be appropriately selected depending on the type and amount of microorganisms, the type and amount of organic or inorganic soil, the concentration of the disinfecting solution, and the like.
除菌液を被除菌体に噴霧して除菌を行うときは、例えば、本発明の液体除菌剤組成物を含む除菌液を発砲洗浄機で起泡させて、０．０５〜０．９ｇ／立法センチメートルの泡、又は泡と液の混合物として、被除菌体に噴霧し、その後、これを静置するか、又は擦り洗いした後、水ですすぐ。発泡洗浄機としては、エア駆動式ダイアフラムポンプにて送液し、圧縮空気と発泡洗浄剤組成物の希釈液を混合して発泡並びに噴霧する装置が挙げられ、例えば、ＤＥＭＡ社製９１０Ｎ ＰＯＲＴＡＢＬＥ ＦＯＡＭＥＲが使用できる。 When the disinfectant is sprayed onto the body to be disinfected to disinfect, for example, the disinfectant containing the liquid disinfectant composition of the present invention is foamed with a foam washing machine, 0.05 to 0 .9 g / cubic centimeter foam or a mixture of foam and liquid, spray onto the body to be disinfected, then let it sit or scrub and rinse with water. Examples of the foam cleaning apparatus include a device that sends liquid by an air-driven diaphragm pump, mixes compressed air and a diluted solution of a foaming cleaner composition, and foams and sprays, for example, 910 N PORTABLE FOAMER manufactured by DEMA. It can be used.
以下、本発明を実施例と比較例により具体的に説明する。実施例、比較例において配合に用いた各成分を下記に示す。なお、以下の実施例等において「％」は特に記載がない限り質量％を表し、表中における実施例及び比較例の配合の数値は純分の質量％を表す。実施例、比較例において使用した化合物を以下に記す。また、アルキル基の表記について、例えば、アルキル（Ｃ８〜１８）と表記されている場合、炭素数８以上、１８以下のアルキル基を有する混合物を表す。 Hereinafter, the present invention will be specifically described by way of examples and comparative examples. Each component used for combination in an example and a comparative example is shown below. In the following examples and the like, “%” represents mass% unless otherwise specified, and the numerical values of the formulations of the examples and comparative examples in the table represent mass% of pure components. The compounds used in Examples and Comparative Examples are described below. Moreover, about the notation of an alkyl group, when it describes, for example as alkyl (C8-18), it represents a mixture having an alkyl group having 8 to 18 carbon atoms.
（Ａ）成分
Ａ−１：ラウリルジアミノエチルグリシンナトリウム（商品名：レボンＳ、三洋化成工業社製、一般式（１）で表される化合物であり、Ｒ１は主として炭素数１２の炭化水素基であり、Ｒ２は水素原子であり、ｍは２であり、ｎは０である）
Ａ−２：アルキル（Ｃ１２〜１４）ジアミノエチルグリシン塩酸塩（商品名：レボンＴ−２、三洋化成工業社製、一般式（１）で表される化合物であり、Ｒ１は主として炭素数１２〜１４の炭化水素基であり、Ｒ２は水素原子であり、ｍは２であり、ｎは０である）
Ａ−３：アルキルポリアミノエチルグリシン塩酸塩（商品名：レボン５０、三洋化成工業社製、一般式（１）で表される化合物であり、Ｒ１およびＲ２は主として炭素数８の炭化水素基であり、ｍは１又は２であり、ｎは０又は１である）
(A) Component A-1: lauryldiaminoethylglycine sodium (trade name: Levon S, a compound represented by General Formula (1), manufactured by Sanyo Chemical Industries, Ltd., R 1 is a hydrocarbon group mainly having 12 carbon atoms And R 2 is a hydrogen atom, m is 2 and n is 0)
A-2: alkyl (C12-14) diaminoethyl glycine hydrochloride (trade name: Revon T-2, manufactured by Sanyo Chemical Industries, Ltd., a compound represented by the general formula (1), R 1 mainly has 12 carbon atoms To 14 hydrocarbon groups, R 2 is a hydrogen atom, m is 2 and n is 0)
A-3: alkyl polyaminoethyl glycine hydrochloride (trade name: Levon 50, a compound represented by General Formula (1), manufactured by Sanyo Chemical Industries, Ltd., R 1 and R 2 are mainly hydrocarbon groups having 8 carbon atoms M is 1 or 2 and n is 0 or 1)
（Ａ）成分の比較成分
Ａ′−１：ラウリルジメチルアミノ酢酸ベタイン（商品名：アンヒトール２０ＢＳ、花王社製）
(A) Component Comparison Component A'-1: lauryl dimethylaminoacetic acid betaine (trade name: Anthole 20BS, manufactured by Kao Corporation)
（Ｂ）成分
Ｂ−１：ジオクチルジメチルアンモニウムクロライド
Ｂ−２：アルキル（Ｃ８〜１８）ジメチルベンジルアンモニウムクロライド
Ｂ−３：ジデシルジメチルアンモニウムクロライド
Ｂ−４：ラウリルジメチルエチルアンモニウムエチルサルフェート
Ｂ−５：ベンゼトニウムクロライド
(B) Component B-1: dioctyl dimethyl ammonium chloride B-2: alkyl (C 8-18) dimethyl benzyl ammonium chloride B-3: didecyl dimethyl ammonium chloride B-4: lauryl dimethyl ethyl ammonium ethyl sulfate B-5: benzethonium Chloride
（Ｃ）成分
Ｃ−１：エチレンジアミン四酢酸ナトリウム
Ｃ−２：エチレンジアミン四酢酸モノエタノールアミン塩
Ｃ−３：エチレンジアミン四酢酸モノイソプロパノールアミン塩
Ｃ−４：メチルグリシン二酢酸モノエタノールアミン塩
Ｃ−５：グルタミン酸二酢酸モノエタノールアミン塩
Ｃ−６：トリポリリン酸ナトリウム
(C) Component C-1: Sodium ethylenediaminetetraacetic acid C-2: Ethylenediaminetetraacetic acid monoethanolamine salt C-3: Ethylenediaminetetraacetic acid monoisopropanolamine salt C-4: Methylglycine diacetic acid monoethanolamine salt C-5: Glutamate diacetic acid monoethanolamine salt C-6: sodium tripolyphosphate
（Ｄ）成分
Ｄ−１：水道水
(D) Component D-1: Tap water
（Ｅ）成分
Ｅ−１：オクチルジメチルアミンオキサイド
Ｅ−２：デシルジメチルアミンオキサイド
Ｅ−３：テトラデシルジメチルアミンオキサイド
Ｅ−４：ヘキサデシルジメチルアミンオキサイド
(E) Component E-1: Octyldimethylamine oxide E-2: Decyldimethylamine oxide E-3: Tetradecyldimethylamine oxide E-4: Hexadecyldimethylamine oxide
（Ｆ）成分
Ｆ−１：１，２−ベンズイソチアゾリン−３−オン
Ｆ−２：２−メチル−４−イソチアリゾン−３−オン
(F) Component F-1: 1,2-benzisothiazolin-3-one F-2: 2-methyl-4-isothializone-3-one
可溶化剤
（Ｇ）成分
Ｇ−１：グリセリン
Ｇ−２：エタノール
Solubilizing agent (G) Component G-1: Glycerin G-2: Ethanol
ｐＨ調整剤
（Ｈ）成分
Ｈ−１：塩酸
Ｈ−２：水酸化ナトリウム
pH adjuster (H) component H-1: hydrochloric acid H-2: sodium hydroxide
その他成分
（Ｉ）成分
Ｉ−１：ポリアクリル酸ナトリウム（重量平均分子量が４，０００）
Ｉ−２：アクリル酸−マレイン酸共重合体ナトリウム（重量平均分子量が１０，０００）
Ｉ−３：アクリル酸−スルホン酸共重合体ナトリウム（重量平均分子量が５，０００）
Ｉ−４：ε−ポリリジン（商品名：ε‐ポリリジン、ＪＮＣ社製）
Other component (I) component I-1: sodium polyacrylate (weight average molecular weight is 4,000)
I-2: Acrylic acid-maleic acid copolymer sodium (weight average molecular weight is 10,000)
I-3: Acrylic acid-sulfonic acid copolymer sodium (weight average molecular weight is 5,000)
I-4: ε-polylysine (trade name: ε-polylysine, manufactured by JNC)
各実施例の組成物は、（Ｄ）成分の水を組成物の合計が１００質量％となるように混合槽に加え、次いで（Ａ）成分、（Ｂ）成分、（Ｃ）成分（必要に応じて（Ｅ）成分、（Ｆ）成分、（Ｇ）成分、（Ｈ）成分、（Ｉ）成分）を混合槽中に配合し、十分に混合撹拌して調製した。 In the composition of each example, water of the component (D) is added to the mixing tank so that the total of the composition is 100% by mass, and then the components (A), (B), (C) Accordingly, the component (E), the component (F), the component (G), the component (H), and the component (I) were mixed in a mixing tank and thoroughly mixed and stirred.
実施例１〜８０、比較例１〜７
表１〜表９に示す除菌洗浄剤組成物を調製した。各除菌洗浄剤組成物を用いて、除菌性、金属腐食防止性、貯蔵安定性を測定した。表１〜８に実施例１〜８０の結果を、表９に比較例１〜７の結果をそれぞれ示す。
Examples 1 to 80, Comparative Examples 1 to 7
The disinfectant cleaner composition shown in Tables 1 to 9 was prepared. Using each of the disinfectant cleaner compositions, the disinfectability, metal corrosion inhibition, and storage stability were measured. Tables 1 to 8 show the results of Examples 1 to 80, and Table 9 shows the results of Comparative Examples 1 to 7.
※１：ｐＨの測定方法
ｐＨメーター（ＨＯＲＩＢＡ製；ｐＨ／イオンメーター Ｆ−２３）にｐＨ測定用複合電極（ＨＯＲＩＢＡ製；ガラス摺り合わせスリーブ型）を接続し、電源を入れる。ｐＨ電極内部液としては、飽和塩化カリウム水溶液（３．３３ｍｏｌ／Ｌ）を使用した。
次に、ｐＨ４．０１標準液（フタル酸塩標準液）、ｐＨ６．８６（中性リン酸塩標準液）、ｐＨ９．１８標準液（ホウ酸塩標準液）をそれぞれ１００ｍＬビーカーに充填し、２５℃の恒温槽に３０分間浸漬した。恒温に調整された標準液にｐＨ測定用電極を３分間浸し、ｐＨ６．８６→ｐＨ９．１８→ｐＨ４．０１の順に校正操作を行った。
各除菌洗浄剤組成物をイオン交換水で０．２５質量％に希釈して１００ｍＬビーカーに充填し、恒温槽内にて２５℃に調整した。恒温に調整された試料にｐＨ測定用電極を３分間浸し、希釈液のｐＨを測定した。
* 1: Measurement method of pH The composite electrode for pH measurement (manufactured by HORIBA; glass-laminated sleeve type) is connected to a pH meter (manufactured by HORIBA; pH / ion meter F-23), and the power is turned on. A saturated aqueous potassium chloride solution (3.33 mol / L) was used as the pH electrode internal liquid.
Next, fill each 100 mL beaker with pH 4.01 standard solution (phthalate standard solution), pH 6.86 (neutral phosphate standard solution), pH 9.18 standard solution (borate standard solution), respectively. It was immersed in a constant temperature bath for 30 minutes. The pH measurement electrode was immersed in a standard solution adjusted to a constant temperature for 3 minutes, and the calibration operation was performed in the order of pH 6.86 → pH 9.18 → pH 4.01.
Each disinfectant cleaner composition was diluted to 0.25% by mass with ion exchange water, filled in a 100 mL beaker, and adjusted to 25 ° C. in a thermostat. The pH measurement electrode was immersed for 3 minutes in a sample adjusted to a constant temperature, and the pH of the diluted solution was measured.
※２：除菌性試験（芽胞菌）
供試菌株として、枯草菌（Ｂａｃｉｌｌｕｓ ｓｕｂｔｉｌｉｓ）（ＮＢＲＣ３１３４）、セレウス菌（Ｂａｃｉｌｌｓ ｃｅｒｅｕｓ）（ＮＢＲＣ１５３０５）を用いた。
※ 2: Bactericidal test (spore bacteria)
Bacillus subtilis (NBRC3134) and Bacillus cereus (NBRC15305) were used as test strains.
２−１：芽胞懸濁液の作製
供試菌株をＳＣＤ寒天培地（日水製薬品）に塗抹し、３７℃で培養し、培養後、顕微鏡観察にて芽胞が十分に形成されていることを確認した。平板培地上に滅菌済み純水を１０ｍＬ入れ、コロニーを掻き取り懸濁液を収集した。収集した懸濁液に、１００００ｒｐｍで、４℃、１５分間の条件で遠心洗浄を３回実施し、遠心後、滅菌済み純水を適量加え、２．０〜９．０×１０８ＣＦＵ／ｍｌ程度になるように菌数を調製し、ウォーターバスにて８０℃、１５分間の加熱処理をして芽胞懸濁液とした。
2-1: Preparation of spore suspension The test strain is smeared on SCD agar medium (Nichisui Chemical Co., Ltd.), cultured at 37 ° C., cultured, and then spores are sufficiently formed by microscopic observation. confirmed. 10 mL of sterilized pure water was placed on a plate medium, colonies were scraped off, and a suspension was collected. Centrifuge washing is performed 3 times at 10000 rpm and 4 ° C. for 15 minutes to the collected suspension, and after centrifugation, an appropriate amount of sterilized pure water is added to 2.0 to 9.0 × 10 8 CFU / ml. The number of bacteria was adjusted to a degree, and heated at 80 ° C. for 15 minutes in a water bath to obtain a spore suspension.
２−２：滅菌中和液の調整
大豆レシチンを１０ｇ、Ｔｗｅｅｎ８０を３０ｇ、Ｌ−ヒスチジンを１ｇ、チオ硫酸ナトリウムを２０ｇ、１Ｌの蒸留水に加温溶解し、攪拌しながら冷却をおこなった。その後、スクリューキャップ付き試験管に各９ｍＬ分注し、高圧殺菌（１２１℃、２０分間）をおこない、滅菌中和溶液とした。
2-2: Preparation of Sterile Neutralization Solution 10 g of soybean lecithin, 30 g of Tween 80, 1 g of L-histidine, and 20 g of sodium thiosulfate were dissolved by heating in 1 L of distilled water and cooled while stirring. Thereafter, 9 mL of each was dispensed into test tubes with screw caps, high-pressure sterilization (121 ° C., 20 minutes) was performed, and a sterile neutralization solution was obtained.
２−３：除菌性試験（芽胞菌）
試験方法：
各除菌洗浄剤組成物をイオン交換水で０．２５質量％に希釈して調製した除菌洗浄液１０ｍＬに、終濃度１．５〜５．０×１０５（ＣＦＵ／ｍｌ）となるように各芽胞懸濁液０．１ｍＬを添加し、除菌洗浄液と芽胞懸濁液とを２５℃で１８時間接触させたもの、および４０℃で６０分間接触させたものを試験液とした。各試験液１ｍＬを、滅菌中和溶液に加え、よく攪拌した。混合液をＳＣＤ寒天培地にて混和固化し、３７℃で２日間培養した。培養後、生菌数を測定し、初発菌数との差より、以下の基準で除菌性を評価した。△、○、◎の評価のものを実用性のあるものとして判定した。
2-3: Bactericidal test (spore bacteria)
Test method:
A final concentration of 1.5 to 5.0 × 10 5 (CFU / ml) in 10 mL of a disinfectant wash prepared by diluting each disinfectant cleaner composition to 0.25% by mass with ion-exchanged water 0.1 mL of each spore suspension was added, and the sterilized washing solution and the spore suspension were brought into contact at 25 ° C. for 18 hours, and those brought into contact at 40 ° C. for 60 minutes were used as test solutions. 1 mL of each test solution was added to the sterile neutralization solution and stirred well. The mixture was mixed and solidified in SCD agar medium and cultured at 37 ° C. for 2 days. After the culture, the number of viable cells was measured, and the erasability was evaluated based on the following criteria based on the difference from the number of primary cells. The evaluations of Δ, 、 and ◎ were judged as having practicality.
評価基準
３点：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが３以上
２点：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが２以上、３未満
１点：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが１以上、２未満
０点：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが１未満
として２５℃で１８時間接触させたものと、４０℃で６０分間接触させたものそれぞれについて、生菌数の減少を上記点数で評価して平均値を求め、以下の基準で除菌性を評価した。
◎：平均値が３点
○：平均値が２点以上、３点未満
△：平均値が１点以上、２点未満
×：供平均値が１点未満
Evaluation criteria 3 points: log reduction of the test strain is 3 or more and 2 points: log reduction of the test strain is 2 or more, less than 3 1 point: log reduction of the test strain is 1 or more, less than 2 0: test strain The reduction of viable count was evaluated based on the above score to determine the average value for each of those that were in contact at 25 ° C for 18 hours with a log reduction of less than 1 and those that were in contact at 40 ° C for 60 minutes. Were evaluated for eradication.
:: Average value is 3 points :: Average value is 2 points or more and less than 3 points Δ: Average value is 1 point or more, less than 2 points ×: Average value is less than 1
※３：除菌性試験（カビ胞子）
供試菌株として、アスペルギルスニガー（Ａｓｐｅｒｇｉｌｌｕｓ ｎｉｇｅｒ）（ＩＦＯ９４５５）を用いた。
※ 3: Bactericidal test (mold spore)
As a test strain, Aspergillus niger (IFO 9455) was used.
３−１：胞子懸濁液の調整（アスペルギルスニガー）
供試カビをＰＤＡ寒天培地（日水製薬品）に塗抹し、２５℃で培養し、培養後、顕微鏡観察にて胞子が十分に形成されていることを確認した。平板培地上に滅菌済み０．０５％Ｔｗｅｅｎ２０添加生理食塩水を１０ｍＬ入れ、コロニーを掻き取り懸濁液を収集した。収集した懸濁液は滅菌済みガーゼを通して不要な菌糸を取り除いた後、１００００ｒｐｍで、４℃、１５分間の条件で遠心洗浄を３回実施し、遠心後、滅菌済み０．０５％Ｔｗｅｅｎ２０添加生理食塩水を適量加え、２．０〜９．０×１０８ＣＦＵ／ｍＬ程度になるように菌数を調製し、胞子懸濁液とした。
3-1: Preparation of spore suspension (Aspergillus niger)
The test fungus was smeared on a PDA agar medium (Nichisui Chemical Co., Ltd.), cultured at 25 ° C., and after cultivation, it was confirmed by microscopic observation that spores were sufficiently formed. 10 mL of sterile 0.05% Tween 20-added saline was placed on a plating medium, colonies were scraped off, and a suspension was collected. The collected suspension is passed through sterile gauze to remove unnecessary mycelia, and then centrifuged and washed three times at 10000 rpm and 4 ° C. for 15 minutes, and after centrifugation, sterilized 0.05% Tween 20-added physiological saline An appropriate amount of water was added, and the number of bacteria was adjusted to be about 2.0 to 9.0 × 10 8 CFU / mL to obtain a spore suspension.
３−２：滅菌中和液の調整
大豆レシチンを１０ｇ、Ｔｗｅｅｎ８０を３０ｇ、Ｌ−ヒスチジンを１ｇ、チオ硫酸ナトリウムを２０ｇ、１Ｌの蒸留水に加温溶解し、攪拌しながら冷却をおこなった。その後、スクリューキャップ付き試験管に各９ｍＬ分注し、高圧殺菌（１２１℃、２０分間）をおこない、滅菌中和溶液とした。
3-2: Preparation of sterile neutralized solution 10 g of soybean lecithin, 30 g of Tween 80, 1 g of L-histidine, and 20 g of sodium thiosulfate were dissolved in 1 L of distilled water under heating and cooled with stirring. Thereafter, 9 mL of each was dispensed into test tubes with screw caps, high-pressure sterilization (121 ° C., 20 minutes) was performed, and a sterile neutralization solution was obtained.
３−３：除菌性試験（アスペルギルスニガー）
試験方法：
各除菌洗浄剤組成物をイオン交換水で０．２５質量％に希釈して調製した除菌洗浄液１０ｍＬに、終濃度１．５〜５．０×１０５（ＣＦＵ／ｍＬ）となるように胞子懸濁液０．１ｍＬを添加し、除菌洗浄液と胞子懸濁液とを２５℃にて３０分間接触させたものを試験液とした。この試験液１ｍＬを、滅菌中和溶液に加え、よく攪拌した。混合液をＰＤＡ寒天培地にて混和固化し、３７℃で４日間培養した。培養後、生菌数を測定し、初発菌数との差より、以下の基準で除菌性を評価した。△、○、◎の評価のものを実用性のあるものとして判定した。
評価基準
◎：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが３以上
○：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが２以上、３未満
△：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが１以上、２未満
×：供試菌のｌｏｇ ｒｅｄｕｃｔｉｏｎが１未満
3-3: Bactericidal test (Aspergills niger)
Test method:
A final concentration of 1.5 to 5.0 × 10 5 (CFU / mL) in 10 mL of a disinfectant wash prepared by diluting each disinfectant cleaner composition to 0.25% by mass with ion-exchanged water A test solution was prepared by adding 0.1 mL of spore suspension and bringing the sterilization washing solution and the spore suspension into contact at 25 ° C. for 30 minutes. 1 mL of this test solution was added to the sterile neutralization solution and stirred well. The mixture was mixed and solidified in PDA agar medium and cultured at 37 ° C. for 4 days. After the culture, the number of viable cells was measured, and the erasability was evaluated based on the following criteria based on the difference from the number of primary cells. The evaluations of Δ, 、 and ◎ were judged as having practicality.
Evaluation criteria ◎: log reduction of test bacteria is 3 or more ○: log reduction of test bacteria is 2 or more and less than 3 Δ: log reduction of test bacteria is 1 or more and less than 2 ×: log reduction of test bacteria is Less than 1
※４：除菌性試験（栄養細胞）
供試菌株として、大腸菌（Ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ）（ＮＢＲＣ３９７２）、黄色ブドウ球菌（Ｓｔａｐｈｙｌｏｃｏｃｃｕｓ ａｕｒｅｕｓ）（ＮＢＲＣ１３２７６）、緑膿菌（Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ）（ＮＢＲＣ１３２７５）および陽イオン界面活性剤に抵抗性を示すセラチアマルセッセンス（Ｓｅｒａｔｉａ ｍａｒｃｅｓｃｅｎｓ）（現場分離菌）を用いた。
* 4: Bactericidal test (vegetative cells)
Test strains: Escherichia coli (NBRC3972), Staphylococcus aureus (NBRC13276), Pseudomonas aeruginosa (NBRC13275) and Serratia marcescens resistant to cationic surfactants (Seratia marcescens) (field isolate) was used.
４−１：菌株の培養
大腸菌、黄色ブドウ球菌、緑膿菌はＳＣＤ寒天培地（日水製薬品）に塗抹し、３７℃で２４時間培養し、セラチアマルセッセンスは陽イオン界面活性剤を含有した寒天培地に塗抹し、３０℃で２４時間間培養後、コロニーを掻き取り、それぞれ滅菌リン酸緩衝生理食塩水に希釈したものを菌懸濁液として用いた。
4-1: Cultivation of strain E. coli, Staphylococcus aureus, Pseudomonas aeruginosa are smeared on SCD agar medium (Nissui Pharmaceuticals) and cultured at 37 ° C. for 24 hours, and Serratia marcescens contains cationic surfactant The resulting agar medium was smeared and cultured at 30 ° C. for 24 hours, after which colonies were scraped off and each diluted with sterile phosphate buffered saline was used as a bacterial suspension.
４−２：滅菌中和液の調整
大豆レシチンを１０ｇ、Ｔｗｅｅｎ８０を３０ｇ、Ｌ−ヒスチジンを１ｇ、チオ硫酸ナトリウムを２０ｇ、１Ｌの蒸留水に加温溶解し、攪拌しながら冷却をおこなった。その後、スクリューキャップ付き試験管に各９ｍＬ分注し、高圧殺菌（１２１℃、２０分間）をおこない、滅菌中和溶液とした。
４−３：除菌性試験（栄養細胞）
4-2: Preparation of sterile neutralized solution 10 g of soybean lecithin, 30 g of Tween 80, 1 g of L-histidine, and 20 g of sodium thiosulfate were dissolved in 1 L of distilled water under heating and cooled with stirring. Thereafter, 9 mL of each was dispensed into test tubes with screw caps, high-pressure sterilization (121 ° C., 20 minutes) was performed, and a sterile neutralization solution was obtained.
4-3: Bacterial elimination test (vegetative cells)
試験方法：
各液体除菌剤組成物をイオン交換水で０．２５質量％に希釈して調製した除菌洗浄液１０ｍＬに、終濃度１．５〜５．０×１０８（ＣＦＵ／ｍＬ）となるように各菌懸濁液０．１ｍＬを添加し、２５℃にて１分間接触させたものを試験液とした。各試験液１ｍＬを、滅菌中和溶液に加え、よく攪拌した。混合液を大腸菌、黄色ブドウ球菌、緑膿菌はＳＣＤ寒天培地にて混和固化後、３７℃で２日間培養し、セラチアマルセッセンスはＳＣＤ寒天培地（日水製薬品）にて混和固化後、３０℃で２日間培養した。培養後、生菌数を測定し、初発菌数との差より、以下の基準で除菌性を評価した。△、○、◎の評価のものを実用性のあるものとして判定した。
Test method:
A final concentration of 1.5 to 5.0 × 10 8 (CFU / mL) in 10 mL of the disinfectant cleaning solution prepared by diluting each liquid disinfectant composition to 0.25% by mass with ion-exchanged water 0.1 mL of each bacterial suspension was added and brought into contact at 25 ° C. for 1 minute to obtain a test solution. 1 mL of each test solution was added to the sterile neutralization solution and stirred well. E. coli, S. aureus, and P. aeruginosa are mixed and solidified in SCD agar, and then cultured for 2 days at 37 ° C. Serratia marcescens is mixed and solidified in SCD agar (Nissui Pharmaceutical), The cells were cultured at 30 ° C. for 2 days. After the culture, the number of viable cells was measured, and the erasability was evaluated based on the following criteria based on the difference from the number of primary cells. The evaluations of Δ, 、 and ◎ were judged as having practicality.
評価基準
◎：供試菌のＬｏｇ ｒｅｄｕｃｔｉｏｎが６以上
○：供試菌のＬｏｇ ｒｅｄｕｃｔｉｏｎが３以上、６未満
△：供試菌のＬｏｇ ｒｅｄｕｃｔｉｏｎが１以上、３未満
×：供試菌のＬｏｇ ｒｅｄｕｃｔｉｏｎが１未満
Evaluation criteria ◎: Log reduction of test bacteria is 6 or more ○: Log reduction of test bacteria is 3 or more and less than 6 Δ: Log reduction of test bacteria is 1 or more, less than 3 ×: Log reduction of test bacteria is Less than 1
※５：金属腐食防止性試験（ステンレス）
試験方法：
試験片［ステンレス（ＳＵＳ３０４）、縦５０ｍｍ×横３０ｍｍ×厚さ１ｍｍ］は、予め中性洗剤で洗浄しアセトン処理して乾燥させたものを使用する。炭酸カルシウム換算で、７５ｍｇ／Ｌ［ドイツ硬度４．２°ＤＨ］の硬水で各液体除菌剤組成物を０．２５質量％に希釈した洗浄液６０ｍＬを７０ｍＬ容量の蓋付ガラス瓶に入れ、その中に試験片を浸漬し、８０℃の恒温器内で２４時間浸漬した。その後、試験片を取り出し、イオン交換水にてすすぎ、乾燥させて、試験片表面の外観状態を目視により観察し、下記基準で腐食性を判定した。
評価基準：
○：腐食がない
△：やや腐食がみられるが、使用上問題はない
×：腐食した
とし、○、△を実用性のあるものとして判定した。
※ 5: Metal corrosion prevention test (stainless steel)
Test method:
For the test pieces [stainless steel (SUS304), 50 mm long × 30 mm wide × 1 mm thick], those which have been previously washed with a neutral detergent, treated with acetone, and dried are used. 60 mL of a cleaning solution obtained by diluting each liquid disinfectant composition to 0.25% by mass with hard water of 75 mg / L [German hardness 4.2 ° DH] in terms of calcium carbonate is put in a 70 mL cap glass bottle, among which The test piece was immersed in the sample and immersed in a thermostat at 80.degree. C. for 24 hours. Thereafter, the test piece was taken out, rinsed with ion exchange water, and dried, and the appearance state of the surface of the test piece was visually observed, and the corrosiveness was judged based on the following criteria.
Evaluation criteria:
○: no corrosion Δ: some corrosion was observed, but there was no problem in use ×: it was considered that it was corroded, and it was judged that ○ and Δ were practical.
※６：金属腐食防止性試験（アルミニウム）
試験方法：
試験片［アルミニウム（Ａ１１００Ｐ）、縦５０ｍｍ×横３０ｍｍ×厚さ１ｍｍ］は、予め中性洗剤で洗浄しアセトン処理して乾燥させたものを使用する。炭酸カルシウム換算で、７５ｍｇ／Ｌ［ドイツ硬度４．２°ＤＨ］の硬水で各液体除菌剤組成物を０．２５質量％に希釈した洗浄液６０ｍＬを７０ｍＬ容量の蓋付ガラス瓶に入れ、その中に試験片を浸漬し、４０℃の恒温器内で２４時間浸漬した。その後、試験片を取り出し、イオン交換水にてすすぎ、乾燥させて、試験片表面の外観状態を目視により観察し、下記基準で腐食性を判定した。
評価基準：
○：腐食がない
△：やや腐食がみられるが、使用上問題はない
×：腐食した
とし、○、△を実用性のあるものとして判定した。
※ 6: Metal corrosion prevention test (aluminum)
Test method:
The test pieces [aluminum (A1100P), 50 mm in length × 30 mm in width × 1 mm in thickness] are used after being previously washed with a neutral detergent, treated with acetone, and dried. 60 mL of a cleaning solution obtained by diluting each liquid disinfectant composition to 0.25% by mass with hard water of 75 mg / L [German hardness 4.2 ° DH] in terms of calcium carbonate is put in a 70 mL cap glass bottle, among which The test piece was immersed in the sample and immersed in a 40.degree. C. incubator for 24 hours. Thereafter, the test piece was taken out, rinsed with ion exchange water, and dried, and the appearance state of the surface of the test piece was visually observed, and the corrosiveness was judged based on the following criteria.
Evaluation criteria:
○: no corrosion Δ: some corrosion was observed, but there was no problem in use ×: it was considered that it was corroded, and it was judged that ○ and Δ were practical.
※７：貯蔵安定性試験
試験方法：
各液体除菌剤組成物１００ｇをポリプロピレン製容器に入れ、−５℃、２５℃、４０℃で１ヶ月静置した後に外観を観察した。
評価基準：
◎：分離や濁りが見られず安定である
○：わずかな変化が認められるが、分離や濁りが見られず安定である
△：全体的な分離はなく、若干の濁りが見られるが、使用上問題はない
×：分離もしくは濁りが見られる
とし、△、○、◎を実用性のあるものとして判定した。
※ 7: Storage stability test Test method:
100 g of each liquid disinfectant composition was put in a container made of polypropylene, and after standing for 1 month at -5 ° C, 25 ° C and 40 ° C, the appearance was observed.
Evaluation criteria:
:: Stable with no separation or turbidity ○: Slight change, but no separation or turbidity が: No overall separation, slight turbidity observed, but used There is no problem above ×: separation or turbidity is observed
And △, △ and 、 were judged as having practicality.
Claims (7)
（Ｂ）成分として陽イオン界面活性剤、
（Ｃ）成分としてキレート剤、
（Ｄ）成分として水
を含有し、２５℃におけるｐＨが７．５〜１３である、液体除菌剤組成物。
Cationic surfactant as component (B),
Chelating agent as component (C),
The liquid disinfectant composition which contains water as (D) component and whose pH in 25 degreeC is 7.5-13.
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| JP2021025057A (en) * | 2019-08-01 | 2021-02-22 | 恭治 栗木 | Detergent for dialyzer and method of removing calcium scale in dialyzer using the same |
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| JP2021025057A (en) * | 2019-08-01 | 2021-02-22 | 恭治 栗木 | Detergent for dialyzer and method of removing calcium scale in dialyzer using the same |
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