TW200812590A - Methods for cancer therapy and stem cell modulation - Google Patents
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- TW200812590A TW200812590A TW096106615A TW96106615A TW200812590A TW 200812590 A TW200812590 A TW 200812590A TW 096106615 A TW096106615 A TW 096106615A TW 96106615 A TW96106615 A TW 96106615A TW 200812590 A TW200812590 A TW 200812590A
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Engineering & Computer Science (AREA)
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- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| SG185942A1 (en) * | 2007-11-02 | 2012-12-28 | Agency Science Tech & Res | Methods and compounds for preventing and treating a tumour |
| US8629275B2 (en) | 2008-09-08 | 2014-01-14 | Merck Sharp & Dohme Corp. | AHCY hydrolase inhibitors for treatment of hyper homocysteinemia |
| EP2331543A4 (en) * | 2008-09-26 | 2013-06-19 | Agency Science Tech & Res | 3-deazaneplanocin DERIVATIVES |
| WO2010111712A2 (en) * | 2009-03-27 | 2010-09-30 | Cold Spring Harbor Laboratory | Identification of rnai targets and use of rnai for rational therapy of chemotherapy-resistant leukemia and other cancers |
| US8491927B2 (en) | 2009-12-02 | 2013-07-23 | Nimble Epitech, Llc | Pharmaceutical composition containing a hypomethylating agent and a histone deacetylase inhibitor |
| SG180031A1 (en) * | 2010-10-15 | 2012-05-30 | Agency Science Tech & Res | Combination treatment of cancer |
| WO2012082436A2 (en) * | 2010-12-03 | 2012-06-21 | Epizyme, Inc. | Modulators of histone methyltransferase, and methods of use thereof |
| RU2606514C2 (ru) | 2010-12-03 | 2017-01-10 | Эпизайм, Инк. | Замещенные пуриновые и 7-деазапуриновые соединения |
| WO2012075500A2 (en) | 2010-12-03 | 2012-06-07 | Epizyme, Inc. | 7-deazapurine modulators of histone methyltransferase, and methods of use thereof |
| EP2709612A4 (en) * | 2011-05-19 | 2015-07-01 | Glax L L C | COMPOSITIONS AND METHODS OF TREATMENT AND PREVENTION OF CANCER BY TARGETING AND INHIBITION OF CANCER STEM CELLS |
| WO2013036846A2 (en) * | 2011-09-09 | 2013-03-14 | Koronis Pharmaceuticals, Incorporated | N4 derivatives of deoxycytidine prodrugs |
| EP2869852A4 (en) * | 2012-07-09 | 2016-04-20 | Metheor Therapeutics Corp | Oligonucleotide inhibitors of DNA methyltransferases and their use in the treatment of diseases |
| WO2014026198A1 (en) | 2012-08-10 | 2014-02-13 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
| EP2892536B1 (en) | 2012-09-06 | 2019-12-18 | Epizyme, Inc. | Method of treating leukemia |
| WO2014062978A1 (en) * | 2012-10-17 | 2014-04-24 | Cedars-Sinai Medical Center | Molecular signatures of ovarian cancer |
| US20160010059A1 (en) * | 2013-03-06 | 2016-01-14 | The Regents Of The University Of California | EXPANSION OF HEMATOPOIETIC PROGENITOR CELLS BY HISTONE METHYLTRANSFERASE G9a INHIBITION |
| US9175032B2 (en) | 2013-03-15 | 2015-11-03 | Epizyme, Inc. | Methods of synthesizing substituted purine compounds |
| WO2016022563A1 (en) | 2014-08-04 | 2016-02-11 | Auburn University | Enantiomers of the 1',6'-isomer of neplanocin a |
| US20160271149A1 (en) * | 2015-03-16 | 2016-09-22 | Epinova Therapeutics Corp. | Therapeutic compounds that suppress protein arginine methyltransferase activity for reducing tumor cell proliferation |
| WO2020055663A1 (en) * | 2018-09-11 | 2020-03-19 | The Texas A&M University System | L-oligonucleotide inhibitors of polycomb repressive complex 2 (prc2) |
| WO2020057107A1 (zh) * | 2018-09-17 | 2020-03-26 | 诺未科技（北京）有限公司 | 一种组合物及其用途 |
| WO2023249714A1 (en) * | 2022-06-24 | 2023-12-28 | Memorial Sloan-Kettering Cancer Center | Therapeutic compositions and methods for activating double stranded rna response in cancer patients via dnmt1 targeted therapy |
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| US510260A (en) | 1893-12-05 | Electric-arc-lighting system | ||
| US4968690A (en) | 1986-05-27 | 1990-11-06 | United States Government As Represented By The Secretary Of The Dept. Of Health And Human Services | 3-deazaneplanocin, intermediates for it, and antiviral composition and method of treatment using it |
| US4975434A (en) | 1986-05-27 | 1990-12-04 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Antiviral and anticancer cyclopentenyl cytosine |
| JPH04327587A (ja) | 1991-04-26 | 1992-11-17 | Asahi Chem Ind Co Ltd | ６’−ｃ−アルキル−３−デアザネプラノシンａ誘導体、その製造法およびその用途 |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US6090622A (en) | 1997-03-31 | 2000-07-18 | The Johns Hopkins School Of Medicine | Human embryonic pluripotent germ cells |
| DK1064027T3 (da) | 1998-03-27 | 2008-09-08 | Genentech Inc | APO-2 Ligand-anti-her-2-antistofsynergier |
| SE517975C2 (sv) | 2000-05-30 | 2002-08-13 | Power Ab C | Fackverkskonstruktion av balkar sammansatta till ett tredimensionellt ramverk samt användning av en sådan fackverkskonstruktion |
| US20050191618A1 (en) | 2001-05-18 | 2005-09-01 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of human immunodeficiency virus (HIV) gene expression using short interfering nucleic acid (siNA) |
| EP1536688B1 (en) | 2002-09-13 | 2011-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Mammalian megakaryocyte progenitor cell |
| AU2003295444A1 (en) | 2002-11-15 | 2004-06-15 | The Board Of Trustees Of The University Of Illinois | Methods for in vitro expansion of hematopoietic stem cells |
| US20050245559A1 (en) | 2004-01-23 | 2005-11-03 | Koul Hari K | Treatment and prevention of prostate cancer |
| US20050266093A1 (en) | 2004-04-27 | 2005-12-01 | Mohapatra Shyam S | Nanogene therapy for cell proliferation disorders |
| CA2574176A1 (en) | 2004-07-20 | 2006-02-09 | Schering Corporation | Induction of apoptosis in toll-like receptor expressing tumor cells |
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| EP2522352B1 (en) | 2017-01-11 |
| EP1993553A4 (en) | 2010-07-28 |
| US20120077841A1 (en) | 2012-03-29 |
| JP2009528345A (ja) | 2009-08-06 |
| US8058258B2 (en) | 2011-11-15 |
| US8211869B2 (en) | 2012-07-03 |
| EP1993553B1 (en) | 2013-05-08 |
| AU2006339445A1 (en) | 2007-09-07 |
| JP5468782B2 (ja) | 2014-04-09 |
| JP2013121974A (ja) | 2013-06-20 |
| EP1993553A1 (en) | 2008-11-26 |
| WO2007100304A1 (en) | 2007-09-07 |
| JP5902138B2 (ja) | 2016-04-13 |
| SG170041A1 (en) | 2011-04-29 |
| US20100075915A1 (en) | 2010-03-25 |
| EP2522352A1 (en) | 2012-11-14 |
| JP2014028853A (ja) | 2014-02-13 |
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