TW200716110A - Inhibitors of AKT activity - Google Patents

Inhibitors of AKT activity

Info

Publication number
TW200716110A
TW200716110A TW095113711A TW95113711A TW200716110A TW 200716110 A TW200716110 A TW 200716110A TW 095113711 A TW095113711 A TW 095113711A TW 95113711 A TW95113711 A TW 95113711A TW 200716110 A TW200716110 A TW 200716110A
Authority
TW
Taiwan
Prior art keywords
inhibitors
akt activity
activity
compounds
akt
Prior art date
Application number
TW095113711A
Other languages
English (en)
Inventor
Dirk A Heerding
Meagan B Rouse
Mark Andrew Seefeld
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of TW200716110A publication Critical patent/TW200716110A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
TW095113711A 2005-04-20 2006-04-18 Inhibitors of AKT activity TW200716110A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US67312005P 2005-04-20 2005-04-20

Publications (1)

Publication Number Publication Date
TW200716110A true TW200716110A (en) 2007-05-01

Family

ID=37115929

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095113711A TW200716110A (en) 2005-04-20 2006-04-18 Inhibitors of AKT activity

Country Status (7)

Country Link
US (1) US20080318947A1 (zh)
EP (1) EP1874768A2 (zh)
JP (1) JP2008536938A (zh)
AR (1) AR053364A1 (zh)
PE (1) PE20061378A1 (zh)
TW (1) TW200716110A (zh)
WO (1) WO2006113837A2 (zh)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7625890B2 (en) 2005-11-10 2009-12-01 Smithkline Beecham Corp. Substituted imidazo[4,5-c]pyridine compounds as Akt inhibitors
WO2008070823A2 (en) * 2006-12-07 2008-06-12 University Of South Florida Substrate-mimetic akt inhibitor
RU2541430C2 (ru) 2007-10-05 2015-02-10 Акусела Инк. Композиции и способы лечения нейродегенеративных заболеваний
US9145396B2 (en) 2008-12-01 2015-09-29 Targacept, Inc. Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3ylvinyl)pyrimidine
UA107336C2 (ru) * 2008-12-01 2014-12-25 Таргасепт, Інк. Синтез и солевые формы (r)-5-((e)-2-пирролидин-3-илвинил) пиримидина
JP2012515202A (ja) 2009-01-16 2012-07-05 マサチューセッツ インスティテュート オブ テクノロジー 自閉症圏障害の診断および処置
WO2010146059A2 (en) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarkers for igf-1r inhibitor therapy
JP5860398B2 (ja) 2009-07-02 2016-02-16 アキュセラ インコーポレイテッド 視覚サイクルモジュレーターの薬理
FR3033499A1 (fr) 2015-03-11 2016-09-16 Centre Leon-Berard Composition pour le traitement des tumeurs neuroendocrines pancreatiques
CA2999940A1 (en) 2015-10-23 2017-04-27 Laboratorios Del Dr. Esteve, S.A. Substituted morpholine derivatives having activity against pain
CA3021471A1 (en) 2016-04-28 2017-11-02 Guaili Wu Method for preparing tyrosine kinase inhibitor and derivative thereof
EP3575297A4 (en) * 2017-01-30 2021-07-28 Kyoto University NOVEL COMPOUND AND METHOD FOR PRODUCING REGULATORY T-CELLS
MX2021003093A (es) * 2018-09-18 2021-05-12 Terns Inc Compuestos para tratar ciertas leucemias.
CN112888440A (zh) 2018-10-16 2021-06-01 豪夫迈·罗氏有限公司 Akt抑制剂在眼科中的用途
CN111018767B (zh) * 2019-12-23 2021-09-28 江苏美迪克化学品有限公司 一种d-脯氨酸衍生物及其中间体的制备方法
WO2023155870A1 (en) * 2022-02-18 2023-08-24 Insilico Medicine Ip Limited Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase (pkmyt1) inhibitors and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0206860D0 (en) * 2002-03-22 2002-05-01 Glaxo Group Ltd Compounds
US7547779B2 (en) * 2003-10-06 2009-06-16 Glaxo Group Limited Preparation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors
JP2007507549A (ja) * 2003-10-06 2007-03-29 グラクソ　グループ　リミテッド キナーゼ阻害剤としての１，６，７−三置換アザベンゾイミダゾールの調製

Also Published As

Publication number Publication date
WO2006113837A2 (en) 2006-10-26
PE20061378A1 (es) 2006-12-03
US20080318947A1 (en) 2008-12-25
AR053364A1 (es) 2007-05-02
WO2006113837A3 (en) 2007-08-30
EP1874768A2 (en) 2008-01-09
JP2008536938A (ja) 2008-09-11

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