TW200530180A - New amide compounds with MCH antagonistic activity and medicaments comprising these compounds - Google Patents

New amide compounds with MCH antagonistic activity and medicaments comprising these compounds Download PDF

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Publication number
TW200530180A
TW200530180A TW093140144A TW93140144A TW200530180A TW 200530180 A TW200530180 A TW 200530180A TW 093140144 A TW093140144 A TW 093140144A TW 93140144 A TW93140144 A TW 93140144A TW 200530180 A TW200530180 A TW 200530180A
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Taiwan
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group
alkyl
phenyl
substituted
amino
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TW093140144A
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English (en)
Chinese (zh)
Inventor
Thorsten Lehmann-Lintz
Ralf R H Lots
Philipp Lustenberger
Stephan Georg Mueller
Gerald Juergen Roth
Klaus Rudolf
Marcus Schindler
Dirk Stenkamp
Leo Thomas
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Boehringer Ingelheim Int
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Publication of TW200530180A publication Critical patent/TW200530180A/zh

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Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
US7351719B2 (en) 2002-10-31 2008-04-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds
US7605176B2 (en) 2004-03-06 2009-10-20 Boehringer Ingelheim International Gmbh β-ketoamide compounds with MCH antagonistic activity
AU2006226775A1 (en) * 2005-03-24 2006-09-28 Janssen Pharmaceutica, N.V. Biaryl derived amide modulators of vanilloid VR1 receptor
US20070111981A1 (en) * 2005-10-26 2007-05-17 Roth Gerald J New (hetero)aryl compounds with MCH antagonistic activity and medicaments comprising these compounds
US7977346B2 (en) * 2006-01-17 2011-07-12 Guoqing Paul Chen Spiro compounds and methods of use
CA2657183A1 (en) 2006-08-25 2008-02-28 Boehringer Ingelheim International Gmbh New pyridone derivatives with mch antagonistic activity and medicaments comprising these compounds
TW200831485A (en) 2006-12-11 2008-08-01 Boehringer Ingelheim Int New pyridazine derivatives with MCH antagonistic activity and medicaments comprising these compounds
JP5722892B2 (ja) 2010-07-15 2015-05-27 武田薬品工業株式会社 複素環化合物
WO2022165513A1 (en) 2021-01-29 2022-08-04 Cedilla Therapeutics, Inc. Cdk2 inhibitors and methods of using the same
US12053459B2 (en) 2021-06-26 2024-08-06 Cedilla Therapeutics, Inc. CDK2 inhibitors and methods of using the same

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8530507D0 (en) * 1985-12-11 1986-01-22 Glaxo Group Plc Chemical compounds
JPH0454118A (ja) * 1990-06-20 1992-02-21 Tanabe Seiyaku Co Ltd ５―リポキシゲナーゼ阻害剤
EP0810220B1 (en) * 1996-05-28 2001-12-12 Pfizer Inc. Arylacrylamide derivatives as 5HT1 agonists or antagonists
EP1037880B1 (en) * 1997-12-11 2004-06-30 Janssen Pharmaceutica N.V. Retinoic acid mimetic anilides
JP2000143635A (ja) * 1998-06-10 2000-05-26 Takeda Chem Ind Ltd 血管新生阻害剤
JP2000086603A (ja) * 1998-07-15 2000-03-28 Yoshitomi Pharmaceut Ind Ltd 桂皮酸アミド誘導体および３―フェニルプロピオン酸アミド誘導体
WO2000005223A2 (en) * 1998-07-23 2000-02-03 Astrazeneca Ab Heterocyclic derivatives and their use as integrin inhibitors
DK1153017T3 (da) * 1999-02-16 2006-07-17 Aventis Pharma Ltd Bicykliske forbindelser og deres anvendelse som integrinreceptorligander
CA2376553A1 (en) * 1999-07-01 2001-01-11 Taisho Pharmaceutical Co., Ltd. Aminobenzoic acid derivatives
JP2002003370A (ja) * 1999-09-20 2002-01-09 Takeda Chem Ind Ltd メラニン凝集ホルモン拮抗剤
DE10115994A1 (de) * 2001-03-30 2002-10-10 Wella Ag (p-Amino-hydroxyphenyl)acrylamid-Derivate und diese Verbindungen enthaltende Färbemittel
EP1391199B1 (en) * 2001-05-10 2008-12-10 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
US6897220B2 (en) * 2001-09-14 2005-05-24 Methylgene, Inc. Inhibitors of histone deacetylase
WO2003045920A1 (en) * 2001-11-27 2003-06-05 Merck & Co., Inc. 4-aminoquinoline compounds
JP2005519876A (ja) * 2001-11-27 2005-07-07 メルク　エンド　カムパニー　インコーポレーテッド ２−アミノキノリン化合物
CA2468544A1 (en) * 2001-12-10 2003-06-19 Amgen Inc. Vanilloid receptor ligands
ES2444550T3 (es) * 2002-08-29 2014-02-25 Temple University - Of The Commonwealth System Of Higher Education Arilpropenamidas y heteroarilpropenamidas, derivados de las mismas y usos terapéuticos de las mismas
CA2514940A1 (en) * 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Quinoline-derived amide modulators of vanilloid vr1 receptor
WO2004072018A1 (ja) * 2003-02-12 2004-08-26 Takeda Pharmaceutical Company Limited アミン誘導体
JP4630555B2 (ja) * 2003-02-12 2011-02-09 武田薬品工業株式会社 アミン誘導体
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

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CA2550649A1 (en) 2005-07-14
JP2007520466A (ja) 2007-07-26
EP1708698A1 (de) 2006-10-11
AR048019A1 (es) 2006-03-22
UY28689A1 (es) 2005-08-31

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