TW200504020A - Process for preparing pyridine-substituted amino ketal derivatives - Google Patents

Process for preparing pyridine-substituted amino ketal derivatives

Info

Publication number
TW200504020A
TW200504020A TW093102879A TW93102879A TW200504020A TW 200504020 A TW200504020 A TW 200504020A TW 093102879 A TW093102879 A TW 093102879A TW 93102879 A TW93102879 A TW 93102879A TW 200504020 A TW200504020 A TW 200504020A
Authority
TW
Taiwan
Prior art keywords
substituted amino
ketal derivatives
preparing pyridine
amino ketal
formula
Prior art date
Application number
TW093102879A
Other languages
Chinese (zh)
Other versions
TWI316054B (en
Inventor
Hans-Wolfram Flemming
Gerhard Korb
Juergen Mueller-Lehar
Walter Weber
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of TW200504020A publication Critical patent/TW200504020A/en
Application granted granted Critical
Publication of TWI316054B publication Critical patent/TWI316054B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/51—Acetal radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

The present invention relates to an efficient process for preparing derivatives of 1-(pyridinyl)-1, 1-dialkoxy-2-aminoethane of the formula(I), with which compounds of fomula (I) can be prepared in high purity and yield and in the form of the free base without isolating the acetylpyridine oxime of the formula (XI) which is a critical product from a safety point of view as a solid.
TW093102879A 2003-02-11 2004-02-09 Process for preparing pyridine-substituted amino ketal derivatives TWI316054B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10305391A DE10305391A1 (en) 2003-02-11 2003-02-11 Preparation of 1-(pyridinyl)-1,1-dialkoxy-1-aminoethane derivatives involves reacting acetylpyridine tosyl oxime with mixture of alkali metal alkoxide or hydroxide or alkaline earth metal alkoxide or hydroxide with alcohol

Publications (2)

Publication Number Publication Date
TW200504020A true TW200504020A (en) 2005-02-01
TWI316054B TWI316054B (en) 2009-10-21

Family

ID=32730947

Family Applications (1)

Application Number Title Priority Date Filing Date
TW093102879A TWI316054B (en) 2003-02-11 2004-02-09 Process for preparing pyridine-substituted amino ketal derivatives

Country Status (20)

Country Link
EP (1) EP1601648A2 (en)
JP (1) JP4709741B2 (en)
KR (1) KR101114893B1 (en)
CN (1) CN100393701C (en)
AR (1) AR043132A1 (en)
AU (1) AU2004212038B2 (en)
BR (1) BRPI0407349A (en)
CA (1) CA2514255C (en)
CO (1) CO5690583A2 (en)
DE (1) DE10305391A1 (en)
HK (1) HK1086007A1 (en)
IL (1) IL169900A (en)
MX (1) MXPA05007961A (en)
NO (1) NO332353B1 (en)
NZ (1) NZ541735A (en)
PL (1) PL376654A1 (en)
RU (1) RU2336271C2 (en)
TW (1) TWI316054B (en)
WO (1) WO2004072026A2 (en)
ZA (1) ZA200505298B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115477926A (en) * 2022-09-15 2022-12-16 江苏科技大学 Phase change material and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746669A (en) * 1985-12-23 1988-05-24 Merck & Co., Inc. Substituted thiazoles as immunoregulants
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment
US5792871A (en) * 1996-07-22 1998-08-11 Merck & Co., Inc. Process for N-Boc-N-(R)-2(3-pyridyl)-2-hydroxy-ethyl)-N-2(4-aminophenyl)ethyl amine and 2-(4-aminophenyl)-N-2-(2(R)-hydroxy-2-phyridin-S-yl-ethyl)acetamide
FR2780973B1 (en) * 1998-07-09 2001-10-05 Hoechst Marion Roussel Inc PROCESS FOR THE PREPARATION OF 4- (3-PYRIDINYL) -1H-IMIDAZOLE, AND THE INTERMEDIATES USED

Also Published As

Publication number Publication date
IL169900A (en) 2010-12-30
WO2004072026A3 (en) 2004-09-30
CO5690583A2 (en) 2006-10-31
CA2514255C (en) 2012-01-24
CA2514255A1 (en) 2004-08-26
NO332353B1 (en) 2012-09-03
HK1086007A1 (en) 2006-09-08
RU2336271C2 (en) 2008-10-20
NO20054167D0 (en) 2005-09-07
TWI316054B (en) 2009-10-21
MXPA05007961A (en) 2005-09-20
CN1747932A (en) 2006-03-15
RU2005128281A (en) 2006-02-10
WO2004072026A2 (en) 2004-08-26
DE10305391A1 (en) 2004-08-19
KR101114893B1 (en) 2012-03-06
KR20050101205A (en) 2005-10-20
BRPI0407349A (en) 2006-01-10
JP2006518716A (en) 2006-08-17
IL169900A0 (en) 2007-07-04
ZA200505298B (en) 2008-01-30
PL376654A1 (en) 2006-01-09
AR043132A1 (en) 2005-07-20
EP1601648A2 (en) 2005-12-07
JP4709741B2 (en) 2011-06-22
NO20054167L (en) 2005-10-31
CN100393701C (en) 2008-06-11
AU2004212038B2 (en) 2010-11-25
WO2004072026B1 (en) 2004-11-18
NZ541735A (en) 2008-06-30
AU2004212038A1 (en) 2004-08-26

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Legal Events

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MM4A Annulment or lapse of patent due to non-payment of fees