TW200616992A - Enantioselective separation method - Google Patents
Enantioselective separation methodInfo
- Publication number
- TW200616992A TW200616992A TW094124800A TW94124800A TW200616992A TW 200616992 A TW200616992 A TW 200616992A TW 094124800 A TW094124800 A TW 094124800A TW 94124800 A TW94124800 A TW 94124800A TW 200616992 A TW200616992 A TW 200616992A
- Authority
- TW
- Taiwan
- Prior art keywords
- enantioselective
- trifluoromethyl
- ester
- substituted
- carboxylic acid
- Prior art date
Links
- 238000000926 separation method Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 5
- 238000004587 chromatography analysis Methods 0.000 abstract 2
- ZVJQJFFPHAQYQP-UHFFFAOYSA-N 2-(trifluoromethyl)-1,2-dihydroquinoline-3-carboxylic acid Chemical class C1=CC=C2NC(C(F)(F)F)C(C(=O)O)=CC2=C1 ZVJQJFFPHAQYQP-UHFFFAOYSA-N 0.000 abstract 1
- QSLSQLYQCKEGMS-UHFFFAOYSA-N 2-(trifluoromethyl)-2h-chromene-3-carboxylic acid Chemical class C1=CC=C2OC(C(F)(F)F)C(C(=O)O)=CC2=C1 QSLSQLYQCKEGMS-UHFFFAOYSA-N 0.000 abstract 1
- ASSYTOFEDCYDMO-UHFFFAOYSA-N 2-(trifluoromethyl)-2h-thiochromene-3-carboxylic acid Chemical class C1=CC=C2SC(C(F)(F)F)C(C(=O)O)=CC2=C1 ASSYTOFEDCYDMO-UHFFFAOYSA-N 0.000 abstract 1
- DUDODQRMHXHBKM-UHFFFAOYSA-N 3-(trifluoromethyl)-3,4-dihydronaphthalene-2-carboxylic acid Chemical class C1=CC=C2CC(C(F)(F)F)C(C(=O)O)=CC2=C1 DUDODQRMHXHBKM-UHFFFAOYSA-N 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000004064 recycling Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1857—Reactive simulated moving beds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Sustainable Development (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59051604P | 2004-07-23 | 2004-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW200616992A true TW200616992A (en) | 2006-06-01 |
Family
ID=34979492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW094124800A TW200616992A (en) | 2004-07-23 | 2005-07-22 | Enantioselective separation method |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20060020022A1 (zh) |
| EP (1) | EP1773802A1 (zh) |
| JP (1) | JP2008507502A (zh) |
| AR (1) | AR050179A1 (zh) |
| BR (1) | BRPI0512251A (zh) |
| CA (1) | CA2574363A1 (zh) |
| MX (1) | MX2007000880A (zh) |
| TW (1) | TW200616992A (zh) |
| WO (1) | WO2006011047A1 (zh) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8076511B2 (en) * | 2007-05-18 | 2011-12-13 | Ampac Fine Chemicals Llc. | Preparative-scale separation of enantiomers of chiral carboxylic acids |
| US8608967B2 (en) * | 2011-03-03 | 2013-12-17 | The Board Of Trustees Of The University Of Arkansas | Multiple stationary phase matrix and uses thereof |
| US20130177994A1 (en) * | 2012-01-05 | 2013-07-11 | Clinical Reference Laboratory, Inc. | METHODS FOR QUANTITATIVE CHIRAL DETERMINATION OF THE d- AND l- ENANTIOMERS OF AMPHETAMINE AND METHAMPHETAMINE |
| TWI646091B (zh) * | 2012-12-28 | 2019-01-01 | 日商衛斯克慧特股份有限公司 | 鹽類及晶形 |
| ES2947910T3 (es) | 2019-01-22 | 2023-08-24 | Askat Inc | Proceso para la transformación asimétrica impulsada por solubilidad diferencial de ácidos 2H-cromeno-3-carboxílicos sustituidos |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514818A (en) * | 1993-09-17 | 1996-05-07 | Daicel Chemical Industries, Ltd. | Resolution of stereoisomers of aliphatic epoxides |
| EP0747341B1 (en) * | 1994-02-25 | 2002-05-22 | Daicel Chemical Industries, Ltd. | Process for producing optically active mevalonolactone compounds |
| US6043271A (en) * | 1994-08-03 | 2000-03-28 | Sarawak Medichem Pharmaceuticals, Inc. | Method for the preparation of (±)-calanolide A and intermediates thereof |
| US5892060A (en) * | 1994-08-03 | 1999-04-06 | Sarawak Medichem Pharmaceuticals, Inc. | Method for the preparation of (+)-calanolide a and analogues thereof |
| US5977385A (en) * | 1994-08-03 | 1999-11-02 | Sarawak Medichem Pharmaceuticals | Method for the preparation of (+)-calanolide A and analogues thereof |
| US5489697A (en) * | 1994-08-03 | 1996-02-06 | Medichem Research, Inc. | Method for the preparation of (+)-calanolide A and intermediates thereof |
| US6277879B1 (en) * | 1994-08-03 | 2001-08-21 | Sarawak Medichem Pharmaceuticals, Inc. | Calanolide analogues and methods of their use |
| US6458955B1 (en) * | 1994-12-16 | 2002-10-01 | Uop Llc | Process for preparation of pharmaceutically desired enantiomers |
| US6455736B1 (en) * | 1994-12-16 | 2002-09-24 | Uop Llc | Process for preparation of pharmaceutically desired sertraline and sertraline analogs |
| US5630943A (en) * | 1995-11-30 | 1997-05-20 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Discontinuous countercurrent chromatographic process and apparatus |
| KR100343832B1 (ko) * | 1996-08-27 | 2002-07-20 | 시오노기세이야쿠가부시키가이샤 | 크로멘-3-카르복실산 유도체 |
| US6130353A (en) * | 1997-03-18 | 2000-10-10 | Chiral Technologies, Inc. | Chiral separations of amino acids |
| US6077850A (en) * | 1997-04-21 | 2000-06-20 | G.D. Searle & Co. | Substituted benzopyran analogs for the treatment of inflammation |
| US6063284A (en) * | 1997-05-15 | 2000-05-16 | Em Industries, Inc. | Single column closed-loop recycling with periodic intra-profile injection |
| US5928515A (en) * | 1997-12-12 | 1999-07-27 | Uop Llc | Adsorptive separation of 3-hydroxytetrahydrofuran enantiomers |
| US6107492A (en) * | 1998-05-08 | 2000-08-22 | Ucb, S.A. | Process for the preparation of levetiracetam |
| AU1705400A (en) * | 1998-10-15 | 2000-05-01 | Sarawak Medichem Pharmaceuticals, Inc. | Method and composition for treating and preventing tuberculosis |
| US20020103141A1 (en) * | 1998-12-23 | 2002-08-01 | Mckearn John P. | Antiangiogenic combination therapy for the treatment of cancer |
| JP4350946B2 (ja) * | 2000-10-31 | 2009-10-28 | メルク エンド カムパニー インコーポレーテッド | 糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体 |
| US7339062B2 (en) * | 2002-09-20 | 2008-03-04 | Nissan Chemical Industries, Ltd. | Method for producing a 3,5-dihydroxy-6-heptenoate |
| US20050148627A1 (en) * | 2003-03-31 | 2005-07-07 | Jeffery Carter | Benzopyran compounds for use in the treatment and prevention of inflammation related conditions |
| US7259266B2 (en) * | 2003-03-31 | 2007-08-21 | Pharmacia Corporation | Benzopyran compounds useful for treating inflammatory conditions |
-
2005
- 2005-07-11 JP JP2007522063A patent/JP2008507502A/ja not_active Abandoned
- 2005-07-11 BR BRPI0512251-1A patent/BRPI0512251A/pt not_active IP Right Cessation
- 2005-07-11 CA CA002574363A patent/CA2574363A1/en not_active Abandoned
- 2005-07-11 WO PCT/IB2005/002202 patent/WO2006011047A1/en active Application Filing
- 2005-07-11 MX MX2007000880A patent/MX2007000880A/es not_active Application Discontinuation
- 2005-07-11 EP EP05759425A patent/EP1773802A1/en not_active Withdrawn
- 2005-07-21 AR ARP050103020A patent/AR050179A1/es not_active Application Discontinuation
- 2005-07-22 TW TW094124800A patent/TW200616992A/zh unknown
- 2005-07-22 US US11/187,464 patent/US20060020022A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0512251A (pt) | 2008-02-19 |
| JP2008507502A (ja) | 2008-03-13 |
| WO2006011047A1 (en) | 2006-02-02 |
| MX2007000880A (es) | 2007-03-12 |
| US20060020022A1 (en) | 2006-01-26 |
| EP1773802A1 (en) | 2007-04-18 |
| CA2574363A1 (en) | 2006-02-02 |
| AR050179A1 (es) | 2006-10-04 |
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