TW201325707A - Fluid-mixing chip - Google Patents

Abstract

A fluid-mixing chip comprises a chip, which installs a first mixing trough and a second mixing trough that pass through the chip. Two ends of the first mixing trough and two ends of the second mixing trough are closed by a closing unit, respectively. In which one closing unit installs an opening to corresponding with the first mixing trough, and between the first mixing trough and the second mixing trough forms a micro way. The micro way is extending to the second mixing trough from the first mixing trough, and connected with the first mixing trough and second mixing trough.

Description

Fluid hybrid wafer

The present invention relates to a fluid mixing wafer, and more particularly to a fluid mixing wafer which can mix a plurality of liquids and increase the mixing effect thereof to improve the detection accuracy.

The traditional technique for mixing a plurality of liquids relies on the operator to separately inject different liquids into a container, and through shaking or stirring, the liquids can be uniformly mixed, and finally the liquid is uniformly mixed from the liquid. The part is taken out for testing for specific experiments or for other purposes. On the whole, the steps of the traditional mixing technology are not only too cumbersome, but also must rely on the external force to achieve the effect of uniform mixing of multiple liquids. Therefore, there are many operational inconveniences, and the liquid mixing and detection efficiency are always impossible. A breakthrough.

For this reason, the current industry is striving to develop a member capable of rapidly and uniformly mixing a plurality of liquids and directly detecting the mixed liquid, and it is expected to achieve a remarkable improvement in liquid mixing and detection efficiency.

Referring to FIG. 1, a conventional fluid mixing wafer 9 is disclosed. The fluid mixing wafer 9 includes a base 91, a first body 92 and a second body 93. The base 91 has a liquid storage tank 911. The first base body 92 is disposed above the base 91. The upper surface of the first base body 92 is provided with a mixing zone 921 and a plurality of flow passages 922. One end of the 922 is respectively connected to the mixing zone 921, and the other end is respectively formed with a free end 923, and the mixing zone 921 is connected to the liquid storage tank 911 through a central hole 924; the second seat body 93 is arranged The first base body 92 is disposed above the first seat body 92, and the second seat body 93 is provided with a plurality of injection holes 931 which are in position communication with the free end 923 of the first seat body 92. Therefore, when a plurality of liquids are injected one by one through the injection holes 931, respectively, they can flow through the respective flow channels 922 via their corresponding free ends 923, and merge into the mixing zone 921 for mixing, and finally, Then, the liquid hole 924 flows into the liquid storage tank 911 to complete the conventional liquid mixing operation.

However, the conventional fluid mixing chip 9 is configured to flow a plurality of liquids to the mixing zone 921 by air pressure, and then flows into the liquid storage tank 911 through the center hole 924 to form a single mixing operation, and the liquid cannot be re-energized at all times. The mixing zone 921 and the injection hole 931 are mixed back and forth, so that the conventional fluid mixing chip 9 can not only ensure the mixing uniformity of the plurality of liquids, but also affect the accuracy of subsequent detection, which seriously leads to experimental data and results. Even though, the injection holes 931 of the conventional fluid mixing chip 9 are designed to be open, and most of them can only rely on the number of holes 931 of the injection hole 931 opened by the second body 93, and the decision can be made simultaneously. The total amount of liquid to be mixed, although the liquid is pushed to the injection hole 931 at an additional pressure, can only cause the liquid to flow directly to the reservoir 911 via the mixing zone 921, and can no longer be remixed with the mixed liquid therein. Thus, the conventional fluid mixing chip is limited by the number of holes of the injection hole 931, and no additional liquid can be mixed, which seriously causes the practicality of the conventional fluid mixing chip 9 to be inferior, and the problem that the injected liquid is difficult to control. However, it is not always possible to mix wafer designs with simple fluids to improve the uniformity of mixing of multiple liquids. In this way, it is easy to detect the subsequent liquid, facing the problem of poor detection accuracy, and can not obtain accurate detection values, as an effective reference for the substance content.

In view of this, it is indeed necessary to develop a fluid hybrid wafer which can uniformly mix a plurality of liquids and effectively improve the detection accuracy, without being limited to the total number of mixed liquids, to solve various problems as described above.

SUMMARY OF THE INVENTION It is a primary object of the present invention to ameliorate the above disadvantages to provide a fluid mixing wafer which is capable of mixing a plurality of liquids in a mixing tank for multiple times to increase fluid mixing uniformity while at the same time increasing its utility.

A second object of the present invention is to provide a fluid mixing wafer capable of simultaneously mixing a plurality of sets of liquids to be tested to be tested, and performing simultaneous detection after uniform mixing to increase mixing and detection efficiency.

In order to achieve the above object, the fluid mixing wafer of the present invention is made of a wafer body having a first mixing tank and a second mixing tank, the first mixing tank and the second mixed liquid. The two ends of the groove are respectively closed by a closing member, wherein a sealing member is provided with an opening corresponding to the first mixing tank, and a micro flow channel is formed between the first mixing tank and the second mixing tank, the micro flow The tract system extends from the first mixing tank to the second mixing tank, and is in communication with the first mixing tank and the second mixing tank.

The wafer body of the present invention has two corresponding first surfaces and a second surface, and the first mixed liquid tank and the second mixed liquid tank respectively form corresponding openings on the first surface and the second surface, and the micro flow The passage is disposed on the second surface and extends in a curved shape from the first mixing tank to the second mixing tank.

The first surface of the wafer body is covered with a first sealing member, and the first sealing member is configured to close the opening of the second liquid mixing groove, and the first sealing member is further provided with an opening. The port is connected to the first mixing tank, and the opening is located at the first surface of the first mixing tank to jointly form the liquid inlet. The second surface of the wafer body is covered with a second sealing member for closing the opening of the first mixing tank and the second mixing tank at the second surface, and is used for the micro flow passage. Close it.

The wafer system of the present invention may be selected to have a circular shape, and the plurality of first mixed liquid tanks and the plurality of second mixed liquid tanks are formed by using the center of the wafer body as a reference array, and corresponding to each other, and the plurality of second mixed liquid tanks The system is closed. Alternatively, the wafer system may be selected to have a rectangular shape, and the plurality of first mixed liquid tanks and the plurality of second mixed liquid tanks are mutually arrayed and formed on the wafer body, and the second mixed liquid tank is closed.

The above and other objects, features and advantages of the present invention will become more <RTIgt;

Referring to FIG. 2 , which is a preferred embodiment of the present invention, the fluid mixing chip is made of a wafer body 1 , and the wafer body 1 is provided with a first mixing tank 11 and a second mixing tank. 12. A micro flow channel 13 is formed between the first mixing tank 11 and the second mixing tank 12. The wafer body 1 can be made of a glass material, a polymer material or a metal material, and the above-mentioned structural design can be completed in a laser ablation manner conveniently and quickly. The preferred embodiment of the present invention is particularly The wafer body 1 is selected to be made of polymethyl methacrylate [PMMA] to effectively increase the production efficiency and reduce the cost required for fabrication.

In the embodiment, the wafer body 1 is formed with two corresponding first surface S1 and a second surface S2, and the first mixed liquid tank 11 and the second mixed liquid tank 12 are penetrated through the wafer body 1. And forming a corresponding opening H on the first surface S1 and the second surface S2; the micro flow channel 13 is preferably disposed on the second surface S2 of the wafer body 1 and curved from the first liquid mixing tank 11 The ground extends to the second mixing tank 12, and communicates with the first mixing tank 11 and the second mixing tank 12. Thereby, the liquid circulation time can be prolonged, and the probability of liquid mixing is relatively increased, so as to achieve the effect of improving the uniformity of liquid mixing.

In addition, the first surface S1 of the wafer body 1 is covered with a first sealing member 14 for closing the opening H of the second mixing tank 12 opened on the first surface S1, and the first surface The opening 14 is further provided with an opening 141 which communicates with the first mixing tank 11 , in particular, the opening H of the first mixing tank 11 opened at the first surface S1 to jointly form a liquid inlet. The liquid filling port 遂 can supply a liquid from the liquid filling port 141 into the first mixing tank 11. Furthermore, the second surface S2 of the wafer body 1 is covered with a second sealing member 15 for closing the first mixing tank 11 and the second mixing tank 12 to open on the second surface S2. The opening H is used to close the micro flow channel 13. The first wafer member 14 and the second sealing member 15 are selected in a thermally bonded manner by means of thermal bonding or bonding. It is closely attached to the wafer body 1 to provide a better sealing effect to prevent liquid from leaking through the gap between the wafer bodies.

It should be noted that the first sealing member 14 and the second sealing member 15 can be integrally formed with the wafer body 1 so as to be able to form the structure as described above on the wafer body 1 as a main principle. The preferred embodiment is not limited.

The fluid mixed wafer after the assembly is completed, as shown in FIGS. 3 and 4, the first mixed liquid tank 11 and the second mixed liquid tank 12 are communicated through the micro flow passage 13 so as to be injected into the first mixed liquid tank 11 The liquid can enter the second mixing tank 12 via the microchannel 13 and flow back and forth between the first mixing tank 11 and the second mixing tank 12. The type of the first mixing tank 11 and the second mixing tank 12 may be any geometric shape, and in particular, it is preferable to generate eddy current mixing for the liquid in the first mixing tank 11 and the second mixing tank 12. In principle, this embodiment selects a circular groove design to provide a better liquid vortex mixing effect to improve the uniformity of liquid mixing and to relatively increase the detection accuracy of subsequent detection.

In the subsequent operation, as shown in FIG. 4, the mixed fluid wafer of the present invention can also be combined with a fluid pressure member 2 to supply a stable pressure source from the fluid pressure member 2, and is activated in the following process. A variety of liquids for the purpose of uniform mixing. Wherein, the fluid pressure member 2 can be selected as any pressurizable member such as a pneumatic pump, and it is a preferable principle to supply a suitable pressure source without limitation.

Referring to Figures 4-6, in the actual operation of the fluid mixing chip of the present invention, a pneumatic pressure pushing platform is used to provide a stable pressure source, and a pressurized end 21 is inserted into the first mixing tank 11. And adjusting the pressure source is preferably 2 Kg/cm ² to achieve a better effect of pushing the liquid by the air pressure.

In detail, the fluid mixing chip of the present invention is used to perform a plurality of liquid mixing operations, first in the direction of the arrow shown in FIG. 4, without opening the fluid pressing member 2, and injecting the first liquid to be mixed therein. The first liquid mixing tank 11 allows the first liquid to be temporarily stored in the first mixing tank 11. Then, in the direction of the arrow shown in FIG. 5, the second liquid to be mixed with the first liquid is injected into the first mixing tank 11, and the pressure is supplied to the pressure source through the fluid pressure member 2 a mixing tank 11 forcing the first liquid and the second liquid to advance together into the second mixing tank 12 via the microchannel 13 [as shown in FIG. 5], and generating vortex mixing in the second mixing tank 12. And the liquid to be mixed [that is, the first liquid is mixed with the second liquid, hereinafter referred to as the hydrazine mixed liquid nickname] is completely injected into the second mixing tank 12, and the fluid pressurizing member 2 can be closed and removed. The pressure source instantaneously disappears from the first mixing tank 11 . At this time, the second mixing tank 12 is closed and there is air pressure, so that the gas pressure in the second mixing tank 12 is greater than the first mixing tank 11 . Therefore, when the gas pressure in the second mixing tank 12 generates a thrust according to the direction of the arrow shown in FIG. 6, the mixed liquid in the second mixing tank 12 is forced to be pushed again to the first through the microchannel 13 In the mixing tank 11 to be between the first mixing tank 11 and the second mixing tank 12 After the gas pressure balance can be obtained in the first mixing tank mixed liquor within 11 preliminarily mixed, the mixing of the liquid to a subsequent detection purposes.

Even when it is necessary to additionally mix other kinds of liquids, the above steps are continued, and as shown in FIG. 4, a third liquid is injected into the first mixing tank 11 and pressurized by the fluid pressing member 2. The method further supplies a pressure source, repeating the steps as described above, so that the third liquid can be mixed again with the mixed liquid, and back and forth between the first mixing tank 11 and the second mixing tank 12 several times to achieve comparison. Good mixing uniformity. In this way, a plurality of liquids can be sequentially mixed under the above principles, and the need for subsequent testing can be easily understood and applied by those skilled in the art, and the description is not repeated one by one.

It should be noted that the operator can select whether to repeat the above steps according to the viscosity coefficient [viscosity] of the liquid to be mixed, and again pressurize the mixed liquid which has been initially mixed through the fluid pressing member 2, and re-pass The microchannel 13 is pushed to the second mixing tank 12, and the mixing operation is repeated a plurality of times in the same manner until the mixed liquid has a preferable mixing uniformity. For example, when mixing a liquid with a small viscosity [viscosity coefficient of about 10 cp], it is only necessary to perform a single mixing according to the above means to achieve the effect of proper mixing of the liquid; conversely, mixing a liquid having a relatively high viscosity [viscous] When the coefficient is about 50 cp or more, it is necessary to repeat the mixing 2 to 3 times in accordance with the above means to achieve the effect of proper mixing of the liquid. In short, when operating the fluid mixing wafer of the present invention, it is only necessary to selectively control the number of round trips between the first mixing tank 11 and the second mixing tank 12 according to the viscosity coefficient of the liquid. Achieve the effect of improving the mixing uniformity. As described above, those skilled in the art can easily understand and apply the present invention with reference to the description of the present invention, and the mixing of a particular liquid will not be described in detail.

In summary, the main feature of the fluid mixing chip of the present invention is that the micro flow channel 13 between the first mixing tank 11 and the second mixing tank 12 is designed, and the second mixing tank 12 is closed. The air pressure is stored, so that in actual operation, the stable pressure source provided by the fluid pressure member 2 can be matched, and the liquid is forced to pass from the first mixing tank 11 to the second mixing tank 12 via the microchannel 13 . And simultaneously generating a phenomenon of liquid vortex mixing in the second mixing tank 12, and after the pressure source is removed, the instantaneous relative pressure difference generated between the second mixing tank 12 and the first mixing tank 11 is obtained. The air pressure in the second mixing tank 12 generates a reverse thrust, which further forces the liquid of the second mixing tank 12 to flow back to the first mixing tank 11 via the microchannel 13 again. In this way, the liquid to be mixed can be flowed back and forth between the first mixing tank 11 and the second mixing tank 12 to increase the mixing probability between the liquids, and under the above principle, it is suitable for the mixing operation of a plurality of liquids. The effect of improving the mixing uniformity of the plurality of liquids is achieved by repeated mixing, and thus the utility of the fluid mixing wafer of the present invention is increased; even, the pressure difference principle of the fluid mixing wafer of the present invention is used, and the second mixing tank is matched. 12 is a closed design, which can also accelerate the mixing efficiency of liquids. When applied to subsequent inspections, it can reduce the time required for testing, and at the same time improve the detection accuracy and quality.

In addition to the above, the fluid hybrid wafer of the present invention can also have different implementations in response to subsequent simultaneous detection of a plurality of mixed liquids. The fluid mixing chip of the present invention is selectively provided with a plurality of first mixing tanks 11 and a plurality of second mixing tanks 12 in the wafer body 1, and the plurality of first mixing tanks 11 and the corresponding plurality of second mixed liquids A microchannel 13 is formed between the slots 13 respectively. Please refer to FIGS. 7 and 8 for different reference embodiments, and for a plurality of first mixing tanks 11 and several The arrangement of the two mixing tanks 12 in the wafer body 1 is mainly different, and is described below in conjunction with the corresponding combination of the above, and the rest of the design of the above-mentioned members will not be described again.

As shown in FIG. 7, which is another preferred embodiment of the present invention, the fluid mixing chip is made of a circular wafer body 1', which also has several numbers as described above. A mixing tank 11 and a plurality of second mixing tanks 12. The plurality of first mixing tanks 11 and the plurality of second mixing tanks 12 are formed by the center of the wafer body 1' as a reference array, and are corresponding to each other, and the plurality of second mixing tanks 12 are closed. . In particular, the plurality of first liquid mixing tanks 11 are preferably formed at a center away from the center of the wafer body 1' with the center of the wafer body 1' as a reference array, and the plurality of second liquid mixing tanks 12 are preferably the wafer. The center of the body 1' is formed as a reference array adjacent to the center of the wafer body 1' and corresponds to the plurality of first liquid mixing tanks 11. Similarly, a microchannel 13 is formed between each of the plurality of first mixing tanks 11 and the corresponding plurality of second mixing tanks 12, and the microchannels 13 are curved from the first mixing tank 11 It extends to the second mixing tank 12.

Alternatively, as shown in Fig. 8, a further preferred embodiment of the present invention is disclosed. The fluid mixing wafer is made of a rectangular wafer body 1", which also has several of the above-mentioned The first mixing tank 11 and the plurality of second mixing tanks 12. The plurality of first mixed liquid 11 tanks and the plurality of second mixed liquid storage tanks 12 are mutually arrayed and formed on the wafer body 1", and the second mixed liquid tank 12 is closed. In particular, the plurality of The first mixing tank 11 is preferably formed in an array adjacent to the corresponding two sides of the wafer body 1", and the plurality of second mixing tanks 12 are preferably array formed adjacent to the center of the wafer body 1", and A plurality of first mixing tanks 11 are correspondingly formed. Similarly, a microchannel 13 is formed between each of the plurality of first mixing tanks 11 and the corresponding plurality of second mixing tanks 12, and the microchannels 13 are The first mixing tank 11 extends in a curved shape to the second mixing tank 12.

In this way, the fluid mixing wafer of the present invention can not only be under the air pressure due to the closure of one of the mixing tanks, but also has a significant pressure difference change between the other mixing tanks, so that the liquid is repeatedly returned to and from the mixing tank. Mixing a variety of liquids to increase the utility of the fluid-mixed wafer while achieving improved mixing uniformity and detection accuracy. In addition, the fluid mixed wafer of the present invention can be further mixed with a plurality of sets of liquids to be tested, and simultaneously mixed and uniformly detected after being uniformly mixed, as described in the above-mentioned plurality of types of designs [as shown in FIGS. 7 and 8]. Achieve increased mixing and detection efficiency.

While the invention has been described in connection with the preferred embodiments described above, it is not intended to limit the scope of the invention. The technical scope of the invention is protected, and therefore the scope of the invention is defined by the scope of the appended claims.

[this invention]

1, 1', 1"... wafer body

11. . . First mixing tank

12. . . Second mixing tank

13. . . Microchannel

14. . . First closure

141. . . Opening

15. . . Second closure

S1. . . First surface

S2. . . Second surface

H. . . Opening

2. . . Fluid pressure

twenty one. . . Pressurized end

[知知]

9. . . Fluid hybrid wafer

91. . . Pedestal

911. . . Reservoir

92. . . First body

921. . . Mixed area

922. . . Runner

923. . . Free end

924. . . Center hole

93. . . Second body

931. . . Injection hole

Figure 1: An exploded perspective view of a conventional fluid hybrid wafer.

Figure 2: An exploded perspective view of a fluid hybrid wafer of the present invention.

Figure 3: A top view of the combination of the fluid mixing wafers of the present invention.

Figure 4: Combined view of the fluid mixing wafer of the present invention.

Figure 5: Schematic diagram 1 of the operation of the fluid hybrid wafer of the present invention.

Figure 6: Schematic diagram 2 of the operation of the fluid hybrid wafer of the present invention.

Figure 7: A top view of a combination of another aspect of the fluid hybrid wafer of the present invention.

Figure 8 is a top plan view of a further aspect of a fluid hybrid wafer of the present invention.

1. . . Wafer body

11. . . First mixing tank

12. . . Second mixing tank

13. . . Microchannel

14. . . First closure

141. . . Opening

15. . . Second closure

S1. . . First surface

S2. . . Second surface

H. . . Opening

Claims (6)

A fluid mixing wafer is formed by a wafer body, the wafer body is provided with a first mixing tank and a second mixing tank, and the two ends of the first mixing tank and the second mixing tank are respectively The closure member is closed, wherein a closure member is provided with an opening corresponding to the first mixing tank, and a microchannel is formed between the first mixing tank and the second mixing tank, the microchannel is from the first mixing tank Extending to the second mixing tank and communicating with the first mixing tank and the second mixing tank. The fluid mixing wafer of claim 1, wherein the wafer body has two corresponding first surfaces and a second surface, and the first mixing tank and the second mixing tank are respectively on the first surface. And forming a corresponding opening on the second surface, the micro flow channel is disposed on the second surface, and extends from the first mixed liquid tank to the second mixed liquid tank in a curved shape. The fluid-mixed wafer of claim 2, wherein the first surface of the wafer body is covered with a first sealing member, and the first sealing member is configured to close the opening of the second mixing solution opening at the first surface. And the first sealing member is further provided with an opening, the opening is connected to the first mixing tank, and the opening is located at the first surface of the first mixing tank to jointly form a liquid inlet. The fluid mixing wafer of claim 2, wherein the second surface of the wafer body is covered with a second sealing member for closing the first mixing tank and the second mixing tank. The opening of the second surface is used to close the microchannel. The fluid mixing wafer of claim 1, 2, 3 or 4, wherein the wafer system has a circular shape, and the plurality of first mixing tanks and the plurality of second mixing tanks are centered on the wafer body The reference arrays are shaped and correspond to each other, and the plurality of second mixing tanks are closed. The fluid-mixed wafer of claim 1, 2, 3 or 4, wherein the wafer system has a rectangular shape, and the plurality of first mixing tanks and the plurality of second mixing tanks are formed in an array corresponding to each other. The wafer body, and the second liquid mixing tank is closed.