IN2012DN01251A - - Google Patents
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- Publication number
- IN2012DN01251A IN2012DN01251A IN1251DEN2012A IN2012DN01251A IN 2012DN01251 A IN2012DN01251 A IN 2012DN01251A IN 1251DEN2012 A IN1251DEN2012 A IN 1251DEN2012A IN 2012DN01251 A IN2012DN01251 A IN 2012DN01251A
- Authority
- IN
- India
- Prior art keywords
- group
- integer
- hydrogen atom
- alkyl group
- alkynyl
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 abstract 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 abstract 1
- 125000004618 benzofuryl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Provided is a compound represented by the Formula (I) having a HER2 inhibitory action or a pharmacologically acceptable salt thereof, wherein T1 is a phenyl group, an indazolyl group, or a benzofuryl group, n is an integer of 0 to 3, R1 is a hydrogen atom, a halogen atom, a C1-4 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or a C1-4 alkoxy group, m is an integer of 0 to 3, R2 is a hydroxy group or a C1-4 alkyl group optionally substituted with one or two C1-4 alkoxy groups, and R3 is a hydrogen atom, a C1-4 alkyl group, or a C2-6 alkynyl group.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009175619 | 2009-07-28 | ||
| PCT/JP2010/062602 WO2011013656A1 (en) | 2009-07-28 | 2010-07-27 | Pyrrolo[2,3-d]pyrimidine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IN2012DN01251A true IN2012DN01251A (en) | 2015-05-15 |
Family
ID=43529310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IN1251DEN2012 IN2012DN01251A (en) | 2009-07-28 | 2010-07-27 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20120149902A1 (en) |
| EP (1) | EP2511276A4 (en) |
| JP (1) | JPWO2011013656A1 (en) |
| KR (1) | KR20120065321A (en) |
| CN (1) | CN102482281A (en) |
| AU (1) | AU2010279188A1 (en) |
| CA (1) | CA2768821A1 (en) |
| IN (1) | IN2012DN01251A (en) |
| TW (1) | TW201107328A (en) |
| WO (1) | WO2011013656A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837841A (en) * | 2012-09-26 | 2015-08-12 | 拜耳制药股份公司 | Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperproliferative diseases |
| WO2014048894A1 (en) | 2012-09-26 | 2014-04-03 | Bayer Pharma Aktiengesellschaft | Substituted indazol-pyrrolopyrimidines useful in the treatment of hyperfoliferative disorders |
| MX2018012797A (en) * | 2016-04-19 | 2020-01-09 | Univ California | Erbb inhibitors and uses thereof. |
| RU2019108464A (en) * | 2016-08-26 | 2020-09-28 | Мицубиси Танабе Фарма Корпорейшн | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC COMPOUND |
| CN113277990A (en) * | 2021-06-22 | 2021-08-20 | 仪征市海帆化工有限公司 | Synthesis method of 1, 4-bis (p-toluenesulfonyl) triazacyclononane |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE212993T1 (en) * | 1995-07-06 | 2002-02-15 | Novartis Erfind Verwalt Gmbh | PYROLOPYRIMIDINES AND METHOD FOR THE PRODUCTION THEREOF |
| GB9604361D0 (en) * | 1996-02-29 | 1996-05-01 | Pharmacia Spa | 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors |
| DK0938486T3 (en) * | 1996-08-23 | 2008-07-07 | Novartis Ag | Substituted pyrrolopyrimidines and methods for their preparation |
| GB0119249D0 (en) * | 2001-08-07 | 2001-10-03 | Novartis Ag | Organic compounds |
| TW200300350A (en) * | 2001-11-14 | 2003-06-01 | Bristol Myers Squibb Co | C-5 modified indazolylpyrrolotriazines |
| MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| DE602006004976D1 (en) * | 2005-03-28 | 2009-03-12 | Bristol Myers Squibb Co | COMPETITIVE ATP KINASE HEMMER |
-
2010
- 2010-07-27 EP EP10804402A patent/EP2511276A4/en not_active Withdrawn
- 2010-07-27 IN IN1251DEN2012 patent/IN2012DN01251A/en unknown
- 2010-07-27 CN CN2010800334905A patent/CN102482281A/en active Pending
- 2010-07-27 US US13/387,181 patent/US20120149902A1/en not_active Abandoned
- 2010-07-27 WO PCT/JP2010/062602 patent/WO2011013656A1/en active Application Filing
- 2010-07-27 AU AU2010279188A patent/AU2010279188A1/en not_active Abandoned
- 2010-07-27 JP JP2011524786A patent/JPWO2011013656A1/en not_active Ceased
- 2010-07-27 CA CA2768821A patent/CA2768821A1/en not_active Abandoned
- 2010-07-27 TW TW099124621A patent/TW201107328A/en unknown
- 2010-07-27 KR KR1020127003309A patent/KR20120065321A/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010279188A1 (en) | 2012-02-23 |
| KR20120065321A (en) | 2012-06-20 |
| EP2511276A1 (en) | 2012-10-17 |
| EP2511276A4 (en) | 2012-12-19 |
| US20120149902A1 (en) | 2012-06-14 |
| TW201107328A (en) | 2011-03-01 |
| CN102482281A (en) | 2012-05-30 |
| CA2768821A1 (en) | 2011-02-03 |
| JPWO2011013656A1 (en) | 2013-01-07 |
| WO2011013656A1 (en) | 2011-02-03 |
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