TW200906818A - Chemical compounds - Google Patents

Chemical compounds Download PDF

Info

Publication number
TW200906818A
TW200906818A TW097128670A TW97128670A TW200906818A TW 200906818 A TW200906818 A TW 200906818A TW 097128670 A TW097128670 A TW 097128670A TW 97128670 A TW97128670 A TW 97128670A TW 200906818 A TW200906818 A TW 200906818A
Authority
TW
Taiwan
Prior art keywords
group
alkyl
heterocyclic
optionally substituted
carbon
Prior art date
Application number
TW097128670A
Other languages
English (en)
Chinese (zh)
Inventor
Lynsie Almeida
Brian Aquila
Claudio Edmundo Chuaqui
Hui-Ping Guan
Shan Huang
Stephanos Ioannidis
Michelle Lamb
Bo Peng
Jie Shi
Mei Su
Qibin Su
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40304964&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW200906818(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of TW200906818A publication Critical patent/TW200906818A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW097128670A 2007-07-31 2008-07-29 Chemical compounds TW200906818A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95315807P 2007-07-31 2007-07-31

Publications (1)

Publication Number Publication Date
TW200906818A true TW200906818A (en) 2009-02-16

Family

ID=40304964

Family Applications (1)

Application Number Title Priority Date Filing Date
TW097128670A TW200906818A (en) 2007-07-31 2008-07-29 Chemical compounds

Country Status (6)

Country Link
AR (1) AR069899A1 (fr)
CL (1) CL2008002243A1 (fr)
PE (1) PE20090895A1 (fr)
TW (1) TW200906818A (fr)
UY (1) UY31254A1 (fr)
WO (1) WO2009016410A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX346801B (es) 2009-03-13 2017-03-31 Agios Pharmaceuticals Inc Métodos y composiciones para trastornos relacionados con la proliferación celular.
US20120238576A1 (en) * 2009-06-08 2012-09-20 California Capital Equity, Llc Triazine Derivatives and their Therapeutical Applications
EP2440053A4 (fr) * 2009-06-09 2012-10-31 California Capital Equity Llc Dérivés de la triazine substituée au benzyle et leurs applications thérapeutiques
KR101850813B1 (ko) 2009-06-29 2018-04-20 아지오스 파마슈티컬스 아이엔씨. 치료용 화합물 및 조성물
ES2594402T3 (es) 2009-10-21 2016-12-20 Agios Pharmaceuticals, Inc. Métodos y composiciones para trastornos relacionados con la proliferación celular
ME03074B (fr) 2011-05-03 2019-01-20 Agios Pharmaceuticals Inc Activateurs de la pyruvate kinase destinés à être utilisés en thérapie
CN102827073A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
CN102827170A (zh) 2011-06-17 2012-12-19 安吉奥斯医药品有限公司 治疗活性组合物和它们的使用方法
US9474779B2 (en) 2012-01-19 2016-10-25 Agios Pharmaceuticals, Inc. Therapeutically active compositions and their methods of use
AR091858A1 (es) * 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
AU2013331626B2 (en) 2012-10-15 2018-08-02 Agios Pharmaceuticals, Inc. Therapeutic compounds and compositions
CN105517996B (zh) * 2013-07-11 2019-03-26 安吉奥斯医药品有限公司 治疗活性化合物及其使用方法
WO2015003355A2 (fr) * 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
US9579324B2 (en) 2013-07-11 2017-02-28 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
WO2015003360A2 (fr) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composés thérapeutiquement actifs et leurs méthodes d'utilisation
CA2917671A1 (fr) 2013-07-11 2015-01-15 Agios Pharmaceuticals, Inc. Composes de 2,4 ou de 4,6-diaminopyrimidine en tant qu'inhibiteurs des mutants idh2 pour le traitement du cancer
US20150031627A1 (en) 2013-07-25 2015-01-29 Agios Pharmaceuticals, Inc Therapeutically active compounds and their methods of use
US9968595B2 (en) 2014-03-14 2018-05-15 Agios Pharmaceuticals, Inc. Pharmaceutical compositions of therapeutically active compounds
EP3245190B1 (fr) 2015-01-16 2018-12-26 Bayer CropScience Aktiengesellschaft Procédé de production de 4-cyanopipéridine-chlorhydrate
JP7320339B2 (ja) 2015-06-11 2023-08-03 アジオス ファーマシューティカルズ， インコーポレイテッド ピルビン酸キナーゼ活性化因子を使用する方法
KR20180067658A (ko) 2015-10-15 2018-06-20 아지오스 파마슈티컬스 아이엔씨. 악성 종양의 치료를 위한 조합물 요법
MX2018004587A (es) 2015-10-15 2018-08-14 Agios Pharmaceuticals Inc Terapia de combinacion para tratar tumores malignos.
US10980788B2 (en) 2018-06-08 2021-04-20 Agios Pharmaceuticals, Inc. Therapy for treating malignancies
EP3810600A1 (fr) * 2018-06-22 2021-04-28 Aduro BioTech, Inc. Composés de triazine et leurs utilisations
CN109020951B (zh) * 2018-08-24 2020-06-02 大连理工大学 含三取代三聚氯氰的萘酰亚胺类衍生物及其合成方法和应用
CN111454214B (zh) * 2020-05-27 2023-04-07 龙曦宁（上海）医药科技有限公司 一种2-甲氧基1-嘧啶乙胺盐酸盐的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100876069B1 (ko) * 2000-09-15 2008-12-26 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 억제제로서 유용한 피라졸 화합물 및 이를 포함하는 약제학적 조성물
MXPA03005610A (es) * 2000-12-21 2003-10-06 Vertex Pharma Compuestos de pirazol utiles como inhibidores de la proteina cinasa.
AU2003225800A1 (en) * 2002-03-15 2003-09-29 Hayley Binch Azolylaminoazine as inhibitors of protein kinases
KR20080015409A (ko) * 2005-05-16 2008-02-19 아스트라제네카 아베 티로신 키나제 억제제로서 유용한 피라졸릴아미노피리미딘 유도체
EP1945631B8 (fr) * 2005-10-28 2013-01-02 AstraZeneca AB Derives 4-(3-aminopyrazole)pyrimidine et leur utilisation en tant qu' inhibiteurs de tyrosine kinases dans le cadre d un traitement anticancereux

Also Published As

Publication number Publication date
WO2009016410A2 (fr) 2009-02-05
PE20090895A1 (es) 2009-08-08
AR069899A1 (es) 2010-03-03
WO2009016410A3 (fr) 2009-07-02
CL2008002243A1 (es) 2009-08-21
UY31254A1 (es) 2009-04-30

Similar Documents

Publication Publication Date Title
TW200906818A (en) Chemical compounds
JP6666263B2 (ja) グルタミナーゼの新規阻害剤
JP6140170B2 (ja) 過増殖性疾患の処置におけるｂｕｂ１キナーゼ阻害剤として使用するための置換ベンジルインダゾール類
CN105228997B (zh) Carm1抑制剂及其用途
ES2502941T3 (es) Método de preparación de compuestos de amida de dihidroindeno, las composiciones farmacéuticas que contienen dichos compuestos y el uso como inhibidor de proteína quinasas
JP7191799B2 (ja) ピリミジン化合物及びその医薬用途
TWI406864B (zh) 化合物
CN108602776A (zh) 用作irak抑制剂的杂芳基化合物及其用途
CN106536506A (zh) 苯并咪唑衍生物作为erbb酪氨酸激酶抑制剂用于治疗癌症
CN109843858A (zh) 某些化学实体、组合物及方法
TW200846344A (en) Chemical compounds
CN104053442A (zh) 某些化学实体、组合物及方法
CN107428765A (zh) 用作irak抑制剂的哒嗪酮类大环化合物及其用途
TWI762743B (zh) 磺醯胺化合物及其用途
TW201838981A (zh) 嘧啶基-吡啶氧基-萘基化合物以及治療ire1相關之疾病及病症的方法
JP7384536B2 (ja) キナゾリン化合物並びにその調製方法、使用及び医薬組成物
TW201006830A (en) Chemical compounds
JP2013534221A (ja) Ａｌｋ阻害剤としての４−（１ｈ−インドール−３−イル）−ピリミジン
TWI710554B (zh) 新穎苯并咪唑化合物及其醫藥用途
BR112020018094A2 (pt) Compostos de aminopirazina diol como inibidores de pi3k-¿
CN104470934A (zh) 蛋白激酶抑制剂
JP2024505732A (ja) ピリドピリミジノン系誘導体及びその製造方法と使用
KR20140117651A (ko) 이소퀴놀린 및 나프티리딘 유도체
TW201710250A (zh) 經取代之喹喏啉衍生物
TW201011017A (en) Chemical compounds 495-1