TW201302189A - 氣化吸入用鎮靜劑及含有其之鎮靜香料組合物 - Google Patents
氣化吸入用鎮靜劑及含有其之鎮靜香料組合物 Download PDFInfo
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Abstract
本發明之課題在於提供一種藉由氣化吸入可安全且有效地帶來鎮靜效果之新穎物質。一種氣化吸入用鎮靜劑,其含有3-甲氧基-5-甲基苯酚作為有效成分。
Description
本發明係關於一種鎮靜劑及含有其之鎮靜香料組合物,更詳細而言,係關於一種藉由吸入經氣化之有效成分而帶來鎮靜作用之鎮靜劑。
於被稱為壓力社會之現代社會中,由壓力所引起之失眠症等各種各樣生理上或心理上的影響已成為很大的社會問題,在對於緩解壓力與安眠之關心高漲之中,藉由芳香療法使精神鎮靜從而減輕由壓力引起之焦躁之方法受到關注。例如,一般口傳認為薰衣草或洋甘菊等精油具有鎮靜效果,由於該等天然香料可藉由吸入香味而發揮鎮靜效果,因此與藥劑之經口投予或注射投予等相比,具有於投予時不會附加另外之壓力之優點。
然而,先前之使用該種天然香料之方法中,有因天然香料之產地或收穫年份、香料之採取方法等不同從而香料之組成不同之情況,有未必能夠期待具有再現性且穩定之效果之問題。
近年來,報告有如1,3-二甲氧基-5-甲基苯(專利文獻1)、或三甲氧基苯等三烷氧基苯(專利文獻2)、進而二甲氧基苯(專利文獻3)之單一之香料成分具有鎮靜效果。
然而,僅以該等所報告之鎮靜香料成分可調配製作之香料或香味之品質具有侷限性,為了廣泛應對多樣之愛好以及各種製品之應用,仍強烈期待開發出新穎之氣化吸入用
鎮靜劑。
[專利文獻1]日本專利特開平6-172781號公報
[專利文獻2]日本專利特開2000-86478號公報
[專利文獻3]日本專利特開2006-290823號公報
本發明係鑒於如上述之情況而成者,其目的在於提供一種可藉由氣化吸入帶來鎮靜作用,且對於各種香味均具有適合性之新穎之氣化吸入用鎮靜劑。
本發明者為了達成上述目標進行努力研究,結果發現蘭花或橡木苔等中所含之香氣成分即3-甲氧基-5-甲基苯酚可藉由氣化吸入帶來鎮靜效果,從而完成本申請案發明。
本發明之氣化吸入用鎮靜劑之特徵在於:其含有3-甲氧基-5-甲基苯酚作為有效成分。使用苯酚之類或橡木苔之類之具有芬芳良好之香味的3-甲氧基-5-甲基苯酚,藉由以各種各樣之態樣下之氣化吸入可簡單且有效地帶來鎮靜效果。
本發明之氣化吸入用鎮靜劑亦可進而含有例如1,3-二甲氧基-5-甲基苯之類之其他鎮靜成分。藉由適當地組合具有鎮靜效果之香氣成分,可更有效地帶來鎮靜作用。
本發明之鎮靜香料組合物之特徵在於:以上述氣化吸入
用鎮靜劑作為有效成分,3-甲氧基-5-甲基苯酚之調配量為0.001~50質量%。
本發明之氣化吸入用鎮靜劑係以蘭花等之香氣成分之具有芬芳良好之香味之3-甲氧基-5-甲基苯酚作為有效成分,單獨或與其他香料成分調配從而構成較佳之香氣,藉由氣化吸入可安全且簡單地使精神鎮靜,從而可有效地減輕因壓力所引起之焦躁或失眠。
本發明之氣化吸入用鎮靜劑以3-甲氧基-5-甲基苯酚作為有效成分。3-甲氧基-5-甲基苯酚係蘭花或橡木苔、地衣類、菌類等中所含之香氣成分,例如,於本發明中可較佳地使用由Givaudan Japan股份有限公司所市售之Orcinyl 3(商品名)。
本發明之氣化吸入用鎮靜劑,只要含有3-甲氧基-5-甲基苯酚作為有效成分從而可達成本發明之效果,則可進而含有藉由氣化吸入可帶來鎮靜作用之其他鎮靜成分。作為該種其他之鎮靜成分,並無限定,例如可列舉:1,3-二甲氧基-5-甲基苯、三甲氧基苯等三烷氧基苯、二甲氧基苯等,尤其是1,3-二甲氧基-5-甲基苯,由於香味並不強烈,因此適合於本發明中與3-甲氧基-5-甲基苯酚一併調配。又,於不妨礙本發明之效果之範圍內,可含有載體、稀釋劑、助劑等任意之其他成分。
進而,只要不損害本發明之效果,則可將本發明之氣化
吸入用鎮靜劑與其他通常之香料成分適當地調配,從而調製具有所需之香味之鎮靜香料組合物。香料組合物中之3-甲氧基-5-甲基苯酚之調配量只要考慮使用目的等適當決定即可,通常為0.001~50質量%,更佳為0.01~30質量%。本發明之香料組合物,可直接吸入使用,或亦可添加於任意之對象物中使用。
若調配有本發明之氣化吸入用鎮靜劑或含有其之香料組合物之對象物為能夠以可氣化吸入3-甲氧基-5-甲基苯酚之形態調配者,則可為任意者,並非根據其劑型或製品形態而有限定者。又,視其對象物之種類,除上述有效成分以外,可進而含有通常其對象物中所含之任意之構成要素。
作為調配有本發明之氣化吸入用鎮靜劑等之製品形態,並無限定,可列舉:化妝品、醫藥品、準藥品、食品、飲料等,又,作為其劑形,例如可列舉:液劑、粉末劑、顆粒劑、霧劑、固體劑、凝膠劑等。
作為尤其較佳之態樣之一之化妝品,並無限定,例如可列舉:香水、淡香水、古龍水、乳霜、乳液類、化妝水、粉底類、蜜粉、口紅、肥皂、洗髮精‧潤絲精類、沐浴露、潤膚露、香體粉類、沐浴液類等。
進而,例如,可於芳香劑、除臭劑、香薰蠟燭、熏香、文具、錢包、袋子、鞋子等任意雜貨類或例如內衣、西服、帽子、長筒襪、襪子等任意衣服類中含有本發明之氣化吸入用鎮靜劑等。亦可於該等素材或製品中之任一者中添加本發明之氣化吸入用鎮靜劑等。
如上述之對象物中之本發明之氣化吸入用鎮靜劑之調配量可根據其他調配成分及用途等適當選擇,並無特別限定,通常,較佳為相對於對象物之總質量為0.000001質量%以上,更佳為0.00001質量%以上,進而較佳為0.0001質量%以上。於調配於化妝品中之情形時,化妝品中之氣化吸入用鎮靜劑之調配量並無特別限定,但通常之濃度範圍可設為例如相對於化妝品總量為0.001~50質量%。
再者,例示有本發明之氣化吸入用鎮靜劑之各種各樣之使用態樣,但並不限定於該等,只要可達成本發明之效果,則可以任意之態樣使用。
以下,列舉實施例具體地說明本發明,但本發明並不限定於下述實施例。
研究下述式所表示之3-甲氧基-5-甲基苯酚及其結構異構物之2-甲氧基-4-甲基苯酚之鎮靜效果。
3-甲氧基-5-甲基苯酚顯示出芬芳、動物之類、苯酚之類、橡木苔之類之香氣,為蘭花或橡木苔、地衣類、菌類
等中所含之香氣成分。另一方面,2-甲氧基-4-甲基苯酚顯示出芬芳濃烈之苯酚、皮革之類之香氣,同樣地自蘭花等中發現。3-甲氧基-5-甲基苯酚係使用由Givaudan Japan股份有限公司所市售之Orcinyl 3(商品名),又,2-甲氧基-4-甲基苯酚係使用由Symrise股份有限公司所市售之creosol。以3-甲氧基-5-甲基苯酚成為0.2%,2-甲氧基-4-甲基苯酚成為0.01%之濃度之方式利用乙醇稀釋從而製成試驗試樣。
將共計9名20多歲的女性作為受測者。事先對受測者說明試驗內容,以書面形式獲得參加試驗之同意。
為了研究香料成分之鎮靜效果,測定被稱作伴隨性負電位變化(Contigent Negative Variation以下,稱作CNV)之作為事件相關電位之一種的負電位之變化。報告有CNV腦電波之早期成分之變動之大小顯示出與意識之覺醒水準之正相關性,可對香味影響意識水準之效果(精神鎮靜/高昂效果)進行定量評價(Torii S et al:伴隨性負電位變化(CNV)及氣味對心理之影響(Contingent negative variation(CNV)and the psychological effects of odour)。香水:香味心理學與生物學(In Perfumery:The Psychology and Biology of Fragrance),Toller SV and Dodd GH出版,107-120,Chapman and Hall,London(1998))。
進行如下之課題:於受測者之頭頂部(Cz)、前頭極部中央(Fpz)、左耳(A1)、右耳(A2)安裝鉑電極,將Fpz設為接地,藉由腦電波儀(誘導電位檢查裝置MEB-2216,日本光
電工業股份有限公司)測量Cz-(A1+A2)之電位差。使受測者利用頭戴式耳機聽咔噠聲,且於咔噠聲開始數秒後配合亮暗交替之發光二極體之點亮按下手邊之開關,從而測量伴隨課題之完成所產生之CNV腦電波。
於使受測者吸入香料成分之情形時,使5 μl各試驗試樣滲入約0.5 cm×0.5 cm見方之棉布中,使乙醇充分揮發之後,貼附於受測者之鼻子下方,使其於一系列之動作中間與平常呼吸一併地吸入香料成分。又,於不吸入香料成分之情形時,使僅5 μl之乙醇滲入約0.5 cm×0.5 cm見方之棉布中,並且貼附於鼻子下方,並使其進行同樣之操作。對於吸入香料成分之情形與不吸入香料成分之情形分別重複進行30次,測量CNV腦電波,算出累計腦電波形,比較自咔噠聲開始450 ms~1000 ms之CNV腦電波早期成分面積,從而評價香料成分之吸入效果。對於吸入香料成分之情形與不吸入香料成分之情形進行對應性之t檢驗,判定於危險率未達5%之情形時統計上有顯著之差異。
算出吸入香料成分之情形中之CNV早期成分累計值(μV/s)相對於不吸入香料成分之情形(對照)中之CNV早期成分累計值(μV/s)的比(相對CNV早期成分累計值(%))。將結果示於圖1中。於相對CNV早期成分累計值大於100之情形時表示具有覺醒效果,於小於100之情形時表示具有鎮靜效果。
藉由吸入3-甲氧基-5-甲基苯酚,與不吸入之情形相比,CNV早期成分累計值顯著(P=0.046)減少,即意識水準經抑
制,表示3-甲氧基-5-甲基苯酚具有鎮靜效果。另一方面,於同樣地為蘭花之香氣成分之結構異構物之2-甲氧基-4-甲基苯酚之情形時,CNV早期成分累計值無顯著差異(P=0.56),故無法發現2-甲氧基-4-甲基苯酚具有鎮靜效果。
以下,將含有本發明之氣化吸入用鎮靜劑之鎮靜香料組合物之具體之配方例作為應用例而表示。再者,作為本發明之氣化吸入用鎮靜劑,可單獨為3-甲氧基-5-甲基苯酚或將其與1,3-二甲氧基-5-甲基苯組合調配。調配量全部以相對於製品總量之質量%表示。
以下,將調配有含有本發明之氣化吸入用鎮靜劑之鎮靜香料組合物的外用組合物或雜貨類之典型之製品形態之調配例作為應用例表示。
質量%
於銅銨纖維素溶液(纖維素濃度10質量%、銨濃度7質量%、銅濃度3.6質量%)中,於相對於纖維素質量為0.1~20質量%之範圍內添加內包有本發明之鎮靜香料組合物之微膠囊(粒子徑50 μm以下,3-甲氧基-5-甲基苯酚於微膠囊中所佔之比例為50質量%),混合之後,依據通常之濕式紡絲方法進行紡絲,經過精煉步驟、乾燥步驟從而獲得芳香性纖維。
圖1係表示針對成為意識水準之指標之CNV早期成分累計值(μV/s)之香味之效果的圖表。
Claims (3)
- 一種氣化吸入用鎮靜劑,其含有3-甲氧基-5-甲基苯酚作為有效成分。
- 如請求項1之氣化吸入用鎮靜劑,其進而含有1,3-二甲氧基-5-甲基苯。
- 一種鎮靜香料組合物,其含有如請求項1或2之氣化吸入用鎮靜劑,且3-甲氧基-5-甲基苯酚之調配量為0.001~50質量%。
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