NO20054167L - Process for the preparation of pyridine-substituted amino ketal derivatives - Google Patents

Process for the preparation of pyridine-substituted amino ketal derivatives

Info

Publication number
NO20054167L
NO20054167L NO20054167A NO20054167A NO20054167L NO 20054167 L NO20054167 L NO 20054167L NO 20054167 A NO20054167 A NO 20054167A NO 20054167 A NO20054167 A NO 20054167A NO 20054167 L NO20054167 L NO 20054167L
Authority
NO
Norway
Prior art keywords
preparation
pyridine
substituted amino
ketal derivatives
formula
Prior art date
Application number
NO20054167A
Other languages
Norwegian (no)
Other versions
NO332353B1 (en
NO20054167D0 (en
Inventor
Walter Weber
Gerhard Korb
Hans-Wolfram Flemming
Juergen Mueller-Lehar
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of NO20054167D0 publication Critical patent/NO20054167D0/en
Publication of NO20054167L publication Critical patent/NO20054167L/en
Publication of NO332353B1 publication Critical patent/NO332353B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/51—Acetal radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

Det beskrives en effektiv prosess for fremstilling av derivater av l-(pyridinyl)-l,l-dialkoksy-2-aminoetan med formel (I), ved hjelp av hvilke forbindelser med formel (I) kan fremstilles i høy renhet og utbytte og i form av den frie base uten å isolere acetylpyridinoksimet med formel (XI) som er et kritisk produkt fra et sikkerhetssynspunkt, som et faststoff.An efficient process is described for the preparation of derivatives of 1- (pyridinyl) -1,1-dialkoxy-2-aminoethane of formula (I), by which compounds of formula (I) can be prepared in high purity and yield and in form of the free base without isolating the acetylpyridine oxide of formula (XI) which is a critical product from a safety point of view, such as a solid.

NO20054167A 2003-02-11 2005-09-07 Process for the preparation of pyridine-substituted amino ketal derivatives NO332353B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10305391A DE10305391A1 (en) 2003-02-11 2003-02-11 Preparation of 1-(pyridinyl)-1,1-dialkoxy-1-aminoethane derivatives involves reacting acetylpyridine tosyl oxime with mixture of alkali metal alkoxide or hydroxide or alkaline earth metal alkoxide or hydroxide with alcohol
PCT/EP2004/000640 WO2004072026A2 (en) 2003-02-11 2004-01-27 Process for preparing pyridine-substituted amino ketal derivatives

Publications (3)

Publication Number Publication Date
NO20054167D0 NO20054167D0 (en) 2005-09-07
NO20054167L true NO20054167L (en) 2005-10-31
NO332353B1 NO332353B1 (en) 2012-09-03

Family

ID=32730947

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20054167A NO332353B1 (en) 2003-02-11 2005-09-07 Process for the preparation of pyridine-substituted amino ketal derivatives

Country Status (20)

Country Link
EP (1) EP1601648A2 (en)
JP (1) JP4709741B2 (en)
KR (1) KR101114893B1 (en)
CN (1) CN100393701C (en)
AR (1) AR043132A1 (en)
AU (1) AU2004212038B2 (en)
BR (1) BRPI0407349A (en)
CA (1) CA2514255C (en)
CO (1) CO5690583A2 (en)
DE (1) DE10305391A1 (en)
HK (1) HK1086007A1 (en)
IL (1) IL169900A (en)
MX (1) MXPA05007961A (en)
NO (1) NO332353B1 (en)
NZ (1) NZ541735A (en)
PL (1) PL376654A1 (en)
RU (1) RU2336271C2 (en)
TW (1) TWI316054B (en)
WO (1) WO2004072026A2 (en)
ZA (1) ZA200505298B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115477926B (en) * 2022-09-15 2024-06-25 江苏科技大学 Phase change material and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746669A (en) * 1985-12-23 1988-05-24 Merck & Co., Inc. Substituted thiazoles as immunoregulants
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment
US5792871A (en) * 1996-07-22 1998-08-11 Merck & Co., Inc. Process for N-Boc-N-(R)-2(3-pyridyl)-2-hydroxy-ethyl)-N-2(4-aminophenyl)ethyl amine and 2-(4-aminophenyl)-N-2-(2(R)-hydroxy-2-phyridin-S-yl-ethyl)acetamide
FR2780973B1 (en) * 1998-07-09 2001-10-05 Hoechst Marion Roussel Inc PROCESS FOR THE PREPARATION OF 4- (3-PYRIDINYL) -1H-IMIDAZOLE, AND THE INTERMEDIATES USED

Also Published As

Publication number Publication date
EP1601648A2 (en) 2005-12-07
CA2514255C (en) 2012-01-24
CA2514255A1 (en) 2004-08-26
WO2004072026A2 (en) 2004-08-26
AR043132A1 (en) 2005-07-20
CO5690583A2 (en) 2006-10-31
JP4709741B2 (en) 2011-06-22
NO332353B1 (en) 2012-09-03
NZ541735A (en) 2008-06-30
JP2006518716A (en) 2006-08-17
IL169900A0 (en) 2007-07-04
CN100393701C (en) 2008-06-11
ZA200505298B (en) 2008-01-30
WO2004072026A3 (en) 2004-09-30
KR20050101205A (en) 2005-10-20
HK1086007A1 (en) 2006-09-08
AU2004212038B2 (en) 2010-11-25
PL376654A1 (en) 2006-01-09
KR101114893B1 (en) 2012-03-06
TWI316054B (en) 2009-10-21
CN1747932A (en) 2006-03-15
AU2004212038A1 (en) 2004-08-26
IL169900A (en) 2010-12-30
MXPA05007961A (en) 2005-09-20
TW200504020A (en) 2005-02-01
RU2336271C2 (en) 2008-10-20
BRPI0407349A (en) 2006-01-10
RU2005128281A (en) 2006-02-10
WO2004072026B1 (en) 2004-11-18
DE10305391A1 (en) 2004-08-19
NO20054167D0 (en) 2005-09-07

Similar Documents

Publication Publication Date Title
NO20050828L (en) indole-3-sulfur derivatives
NO20051600L (en) 1,4-disubstituted piperidine derivatives and their use as 11-betaHSD1 inhibitors
NO20073926L (en) Pyrazole compounds that modulate activity of CDK, GSK and aurorakinases
WO2006128852A3 (en) Heterocyclic spiro-compounds as aldosterone synthase inhibitors
NO20080186L (en) Heterocyclic aspartyl protease inhibitors, preparation and use thereof
TNSN05160A1 (en) Novel fluoroglycoside heterocyclic derivatives, pharmaceutical products containing said compounds and the use thereof
TW200714586A (en) Crystalline forms of a biphenyl compound
NO20061157L (en) 4-pyramidone derivatives and their use as peptidyl peptide inhibitors
NO20092770L (en) Novel aminopyrimidine derivatives as PLK1 inhibitors
NO20071140L (en) New piperidine derivatives such as histamine H3 receptor ligands for the treatment of depression
NO20062256L (en) Hydroxyalkyl-substituted pyrido-7-pyrimidin-7-ones
NO20071290L (en) Enantiomerically pure amino heteroaryl compounds as protein kinase inhibitors
WO2002048157A3 (en) Imidazolidinones and their related derivatives as hepatitis c virus ns3 protease inhibitors
NO20083411L (en) Indanacetic acid derivatives and their use as pharmaceutical agents, intermediates and methods of preparation
NO20025601L (en) Arylmethylamine derivatives for use as tryptase inhibitors
NO20060963L (en) Nicotinamide derivatives useful as PDE4 inhibitors
NO20092692L (en) MAPK / ERK kinase inhibitors
NO20044606L (en) Polymorphic forms of lansoprazole and processes for their preparation
NO20074258L (en) Pyridine-2-carboxamide derivatives as MGLUR5 antagonists
NO20063330L (en) Amide derivatives with a cyclopropylaminocarbonyl substituent useful as cytokine inhibitors
NO20055068L (en) Chemical connections
NO20072053L (en) Novel bis-azaindole derivatives, their preparation and pharmaceutical use as kinase inhibitors
NO20061791L (en) Polymorphic form of 3-phenylsulfonyl-8-piperazin-1-yl-quinoline
ME00428B (en) 5-chloro-3-(4-methanesulfonylphenyl)-6'-methyl- [2,3'] bipyridinyl in pure crystalline form and process for synthesis
NO20042861L (en) N- (3-butyn-1-yl) -N-hydroxyurea

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees