JP2010037295A - Germicidal disinfectant solution and germicidal disinfectant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a germicidal disinfectant solution capable of effectively exhibiting a germicidal disinfectant effect by preventing adsorption on a base cloth and to provide a germicidal disinfectant composed of a base cloth soaked with the germicidal disinfectant. <P>SOLUTION: The germicidal disinfectant solution used by being carried by a base cloth constituted from a fibrous material is a germicidal disinfectant solution containing a positively charged germicidal disinfectant component, at least one amino acid selected from among lysine, arginine, histidine, and hydrochlorides thereof and a nonionic surfactant, and having a pH adjusted to 4-9 is provided. A bactericidal disinfectant composed of a bleached base cloth and the bactericidal disinfectant soaked therein is also provided. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a sterilizing liquid having a positively charged sterilizing and disinfecting component such as a quaternary ammonium salt or a biguanide compound, and a sterilizing and disinfecting agent obtained by impregnating the sterilizing liquid with a base cloth.

  Quaternary ammonium salts such as benzalkonium chloride and benzethonium chloride are widely used as sterilization and disinfection solutions for fingers and affected areas. These sterilizing and disinfecting liquids are often used by impregnating appropriate amounts of base fabric such as absorbent cotton, gauze, and non-woven fabric.

  However, such a method of use has the disadvantage that these sterilizing / disinfecting components are adsorbed on the base fabric and cannot effectively exhibit the sterilizing / disinfecting effect.

Therefore, conventionally, in order to eliminate such inconvenience, a method of adding cetyltrimethylammonium halide or cetylpyridinium halide (see Patent Document 1), N-coconut oil fatty acid acyl which is an amino acid type surfactant, and the like. A method of adding -L-arginine ethyl DL-pyrrolidone carboxylate (see Patent Document 2) has been proposed.
Japanese Examined Patent Publication No. 6-102604 JP 2000-191521 A

  However, in the case of a method of adding cetyltrimethylammonium halide or cetylpyridinium halide, it is necessary to add a large amount of these agents, and there is a disadvantage that the irritation of these agents to the skin is strong.

  In addition, in the case of the method of adding an amino acid type surfactant, the price is very high, which causes inconvenience in terms of cost when considering commercialization.

  The present invention has been made in view of such circumstances, and a sterilizing liquid capable of effectively exhibiting a sterilizing and disinfecting effect by preventing adsorption to the base cloth, and immersing the sterilizing and disinfecting liquid in the base cloth. The purpose is to provide an antiseptic and disinfectant.

  The sterilizing liquid of the present invention for solving the above-mentioned problems is a sterilizing liquid used by being supported on a base fabric made of a fiber material, a sterilizing component having a positive charge, lysine, arginine, histidine. And at least one amino acid selected from the hydrochlorides thereof and a nonionic surfactant, and is adjusted to pH 4-9. In the sterilizing liquid, the sterilizing and disinfecting component comprising 0.01 to 5% by weight of a quaternary ammonium salt and / or a biguanide compound, 0.05 to 10% by weight of amino acid, and 0.05 to 10% by weight. % Nonionic surfactant and an aqueous solution containing it. Further, the nonionic surfactant is polyoxyethylene hydrogenated castor oil or polyoxyethylene sorbitan fatty acid ester.

  Moreover, the disinfection agent of this invention for solving the said subject is what the said disinfection liquid is impregnated to a base fabric.

  The sterilizing / disinfecting component is not particularly limited as long as it has a positive charge. Specifically, at least one selected from quaternary ammonium salts such as benzalkonium chloride, benzethonium chloride, cetylpyridinium chloride, cetrimide, biguanide compounds such as chlorhexidine gluconate, chlorhexidine hydrochloride, chlorhexidine and the like. Can be used. The concentration used is not particularly limited as long as it is a concentration used for normal sterilization, and is used at a concentration of 0.01 to 5% by weight, more preferably 0.01 to 1% by weight. . When it is less than 0.01% by weight, a sufficient bactericidal effect cannot be achieved. On the other hand, if it exceeds 5% by weight, irritation to the skin becomes strong, the bactericidal effect is limited, and it becomes uneconomical.

  As the amino acid, at least one selected from lysine, arginine, histidine, and hydrochlorides thereof having a positive charge at pH 9.0 or lower can be used. As the use concentration, the amino acid is used in a concentration of 0.05 to 10% by weight, more preferably 0.1 to 3% by weight. The standard of use is 0.01 to 1000 (preferably 0.01 to 60) parts by weight of amino acid per 1 part by weight of the sterilizing and disinfecting component. If the amino acid content is less than 0.05% by weight, a large amount of nonionic surfactant must be added, which increases costs. Further, when the amino acid exceeds 10% by weight, the cost becomes high. In particular, when arginine, histidine, or lysine is used, a large amount of acid is required to neutralize them, leading to high costs.

  As the nonionic surfactant, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, and the like can be used. As a use concentration, a nonionic surfactant is used at a concentration of 0.05 to 10% by weight, more preferably 0.1 to 5% by weight. The standard of use is 0.01 to 1000 (preferably 0.01 to 100) parts by weight of a nonionic surfactant with respect to 1 part by weight of the sterilizing and disinfecting component. If the nonionic surfactant is less than 0.05% by weight, a large amount of amino acid must be blended, resulting in an increase in cost. On the other hand, if the nonionic surfactant exceeds 10% by weight, the effect is saturated, so there is no point in adding more and the cost becomes high.

  As a solvent for the sterilizing / disinfecting solution, water, lower alcohol, or a mixed solvent thereof can be used. The sterilizing / disinfecting solution is constituted by dissolving the above-described sterilizing / disinfecting component, the above-described amino acid, and the above-described nonionic surfactant in this solvent.

  Other drugs that can be included in the disinfectant solution include local anesthetics such as lidocaine, dibucaine and their salts, vasoconstrictors such as naphazoline, ephedofrine and their salts, adrenal lipids such as hydrocortisone, prednisolone and their salts Hormonal agents, diphenhydramine, chlorpheniramine, antihistamines such as their salts, astringents such as zinc oxide and zinc paraphenolsulfonate, antipruritic agents such as crotamiton and camphor, glycyrrhetinic acid and its derivatives, analgesics such as indomethacin and felbinac Anti-inflammatory agents such as anti-inflammatory agents, bifonazole and tolnaftate, sulfa drugs such as sulfisoxazole and sulfadiazine, keratolytic agents such as urea, salicylic acid and resorcin, tissue repair agents such as allantoin, tocopherol and its salts, bi Vitamins such as Min B, Vitamin A and Vitamin D, benzoic acid and its sodium salt, preservatives such as paraoxybenzoic acid ester, water, polyhydric alcohols such as ethanol, isopropanol and propylene glycol, and mixed solvents thereof Examples thereof include oily solvents such as aqueous solvents, alcohols such as octyldodecanol, fatty acids such as stearic acid and oleic acid, or a mixed solution thereof.

  Further, since the sterilizing / disinfecting solution often has a pH of 10 or more depending on the added amino acid, it is finally adjusted to have a pH of 4-9. This pH adjustment is adjusted to pH 4-9, preferably pH 5.0-7.0. When this pH is less than 4, the skin irritation becomes strong, which is not preferable. On the other hand, if the pH exceeds 9, the effects of amino acids and nonionic surfactants cannot be sufficiently exhibited. As the acid used for this adjustment, citric acid, hydrochloric acid, gluconic acid, succinic acid, acetic acid, tartaric acid, lactic acid, boric acid, maleic acid, methanesulfonic acid, malic acid, phosphoric acid, sulfuric acid and the like can be used. . In addition, since it may become pH 4-9 depending on the case where the hydrochloride of an amino acid is used as an amino acid or other cases, it is not necessary to adjust pH in such a case.

  An appropriate amount of the sterilizing / disinfecting liquid is supported on a base fabric such as absorbent cotton, gauze, or non-woven fabric. The method for supporting the sterilizing / disinfecting liquid on the base cloth is not particularly limited. For example, the sterilizing / disinfecting liquid may be sprayed on the base cloth, or the sterilizing / disinfecting liquid may be directly applied from the medicine bottle. It may be soaked in. Further, the sterilizing liquid may be injected into the bag sealed with the base cloth, or the base cloth may be immersed in the sterilizing liquid. It may be flow-coated through a base fabric.

The base fabric includes a bleaching step in the manufacturing process, and in this bleaching step, the 6th position of glucose in the cellulose molecule is oxidized and the carboxyl group becomes (COO ⁻ ), and thus has a negative charge. Yes.

Accordingly, when the sterilizing / disinfecting liquid is supported on the base cloth, there is a concern that the sterilizing / disinfecting component in the sterilizing / disinfecting liquid may be bonded to and adsorbed with the carboxyl group (COO ⁻ ) of the base cloth. However, since at least one amino acid selected from lysine, arginine, histidine and a hydrochloride thereof or a hydrochloride thereof has a positive charge at a pH of 9.0 or less, the amino acid precedes the disinfecting component. It binds to the carboxyl group (COO ⁻ ) of the base fabric to prevent adsorption of the sterilizing and disinfecting components. In this case, the action of the amino acid binding to the carboxyl group (COO ⁻ ) of the base fabric prior to the sterilizing / disinfecting component is exhibited by the nonionic surfactant in the sterilizing / disinfecting solution.

  This sterilizing / disinfecting solution can be used without wasting the active ingredients of the sterilizing / disinfecting solution. Moreover, other components that prevent this active ingredient from adsorbing to the base fabric are amino acids and nonionic surfactants, both of which are widely used and inexpensive. Therefore, this sterilizing / disinfecting solution can effectively exhibit the sterilizing / disinfecting effect, and can be configured safely and inexpensively.

  This sterilizing / disinfecting solution may be preliminarily immersed in a base cloth and configured as a sterilizing / disinfecting agent. As the base fabric, a fabric subjected to bleaching treatment is used. Of course, the fact that the carboxyl group of the base fabric is negatively charged is not always due to the bleaching treatment, so even if the base fabric has not been bleached, the antibacterial disinfectant can prevent adsorption. Is obtained. Specific examples of the base fabric include cotton, rayon, pulp / rayon nonwoven fabric, absorbent cotton, and gauze. In addition, it can be used as a base fabric, either water-degradable or non-water-degradable. However, when a water-degradable material such as a pulp / rayon nonwoven fabric is used, the effect of preventing the adsorption of sterilizing and disinfecting components is further improved. Become prominent.

  In this way, in the case of a disinfectant preliminarily impregnated in a base cloth, the time until actual use, that is, the time in which the disinfectant is impregnated in the base cloth is long. The anti-adsorption effect of the disinfecting component can be exhibited more remarkably.

  The amount of the sterilizing / disinfecting solution to be immersed in the base cloth is 1 to 5 parts by weight, preferably 2 to 4 parts by weight with respect to 1 part by weight of the base cloth. When the amount of the sterilizing liquid is less than 1 part by weight, the absolute amount of the sterilizing liquid is small, so even if an anti-adsorption effect of the sterilizing liquid is obtained, a sufficient amount of the sterilizing liquid must be secured. Will not be able to. When the amount of the sterilizing / disinfecting liquid is more than 5 parts by weight, the sterilizing / disinfecting liquid cannot be carried on the base cloth, and the sterilizing / disinfecting liquid is wasted.

Depending on the sterilizing and disinfecting component, if half of the initial charge amount (for example, if the disinfecting and disinfecting component is 0.01% by weight of the lower limit value, 0.005% by weight which is a half thereof) remains, Since there are those that are expected to have sufficient effects, the amount of antibacterial disinfecting component, amino acid, and nonionic surfactant should be adjusted appropriately as a guideline for the adsorption preventing effect within a range where the adsorption rate is 50% or less. Adjusted. Needless to say, it is possible to prevent adsorption by adjusting the respective amounts and pH of the sterilizing / disinfecting component, amino acid and nonionic surfactant optimally. These are determined according to the amount of active ingredients required for each disinfectant.
Below, the specific example of a disinfection disinfectant is shown.

1. Antiepileptic drug benzalkonium chloride 0.1 wt%, lidocaine 3.0 wt%, dl-methylephedrine hydrochloride 0.5 wt%, L-arginine 0.4 wt% and polyoxyethylene hydrogenated castor oil 60 0.5 wt% 3 ml of a non-woven fabric made of pulp / rayon (20 × 10 cm) is wetted in an aluminum laminate film and heat sealed.

2. Athlete's footworm bifonazole 1.0% by weight, crotamiton 5.0% by weight, glycyrrhetinic acid 0.5% by weight, lidocaine 2.0% by weight, benzethonium chloride 0.05% by weight, L-arginine 0.4% by weight and 3 ml of an aqueous solution containing 0.5% by weight of polyoxyethylene hydrogenated castor oil 60 is wetted with a non-woven fabric (20 × 10 cm) made of rayon, put into an aluminum laminate film, and heat sealed.

3. Kazu medicine 0.1% by weight of benzalkonium chloride, 0.2% by weight of allantoin, 0.2% by weight of chlorpheniramine maleate, 0.4% by weight of L-arginine and 60% by weight of polyoxyethylene hydrogenated castor oil 60 3 ml of an aqueous solution containing% is wetted with a non-woven fabric (20 × 10 cm) made of gauze or rayon, placed in an aluminum laminate film, and heat sealed.

4). Disinfectant for finger or infected skin surface An aqueous solution containing 0.05% by weight of benzalkonium chloride, 0.4% by weight of L-arginine and 0.5% by weight of polyoxyethylene hydrogenated castor oil 60 is a nonwoven fabric made of rayon ( 20 ml × 10 cm) is wetted and placed in an aluminum laminate film and heat sealed.

5). Antipruritic agent Diphenhydramine 1.0 wt%, Dipotassium glycyrrhizinate 1.0 wt%, Benzalkonium chloride 0.1 wt%, Lidocaine 2.0 wt%, Tocopherol acetate 0.5 wt%, L-arginine 0.4 wt% % And polyoxyethylene hydrogenated castor oil 60 0.5% by weight of an aqueous solution made of pulp / rayon (20 × 10 cm) is wetted by 3 ml, placed in an aluminum laminate film and heat sealed.

6). Clean cotton: 9 ml of an aqueous solution containing 0.1% by weight of benzalkonium chloride, 0.4% by weight of L-arginine and 0.5% by weight of polyoxyethylene hydrogenated castor oil 60 is moistened with 3 g of absorbent cotton and placed in an aluminum laminate film. Heat seal and make.

7). Disinfectant of instrument An aqueous ethanol solution containing 0.1% by weight of benzalkonium chloride, 0.4% by weight of L-arginine and 0.5% by weight of polyoxyethylene hydrogenated castor oil 60 is a nonwoven fabric made of rayon (20 × 10 cm). 3 ml), put in an aluminum laminate film and heat-seal.

  As described above, according to the present invention, it is possible to effectively exhibit the sterilizing and disinfecting effect by preventing the sterilizing and disinfecting component from being adsorbed on the base fabric.

  In addition, the antibacterial disinfecting component can be prevented from adsorbing on the base cloth by adding at least one amino acid selected from lysine, arginine, histidine and their hydrochlorides to the disinfecting disinfecting solution, and a nonionic surfactant. Can be achieved safely and inexpensively by adjusting to pH 4-9.

Embodiments of the present invention will be described below.
-Examples 1-22, Comparative Examples 1-5
As shown in Table 1, various sterilizing / disinfecting components, amino acids, and nonionic surfactants were blended in the blending amounts shown in Table 1 to obtain an aqueous solution adjusted in pH with citric acid. Each sample was prepared by impregnating each aqueous solution with these aqueous solutions so as to be 3 times the weight of the base fabric.

  Each sample was allowed to stand at 25 ° C.-65% RH for 1 day, and then the concentration of the sterilizing / disinfecting component in the juice was measured.

  The test was performed three times with the samples prepared for each base fabric, and the adsorption rate of the sterilizing / disinfecting component to the base fabric was determined from the measured average concentration of the sterilizing / disinfecting component. As a standard, the effect of preventing the disinfecting and disinfecting components from adsorbing to the base fabric was confirmed.

For comparison, an aqueous solution containing 0.1% by weight of benzalkonium chloride, which is a sterilizing and disinfecting component, was prepared, and the same measurement was performed on each base fabric impregnated with this aqueous solution.
The results are shown in Table 1.

  From the results in Table 1, it was confirmed that in all the examples, the aqueous solution adjusted to a predetermined pH by adding an amino acid and a nonionic surfactant can prevent the disinfecting component from being adsorbed on various base fabrics. .

-Examples 23-38, Comparative Examples 6-9-
As shown in Table 2, various sterilizing / disinfecting components, amino acids, and nonionic surfactants were blended in the blending amounts shown in Table 2, and the aqueous solution was adjusted to pH with citric acid. Each sample was prepared by impregnating each aqueous solution with these aqueous solutions so as to be 3 times the weight of the base fabric.

  Each sample was allowed to stand at 25 ° C.-65% RH for 1 day, and then the concentration of the sterilizing / disinfecting component in the juice was measured.

  The test was performed three times with the samples prepared for each base fabric, and the adsorption rate of the sterilizing / disinfecting component to the base fabric was determined from the measured average concentration of the sterilizing / disinfecting component. As a standard, the effect of preventing the disinfecting and disinfecting components from adsorbing to the base fabric was confirmed.

Moreover, the same measurement was performed also about what adjusted the aqueous solution of each compounding quantity shown in Table 2 as a comparison object, and impregnated these aqueous solutions to the base fabric.
The results are shown in Table 2.

  From the results in Table 2, it can be confirmed that the disinfecting component can be prevented from adsorbing to the base fabric even when the amount of each of the disinfecting component, amino acid, and nonionic surfactant is extremely large or extremely small. It was.

-Examples 39 and 40, Comparative Example 10-
As shown in Table 3, 0.1% by weight of benzalkonium chloride as a sterilizing and disinfecting component, 0.4% by weight of L-arginine as an amino acid, and 0.5% by weight of polyoxyethylene hydrogenated castor oil as a nonionic surfactant. The aqueous solutions were mixed and adjusted to pH 9 and pH 8 with citric acid, respectively. Each sample was prepared by impregnating each aqueous solution with these aqueous solutions so as to be 3 times the weight of the base fabric.

  Each sample was allowed to stand at 25 ° C.-65% RH for 1 day, and then the concentration of the sterilizing / disinfecting component in the juice was measured.

  The test was performed three times with the samples prepared for each base fabric, and the adsorption rate of the sterilizing / disinfecting component to the base fabric was determined from the measured average concentration of the sterilizing / disinfecting component. As a standard, the effect of preventing the disinfecting and disinfecting components from adsorbing to the base fabric was confirmed.

For comparison, an aqueous solution that was not adjusted in pH with citric acid was used, and the same measurement was carried out on a base fabric impregnated with this aqueous solution.
The results are shown in Table 3.

  From the results shown in Table 3, it was confirmed that the adsorption preventing effect of the sterilizing / disinfecting component on the base fabric was greatly influenced by the pH adjustment, and that the adsorption preventing effect could be sufficiently exhibited at pH 9 or lower.

  The present invention is used as various preparations in which a disinfectant solution is immersed in a base cloth.

Claims (6)

  At least one or more selected from among sterilizing and disinfecting components having a positive charge and lysine, arginine, histidine, and their hydrochlorides as a disinfecting and disinfecting solution used by being supported on a base fabric composed of a fiber material A sterilizing and disinfecting liquid characterized by comprising an amino acid and a nonionic surfactant and adjusted to pH 4-9.   A sterilizing and disinfecting component comprising 0.01 to 5% by weight of a quaternary ammonium salt and / or a biguanide compound, 0.05 to 10% by weight of an amino acid, and 0.05 to 10% by weight of a nonionic surfactant; The sterilizing / disinfecting solution according to claim 1, comprising an aqueous solution containing   The sterilizing liquid according to claim 1 or 2, wherein the nonionic surfactant is polyoxyethylene hydrogenated castor oil or polyoxyethylene sorbitan fatty acid ester.   A sterilizing / disinfecting agent according to any one of claims 1 to 3, wherein the sterilizing / disinfecting solution is impregnated in a bleached base cloth.   The disinfectant according to claim 4, wherein the base fabric is water-degradable. The disinfectant according to claim 5, wherein the base fabric is a pulp / rayon nonwoven fabric.