BRPI0512251A - método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo - Google Patents

método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo

Info

Publication number
BRPI0512251A
BRPI0512251A BRPI0512251-1A BRPI0512251A BRPI0512251A BR PI0512251 A BRPI0512251 A BR PI0512251A BR PI0512251 A BRPI0512251 A BR PI0512251A BR PI0512251 A BRPI0512251 A BR PI0512251A
Authority
BR
Brazil
Prior art keywords
carboxylic acid
trifluoromethyl
substituted
chromen
enantioselective
Prior art date
Application number
BRPI0512251-1A
Other languages
English (en)
Inventor
Brian P Chekal
Ernst Freund
Charles Minard Grill
Elke Huthmann
Markus Juza
Vera Leshchinskaya
Mark Thomas Maloney
Lawarence Marvin Miller Jr
Ying Wang
Ming Zeng
Original Assignee
Pharmacia & Upjohn Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Co Llc filed Critical Pharmacia & Upjohn Co Llc
Publication of BRPI0512251A publication Critical patent/BRPI0512251A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
    • B01D15/1857—Reactive simulated moving beds

Abstract

MéTODO ENANTIOSELETIVO PARA SEPARAçãO DE DERIVADOS DO áCIDO 2-TRIFLUORMETIL-2H-CROMENO-3 -CARBOXìLICO SUBSTITUìDO Essa invenção se refere a um método para separação de enantiómeros de um ácido ou éster 2-trifluormetil-2H-cromeno-3-carboxílico substituído, um ácido ou éster de 2-trifluormetil-1,2-diidro-quinolina-3-carboxílíco substituído, um ácido ou éster de 2-trifluormetil-2H-tiocromeno-3-carboxílico substituído, um ácido ou éster de 3-trifluormetil-3, 4-diidro-naftaleno-2-carboxílico substituído ou um sal farmaceuticamente aceitável dos ácidos ou ésteres, empregando cristalização fracional enantioseletiva, cromatografia líquida de alto desempenho enantioseletiva, cromatografia de reciclagem de estado firme enantioseletiva ou cromatografia de múltiplas colunas enantioseletiva.
BRPI0512251-1A 2004-07-23 2005-07-11 método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo BRPI0512251A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59051604P 2004-07-23 2004-07-23
PCT/IB2005/002202 WO2006011047A1 (en) 2004-07-23 2005-07-11 Enantioselective method for separing substituted 2-trifluoromethyl-2h-chromene-3-carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
BRPI0512251A true BRPI0512251A (pt) 2008-02-19

Family

ID=34979492

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0512251-1A BRPI0512251A (pt) 2004-07-23 2005-07-11 método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo

Country Status (9)

Country Link
US (1) US20060020022A1 (pt)
EP (1) EP1773802A1 (pt)
JP (1) JP2008507502A (pt)
AR (1) AR050179A1 (pt)
BR (1) BRPI0512251A (pt)
CA (1) CA2574363A1 (pt)
MX (1) MX2007000880A (pt)
TW (1) TW200616992A (pt)
WO (1) WO2006011047A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8076511B2 (en) 2007-05-18 2011-12-13 Ampac Fine Chemicals Llc. Preparative-scale separation of enantiomers of chiral carboxylic acids
US8608967B2 (en) * 2011-03-03 2013-12-17 The Board Of Trustees Of The University Of Arkansas Multiple stationary phase matrix and uses thereof
WO2013103841A1 (en) * 2012-01-05 2013-07-11 Clinical Reference Laboratory, Inc. METHODS FOR QUANTITATIVE CHIRAL DETERMINATION OF THE d- AND l- ENANTIOMERS OF AMPHETAMINE AND METHAMPHETAMINE
TWI646091B (zh) * 2012-12-28 2019-01-01 日商衛斯克慧特股份有限公司 鹽類及晶形
US11555023B2 (en) 2019-01-22 2023-01-17 Askat Inc. Process for the differential solubility-driven asymmetric transformation of substituted 2H-chromene-3-carboxylic acids

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514818A (en) * 1993-09-17 1996-05-07 Daicel Chemical Industries, Ltd. Resolution of stereoisomers of aliphatic epoxides
EP0747341B1 (en) * 1994-02-25 2002-05-22 Daicel Chemical Industries, Ltd. Process for producing optically active mevalonolactone compounds
US6043271A (en) * 1994-08-03 2000-03-28 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (±)-calanolide A and intermediates thereof
US5977385A (en) * 1994-08-03 1999-11-02 Sarawak Medichem Pharmaceuticals Method for the preparation of (+)-calanolide A and analogues thereof
US5892060A (en) * 1994-08-03 1999-04-06 Sarawak Medichem Pharmaceuticals, Inc. Method for the preparation of (+)-calanolide a and analogues thereof
US5489697A (en) * 1994-08-03 1996-02-06 Medichem Research, Inc. Method for the preparation of (+)-calanolide A and intermediates thereof
US6277879B1 (en) * 1994-08-03 2001-08-21 Sarawak Medichem Pharmaceuticals, Inc. Calanolide analogues and methods of their use
US6458955B1 (en) * 1994-12-16 2002-10-01 Uop Llc Process for preparation of pharmaceutically desired enantiomers
US6455736B1 (en) * 1994-12-16 2002-09-24 Uop Llc Process for preparation of pharmaceutically desired sertraline and sertraline analogs
US5630943A (en) * 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
AU3867997A (en) * 1996-08-27 1998-03-19 Shionogi & Co., Ltd. Chromene-3-carboxylate derivatives
AU6567398A (en) * 1997-03-18 1998-10-12 Ronald J. Bopp Chiral separations of amino acids
US6077850A (en) * 1997-04-21 2000-06-20 G.D. Searle & Co. Substituted benzopyran analogs for the treatment of inflammation
US6063284A (en) * 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
US5928515A (en) * 1997-12-12 1999-07-27 Uop Llc Adsorptive separation of 3-hydroxytetrahydrofuran enantiomers
US6107492A (en) * 1998-05-08 2000-08-22 Ucb, S.A. Process for the preparation of levetiracetam
WO2000021514A2 (en) * 1998-10-15 2000-04-20 Sarawak Medichem Pharmaceuticals, Inc. Method and composition for treating and preventing tuberculosis
US20020103141A1 (en) * 1998-12-23 2002-08-01 Mckearn John P. Antiangiogenic combination therapy for the treatment of cancer
EP1347755A2 (en) * 2000-10-31 2003-10-01 Merck & Co., Inc. Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
ATE485277T1 (de) * 2002-09-20 2010-11-15 Nissan Chemical Ind Ltd Verfahren zur herstellung eines 3,5-dihydroxy-6- heptenoats
US7259266B2 (en) * 2003-03-31 2007-08-21 Pharmacia Corporation Benzopyran compounds useful for treating inflammatory conditions
US20050148627A1 (en) * 2003-03-31 2005-07-07 Jeffery Carter Benzopyran compounds for use in the treatment and prevention of inflammation related conditions

Also Published As

Publication number Publication date
EP1773802A1 (en) 2007-04-18
WO2006011047A1 (en) 2006-02-02
MX2007000880A (es) 2007-03-12
CA2574363A1 (en) 2006-02-02
TW200616992A (en) 2006-06-01
AR050179A1 (es) 2006-10-04
US20060020022A1 (en) 2006-01-26
JP2008507502A (ja) 2008-03-13

Similar Documents

Publication Publication Date Title
DK1713458T3 (da) Fremgangsmåde til forstærkning af biotilgængeligheden af ospemifen
BRPI0512251A (pt) método enantioseletivo para separação de derivados do ácido 2-trifluormetil-2h-cromeno-3-carboxìlico substituìdo
WO2006016178A8 (en) Enantioselective process
BR112012008036A2 (pt) purificação cromatográfica, célula de fluxo uv ótico, tampa de extremidade para uma coluna de cromatografia, coluna de cromatografia, método para operar uma coluna de cromatografia, dispositivo de cassete, método para operar um dispositivo de cassete, sistema de purificação, e, método para formar uma célula de fluxo uv ótico
CY1111689T1 (el) Στερεες φαρμακοτεχνικες μορφες ospemifene
NZ623602A (en) N-[(2’r)-2’-deoxy-2’-fluoro-2’-methyl-p-phenyl-5’-uridylyl]-l-alanine 1-methylethyl ester and process for its production
EA200801619A1 (ru) Способ улучшения фармакокинетики ингибиторов интегразы вич (варианты), набор и фармацевтическая композиция (варианты)
PT1858881E (pt) Processo para a preparação de derivados opticamente activos de 2-(2-piridilmetilsulfinil)-benzimidazole via complexo de inclusão com 1,1'-binaftaleno-2,2'-diol
ATE534631T1 (de) Verfahren zur optischen trennung von isochinolinderivaten
WO2008092939A3 (en) Process for the preparation of optically pure omeprazole via salt formation with a chiral amine or treatment with an entiomer converting enzyme and chromatographic separation
AR068174A1 (es) Metodo para la elaboracion de escitalopram por resolucion en sus enantiomeros
DK1665922T3 (da) Höbjergningsmaskine
Toribio et al. Semipreparative chiral supercritical fluid chromatography in the fractionation of lansoprazole and two related antiulcer drugs enantiomers
FR2905374B1 (fr) Procede de preparation d'hydroquinone de purete elevee.
TW200607786A (en) Photoracemization method
WO2008001175A3 (en) Dipeptide compounds containing d-histidine
WO2008155918A1 (ja) ＭＴ１－ＭＭＰ、ｉＦＩＨ、ＦＩＨ－１によるＨＩＦ－１の制御
IL180571A0 (en) Method for producing enantiomeric from of 2,3-diaminopropionic acid derivatives
CN103728400A (zh) 一种用高效液相色谱法分离阿西马朵林光学异构体的方法
AU2020902277A0 (en) Method for Detecting Disease
HUP0600278A2 (en) Resoluti on of optical isomers of furane-2-on derivatives by liquid chromatography
WO2007088294A8 (fr) Procede pour adapter un appareil de detection destine a etre couple a une colonne de chromatographie en phase liquide et equipe de moyens permettant la formation et le transfert d'un aerosol
WO2009027803A3 (en) Polymorphs of (3-(((4-tert-butyl-benzyl)-(pyridine-3-sulfonyl)-amino)-methyl)- phenoxy)-acetic acid, free acid
Oliveira et al. Chiral Analysis of and Investigation of Matrix Effects on Ifosfamide and its Dechloroethylated Metabolites in Human Plasma by LC/MS
FR2869905B1 (fr) Procede de preparation d'ester de l'acide 1,5-diphenylpyrazole carboxylique.

Legal Events

Date Code Title Description
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.: A01B 71/04; C07D 311/92; C07D 215/48; C07D 335/06; C07D 335/08

Ipc: C07D 311/24 (2006.01), C07D 311/92 (2006.01), C07D

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.