TW201107328A - Pyrrolo [2,3-d] pyrimidine derivatives - Google Patents

Info

Publication number

TW201107328A

TW201107328A TW099124621A TW99124621A TW201107328A TW 201107328 A TW201107328 A TW 201107328A TW 099124621 A TW099124621 A TW 099124621A TW 99124621 A TW99124621 A TW 99124621A TW 201107328 A TW201107328 A TW 201107328A

Authority

TW

Taiwan

Prior art keywords

compound

group

cancer

formula

hydrogen atom

Prior art date

2009-07-28

Links

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• 150000004943 pyrrolo[2,3-d]pyrimidines Chemical class 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims abstract description 157
• -1 C1-4lkyl Chemical group 0.000 claims abstract description 108
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 48
• 150000003839 salts Chemical class 0.000 claims abstract description 33
• 125000005843 halogen group Chemical group 0.000 claims abstract description 16
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 11
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims abstract description 7
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims abstract description 6
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
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• 125000000217 alkyl group Chemical group 0.000 claims description 24
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 22
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 18
• 125000003545 alkoxy group Chemical group 0.000 claims description 16
• 229910052739 hydrogen Inorganic materials 0.000 claims description 15
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• 239000000126 substance Substances 0.000 claims description 12
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• 239000004480 active ingredient Substances 0.000 claims description 10
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• 229910052731 fluorine Inorganic materials 0.000 claims description 9
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 8
• 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 8
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