TW201105657A - Methods of treating PDNV and PONV with extended release ondansetron compositions - Google Patents
Methods of treating PDNV and PONV with extended release ondansetron compositions Download PDFInfo
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- TW201105657A TW201105657A TW099122021A TW99122021A TW201105657A TW 201105657 A TW201105657 A TW 201105657A TW 099122021 A TW099122021 A TW 099122021A TW 99122021 A TW99122021 A TW 99122021A TW 201105657 A TW201105657 A TW 201105657A
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- ondansetron
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- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
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- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
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Landscapes
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| US22321809P | 2009-07-06 | 2009-07-06 | |
| US12/688,493 US20110003005A1 (en) | 2009-07-06 | 2010-01-15 | Methods of Treating PDNV and PONV with Extended Release Ondansetron Compositions |
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| JP6250394B2 (ja) | 2010-08-19 | 2017-12-20 | バック・インスティテュート・フォー・リサーチ・オン・エイジング | 軽度の認知障害（ｍｃｉ）および関連障害の処置方法 |
| EP2814491A4 (en) * | 2012-02-18 | 2015-08-26 | Buck Inst For Res On Aging | FORMULATIONS AND METHODS FOR TREATING OR PROPHYLAXIS OF PRE-MCI AND / OR PRE-ALZHEIMER ILLNESSES |
| WO2014004126A1 (en) * | 2012-06-26 | 2014-01-03 | Fleming C Andrew | Treating postoperative nausea and vomiting |
| US9636305B2 (en) * | 2013-03-14 | 2017-05-02 | Redhill Biopharma Ltd. | Antiemetic extended release solid dosage forms |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| SG11201607511WA (en) * | 2014-03-11 | 2016-10-28 | Redhill Biopharma Ltd | Ondansetron extended release solid dosage forms for treating either nausea, vomiting or diarrhea symptoms |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
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| GB201618425D0 (en) * | 2016-11-01 | 2016-12-14 | Acacia Pharma Ltd | method |
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| DD146547A5 (de) * | 1978-07-15 | 1981-02-18 | Boehringer Sohn Ingelheim | Arzneimittel-retardform mit unloeslichen poroesen diffusionshuellen |
| IE48715B1 (en) * | 1978-12-22 | 1985-05-01 | Elan Corp Plc | New galencial forms for administration of medicaments by oral route,with programmed release and processes for preparing same |
| DE3000979A1 (de) * | 1980-01-12 | 1981-07-23 | Dr. Karl Thomae Gmbh, 7950 Biberach | Neue dipyridamol-retardformen und verfahren zu ihrer herstellung |
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| US4826688A (en) * | 1985-11-13 | 1989-05-02 | 501 Elan Corporation PLC. | Controlled absorption pharmaceutical formulation |
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| IE58401B1 (en) * | 1986-06-20 | 1993-09-08 | Elan Corp Plc | Controlled absorption pharmaceutical composition |
| DE3627423A1 (de) * | 1986-08-13 | 1988-02-18 | Thomae Gmbh Dr K | Arzneimittel enthaltend dipyridamol oder mopidamol und o-acetylsalicylsaeure bzw. deren physiologisch vertraegliche salze, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung der thrombusbildung |
| EP0585355B1 (en) * | 1991-05-20 | 1995-03-22 | Marion Laboratories, Inc. | Multi-layered controlled release formulation |
| US5464632C1 (en) * | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| US5837284A (en) * | 1995-12-04 | 1998-11-17 | Mehta; Atul M. | Delivery of multiple doses of medications |
| US5705190A (en) * | 1995-12-19 | 1998-01-06 | Abbott Laboratories | Controlled release formulation for poorly soluble basic drugs |
| US5840329A (en) * | 1997-05-15 | 1998-11-24 | Bioadvances Llc | Pulsatile drug delivery system |
| CA2322315C (en) * | 1998-03-06 | 2008-09-16 | Eurand International S.P.A. | Fast disintegrating tablets |
| US6602521B1 (en) * | 1998-09-29 | 2003-08-05 | Impax Pharmaceuticals, Inc. | Multiplex drug delivery system suitable for oral administration |
| EP1126826B3 (en) * | 1998-11-02 | 2019-05-15 | Alkermes Pharma Ireland Limited | Multiparticulate modified release composition of methylphenidate |
| US6383471B1 (en) * | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
| US6936275B2 (en) * | 1999-12-20 | 2005-08-30 | Scolr, Inc. | Amino acid modulated extended release dosage form |
| CN1404388A (zh) * | 2000-01-20 | 2003-03-19 | 德尔西斯药品公司 | 多级药物剂型 |
| US6627223B2 (en) * | 2000-02-11 | 2003-09-30 | Eurand Pharmaceuticals Ltd. | Timed pulsatile drug delivery systems |
| US6500457B1 (en) * | 2000-08-14 | 2002-12-31 | Peirce Management, Llc | Oral pharmaceutical dosage forms for pulsatile delivery of an antiarrhythmic agent |
| PT1405621E (pt) * | 2001-06-20 | 2011-05-31 | Takeda Pharmaceutical | Processo de prepara??o de comprimidos |
| DE10149674A1 (de) * | 2001-10-09 | 2003-04-24 | Apogepha Arzneimittel Gmbh | Orale Darreichungsformen für Propiverin oder seinen pharmazeutisch annehmbaren Salzen mit verlängerter Wirkstoffreisetzung |
| US20040019096A1 (en) * | 2001-10-23 | 2004-01-29 | Vlassios Andronis | Novel formulations of carvedilol |
| US6663888B2 (en) * | 2001-12-14 | 2003-12-16 | Eurand Pharmaceuticals Ltd. | Pulsatile release histamine H2 antagonist dosage form |
| TWI355936B (en) * | 2003-02-18 | 2012-01-11 | Helsinn Healthcare Sa | Uses of palonosetron hydrochloride |
| US20040265375A1 (en) * | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| US8545881B2 (en) * | 2004-04-19 | 2013-10-01 | Eurand Pharmaceuticals, Ltd. | Orally disintegrating tablets and methods of manufacture |
| CA2579767A1 (en) * | 2004-04-30 | 2005-11-10 | Astellas Pharma Inc. | Oral pharmaceutical composition in timed-release particle form and fast-disintegrating tablets containing this composition |
| US20060280795A1 (en) * | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
| CA2635313C (en) * | 2005-12-29 | 2013-12-31 | Osmotica Corp. | Triple combination release multi-layered tablet |
| RU2428176C2 (ru) * | 2006-01-27 | 2011-09-10 | Юранд, Инк. | Системы доставки лекарственного средства, содержащие слабоосновные лекарственные средства и органические кислоты |
| CN103211779B (zh) * | 2006-01-27 | 2016-03-16 | 阿代尔制药股份有限公司 | 包含弱碱性选择性5-羟色胺5-ht3阻断剂和有机酸的药物递送系统 |
| CN101573106B (zh) * | 2006-10-24 | 2013-07-24 | 赫尔辛医疗股份公司 | 具有改进的稳定性和生物利用度的含帕洛司琼盐酸盐的软胶囊剂 |
| US8133506B2 (en) * | 2008-03-12 | 2012-03-13 | Aptalis Pharmatech, Inc. | Drug delivery systems comprising weakly basic drugs and organic acids |
-
2010
- 2010-01-15 US US12/688,493 patent/US20110003005A1/en not_active Abandoned
- 2010-07-02 EP EP10797661A patent/EP2451276A4/en not_active Withdrawn
- 2010-07-02 BR BR112012000095A patent/BR112012000095A2/pt not_active IP Right Cessation
- 2010-07-02 WO PCT/US2010/040868 patent/WO2011005671A1/en not_active Ceased
- 2010-07-02 JP JP2012519612A patent/JP2012532194A/ja active Pending
- 2010-07-05 TW TW099122021A patent/TW201105657A/zh unknown
- 2010-07-06 AR ARP100102430A patent/AR077394A1/es unknown
- 2010-07-07 UY UY0001032767A patent/UY32767A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BR112012000095A2 (pt) | 2017-06-13 |
| EP2451276A4 (en) | 2012-12-19 |
| WO2011005671A1 (en) | 2011-01-13 |
| AR077394A1 (es) | 2011-08-24 |
| UY32767A (es) | 2010-12-31 |
| JP2012532194A (ja) | 2012-12-13 |
| US20110003005A1 (en) | 2011-01-06 |
| EP2451276A1 (en) | 2012-05-16 |
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