TW201041602A - Oil gelling agent, composition containing oil gelling agent, and external preparation or cosmetic for skin - Google Patents

Abstract

Provided is an oil gelling agent capable of forming a gel that is highly stable and highly transparent by the addition thereof in a small amount to a nonpolar or low-polarity oil-based preparation. The oil gelling agent is produced by mixing a 1,2-bis(acylamino)cyclohexane derivative wherein the acyl segment is a linear alkyl group having 15 to 21 carbons, and a bis(acylamino)cyclohexane derivative wherein the acyl segment is a linear alkyl group having a total number of carbons of 15 to 21 and a linear alkyl group as a substituent group at position 1.

Description

201041602 VI. Description of the Invention: [Technical Field] The present invention relates to a bis(indenylamino)cyclohexane derivative containing a linear alkyl group, and a bis(indenylamine) having a branched alkyl group. An oil gelling agent of a cyclohexane derivative, an oil gel composition containing the oil gelling agent, and a cosmetic or skin external preparation to which the oil gel composition is added. [Prior Art] In the field of cosmetics, it is a liquid or solid oily cosmetic base at room temperature! (: From the agent) at the time of cosmetics' a. The shape of the cosmetics is increased and the usability is improved. The oil gelling agent is added to the gelled gel composition and then added to the cosmetic. In order to control the dryness or constructability of the oil agent to improve the usability and enhance the stability or feeling of use of the oil-containing agent during makeup, the gelling agent plays an important role as the 'oil gel added to the soot. The chemical agent is used to make the dextrin fat, such as the oily acid vinegar and the base stearic acid, and the H # (4) is used for the oil gel composition of the (four) product. When used as an oil gelling agent, 'oil gelTM turbidity = at the concentration of forming an ampoule. In addition, there will be an uncomfortable situation when the dextrin fatty acid is widely used in cosmetics. The oil gel group of the oil gel: as an oil gelling agent When used, it can be formed to be easy to soften, etc., but it is based on the necessity of mixing at a high concentration, and at a high temperature, when it is mixed with cosmetics, there is no 146883.doc 201041602. Furthermore, when 12-hydroxystearic acid is used as the oil gelling agent, the type of gelling agent can be made small, and even if gelatinizable, the obtained gel composition is only a coarse gelatinous form. There are still some shortcomings in usability. On the other hand, a composition of a pharmaceutical, a cosmetic, a food, or the like containing a bis(arginylamino)cyclohexane derivative has been proposed by the prior art for a diamine-based cyclohexane derivative (see Patent Document 1). An organic liquid gelled or an organic compound in which one or two or more kinds of a straight amine bond having a carbon number of 6 to 22 and/or one or more of the branched fatty acids are used as an active ingredient A curing agent has also been proposed by the manufacturer (see Patent Document 2). [Provisions of the Invention] [Patent Document 1] Japanese Laid-Open Patent Publication No. Hei No. Hei. No. Hei. No. Hei. An oil gelling agent which forms a gel having high stability and high transparency by mixing in a small amount in a non-polar or low-polarity oil agent. [Means for Solving the Problem] In order to solve the above problems, the inventors have continued to research and develop the 1,2-bis(indenylamino) ring having a linear alkyl group having a carbon number of 15 to 21 in the thiol moiety. The hexane derivative and the fluorenyl moiety are a linear alkyl group having a total carbon number of 15 to 2 1, and the linear alkyl group has a linear alkyl group as a substituent at the 丨_ position 146883.doc 201041602 Ο Ο An oil gelling agent prepared by mixing a 1,2-bis(decylamino)cyclohexane derivative, respectively, when added to an oil agent, even if added to the previous oil gelling agent Compared with the low concentration, the transparency is also high, and the stability is also good, and a gel suitable for mixing in cosmetics can be formed. Further, when the brewing base portion has a linear group of a carbon number b to 21, the u•bis(hydro-amino)cyclohexane derivative is used as an oil gelling agent alone, and the oil gel composition is cloudy. When the bismuth (bromoamino)cyclohexyl derivative containing a carbon number of 8 in the brewing base is contained in the oil gelling agent, the dissolution temperature is extremely increased, and then 'i In the 2-bis(decylamino)cyclohexane derivative, the cyclohexane ring & (4) thiol moiety '#中—is a straight bond and the other side is a branch, confirming that the gel composition will be cloudy Or the dissolution temperature is increased, and it may be uncomfortable when mixed with cosmetics. The present invention has been completed based on the above knowledge and insights. Specifically, the present invention relates to the following. (1) An oil gelling agent comprising (4): a bis(stylamino)cyclohexane derivative of the formula (1):

...(I

Ah (wherein R, a linear alkyl group having a carbon number of 15 to 21); and (B): a bis(arginylamino)cyclohexane derivative represented by the formula (II). 146883.doc 201041602

(ID (wherein R 2 represents a linear alkyl group having a total order of 15 to 21 and a linear alkyl group as a substituent at the i_ position); or [2] an oil of the above [1] a gelling agent, wherein (A): (B) has a mass ratio of 8 〇: 20 to 20: 80; or [3] an oil gel composition containing the above π] or [2] oil a gelling agent and an oil agent; or [4] an oil gel composition according to [3] above, wherein the oil agent contains a branched polystyrene; or an oil gel of the above [4] a composition wherein the branched polyolefin is hydrogenated polyisobutylene; or [6] - seeded H is characterized by comprising an oil gelling agent as described in (1) or [2] above, or the above [3] An oil gel composition according to any one of [5]; or [7] an external preparation for skin characterized by containing an oil gelling agent such as the above [丨] or [2], or the above [ [Embodiment of the Invention] [Embodiment of the Invention] (An oil gelling agent) The oil gelling agent of the present invention is contained as long as it contains (A) : bis(indenylamino)cyclohexane derivative represented by the above formula (1) 146883.doc 201041602 One or more of the substances (wherein, in the formula (I), 'h represents a linear alkyl group having a carbon number of 15 to 21), and (B): a bis(indenylamino group) represented by the above formula (II) One or two kinds of cyclohexane derivatives, wherein (in the formula (II), R 2 represents a linear carbon group having a total carbon number of 15 to 21 and a linear alkyl group at the oxime position as a substituent. However, there is no particular limitation, but it is preferable to use one type of the above (A) and (B). Further, in the present invention, the Ri of the formula (I) and the formula (II) are respectively the same. The oil gelling agent of the present invention contains not only the oil gelling agents of the above (A) and (B), but also other components as long as they do not interfere with the effects of (A) and (B). In the case of the above-mentioned formula (1), Ri "the linear alkyl group having a carbon number of 15 to 21", specifically, a pentadecyl group, a hexadecyl group or a heptadecyl group is exemplified. , octadecyl, decyl, decyl, fluorenyl. R2 of the above formula (II) has a total carbon number of 15 to 21 and a linear alkyl group as a substituent at the 丨_ position. Straight alkane ", refers to the 丨 位 position of the main chain of the linear chain, that is, the carbon atom bonded to the carbonyl group is substituted with a linear alkyl group, which is an alkyl group having a total carbon number of 15 to 21. The total carbon number is 15 to 21, and a linear alkyl group having a linear alkyl group as a substituent at the 丨_ position, specifically, for example, 丨-methyltetradecyl, 1-decylpentadecyl, 1-methyl Hexadecyl, methylhexadecyl, 1-decyloctadecyl, 1-methylundecyl, 丨-methyldecyl, 1-ethyldodecyl, 1-ethyl Tetradecyl, 丨-ethylpentadecyl, 1-ethylhexadecyl, 1-ethylhexadecyl, oxime ethyl octadecyl, 1-ethylundecyl, 1-propyldodecyl, anthracenyltridecyl, 1-propyltetradecyl, 1·propylpentadecyl, i•propylhexadecane 146883.doc 201041602 base, propyl propyl Heptadecyl, 1-propyl octadecyl, 丨-butylundecyl, 1-butyldodecyl, 1-butyltridecyl, dibutyltetradecyl, 1-butyl Pentadecyl, 1-butylhexadecyl, 丨-butylheptadecyl, 1-pentyldecyl, 1-pentyldec-alkyl, pentyl Dialkyl, pentyltridecyl, 1-pentyltetradecyl, pentylpentadecyl, decylpentadecyl, 1-hexyldecyl, 丨-hexyldecyl, Hexylundecyl, 1-hexyldodecyl,hexyltridecyl,decyltetradecyl, 1-hexylpentadecyl, 1-heptyloctyl, fluorenyl-heptyldecyl, anthracene Heptyl fluorenyl, 1-heptylundecyl, 1-heptyldodecyl, phenylheptyltridecyl, 1-heptyltetradecyl, 1-octyloctyl, fluorenyl-octyl fluorenyl,丨_octyl decyl, 1-octylundecyl, 1-octyldodecyl,octyltridecyl, 1-indenyl, 1-indenyl, phenyl Alkyl, fluorenyl undecyl, 1-mercaptoalkyl ' 1-indenyl---hospital base, and the like. The oil gelling agent of the present invention forms a three-dimensional network structure such as a mesh or a fiber in an oil agent by molecular association by being added to an oil agent, and retains oil molecules and the like in the mesh. It is presumed that it is a composition which can solidify (gelatinize) a liquid oil. Further, other optional components may be contained as long as the effects of the present invention are not impaired. As a method for synthesizing the bis(indenylamino)cyclohexane derivative represented by the above formula (I), a synthetic method may be exemplified by the following conventional methods: hydrazine, 2-diaminocyclohexane, and A method for appropriately arranging an acid dentate obtained by treating a linear saturated fatty acid having a carbon number of 16 to 22 with a sulfonate or the like, or condensing it in the presence of a base; or 1 > 2 - diamine Cyclohexane and a suitably selected linear saturated fatty acid having a carbon number of 16 to 22, if necessary, in the presence of a catalyst such as tin, nickel or the like of a metal such as 146883.doc 201041602, from 1 〇〇 to 250 °c A chemical method for the amidation reaction or the like of a dehydration reaction of about 5 to 20 hours. Then, the products of these reactions can be purified by a purification means including a conventional method such as recrystallization or chromatography. As the above hydrazine, 2-diaminocyclohexene can be a trans-1,2-diaminocyclohexane or a cis-diaminocyclohexane, but a trans-1,2-diamino group. Cyclohexane is preferred. Examples of the linear saturated fatty acid described above include palmitic acid (palmitoic acid), heptadecanoic acid (peric acid), octadecanoic acid (stearic acid), nonadecinal acid, and saponin (fine). Amino acid), decanoic acid, behenic acid (decanoic acid). The method for synthesizing the bis(indenylamino)cyclohexane derivative represented by the above formula (II) includes: hydrazine, 2-diaminocyclohexane, and a carbon number appropriately selected A conventional synthesis method such as the above-described chemical method in which a saturated fatty acid having a linear alkyl group as a substituent is reacted at a 2-position and a 2-position is used. The above 1,2-diaminocyclohexane may be trans-152-diaminocyclohexane or cis-1,2-diaminocyclohexane, but preferably anti-丨, 2_diaminocyclohexane. As the saturated fatty acid having a linear alkyl group as a substituent at the 2-position, specifically, 2-methylhexadecanoic acid, 2-methylhexadecanoic acid, and 2-methylhexadecane are exemplified. Alkanoic acid, 2-methyloctadecanoic acid, 2-methylundecanoic acid, 2-methyldecanoic acid, 2-methyl-decanoic acid, 2•ethyltetradecanoic acid, 2_B Heptadecanoic acid, 2-ethylhexadecanoic acid, 2-ethylheptadecanoic acid, 2-ethyloctadecanoic acid, 2-ethylpentadecanoic acid, 2-ethyl decanoic acid, 2-propyldodecanoic acid, 2-propyl myladyric acid, 2-propylheptadecanoic acid, 2-propylhexadecanoic acid, 2-propylhexadecanoic acid, 2·propyl ten Octaic acid, 2-propyl 19, 146883.doc 201041602 Alkanoic acid, 2-butyldodecanoic acid, 2-butyl heptadecanoic acid, acid, 2-butyloctadecanoic acid, acid, 2 -pentyl tridecanoic acid, acid, 2-pentyl palmitic acid, 2-butyltridecanoic acid, 2-butyltetradecane 2-butylhexadecanoic acid, 2-butylheptadecane 2-pentyl undecanoic acid, 2-pentyldodecane 2-pentyltetradecanoic acid, 2-pentyl heptadecane 2-pentyl succinyl acid, 2-hexyl decanoic acid, 2-hexyl Decanoic acid, 2-hexyldodecane Acid, 2-hexyltridecanoic acid, 2-hexyltetradecanoic acid, 2-hexylpyranomic acid, 2-hexylhexadecanoic acid, 2-heptyldecanoic acid, heptyl money, 2-heptyl ten - Lai, 2_heptyl dodecanoic acid, 2-heptyltridecanoic acid, 2-heptyltetradecanoic acid, 2-heptyl heptadecanoic acid, 2-octyloctanoic acid, 2-octyldecanoic acid, 2 _octyl decanoic acid, octyloctanodecanoic acid, 2-octyldodecanoic acid, 2-octyltridecanoic acid, 2-octyltetradecanoic acid, decyl decanoic acid, 2-hydrazine Base acid, 2-mercaptundecanoic acid, 2-decyl dodecanoic acid, 2-decyltridecanoic acid, 2-mercaptodecanoic acid, 2-nonyl undecanoic acid, dimercapto Dodecanoic acid, 2-undecylundecanoic acid, and the like. (A) in the oil gelling agent of the present invention: a bis(indenylamino)cyclohexane derivative represented by the above formula (1), and (B): a bis(indenyl group) represented by the above formula (11) Base) The mass ratio of the cyclohexane derivative is not particularly limited and should be called. 20~20: 80, more preferably 60: 4〇~2〇: 8〇. When the ratio of the bis(arginylamino)cyclohexane derivative represented by the formula (1) exceeds 80% by mass, the oil gelling agent of the present invention has high crystallinity, is too hard, or has a markedly lowered transparency. Possibility, if it is less than 20% by mass, there is a significant decrease in gel hardness: energy. _ (oily gel composition) containing the above oil gelling agent and oil The oily gel composition of the present invention 146883.doc -10- 201041602 agent. Examples of the oil agent include the following: liquid hydrocarbons such as fluid paraffin, squalane, squalene, polybutene, and hydrogenated polyisobutylene; fatty acids such as palmitic acid, oleic acid, and stearic acid; Zhongyou linseed oil, almond oil, sesame oil, coffee oil, vegetable oil, eucalyptus oil, corn oil, castor oil, safflower oil, sunflower oil, cotton oil, jojoba oil, hawaiian soybean oil, Vegetable oils such as wheat germ oil, soybean oil, groundnut oil, coconut oil, palm oil, palm kernel oil, oyster sauce, evening primrose oil; animal oils such as oyster sauce, fish oil, lard, tallow, etc.; Butyl ester, 2-hexyl decyl adipate, di-2-heptyl undecyl adipate, N-alkyl glycol monoisostearate, isohexadecyl isostearate, three Trimethylolpropane isostearate, hexadecyl 2-ethylhexanoate, ethylene glycol di-2-ethylhexanoate, neopentyl glycol di-2-ethylhexanoate, three 2 -ethylhexanoic acid glyceride, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum , oleic acid oil ester, octyl dodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, amyl acetate, ethyl acetate , butyl acetate, isohexadecyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, lactic acid Ester, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesterol vinegar of 12-hydroxystearic acid, dipentaerythritol fatty acid vinegar , meat, vinegar, vinegar, meat 146883.doc 11 201041602 i: 2-octyl dodecanoate, 2, hexyl decyl citrate, meat citrate, dimethyl Arginic acid hexyl decyl phthalate, ethyl laurate, hexyl laurate, N-lauroside _L_glutamic acid _2 octyl dodecyl ester, malic acid diisostearyl s vinegar; Polyoxyalkylene, methylphenyl polyoxyalkylene, methyl hydrogenated polyoxyalkylene, octamethylcyclotetraoxane, decamethylcyclopentanoxane, dodecamethylcyclohexaoxane , tetramethyltetrahydrocyclotetraoxane, fluorine modification Etc. Silicon alumoxane silicon ketone; perfluorodecane, perfluorooctane, perfluoro polyether and the like of the fluorine-based oil and the like. In order to increase the hardness or transparency of the gel, it is preferable to mix the polyalkylene having a branched chain. Specifically, (C7, 8) isoparaffin, (C8, 9) isochain hydrocarbon, (C9_ll) ) isoparaffin, (cl〇-13) isoparaffin, (C11, 12) iso-chain roast, (Cll-l3) isoparaffin, (C13, 14) isoparaffin, (cm3) iso-chain, (C18_7G) an isochain hydrocarbon such as an isochain hydrocarbon, an olefin oligomer: a hydrogenated C6-14 binding polymer, a polybutene, a hydrogenated polyisobutylene, a gas-concentrating woman, etc. It is preferred to use a V-butylated polyisobutylene or a hydrogenated C6-14 dilute hydrocarbon polymer for transparency or adhesion of the gel. These oil agents may be used alone or in combination of two or more. The method for preparing the oil-based gel composition may be a method in which the above-mentioned (A) and (8) are mixed with the oil agent and then heated to a uniform state or a mixture of the above (A) and (B) is prepared. After the oil gelling agent is added to the heated oil agent, it is mixed and divided into a state of uniformity, and the method is allowed to stand at normal temperature. 146883.doc 12 201041602 Both of the above (A) and (B) are exemplified by the fact that the oily gel composition of the present invention can be prepared by mixing any components as necessary. In the preparation of the oil-based gel composition of the present invention, the amount of the oil gelling agent to be added to the oil agent is not particularly limited, but is preferably 0.01 to 20% by mass, more preferably the total amount of the oil-based gel composition. It is 11 to 15% by mass. Examples of the above-mentioned mixing and dispersing machine include a dispersing mixer, a rolling mill high-viscosity mixer, a universal mixer, and a Hanschel mixer. As the use of the oil-based gel composition of the present invention, cosmetics, skin external use, paints, inks, lubricating oils, etc. are preferred as cosmetics (including slow-acting drugs); as a mixture of the oil-based gel compositions of the present invention Cosmetics, such as lipstick, pearl lipstick, lip balm, lip makeup, oily foundation, oily water and oily emulsion liquid foundation, eye shadow, eyeliner, mascara, etc. Hair care products such as cosmetics, nail coatings, hair care products such as moisturizing essence, moisturizing lotion, hair care cream, hair wax, hair lotion, hair oil, hair cream, etc., lotion, nipple cream, A skin care cosmetic such as a cosmetic liquid, a cosmetic oil, a facial mask, and the like, and a skin external preparation, a preferred embodiment is a suppository, an oily water type, and an oily type emulsified skin external preparation, a lipid preparation, a liposome preparation, and the like. • The above-mentioned oil gel-like composition in the cosmetic or skin external preparation of the present invention has no special limit of $, and the total amount of the cosmetic or skin external sputum is preferably 〇.01 to 100% by mass. More preferably, it is 1 to 99.5 mass%. In the cosmetic or skin external preparation of the present invention, in addition to the above (4) or (B) or the oil agent, the components used in cosmetics, skin external preparations and the like can be appropriately mixed, for example, within the range which does not impair the effects of the present invention, for example. Alcohol, 146883.doc 201041602: Agent: gelling agent, powder, UV absorber, preservative, antibacterial anti-oxidant, pH adjuster, skin care ingredients, topical agents, etc. as: ingredients. These components may be mixed with S in the preparation of the above oil gel-like composition or may be mixed in a gelling agent. The hydrazine is, for example, a lower alcohol such as ethanol 'isopropyl alcohol or a propanol, a diglycerin, a polyglycerol, a diethylene glycol, a polyethylene glycol, a propylene glycol, or a stone β. 1-propanol, polypropylene glycol, 1,3-butanediol, pentaerythritol & alcohol 'sorbitol, maltose, xylitol, reduced maltitol, or cholesterol, sitosterol phytosterol, wool Sterols such as sterols. The humectant may, for example, be urea, hyaluronic acid, chondroitin sulfate, or pyrrolidone carboxylate. The gelling agent is not particularly limited as long as it is an aqueous condensing agent or an oily gelling agent, and for example, as an aqueous gelling agent, gum arabic, tragacanth, and galactose are exemplified. Poly, locust bean gum, guar gum, caramel gum, vegetable gum, pectin, agar, queen seed (from photo, etc.), starch (from rice 'corn, horse, potato, wheat, etc. Plant polymers such as seaweed, tolan gum, and locust bean gum; microbial rain molecules such as xanthan gum, dextran, succinate, and pullulan; collagen, road Protein, albumin, Ming Yue and other mobile molecules; sulfhydryl starch, methyl propyl powder, etc., powdered polymer. Methylcellulose, propylmethylcellulose, 竣methylcellulose , cellulose-based polymer such as methyl cellulose, ethyl cellulose, propyl cellulose, sodium cellulose sulfate, methyl cellulose, etc.; sodium alginate, sodium alginate 146883.doc - 14· 201041602 Alginic acid polymer such as alcoholic vinegar; sodium polyacrylate, carboxyvinyl polymer, alkyl Ethylene-based polymer such as styrene-based polymer, polypropylene-branched amine, polyvinyl alcohol, polyvinylpyrrolidone; polyethylene glycol 'ethylene oxide propylene oxide copolymer, bentonite, strontium Examples of the powders include inorganic powders, organic powders, metal soap powders, colored pigments, pearlescent pigments, and metals. Powder, tar pigment, 天然 natural pigment, etc., regardless of particle shape (spherical, needle, plate, etc.), particle size (smoke, fine particles, pigment grade, etc.), or particle structure (porous, non-porous, etc.) These powders may be used as they are, or may be used in combination of two or more kinds of powders, or may be subjected to surface treatment with an oil agent, an anthrone compound, a fluorine compound or the like. For example, a benzoic acid-based ultraviolet absorber such as _aminobenzoic acid or an o-aminobenzoic acid-based ultraviolet absorber such as o-aminobenzoic acid methyl ester or a salicylic acid-based violet such as methyl salicylate. 〇External absorbent, or methoxy cinnabar A cinnamic acid-based ultraviolet absorber such as octyl octanoate or a benzophenone-based ultraviolet absorber such as 2,4-dihydroxybenzophenone or a urinary acid-based ultraviolet absorber such as ethyl urate or the like. Or an antibacterial agent, for example, p-hydroxybenzoic acid. Sm, benzoic acid, sodium citrate, sorbic acid, potassium sorbate, phenoxyethanol, salicylic acid, carbolic acid, sorbic acid, spirulina Phenol, six-gas phenol, dimercapto fluorenyl-based gasification recorded 'Croxixi bite, three gas carbon aniline, photoreceptor, isopropyl methyl phenol, i, 2_ decane diol and so on. As the antioxidant (IV), for example, lactic acid, lactate, and the like, for example, lactic acid, lactate, and the like, such as lactic acid, lactate, and the like, may be mentioned, for example, a raw material, a butyl group, a butyl group, a 146883.doc 15 201041602 ether, or a dibutyl hydroxytoluene. Citric acid, citrate glycolic acid, succinic acid, tartaric acid, malic acid, potassium carbonate, sodium hydrogencarbonate, hydrogen carbonate, and the like. As a skin-beautifying ingredient, for example, arbutin, sputum, and stalks of the stalks, and the like, and the cell stimulating agent such as royal jelly, photoreceptor, cholesterol derivative, and burdock blood extract are mentioned. ·Skin roughness improver; citric acid vanain, acid vinegar, acid beta-butoxyacetic acid, capsaicin, sulphuric acid, fish fat, caffeine, tannic acid, α_bicyclosene, smoke Acid tocopherol ester, (iv) nicotinic acid ester, cyclomandelic acid ester, cinnamylphenidate: 卞 卞 、 、, 乙 胆 验 、, verapamil, ginseng, oryzanol, etc., zinc oxide, tannic acid Such as skin astringent; anti-lipid leakage agent such as sulfur, methyl mercaptan and the like. The form of the cosmetic or external preparation for skin of the present invention may, for example, be a cream, a gel, a liquid, a solid, or a multilayer; and the formulation of the cosmetic or external preparation for skin of the present invention may be an oily system. , oil-based emulsification system, oil-based emulsion system, solvent system, etc. Hereinafter, the present invention will be specifically described by way of examples, but the technical scope of the present invention is not limited by the examples. [Examples] (Reference Example: Synthesis of 1,2-bis(decylamino)cyclohexane derivative) [Synthesis of Compound (1)] Anthracene, 2·diaminocyclohexane 3.43 g and three Ethylamine 7.29 g was dissolved in 13 〇 mL 2 146883.doc 201041602 tetrahydro sulphate D South (hereinafter referred to as THF), and 16.60 g of sixteen carbon carbon was added under ice cooling. Stir at room temperature for 1 hour, followed by heating for several minutes. Then, 100 mL of acetone was added, and the insoluble matter was collected by filtration and washed with acetone. The obtained compound was immediately dissolved in 100 mL of ethanol and allowed to stand for cooling, and 300 mL of water was added thereto, and the insoluble matter was collected by filtration. After washing with acetone and drying, the obtained crude product was heated and dissolved in 150 mL of ethanol, and then 400 mL of acetone was added thereto, and the white precipitate was collected by filtration to obtain a compound represented by the following formula (III). (1); the yield is 12.91 g : 〇 compound (1)

[Synthesis of Compound (2)] 3.43 g of 1,2-diaminocyclohexane and 7.29 g of triethylamine were dissolved in 130 mL of Q THF, and 21 g of stearyl chloride was added thereto under ice cooling. After stirring at room temperature for 1 hour, it was heated to reflux for several minutes. Then, 1 〇 0 mL of acetone was added and the insoluble matter was filtered off and washed with acetone. The obtained compound was immediately dissolved in 100 mL of ethanol and allowed to stand for cooling, and then 300 mL of water was added to take insoluble matter. After washing with acetone and drying, the obtained crude product was heated and dissolved in 150 mL of ethanol, and 150 mL of acetone was added thereto to obtain a white precipitate, and the following formula (IV) was obtained. Compound (2); yield: 11.5 g: 146883.doc 17 (;V) (;V)201041602 Compound (2)

[Synthesis of Compound (3)] 11.42 g of 1,2-diaminocyclohexane and 24.29 g of triethylamine were dissolved in 250 mL of THF, and 54.98 g of 2-hexylindole chloride was added under ice cooling. After stirring at room temperature for 1 hour, it was heated to reflux for several minutes. After distilling off the THF with an evaporator, 100 mL of acetone was added and the insoluble material was filtered and washed with acetone. The obtained compound was immediately dissolved in 1 mL of ethanol and allowed to stand for cooling, and then 300 ml of water was added thereto, and the insoluble matter was collected by filtration. Thereafter, it was washed with acetone, and after drying, the obtained crude product was recrystallized from 400 mL of acetone, and the white precipitate was collected by filtration to obtain the compound (3) represented by the following formula (V); the yield was 43.14. g : compound (3)

[Synthesis of Compound (4)] 1.23 g of 1,2-diaminocyclohexane and 7.29 g of triethylamine were dissolved in 130 mL of 146883.doc -18- 201041602 THF, and added under ice cooling, 2 - Heptyl eleven carbon helium gas 18.18 g. After stirring at room temperature for 1 hour, it was heated to reflux for several minutes. After distilling off the THF by an evaporator, 100 mL of acetone was added, and the insoluble matter was collected by filtration, and then washed with acetone. Then, the obtained compound was immediately dissolved in 100 mL of ethanol and allowed to stand for cooling, and then 300 ml of water was added to extract an insoluble matter. After that, it was washed with acetone, and after drying, the obtained crude product was recrystallized from 400 mL of acetone, and the white precipitate was collected by filtration to obtain the compound (4) represented by the following formula (VI); 10.81 g : ❹ compound (4)

[Synthesis of Compound (5)] 3.43 g of 1,2-diaminocyclohexane and 7.29 g of triethylamine were dissolved in 130 mL of THF, and 2-(2-mercapto-4) was added under ice cooling. 4-dimethylpentyl)-4-methyl-6,6-dimethylglyoxime chloride 18.18 g. After stirring at room temperature for 1 hour, it was heated to reflux for several minutes. Then, 100 mL of acetone was added, and the insoluble matter was removed by filtration, and the filtrate was distilled off with an evaporator, and then recrystallized from 50 mL of acetone, and the white precipitate was collected by filtration to obtain the following formula (VII). Compound (5); Yield: 6.42 g: 146883.doc -19- • · (VII) 201041602 Compound (5)

[Synthesis of Compound (6)] 1.57 g of 1,2-diaminocyclohexane and 16.70 g of triethylamine were dissolved in 400 mL of THF, and under ice cooling, isostearyl chloride (corundum type) 42.44 was added. g. After stirring at room temperature for 1 hour, it was heated to reflux for several minutes. Then, 300 mL of acetone was added, and the insoluble matter was removed by filtration. After the filtrate was distilled off by an evaporator, it was recrystallized from 300 mL of acetone to obtain 40 g of a crude product. Then, it was dissolved in 50 mL of hot ethanol, and then 200 mL of acetone was added for recrystallization, and the white precipitate was collected by filtration to obtain the compound (6) represented by the following formula (VIII); the yield was 34.5 g. : Compound (6)

(VIII) Here, the silicon carbide type isostearic acid means that the carbon number obtained by hydrogenation of the by-produced unsaturated fatty acid when synthesizing the dibasic acid from oleic acid is 18, and the side chain has 146883.doc -20- 201041602 Isostearic acid with a methyl group and a structural uncertainty. Isostearyl helium (diamond type) refers to a vapor of the above isostearic acid. [Synthesis of Compound (7)] 11.42 g of 込2·diaminocyclohexane and 24.28 g of triethylamine were dissolved in 150 mL of THF. Under ice cooling, 32.53 g of 2-ethylhexyl hexane was added. After 3 hours of scramble at room temperature, it was heated to reflux for several minutes. After cooling to room temperature, the resulting gel was suction filtered. Then, the obtained compound was dissolved in 200 mL of ethanol, and 3 mL of water was added thereto, and the insoluble matter was collected by filtration. Then, the obtained crude product is heated and dissolved in methanol of 丨〇〇mL, and then 600 mL of acetone is added to recrystallize it, and the white precipitated portion is collected by filtration to obtain the following formula (IX). Compound (7); yield is 15.15 g 0 compound (7)

[Preparation of mixture (1) (mixture of compounds (2), (7) and (8)]

1,5 - Fine base % burned 8.57 g and trihexylamine 16.70 g were dissolved in 400 mL of THF. Under ice cooling, 12.20 g of 2-ethylhexyl oxime and 21.10 g of hard fat-brewed chlorine were added. After stirring at room temperature for 1 hour, it was heated under reflux for several minutes. Thereafter, 300 mL of acetone was added, and the insoluble matter was collected by filtration and washed with propylene 146883.doc • 21 · 201041602. Then, it was dissolved in 100 mL of ethanol and left to cool, then 300 mL of water was added and filtered, washed with acetone and dried. The obtained crude product was recrystallized from 400 mL of acetone, and a white solid fraction was collected by filtration to obtain a compound. This compound is a mixture of the compound (8) represented by the following formula (χ) and the above compound (2) and (7); the yield is 1〇81 g : the compound (8)

[Example 1] (Oil-based gel composition for cosmetics: ^ Using the compounds (1) to (7) and the mixture (1) synthesized and produced in the above manner, the sample of the composition shown in Table 1 was prepared. #丄〜# 2 and Comparative Example Sample #1~#8 Oil (4) The sample of the composition. After the full amount of each sample is measured, the - surface is stirred and the surface is heated and dissolved. After dissolution, the solution is cooled and the coating 70 is used to achieve the dissolution temperature and condensation. Glue appearance, gel formation, gel hard!! Evaluation. The dissolution temperature is obtained by mixing the constituents of each sample, and gradually increasing the temperature from room temperature, 'visually judges that each oil gel composition sample dissolves into a transparent one. The temperature at the time of the gel. The gel appearance was obtained by filling each of the above-mentioned samples of the oil gel composition with a single 兀 (10) length of the polymethyl methacrylate resin: when the single 兀 could not be read, the character of the Century 12-character was judged as White turbidity, although it is turbid, it can be judged as "translucent" when it is judged. Almost 146883.doc •22- 201041602 No turbidity can be judged as "transparent" when it is clearly interpreted, and it is evaluated accordingly. The gel hardness is based on the above Oil gel composition After the sample was heated and dissolved to be transparent, it was allowed to stand in a 25 ° C thermostat for 3 hours, and then a rheometer manufactured by FUDOH Co., Ltd. (NRM-2002D.D) was used to measure the entry by using a plunger of φ 2 mm. The speed was 6 cm/min and the load peak 値(g) at 3 mm entry was determined. The results are shown in Table 1. [Table 1]

EXAMPLES Sample Comparative Example Sample #1 #2 #1 #2 #3 #4 #5 #6 #7 #8 Compound (1) 2.5 2.5 Compound (2) 2.5 2.5 2.5 5 2.5 Compound (3) 2.5 Compound (4) 2.5 5 Compound (5) 2.5 t « * ' - it ^(6) 2.5 : .. -, \ ' HH Compound (7) -ίϊ * Mixture (1). 47.5 Ι^ν V - ' 5,, wbB§ * ···& Hydrogenated polyisobutylene 1 47.5 47.5 47.5 47 5 47.5 47.5 47.5 47.5 47.5 Triisooctanoic acid glyceride 47.5 47.5 47.5 47.5 47.5 47.5 47.5 47.5 47.5 47.5 Dissolution temperature (°c) 120 110 110 110 120 120 180 180 200 165 Gel appearance 〇0 0 0 Δ 〇o OX Δ Gel formation 0 0 0 〇0 oooo 〇 Gel hardness (g) 40.2 41.4 3.8 15 39.4 34.6 64 60.4 76.4 38.6 *1 : Parleam 18 (manufactured by 曰本油公司(Criteria for judgment) -23- 146883.doc 201041602 Gel appearance: ◎: Transparent 〇: Translucent △: White turbidity X. Crystallized gel formation: 0: Does not flow back when inverted. A. When it is inverted, part of it flows back to x. All flow back when inverted [Results] Example Compound #1 Compound (1) and Compound (3) The combination, and the combination of the compound (2) and the compound (4) of the sample of Example #2, were all good at the dissolution temperature, the gel appearance, the gel formation, and the gel hardness test; as for the comparative sample #1 The combination of the compound (2) and the compound (5), and the combination of the compound (2) and the compound (6) of the sample of the comparative example 2, the gel hardness is extremely low, 'the uniformity of the gel, the smoothness, and the like. The degree of usability is not suitable as a gelling agent, and when the mixing amount is increased to increase the gel hardness, the transparency of the gel is remarkably lowered. Further, it is confirmed that the thiol moiety of the bis(indenylamino)cyclohexane derivative represented by the formula (11) is a so-called aldol condensed type having a multi-branched courtyard group or a so-called corundum When the type has a burning group, it is not suitable for use as the oil gelling agent of the present invention. Further, the combination of the compound (1) and the compound (7) of the comparative example sample #5, and the compound (2) of the comparative example sample #6 and the compound (7) have a dissolution temperature of 1,800 ° C. It is not appropriate from the viewpoint of the manufacture of the cosmetic or the formability of the filler, and it is confirmed that the thiol moiety is a branched chain and the carbon number is bis(decylamino)cyclohexane derivative, which is used in the present invention. The oil gelling agent is not suitable for 146883.doc -24- 201041602. Further, in the comparative example sample #3, when the compound (4) alone and the compound (4) were separately formed into an oil gelling agent in the sample #4 of Comparative Example, the prepared oil gel composition was cloudy, even in the present invention. The bis(decylamino)cyclohexane derivative used, when used alone, is not suitable in the level of transparency of the prepared oil gel composition. Further, it is also known that the bis(nonylamino)cyclohexane derivative having a carbon number of 8 in the above-mentioned thiol moiety of the compound (7) of Comparative Example #7 is dissolved as an oil gelling agent alone, and dissolved. If the temperature is too high, the gel will crystallize; otherwise, if the mixture of the sample of Comparative Example #8 (1) is a combination of the compounds (2), (7) and (8), the dissolution temperature may become too high or The gel hardness will become too low. [Example 2] (Oil-based gel composition for cosmetics: 2) For the above-mentioned compounds (2) and (4), the mixing ratios were added to the sample samples #3 to #8, and the measurement was carried out in the same manner as above. Dissolution temperature, gel appearance, gel formation, and gel hardness. The results are shown in Table 2. #3 #4 #5 #2 #6 #7 #8 #3 #4 Compound (2) Compound (4) Hydrogenated polyisobutylene*1 Triisooctanoic acid glycerin 4 1 47.5 47.5 3.75 1.25 47.5 47.5 3 2 47.5 47.5 2.5 2.5 47.5 47.5 2 3 47.5 47.5 1.25 3.75 47.5 47.5 1 4 47.5 47.5 5 47.5 47.5 5 47.5 47.5 Dissolution temperature (°c) 120 110 110 110 110 110 110 120 120 Gel appearance 0 0 ο ο ◎ ◎ ◎ Δ Δ Gel formation 〇0 〇0 0 ο ο ο 〇 Gel hardness (g) 35.6 35.4 39.2 43.4 43.2 38.6 35.8 39.4 34.6 146883.doc -25- 201041602 [Results] Compound (2) or compound (4) is separately formed into oil gel oil gel The hydrazine composition is cloudy, and the compound (7) and the compound (4) are combined; the oil gelling agent is evaluated in terms of the unmixing ratio, the degree of white turbidity, and the gel hardness. It can be seen that the compounds (7) and (4) are 60 · 40 to 20: 80 hrs. As an oil gelling agent, it is particularly good: 60~20: 8G' is particularly good in terms of the transparency of the gel. [Example 3] (Oil-based gel composition for cosmetics: 3) 2.5% of each of the above compounds (2) and (4) was added to an oil agent having the composition shown in Table 3 below, and dissolved in the same manner as described above. Temperature, gel appearance, gel formation, gel hardness. The results are shown in Table 3. [Table 3] Side Sweep ~~ #9 #10 #11 #2 #12 #13 Compound (2) 2.5 2.5 2.5 2.5 2.5 2.5 Compound (4) 2.5 2.5 2.5 2.5 2.5 2.5 Hydrogenated polyisobutylene* 1 95 47.5 47.5 47.5 47.5 47.5 Mobile paraffin 47.5 Cetyl isooctanoate 47.5 Diisooctanoic acid glycerin 47.5 47.5 Apple diisostearyl ester 47.5 Dissolution temperature (°c) 120 115 120 120 105 105 Gel appearance ◎ 0 〇〇〇0 Gel Formation 〇〇0 〇0 〇 Gel hardness (g) 59.4 26.2 33.6 41.4 31 13 146883.doc -26- 201041602 [Results] The results confirmed that the oils shown in Table 3, at the dissolution temperature, gel appearance, condensation Both the gel formation and the gel hardness showed good results, indicating that the gelling agent of the present invention has an effect regardless of the type and mixing ratio of the oil agent, and the hydrogenated polycondensation of the branched polycondensate When dibutyl is formed into an oil alone (Example Sample #9), the transparency is very high, and it is particularly suitable when mixed with a cosmetic having a high transparency or gloss. [Example 4] (Oil-based gel composition for cosmetics: 4) For the above-mentioned compounds (2) and (4), a sample of the preparation example #14 was added, and the dissolution temperature, the appearance of the gel, and the appearance of the gel were measured in the same manner as described above. And gel hardness. The results are shown in Table 4. [Table 4] Example Sample #14 Comparative Example Sample #9 Compound (2) 0.5 Compound (4) 1.5 Palmitic acid dextrin * 2 12.0 Hydrogenated polyisobutylene * 1 50.0 50.0 Triisooctanoic acid glyceride 47.85 37.85 Preservative 0.1 0.1 Perfume 0.05 0.05 Dissolution temperature (°C) 110 90 Gel appearance ◎ Transparent 〇 Translucent gel hardness 11.6 6.8 *2 : Rheopearl KL2 (manufactured by Chiba Powder Co., Ltd.) 146883.doc -27- 201041602 [Results] Example of Example # The appearance of the gel of 14 and Comparative Example Sample #9 is shown in Fig. 1. When a gelling agent in combination of the compounds (2) and (4) was used (Example Sample #14), a transparent gel was formed, and when palmitate dextrin was used as a gelling agent (Comparative Example #9 ), forming a translucent gel. The oil gelling agent of the present invention has a gel which is excellent in transparency and can be shaped in an amount of one-sixth of the amount of the gelling agent hitherto used. [Example 5] (sticky lipstick) [Formulation] (% by mass) 1. Ethylene glycol copolymer *3 5.0 2. Compound 1 0.2 3. Compound 3 0.1 4. Triisostearic acid diglyceride 20.0 5. Ten isostearic acid ten glycerin vinegar 10.0 6. polybutene * 4 5.0 7. fluorenone branched polyether modified fluorenone * 5 2.0 8. propylene glycol dicarboxylate 10.0 9. triisooctanoic glyceride remaining 10 . The treatment of iron oxide coated mica*6 2.0 11. Anthrone treatment mica titanium *6 2.0 12. Red 202 0.15 13. Yellow 4 0.7. Titanium oxide 1.5 15. Black iron oxide 0.1 16. Preservative amount 17. Proper amount of antioxidants 18. Proper amount of spices 146883.doc •28- 201041602 *3 : EP-700 (manufactured by Newphase Technology Co., Ltd.) *4: Polybutene 100R (manufactured by Idemitsu Kosan Co., Ltd.) *5 : KF-6028P (Shin-Etsu Chemical Co., Ltd.) Co., Ltd.) *6 : 3% (dimethyl fluorenone / fluorenyl ketone) copolymer treatment [Production method] A: After adding the components 1 to 9 to dissolve, the ingredients 1 〇 15 are added. Mix evenly. B: Add ingredients 16 to 17 in A and mix them evenly. 〇 c : Adding component 18 to B to heat, defoaming, filling in a container, and cooling to obtain a stick-like lipstick. [Results] The stick-shaped lipstick of the present invention can be molded even if the amount of solid oil such as wax is reduced, and has a smooth ductility or gloss, and the appearance color or hair color is also good. [Example 6] (Oil base) [Formulation] (% by mass) 1. Compound 2 2.0 2. Compound 4 3.0 3. Anthrone-supported lauryl-triglyceryl-modified 矽**7 2.0 4. Three different Diglyceryl stearate 10.0 5. Tris(capric acid octanoic acid) glyceride remaining 6. Dimethyl fluorenone *8 5.0 7. Olefin oligomer *9 5.0 8. Asmolyzed cerium oxide *1 〇 0.1 146883 .doc -29· 201041602 1.0 8.0 2.0 15.0 1.0 2.0 0.5 0.1 0.5 Appropriate amount 9. Microparticle titanium oxide 10. Titanium oxide 11. Barium sulfate 12. Sericite 13. Iron oxide 14. Yellow iron oxide 15. Black iron oxide 16. Carboxy Ethylene polymer *11 17-1,3-butanediol 18. Fragrance *7 : KF-6105 (manufactured by Shin-Etsu Chemical Co., Ltd.) *8 : KF-96A-6cs (manufactured by Shin-Etsu Chemical Co., Ltd.) *9 : α-olefin oligomer Polymer (manufactured by Otaru Co., Ltd.) *10. AEROSIL R972 (manufactured by A本 Aerosil Co., Ltd.) *11 : Carbopole 940 (manufactured by Goodrich Co., Ltd.) [Production method] A: After dissolving the components 1 to 7, the component 8 is added. 1 7 Mix evenly. B: The component 18 was added to A to be heated, and after defoaming, it was filled in a metal pan and cooled to obtain an oily foundation. [Results] The oily foundation of the present invention can be molded with a small amount of gelation, smooth and lightly malleable and lustrous, and the appearance color or hair color is good. [Example 7] (Oil eye shadow) ) 146883.doc -30- 201041602 Ο 9·Stearyl modified acesulfate 嗣 嗣 $ 10· sesquioleic acid sorbitan Ο [formula] 1. Compound 1 2. Compound 3 3. Three different Caprylic acid glyceride 4. Olefin oligomer 112 5 · Alkyl polyether modified anthrone 113 6. Pentaerythritol fatty acid ester 114 7. Squalane 8 · Dipropylene glycol propylene glycol 11. Monooleic acid polyoxyethylene (2 〇)Mountain 12. Nylon powder 116 13. Anthrone treatment talc 16 14. Red 202 No. 15. Cyan 404 No. 16. Acetone treatment of titanium oxide 17. Mica titanium 18. Smokey cerium oxide 18 19. Perfume (quality 1.0 3.0 10.0 10.0 7.0 5.0 Remaining 15.0 10.0 0.5 sorbitol 〇8 2.0 10.0 0.5 1.0 2.0 10.0 1.0 Appropriate amount 146883.doc -31 · 1 12 ·Normite HPD-C (made by 曰清Oillio) *13: ABILEM90 (manufactured by Goldschmidt Co., Ltd.) *14: 寇思莫鲁168ARN (made by 曰清Oillio Co., Ltd.) *15 : KP-561P (manufactured by Shin-Etsu Chemical Co., Ltd.) *16: Nylon powder S P-500 (manufactured by Tosoh Corporation) [Production method] 201041602 A: After heating and dissolving the components 1 to 11, the components 12 to 18 are uniformly mixed. B: The component 19 is heated in A, and after defoaming, it is filled in The oily eye shadow is obtained by cooling in a metal plate. [Results] The oily eye shadow of the present invention can be molded with a small amount of gelation, smooth and lightly ductile and lustrous, and excellent in appearance color or hair color. [Example 8] (water-based sunscreen cream in oil) [Formulation] (% by mass) 1. Methyl dimethyl ketone ketone * 17 5.0 2. Acrylic compound - fluorenone treatment of fine particle titanium oxide * 18 5.0 3. Indolone branched-chain lauryl. Polyether modified anthrone *19 0-5 4. Dimethylfluorenone * 20 2.0 5. Trimethyl decyloxy decanoic acid / decamethylcyclopentanoxane Solution *21 5.0 6. Compound 1 0.1 7. Compound 3 0.1 8. Octyl p-methoxycinnamate 3.0 9. Hexadecyl isooctanoate 5.0 10. Oxime ketone branched polyether modified fluorenone *5 2.0 11. Ethanol 7.0 12. Glycerin 2.0 13. Gasified sodium 1.0 14. Preservative amount 15. Anthrone powder *22 2.0 16. Proper amount of flavor 17. Purified water remaining 146883.doc -32 201041602 * 17 : TMF-l.5 (manufactured by Shin-Etsu Chemical Co., Ltd.) *18 : KP-549 (manufactured by Shin-Etsu Chemical Co., Ltd.) treats fine titanium oxide* 19 : KF - 6038 (manufactured by Shin-Etsu Chemical Co., Ltd.) *20 : KF-96-2cs (manufactured by Shin-Etsu Chemical Co., Ltd.) *21 : KF-7312J (manufactured by Shin-Etsu Chemical Co., Ltd.) *22 : KSP-100 (manufactured by Shin-Etsu Chemical Co., Ltd.) [Manufacturing method] A: The components 1 to 3 are subjected to bead mill treatment to be uniform dispersion. B: Components 4 to 10 were dissolved by heating, and A and component 15 were uniformly mixed. c : The components 11 to 14 and the component 17 are mixed and dissolved. D: Emulsify after adding C to B, and then cooling. E: Add ingredient 16 to D to mix evenly to obtain a water-based sun-proof day cream. [Results] The water-based sun-protective cream of the present invention can be smoothly spread and spread when applied to the skin, and can be applied to the skin without astringency, and is excellent in transparency and stability. [Example 9] . (Hairing) (% by mass) 0.5 1.0 1.5 2.0 [Prescription] 1. Gasification of stearyl trimethyl chain 2. Cetyl alcohol 3 · behenyl alcohol 4 · isophthalic acid Trialkyl ester 146883.doc •33· 201041602 5. Compound 2 0.1 6. Compound 4 0.2 7. Dimercaptopurone*8 2.0 8. Decidylcyclopentaoxane 5.0 9. Propylene glycol 5_0 10. Ethanol 5.0 11 Cationized cellulose*23 0.1 12. Astragalus gum*24 〇.1 13. Preservative amount 14. The remaining amount of purified water 15. Flavor amount *23 : Polymer JR400 (manufactured by Union Carbide) *24 : Keltorol (Kelco) [Production Method] A: The components 2 to 8 are warmed and uniformly mixed. B: The component 1 and the components 9 to 14 were warmed and uniformly mixed. C: A was added to B under 80 ° C and emulsified on one side. D: After cooling, the component 15 was added to C to be uniformly mixed to obtain a frost. [Results] The hair cream of the present invention can be smoothly stretched and spread, and has a good affinity for hair when applied to the hair, and the finished hair works without oil, and the gloss and the hair are excellent in integration. [Example 10] (Gummy pearl lipstick) 146883.doc -34- 201041602 [Prescription] (% by mass) 1. Compound 2 0.1 2. Compound 4 0.2 3. Diisostearyl malate 20.0 4. Polybutene *2 60.0 5. Propylene glycol dicaprate 10.0 6. Triisooctanoic acid glycerin S. The remaining 7. Anthrone treatment mica titanium * 6 1.0 8. Red 202 No. 0.02 9. Yellow No. 4 0.04 10. Titanium oxide 0.15 [Industrial Availability] The fat oil gelling agent of the present invention can stably form an oil gel composition having high transparency by mixing in a low concentration in a non-polar or low-polarity oil agent, and mixing the oil gel The cosmetic or skin external preparation of the chemical or oil gel composition is excellent in the aspects of stability, usability, and transparency of appearance. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 shows the appearance of a gel of Comparative Example Sample #9(a) and Example Sample #14(b). 146883.doc -35-

Claims (1)

201041602 VII. Patent application scope: 1. An oil gelling agent comprising: (A) a bis(indenylamino)cyclohexane derivative represented by formula (1): (wherein 'R is a linear alkyl group having a carbon number of 15 to 21); and (B) a bis(indenylamino)cyclohexane derivative represented by the formula (II): :, R2 represents a linear alkyl group having a total carbon number of 15 to 21 and a linear alkyl group as a substituent at a position. 2. The oil gelling agent of claim 1 wherein (8): (8) has a mass ratio of 80. 20~2〇: 80. An oil gel composition is qi with oil. It contains the oil gelling agent of claim 1 or 2 wherein the oil contains a polyolefin having a branched chain 4, an oil gel composition of claim 3, 146883.doc 201041602. 5. 6. 7. The oleogel conjugate of claim 4 * * wherein the branched polyolefin is hydrogenated polyisobutylene. A cosmetic product whose surname is _+, characterized by: containing a chemical agent, or an oil gel such as the test item 1 or 2, 'item 3 to 5', a, a skin external application Agent, from the gel composition. It is characterized in that it is a winter gelling agent, or an oil as claimed in claim 1 or 2, and any of the clothes 3 to 5. Item Oil Gel Combination 1468S3.doc