BRPI0407349A - Process for the preparation of pyridine substituted amino ketal derivatives - Google Patents

Process for the preparation of pyridine substituted amino ketal derivatives

Info

Publication number
BRPI0407349A
BRPI0407349A BR0407349-5A BRPI0407349A BRPI0407349A BR PI0407349 A BRPI0407349 A BR PI0407349A BR PI0407349 A BRPI0407349 A BR PI0407349A BR PI0407349 A BRPI0407349 A BR PI0407349A
Authority
BR
Brazil
Prior art keywords
preparation
substituted amino
formula
pyridine substituted
ketal derivatives
Prior art date
Application number
BR0407349-5A
Other languages
Portuguese (pt)
Inventor
Hans-Wolfram Flemming
Gerhard Korb
Juergen Mueller-Lehar
Walter Weber
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of BRPI0407349A publication Critical patent/BRPI0407349A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/51—Acetal radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE DERIVADOS DE AMINO CETAL SUBSTITUìDOS POR PIRIDINA". A presente invenção refere-se a um processo eficiente para a preparação de derivados de 1-(piridinil)-1,1-dialcóxi-2-aminoetano da fórmula (I), com os quais os compostos da fórmula (I) podem ser preparados em alta pureza e rendimento na forma da base livre sem isolamento da acetilpiridina oxima da fórmula (XI) (XI) que é um produto crítico a partir de um ponto de vista de segurança como um sólido."PROCESS FOR THE PREPARATION OF KETAL AMINO DERIVATIVES REPLACED BY PYRIDINE". The present invention relates to an efficient process for preparing 1- (pyridinyl) -1,1-dialkoxy-2-aminoethane derivatives of formula (I), with which the compounds of formula (I) may be prepared in high purity and yield as the free base without isolation of the acetylpyridine oxime of formula (XI) (XI) which is a safety critical product as a solid.

BR0407349-5A 2003-02-11 2004-01-27 Process for the preparation of pyridine substituted amino ketal derivatives BRPI0407349A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10305391A DE10305391A1 (en) 2003-02-11 2003-02-11 Preparation of 1-(pyridinyl)-1,1-dialkoxy-1-aminoethane derivatives involves reacting acetylpyridine tosyl oxime with mixture of alkali metal alkoxide or hydroxide or alkaline earth metal alkoxide or hydroxide with alcohol
PCT/EP2004/000640 WO2004072026A2 (en) 2003-02-11 2004-01-27 Process for preparing pyridine-substituted amino ketal derivatives

Publications (1)

Publication Number Publication Date
BRPI0407349A true BRPI0407349A (en) 2006-01-10

Family

ID=32730947

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0407349-5A BRPI0407349A (en) 2003-02-11 2004-01-27 Process for the preparation of pyridine substituted amino ketal derivatives

Country Status (20)

Country Link
EP (1) EP1601648A2 (en)
JP (1) JP4709741B2 (en)
KR (1) KR101114893B1 (en)
CN (1) CN100393701C (en)
AR (1) AR043132A1 (en)
AU (1) AU2004212038B2 (en)
BR (1) BRPI0407349A (en)
CA (1) CA2514255C (en)
CO (1) CO5690583A2 (en)
DE (1) DE10305391A1 (en)
HK (1) HK1086007A1 (en)
IL (1) IL169900A (en)
MX (1) MXPA05007961A (en)
NO (1) NO332353B1 (en)
NZ (1) NZ541735A (en)
PL (1) PL376654A1 (en)
RU (1) RU2336271C2 (en)
TW (1) TWI316054B (en)
WO (1) WO2004072026A2 (en)
ZA (1) ZA200505298B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115477926A (en) * 2022-09-15 2022-12-16 江苏科技大学 Phase change material and preparation method thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746669A (en) * 1985-12-23 1988-05-24 Merck & Co., Inc. Substituted thiazoles as immunoregulants
US4798841A (en) * 1987-03-31 1989-01-17 Warner-Lambert Company Tetrahydropyridine oxime cholinergic agents and method of treatment
US5792871A (en) * 1996-07-22 1998-08-11 Merck & Co., Inc. Process for N-Boc-N-(R)-2(3-pyridyl)-2-hydroxy-ethyl)-N-2(4-aminophenyl)ethyl amine and 2-(4-aminophenyl)-N-2-(2(R)-hydroxy-2-phyridin-S-yl-ethyl)acetamide
FR2780973B1 (en) * 1998-07-09 2001-10-05 Hoechst Marion Roussel Inc PROCESS FOR THE PREPARATION OF 4- (3-PYRIDINYL) -1H-IMIDAZOLE, AND THE INTERMEDIATES USED

Also Published As

Publication number Publication date
JP2006518716A (en) 2006-08-17
AU2004212038B2 (en) 2010-11-25
AR043132A1 (en) 2005-07-20
CO5690583A2 (en) 2006-10-31
NZ541735A (en) 2008-06-30
RU2005128281A (en) 2006-02-10
KR20050101205A (en) 2005-10-20
DE10305391A1 (en) 2004-08-19
WO2004072026A3 (en) 2004-09-30
NO20054167D0 (en) 2005-09-07
MXPA05007961A (en) 2005-09-20
TW200504020A (en) 2005-02-01
NO332353B1 (en) 2012-09-03
HK1086007A1 (en) 2006-09-08
CN100393701C (en) 2008-06-11
PL376654A1 (en) 2006-01-09
CN1747932A (en) 2006-03-15
EP1601648A2 (en) 2005-12-07
JP4709741B2 (en) 2011-06-22
KR101114893B1 (en) 2012-03-06
WO2004072026A2 (en) 2004-08-26
IL169900A (en) 2010-12-30
CA2514255A1 (en) 2004-08-26
TWI316054B (en) 2009-10-21
CA2514255C (en) 2012-01-24
IL169900A0 (en) 2007-07-04
RU2336271C2 (en) 2008-10-20
NO20054167L (en) 2005-10-31
AU2004212038A1 (en) 2004-08-26
ZA200505298B (en) 2008-01-30
WO2004072026B1 (en) 2004-11-18

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 12A ANUIDADE.

B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2344 DE 08-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.