TW201026300A - In-situ refillable ophthalmic implant - Google Patents
In-situ refillable ophthalmic implant Download PDFInfo
- Publication number
- TW201026300A TW201026300A TW098143639A TW98143639A TW201026300A TW 201026300 A TW201026300 A TW 201026300A TW 098143639 A TW098143639 A TW 098143639A TW 98143639 A TW98143639 A TW 98143639A TW 201026300 A TW201026300 A TW 201026300A
- Authority
- TW
- Taiwan
- Prior art keywords
- implant
- eye
- release
- opening
- body portion
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims abstract description 71
- 238000011065 in-situ storage Methods 0.000 title claims abstract description 7
- 230000007246 mechanism Effects 0.000 claims abstract description 39
- 239000003814 drug Substances 0.000 claims abstract description 26
- 229940124597 therapeutic agent Drugs 0.000 claims abstract description 23
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 28
- 239000008194 pharmaceutical composition Substances 0.000 claims description 18
- 210000003786 sclera Anatomy 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 9
- 238000013270 controlled release Methods 0.000 claims description 7
- 210000000795 conjunctiva Anatomy 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 4
- 206010016717 Fistula Diseases 0.000 claims description 3
- 230000003890 fistula Effects 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 238000002513 implantation Methods 0.000 claims description 2
- 206010036790 Productive cough Diseases 0.000 claims 1
- 230000004410 intraocular pressure Effects 0.000 claims 1
- 210000003802 sputum Anatomy 0.000 claims 1
- 208000024794 sputum Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 7
- 238000004891 communication Methods 0.000 abstract description 3
- 210000001508 eye Anatomy 0.000 description 36
- 239000007787 solid Substances 0.000 description 6
- 239000002260 anti-inflammatory agent Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- YUWPMEXLKGOSBF-GACAOOTBSA-N Anecortave acetate Chemical compound O=C1CC[C@]2(C)C3=CC[C@]4(C)[C@](C(=O)COC(=O)C)(O)CC[C@H]4[C@@H]3CCC2=C1 YUWPMEXLKGOSBF-GACAOOTBSA-N 0.000 description 2
- 229960001232 anecortave Drugs 0.000 description 2
- 239000004037 angiogenesis inhibitor Substances 0.000 description 2
- 239000000030 antiglaucoma agent Substances 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 210000005252 bulbus oculi Anatomy 0.000 description 2
- 210000004087 cornea Anatomy 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 239000004575 stone Substances 0.000 description 2
- -1 travos (trav〇pr〇st) Chemical compound 0.000 description 2
- MDKGKXOCJGEUJW-VIFPVBQESA-N (2s)-2-[4-(thiophene-2-carbonyl)phenyl]propanoic acid Chemical compound C1=CC([C@@H](C(O)=O)C)=CC=C1C(=O)C1=CC=CS1 MDKGKXOCJGEUJW-VIFPVBQESA-N 0.000 description 1
- AODPIQQILQLWGS-UHFFFAOYSA-N (3alpa,5beta,11beta,17alphaOH)-form-3,11,17,21-Tetrahydroxypregnan-20-one, Natural products C1C(O)CCC2(C)C3C(O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC21 AODPIQQILQLWGS-UHFFFAOYSA-N 0.000 description 1
- 208000010412 Glaucoma Diseases 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 240000006413 Prunus persica var. persica Species 0.000 description 1
- 229940127361 Receptor Tyrosine Kinase Inhibitors Drugs 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 229910052768 actinide Inorganic materials 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003732 agents acting on the eye Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000043 antiallergic agent Substances 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 229960004324 betaxolol Drugs 0.000 description 1
- CHDPSNLJFOQTRK-UHFFFAOYSA-N betaxolol hydrochloride Chemical compound [Cl-].C1=CC(OCC(O)C[NH2+]C(C)C)=CC=C1CCOCC1CC1 CHDPSNLJFOQTRK-UHFFFAOYSA-N 0.000 description 1
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 description 1
- 229960002470 bimatoprost Drugs 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- DQXBYHZEEUGOBF-UHFFFAOYSA-N but-3-enoic acid;ethene Chemical compound C=C.OC(=O)CC=C DQXBYHZEEUGOBF-UHFFFAOYSA-N 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- IAVUPMFITXYVAF-XPUUQOCRSA-N dorzolamide Chemical compound CCN[C@H]1C[C@H](C)S(=O)(=O)C2=C1C=C(S(N)(=O)=O)S2 IAVUPMFITXYVAF-XPUUQOCRSA-N 0.000 description 1
- 229960003933 dorzolamide Drugs 0.000 description 1
- 230000003073 embolic effect Effects 0.000 description 1
- 229960003449 epinastine Drugs 0.000 description 1
- WHWZLSFABNNENI-UHFFFAOYSA-N epinastine Chemical compound C1C2=CC=CC=C2C2CN=C(N)N2C2=CC=CC=C21 WHWZLSFABNNENI-UHFFFAOYSA-N 0.000 description 1
- 239000005038 ethylene vinyl acetate Substances 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 239000002324 mouth wash Substances 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- QEFAQIPZVLVERP-UHFFFAOYSA-N nepafenac Chemical compound NC(=O)CC1=CC=CC(C(=O)C=2C=CC=CC=2)=C1N QEFAQIPZVLVERP-UHFFFAOYSA-N 0.000 description 1
- 229960001002 nepafenac Drugs 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 229960004114 olopatadine Drugs 0.000 description 1
- JBIMVDZLSHOPLA-LSCVHKIXSA-N olopatadine Chemical compound C1OC2=CC=C(CC(O)=O)C=C2C(=C/CCN(C)C)\C2=CC=CC=C21 JBIMVDZLSHOPLA-LSCVHKIXSA-N 0.000 description 1
- 229940023490 ophthalmic product Drugs 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229960001487 rimexolone Drugs 0.000 description 1
- QTTRZHGPGKRAFB-OOKHYKNYSA-N rimexolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CC)(C)[C@@]1(C)C[C@@H]2O QTTRZHGPGKRAFB-OOKHYKNYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000007779 soft material Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004492 suprofen Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- AODPIQQILQLWGS-GXBDJPPSSA-N tetrahydrocortisol Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CC[C@@H]21 AODPIQQILQLWGS-GXBDJPPSSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Prostheses (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14224209P | 2009-01-02 | 2009-01-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW201026300A true TW201026300A (en) | 2010-07-16 |
Family
ID=42077107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW098143639A TW201026300A (en) | 2009-01-02 | 2009-12-18 | In-situ refillable ophthalmic implant |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100174272A1 (enExample) |
| EP (1) | EP2379027A1 (enExample) |
| JP (1) | JP2012514493A (enExample) |
| KR (1) | KR20110119681A (enExample) |
| CN (1) | CN102271632A (enExample) |
| AR (1) | AR076637A1 (enExample) |
| AU (1) | AU2009333100B2 (enExample) |
| BR (1) | BRPI0923810A2 (enExample) |
| CA (1) | CA2750178A1 (enExample) |
| MX (1) | MX2011006726A (enExample) |
| TW (1) | TW201026300A (enExample) |
| WO (1) | WO2010078063A1 (enExample) |
| ZA (1) | ZA201104271B (enExample) |
Families Citing this family (73)
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| CA2683224C (en) | 2001-04-07 | 2014-12-02 | Glaukos Corporation | System and methods thereof for treatment of ocular disorders |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| EP2316394B1 (en) | 2001-06-12 | 2016-11-23 | The Johns Hopkins University | Reservoir device for intraocular drug delivery |
| US8623395B2 (en) | 2010-01-29 | 2014-01-07 | Forsight Vision4, Inc. | Implantable therapeutic device |
| SG173167A1 (en) | 2009-01-29 | 2011-08-29 | Forsight Labs Llc | Posterior segment drug delivery |
| WO2010093945A2 (en) | 2009-02-13 | 2010-08-19 | Glaukos Corporation | Uveoscleral drug delivery implant and methods for implanting the same |
| WO2012071476A2 (en) | 2010-11-24 | 2012-05-31 | David Haffner | Drug eluting ocular implant |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| EP4289416A3 (en) * | 2009-05-18 | 2024-01-03 | Dose Medical Corporation | Drug eluting ocular implant |
| US10206813B2 (en) * | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US8419673B2 (en) | 2009-09-21 | 2013-04-16 | Alcon Research, Ltd. | Glaucoma drainage device with pump |
| US8545431B2 (en) * | 2009-09-21 | 2013-10-01 | Alcon Research, Ltd. | Lumen clearing valve for glaucoma drainage device |
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| US8721580B2 (en) * | 2009-09-21 | 2014-05-13 | Alcon Research, Ltd. | Power saving glaucoma drainage device |
| CA2807508A1 (en) * | 2010-08-05 | 2012-02-09 | Forsight Vision4, Inc. | Subconjunctival implant for posterior segment drug delivery |
| EP2600812B1 (en) * | 2010-08-05 | 2021-09-22 | ForSight Vision4, Inc. | Apparatus to treat an eye |
| HUE054113T2 (hu) | 2010-08-05 | 2021-08-30 | Forsight Vision4 Inc | Injekciós készülék gyógyszerbejuttatáshoz |
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| US9605663B2 (en) * | 2010-08-24 | 2017-03-28 | Qwtip Llc | System and method for separating fluids and creating magnetic fields |
| US8235053B2 (en) | 2010-09-08 | 2012-08-07 | Alcon Research, Ltd. | Implantable punctal plug |
| US8864703B2 (en) | 2010-10-05 | 2014-10-21 | Alcon Research, Ltd. | Drug introduction and placement system |
| WO2012068549A2 (en) | 2010-11-19 | 2012-05-24 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
| US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| WO2013003620A2 (en) | 2011-06-28 | 2013-01-03 | Forsight Vision4, Inc. | Diagnostic methods and apparatus |
| US10307292B2 (en) | 2011-07-18 | 2019-06-04 | Mor Research Applications Ltd | Device for adjusting the intraocular pressure |
| EP2739252A4 (en) * | 2011-08-05 | 2015-08-12 | Forsight Vision4 Inc | SMALL MOLECULE ADMINISTRATION USING AN IMPLANTABLE THERAPEUTIC DEVICE |
| WO2013040247A2 (en) | 2011-09-16 | 2013-03-21 | Forsight Vision4, Inc. | Fluid exchange apparatus and methods |
| US8585631B2 (en) | 2011-10-18 | 2013-11-19 | Alcon Research, Ltd. | Active bimodal valve system for real-time IOP control |
| US8840578B2 (en) | 2011-12-09 | 2014-09-23 | Alcon Research, Ltd. | Multilayer membrane actuators |
| US8579848B2 (en) | 2011-12-09 | 2013-11-12 | Alcon Research, Ltd. | Active drainage systems with pressure-driven valves and electronically-driven pump |
| WO2013090197A1 (en) | 2011-12-12 | 2013-06-20 | Alcon Research, Ltd. | Active drainage systems with dual-input pressure-driven valves |
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| US9339187B2 (en) | 2011-12-15 | 2016-05-17 | Alcon Research, Ltd. | External pressure measurement system and method for an intraocular implant |
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| WO2025172440A1 (en) | 2024-02-16 | 2025-08-21 | F. Hoffmann-La Roche Ag | Port device for introducing a liquid pharmaceutical compound into an intraocular space |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3788327A (en) * | 1971-03-30 | 1974-01-29 | H Donowitz | Surgical implant device |
| US4193397A (en) * | 1977-12-01 | 1980-03-18 | Metal Bellows Corporation | Infusion apparatus and method |
| US4886488A (en) * | 1987-08-06 | 1989-12-12 | White Thomas C | Glaucoma drainage the lacrimal system and method |
| US5122128A (en) * | 1990-03-15 | 1992-06-16 | Alza Corporation | Orifice insert for a ruminal bolus |
| US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
| US5466233A (en) * | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
| US5725493A (en) * | 1994-12-12 | 1998-03-10 | Avery; Robert Logan | Intravitreal medicine delivery |
| US20050119737A1 (en) * | 2000-01-12 | 2005-06-02 | Bene Eric A. | Ocular implant and methods for making and using same |
| US7708711B2 (en) * | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
| DE60135352D1 (de) | 2000-08-30 | 2008-09-25 | Univ Johns Hopkins | Vorrichtung zur intraokularen wirkstoffverabreichung |
| CA2432438C (en) * | 2001-01-09 | 2011-04-26 | Microchips, Inc. | Flexible microchip devices for ophthalmic and other applications |
| US6881198B2 (en) * | 2001-01-09 | 2005-04-19 | J. David Brown | Glaucoma treatment device and method |
| EP2316394B1 (en) * | 2001-06-12 | 2016-11-23 | The Johns Hopkins University | Reservoir device for intraocular drug delivery |
| JP2006516618A (ja) * | 2003-01-24 | 2006-07-06 | コントロール・デリバリー・システムズ・インコーポレイテッド | アドレナリン作動薬を眼へ輸送するために徐放性デバイス及び方法 |
| US20070077270A1 (en) * | 2005-03-28 | 2007-04-05 | Clemson University | Delivery devices and methods for long-term, targeted delivery of therapeutic agents to the eye and ear |
| US20080147021A1 (en) * | 2006-12-15 | 2008-06-19 | Jani Dharmendra M | Drug delivery devices |
-
2009
- 2009-12-18 US US12/641,352 patent/US20100174272A1/en not_active Abandoned
- 2009-12-18 TW TW098143639A patent/TW201026300A/zh unknown
- 2009-12-18 MX MX2011006726A patent/MX2011006726A/es not_active Application Discontinuation
- 2009-12-18 CA CA2750178A patent/CA2750178A1/en not_active Abandoned
- 2009-12-18 EP EP09801617A patent/EP2379027A1/en not_active Withdrawn
- 2009-12-18 KR KR1020117017935A patent/KR20110119681A/ko not_active Withdrawn
- 2009-12-18 AU AU2009333100A patent/AU2009333100B2/en not_active Expired - Fee Related
- 2009-12-18 WO PCT/US2009/068613 patent/WO2010078063A1/en not_active Ceased
- 2009-12-18 BR BRPI0923810-7A patent/BRPI0923810A2/pt not_active IP Right Cessation
- 2009-12-18 JP JP2011544477A patent/JP2012514493A/ja active Pending
- 2009-12-18 CN CN2009801534855A patent/CN102271632A/zh active Pending
- 2009-12-29 AR ARP090105157A patent/AR076637A1/es not_active Application Discontinuation
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2011
- 2011-06-08 ZA ZA2011/04271A patent/ZA201104271B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR076637A1 (es) | 2011-06-29 |
| BRPI0923810A2 (pt) | 2015-07-14 |
| MX2011006726A (es) | 2011-07-20 |
| AU2009333100B2 (en) | 2014-08-14 |
| EP2379027A1 (en) | 2011-10-26 |
| JP2012514493A (ja) | 2012-06-28 |
| CA2750178A1 (en) | 2010-07-08 |
| WO2010078063A1 (en) | 2010-07-08 |
| AU2009333100A1 (en) | 2011-07-07 |
| CN102271632A (zh) | 2011-12-07 |
| KR20110119681A (ko) | 2011-11-02 |
| US20100174272A1 (en) | 2010-07-08 |
| ZA201104271B (en) | 2012-08-29 |
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