TW200716136A - Polymorphic and amorphous salt forms of squalamine dilactate - Google Patents

Polymorphic and amorphous salt forms of squalamine dilactate

Info

Publication number
TW200716136A
TW200716136A TW095114792A TW95114792A TW200716136A TW 200716136 A TW200716136 A TW 200716136A TW 095114792 A TW095114792 A TW 095114792A TW 95114792 A TW95114792 A TW 95114792A TW 200716136 A TW200716136 A TW 200716136A
Authority
TW
Taiwan
Prior art keywords
polymorphic
salt forms
squalamine
amorphous salt
squalamine dilactate
Prior art date
Application number
TW095114792A
Other languages
English (en)
Inventor
Eric Chellquist
Mary Doubleday
Charles Gilbert
Xue-Hai Zhang
Michael Mclane
Kyle Armbruster
Roy C Levitt
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Publication of TW200716136A publication Critical patent/TW200716136A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW095114792A 2005-04-25 2006-04-25 Polymorphic and amorphous salt forms of squalamine dilactate TW200716136A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67453105P 2005-04-25 2005-04-25

Publications (1)

Publication Number Publication Date
TW200716136A true TW200716136A (en) 2007-05-01

Family

ID=37075194

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095114792A TW200716136A (en) 2005-04-25 2006-04-25 Polymorphic and amorphous salt forms of squalamine dilactate

Country Status (8)

Country Link
US (2) US7981876B2 (zh)
EP (2) EP2527355B1 (zh)
JP (1) JP2008539243A (zh)
AU (1) AU2006239811B2 (zh)
CA (2) CA2606077C (zh)
ES (2) ES2732251T3 (zh)
TW (1) TW200716136A (zh)
WO (1) WO2006116309A2 (zh)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8729058B2 (en) * 2009-10-27 2014-05-20 Michael Zasloff Methods and compositions for treating and preventing viral infections
US8623416B2 (en) * 2009-11-25 2014-01-07 Michael Zasloff Formulations comprising aminosterols
US20130281420A1 (en) 2010-08-17 2013-10-24 Ohr Pharmaceutical, Inc. Ophthalmic Formulations of Squalamine
US9982008B2 (en) 2012-06-19 2018-05-29 Intercept Pharmaceuticals, Inc. Preparation and uses of obeticholic acid
DK3336097T3 (da) 2012-06-19 2020-09-28 Intercept Pharmaceuticals Inc Fremstilling af ikke-krystallinsk obeticholsyre
US10040817B2 (en) 2013-10-03 2018-08-07 Enterin Laboratories, Inc. Methods and compositions for stimulation of the intestinal enteroendocrine system for treating diseases or conditions related to the same
TW201720446A (zh) * 2015-11-13 2017-06-16 Ｏｈｒ製藥公司 非典型脈絡膜新生血管（ｃｎｖ）之大小做為以角鯊胺治療之預測子
WO2019050903A1 (en) 2017-09-08 2019-03-14 Enterin Laboratories, Inc. METHODS OF TREATING SLEEP DISORDERS, SLEEP DISTURBANCES AND ASSOCIATED SYMPTOMS USING AMINOSTEROL COMPOSITIONS
EP3704132A4 (en) * 2017-10-30 2021-07-28 Enterin, Inc. NEW SOLID FORMS OF SQUALAMINE AND PROCESSES FOR PRODUCING THEM
JP2023518381A (ja) * 2020-03-19 2023-05-01 エンターイン、 インコーポレイテッド スクアラミンの結晶形
WO2021216399A1 (en) 2020-04-20 2021-10-28 Enterin, Inc. Pulmonary aminosterol compositions and methods of using the same to treat microbial infections

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192756A (en) 1992-03-18 1993-03-09 The Children's Hospital Of Pennsylvania Aminosterol antibiotic
ATE169930T1 (de) 1993-03-10 1998-09-15 Magainin Pharma Steroidderivate, pharmazeutische zusammensetzungen die sie enthalten und ihre verwendung als antibiotika oder desinfektionsmittel
US5716960A (en) * 1995-01-13 1998-02-10 U.S. Bioscience Inc. And Individuals Crystalline trimetrexate salts and the process for making the same
US5792635A (en) 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
WO1997040835A1 (en) 1996-04-26 1997-11-06 Magainin Pharmaceuticals Inc. Treatment of carcinomas using squalamine in combination with other anti-cancer agents
US6596712B2 (en) 1996-04-26 2003-07-22 Genaera Corporation Treatment of carcinomas using squalamine in combination with other anti-cancer agents or modalities
US6262283B1 (en) 1996-12-06 2001-07-17 Magainin Pharmaceuticals Inc. Stereoselective synthesis of 24-hydroxylated compounds useful for the preparation of aminosterols, vitamin D analogs, and other compounds
JP4842514B2 (ja) * 2002-03-20 2011-12-21 エラン ファーマ インターナショナル，リミティド 血管新生抑制剤のナノ粒子組成物
AU2003276525A1 (en) * 2002-11-15 2004-06-15 Orchid Chemicals And Pharmaceuticals Ltd Novel amorphous hydrate of a cephalosporin antibiotic
AU2004288709B2 (en) * 2003-11-07 2011-01-06 Novartis Vaccines And Diagnostics, Inc. Methods for synthesizing quinolinone compounds
US7563812B2 (en) * 2005-06-15 2009-07-21 Hetero Drugs Limited Amorphous esomeprazole hydrate

Also Published As

Publication number Publication date
EP2527355A3 (en) 2014-05-07
US20070010504A1 (en) 2007-01-11
EP1877419B1 (en) 2019-04-03
AU2006239811B2 (en) 2012-02-02
AU2006239811A1 (en) 2006-11-02
EP1877419A2 (en) 2008-01-16
CA2814247C (en) 2016-01-19
ES2732251T3 (es) 2019-11-21
WO2006116309A3 (en) 2007-02-08
WO2006116309A2 (en) 2006-11-02
EP2527355B1 (en) 2019-02-20
CA2606077C (en) 2013-07-09
CA2814247A1 (en) 2006-11-02
US7981876B2 (en) 2011-07-19
JP2008539243A (ja) 2008-11-13
US8716270B2 (en) 2014-05-06
CA2606077A1 (en) 2006-11-02
ES2727284T3 (es) 2019-10-15
EP2527355A2 (en) 2012-11-28
US20120022035A1 (en) 2012-01-26

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