200427412 玖、發明說明： 【發明所屬之技術領域】 本發明係關於一種藉由將花粉殼進行破碎，使含該殼的 花粉全部形成奈米尺寸的超微顆粒，可取出花粉中有效成 分的花粉加工方法。 【先前技術】 花粉是植物的性細胞，蜜蜂求取蜜而潛入花中，富有黏 著性的花粉附著在其體毛上。蜜蜂將花粉集中在後肢上， 在肢節和肢節之間的稱作“擠壓”的部分，將花粉固結為 團粒狀，形成粒徑為1 mm左右的蜜蜂花粉團（蜜蜂花粉 荷），在肢節的外側中變形，周圍由毛圍繞著，在這種叫做 “花粉籃”的部分内，貯藏著上述蜜蜂花粉團。貯藏在上 述“花粉籃”中的蜜蜂花粉團的量，據說達到2 0〜3 0 mg左 右。蜜蜂將上述蜜蜂花粉團和蜂蜜都貯存在巢穴中。為了 將雄蜜蜂養育為成蜂，據說需要平均1 4 5 g的花粉。此意味 著花粉中含有蜜蜂生存、繁殖中不可缺少的營養物質成分。 然而，花粉的粒徑為1 0〜1 0 0 μ m，有堅硬的雙重構造殼在 守衛著，即使使用王水、強酸、強鹼也不能將該殼破壞掉， 只要不破壞上述花粉的殼，我們人類就不能享受到其極好 之營養素的恩惠。 為了破壞花粉的殼，目前是使用酵素處理法、發酵處理 法及機械處理法來破壞花粉殼。而且，作為破壞花粉殼進 而取得花粉成分的花粉加工方法，已揭示於日本專利特開 2 0 0 1 - 1 1 9號公報。 6 312/發明說明書(補件)/92-10/92119930 200427412 [專利文獻1 ] [曰本專利特開2 0 0 1 - 1 1 9號公報] 【發明内容】 (發明所欲解決之問題） 正如上述專利文獻1中所記載，目前所使用的酵素處理 法、發酵處理法及破碎處理法，無論任何一種皆有其優點 及缺點，但仍存在所謂不能使花粉形成超微顆粒的問題。 於專利文獻1中揭示，在高壓下使花粉和液體等的流體 狀物流入至超微顆粒化裝置中，利用該裝置破壞掉上述花 粉殼，微顆粒狀花粉成分和液體等，以流體狀物流出，由 該流體狀物中除去液體等，取出花粉成分。 然而，根據上述專利文獻1中揭示花粉加工方法，其製 造方法並未作具體的公開，在該專利文獻1中公開的方法 中，確實存在著所謂不能將含花粉殼的全部花粉破碎成微 顆粒狀從而不能取出花粉成分的問題，而且，根據專利文 獻1中的[0 0 1 4 ]段的記載，作為從花粉成分的流體狀物中 除去液體等的方法，由於採用喷射熱風蒸發去除液體的所 謂喷霧乾燥方式，所以存在花粉成分中不耐熱的維生素類 被破壞的問題。 本發明係為解決上述問題而開發，其目的在於提供一種 花粉加工方法，即，將花粉顆粒和純水或鹼離子水混合的 流體狀物壓送至超微顆粒化裝置中，使該流體狀物中的花 粉顆粒彼此衝撞，破壞掉花粉殼，同時，使含該殼的花粉 全部形成為奈米尺寸的超微顆粒，抽出花粉成分，將含殼 7 312/發明說明書(補件)/92-10/92119930 200427412 花粉以流體狀物取出，將該流體狀物進行冷凍乾燥，除去 水分，防止維生素因受熱被破壞，可只取出花粉成分。 (解決問題之手段） 本發明採用包括下述加工步驟的方法： 第1步驟，將蜜蜂採集的蜜蜂花粉團洗淨，除去污物和 雜物； 第2步驟，將上述第1步驟中洗淨的蜜蜂花粉團破碎成 微顆粒狀的花粉顆粒，並且對該破碎的花粉顆粒進行殺菌； 第3步驟，用濾器過濾上述第2步驟中破碎、殺菌之花 粉顆粒，取出粒徑5 0 μ m以下的花粉顆粒，然後，將1 5〜2 5 重量％的上述花粉顆粒，添加混入到7 5〜8 5重量％的純水或 鹼離子水中，進行懸濁液調整，調整到使上述花粉顆粒均 勻地分散在上述純水或鹼離子水中，使花粉顆粒與純水或 驗離子水形成流體狀物； 第4步驟，將上述第3步驟中使花粉顆粒分散在純水或 鹼離子水中的流體狀物投入至超微顆粒化裝置中，使上述 流體狀物中的全部花粉顆粒進行超微顆粒化，在殼破碎之 同時抽出該殼包圍的花粉中的内容成分； 第5步驟，檢查上述第4步驟中進行超微顆粒化、包含 抽出花粉中内容成分的花粉顆粒的流體狀物中，是否存在 微生物； 第6步驟，對上述第5步驟中確認不存在微生物的流體 狀物進行冷凍乾燥，蒸發上述流體狀物中的水分，將超微 顆粒化的花粉顆粒以塊狀的乾燥花粉成分取出；和 8 312/發明說明書(補件)/92-10/92119930 200427412 第7步驟，將上述第6步驟中以塊狀取出的乾燥花粉成 分進行破碎，形成規定的粒徑。 或者採用包括下述步驟的加工方法： 第1步驟，將吸引採集到自然附著在花上的花粉洗淨， 除去污物和雜物； 第2步驟，對上述第1步驟中洗淨的花粉進行殺菌； 第3步驟，用濾器過濾上述第2步驟中殺菌的花粉顆 粒，取出粒徑5 0 μ m以下的花粉顆粒，然後，將1 5〜2 5重 量％的上述花粉顆粒，添加混入到7 5〜8 5重量％的純水或驗 離子水中，進行懸濁液調整，調整到使上述花粉顆粒均勻 地分散在上述純水或鹼離子水中，使花粉顆粒與純水或鹼 離子水形成流體狀物； 第4步驟，將上述第3步驟中使花粉顆粒分散在純水或 鹼離子水中的流體狀物投入至超微顆粒化裝置中，使流體 狀物中的全部花粉顆粒進行超微顆粒化，在殼破碎之同時 抽出該殼包圍的花粉中的内容成分； 第5步驟，檢查上述第4步驟中進行超微顆粒化、包含 抽出花粉中内容成分的花粉顆粒的流體狀物中，是否存在 微生物； 第6步驟，對上述第5步驟中確認不存在微生物的流體 狀物進行冷凍乾燥，蒸發上述流體狀物中的水分，將超微 顆粒化的花粉顆粒以塊狀的乾燥花粉成分取出；和 第7步驟，將上述第6步驟中以塊狀取出的乾燥花粉成 分進行破碎，形成規定的粒徑。 9 312/發明說明書(補件)/92-10/92119930 200427412 【實施方式】 下面詳細說明本發明的實施形態。在本發明中，可作為 原料使用的是由蜜蜂採集的具有1 m m左右粒徑的蜜蜂花粉 團、和吸引採集到自然附著在花上的花粉。由於上述蜜蜂 花粉團和花粉的粒徑不同，製造步驟也不同，首先對以蜜 蜂花粉團為原料的花粉加工方法進行說明。 本發明加工方法的第1步驟是洗淨蜜蜂花粉團的洗淨步 驟。即，第1步驟是，作為上述由蜜蜂採集的原料的蜜蜂 花粉團，由於附著有污物並混有塵埃等雜物，所以將它們 放入水中進行循環洗淨，去除污物、塵埃等雜物。 本發明加工方法的第2步驟是將蜜蜂花粉團破碎及殺菌 的步驟。即，第2步驟是，完成上述洗淨步驟的蜜蜂花粉 團，粒徑很大，並且在蜜蜂採集花粉時，附著有雜菌地固 結成團粒狀，因此利用噴射水流將1 m m左右粒徑的蜜蜂花 粉團破碎，形成微顆粒狀的花粉顆粒，然後，例如將上述 花粉顆粒投入紫外線殺菌線中，對上述破碎的蜜蜂花粉團 進行殺菌。 本發明加工方法的第3步驟是懸濁液調整步驟。即，第 3步驟是，用濾器過濾完成上述破碎及殺菌步驟的花粉顆 粒，取出粒徑5 0 μ m以下的花粉顆粒，然後，將1 5〜2 5重 量％、較佳為2 0重量％的上述花粉顆粒添加混入到7 5〜8 5 重量％、較佳為8 0重量％的純水或鹼離子水中，攪拌混合， 進行懸濁液調整，調整到使上述花粉顆粒均句地分散在上 述純水或驗離子水中，使花粉顆粒與純水或驗離子水形成 10 312/發明說明書(補件)/92-10/92119930 200427412 流體狀物。另外，不使用自來水而使用上述純水或鹼離子 水，是因為使用不混入氣等雜物的水，可得到高質量的花 粉成分。 本發明加工方法的第4步驟是殼破碎、内容成分抽出的 步驟。即，第4步驟是，將上述經過懸濁液調整步驟的花 粉顆粒和純水或鹼離子水形成的流體狀物投入至超微顆粒 化裝置中，上述流體狀物中的花粉顆粒全部超微顆粒化， 破壞掉外殼，同時抽出該殼所包圍的花粉中的内容成分。 作為上述超微顆粒化裝置Μ，並無特殊限定，但較佳推 薦使用圖1〜圖8所示的裝置。如圖1所示，超微顆粒化裝 置Μ之構成係：上述流體狀物的供給容器11 ;對該流體狀 物進行加壓的高壓泵1 2 ;將由該高壓泵1 2壓送的流體狀 物在高頻及超音波的作用下進行衝撞、破壞掉殼、將含該 殼的花粉全部形成奈米尺寸的超微顆粒的超微顆粒化構件 1 3;及貯存從超微顆粒化構件1 3排出含有破碎殼並進行超 微顆粒化的花粉之流體狀物的貯存槽1 4。 上述超微顆粒化構件1 3是在箱體（c a s i n g ) 1 5内裝入第 1圓板1 6、第2圓板1 7，並緊密地重合固定，在該等圓板 1 6、1 7的板面上，分別形成具有可使上述流體狀物藉由的 寬度的透孔16a、16b及17a、17b和連接該透孔16a、16b 及1 7 a、1 7 b的縫隙狀導引槽1 6 c、1 7 c，由該等形成下述 的流入路1 8、導引路1 9，混合室2 0和流出路21。 下面參照圖2〜圖6說明上述第1、第2圓板1 6、17，各 圓板1 6、1 7由富有燒結金剛石、單結晶金剛石等耐磨損性 11 312/發明說明書(補件)/92-10/92119930 200427412 的材料形成，並且直徑相同。 如圖2、圖3和圖6所示，上述第1圓板1 6，相對於板 面中心，在上下對稱位置上貫通形成同徑流入用的透孔 16a、16b，另外，在與第2圓板17相接合的面上設置連通 上述透孔1 6 a、1 6 b的相對端部側的第1導引槽1 6 c。 如圖3〜圖7所示，上述第2圓板17，在與上述第1圓 板1 6相結合的相對面上，設置與該第1圓板1 6的上述第 1導引槽1 6 c垂直相交的第2導引槽1 7 c，同時，在第2 導引槽1 7 c的兩端貫通形成同徑流出用的透孔1 7 a、1 7 b。 由上述結構構成的第1、第2圓板1 6、1 7，以第1導引 槽1 6 c和第2導引槽1 7 c十字狀地垂直相交的方式緊密重 合，並裝入固定在利用螺栓2 4將第1圓筒體2 2和第2圓 筒體23連接成一體地形成的箱體15内。而且，構成上述 箱體15的第1圓筒體22 —側的開口部22a與上述高壓泵 1 2連接，同時，第2圓筒體2 3另一側的開口部2 3 a與上 述貯存槽1 4連接。 在上述箱體15内，緊密重合固定的第1圓板16和第2 圓板1 7的第1導引槽1 6 c和第2導引槽1 7 c十字狀地垂直 相交，在上述第1、2圓板1 6、1 7的中心部形成混合室2 0。 上述流入用透孔1 6 a、1 6 b形成流入路1 8，第1導引槽1 6 c 形成朝向中心的導引路1 9，更且，第2導引槽1 7 c和流出 用透孔1 7 a、1 7 b形成流出路2 1。因此，如圖8所示，按 照流入路1 8、導引路1 9、混合室2 0和流出路2 1的順序， 形成上述流體狀物流動的液體通路。 12 312/發明說明書(補件)/92-10/92119930 200427412 另外，圖中1 6 d、1 7 d分別是設置在第1、2圓板1 6、1 7 上的定位用透孔，當密閉重合地固定該第1、第2圓板1 6、 17時，以可貫通上述各定位用透孔16d、17d的方式進行 重合，將未圖示的栓（pin)等貫通固定於定位用透孔16d、 1 7 d中，由此上述第1、第2導引槽1 6 c、1 7 c能準確地形 成十字狀垂直相交，並可以固定住第1、第2圓板16、17。 下面對由上述結構構成的超微顆粒化裝置Μ的作用進行 說明。利用高壓泵1 2，以1 3 0 Μ P a左右的壓力，將投入至 供給容器1 1内的上述流體狀物壓送到構成超微顆粒化構 件1 3的箱體1 5 —側的開口部2 2 a内。壓送到上述一側的 開口部2 2 a的流體狀物，由第1圓板1 6的兩個流入用透孔 1 6 a、1 6 b高速地流入，進而，在由上述流入用透孔1 6 a、 1 6 b和第1導引槽1 6 c兩端部形成的流入路1 8内高速地流 動，接著，轉換流動方向，分別流入由上述第2圓板1 7 板面和第1導引槽1 6 c形成的壓送方向相對向的導引路 1 9、1 9 中。 在由第1導引槽1 6c和第2導引槽1 7c垂直相交的中心 部形成的混合室2 0内，兩股壓送方向相對向的上述流體狀 物形成激烈的衝撞，在十字狀垂直相交的第2導引槽1 7 c 内轉變9 0度方向之際，該流體狀物進行衝撞，並形成紊 流，進而撞擊上述第2導引槽1 7 c的壁面，產生空穴（空洞 化現象）。 當該空穴的空洞部崩壞時，局部產生非常高的壓力差， 從而破碎掉上述流體狀物中的固體顆粒（花粉顆粒）。這種 13 312/發明說明書(補件)/92-10/92119930 200427412 固體顆粒破碎現象在數微秒如此極短的時間内發生， 體狀物瞬時施加強大能量，藉由這種能量使整個含有 殼的花粉形成奈米尺寸的超微顆粒，破碎掉外殼，並 各花粉的内部成分。 如上所述，在將含花粉殼的全部花粉形成超微顆粒 時、外殼被破碎、抽出各花粉内部成分的流體狀物， 第2導引槽1 7 c和第1圓板1 6板面及流出用透孔1 7 £ 形成的流出路21中，經過上述箱體1 5另一側開口部 容易排出，貯存在貯存槽1 4内。藉由通過上述流出库 之期間，流體狀物撞擊第2導引槽1 7 c的壁面，即， 與混合室2 0相對向部位的壁面和與流出用透孔1 7 a、 連通的端部壁面，進一步進行細微顆粒化。 即，超微顆粒化裝置Μ，是在流體狀物的流徑路中 重合固定地配置兩塊圓板1 6、1 7，使流體狀物藉由在 圓板1 6、1 7的重合面形成的狹縫狀導引槽1 6 c、1 7 c 邊改變其流動方向，一邊與壁面進行衝撞及流體狀物 此進行撞擊，在破碎花粉殼的同時，含該殼的全部花 成超微顆粒，並排出至箱體1 5外，移向第5步驟。 本發明加工方法的第5步驟是微生物檢查步驟。即 5步驟是，對在上述超微顆粒化步驟中使含殼花粉全， 行超微顆粒化後含有破碎花粉顆粒内容成分的流體狀 檢查是否存在微生物。 本發明加工方法的第6步驟是乾燥步驟。即，第6 是，在上述微生物檢查步驟中確認流體狀物中不存在 312/發明說明書(補件)/92-10/92119930 對流 花粉 抽出 的同 在由 n 17b 23a "1 撞擊 17b 緊密 該各 也彼 粉形 ，第 印進 物， 步驟 微生 14 200427412 物時，將藉由檢查的流體狀物進行冷凍乾燥，蒸發掉上述 流體狀物中的水分，使超微顆粒化的花粉顆粒以塊狀的乾 燥花粉成分取出。 在本發明的花粉加工方法中，並非採用喷霧乾燥的加熱 乾燥，而是採用凍幹的冷凍乾燥。即，冷凍乾燥是將流體 狀物冷凍到-4 0 °C左右後，在1 2小時内慢慢恢復到常溫， 蒸發掉流體狀物中的水分，取出花粉顆粒。藉由這種冷凍 乾燥，可防止作為花粉内容成分的維生素等有效成分因受 熱而被破壞掉。相對於此，在1 8 0 °C左右的溫度下進行噴 霧乾燥的加熱乾燥中，由於上述維生素等有效成分會因受 熱破壞掉，所以在本發明的花粉加工方法中不採用。 本發明加工方法的第7步驟是乾燥花粉成分的破碎步 驟。即，第7步驟是，由於經上述第6步驟中的乾燥步驟 洛發水分後形成塊狀的乾無化粉成分’為了將該乾無化粉 成分變成粉末狀最終製品或者進行製錠形成錠劑狀等的最 終製品，利用粉碎機等將上述塊狀的乾燥花粉成分破碎得 很細，直至規定的粒徑。第7步驟結束後，按照最終製品 的性狀，直接包裝，或者用製錠機製錠，形成最終製品。 下面對作為本發明另一實施形態的以吸引採集到的自 然附著在花上的花粉為原料的花粉加工方法進行描述，上 述吸引採集到的自然附著在花上的花粉，粒徑與上述蜜蜂 花粉團的粒徑不同，大體為2 0 μ m〜1 0 0 μ m左右，作為以上 述蜜蜂花粉團為原料的花粉加工方法來說，僅第1〜第3步 驟稍有不同，以後的步驟是相同的。 15 312/發明說明書(補件)/92-1 〇/9211993〇 200427412 使用吸引採集到的自然附著在花上的花粉 發明加工方法的第1步驟是洗淨採集該採集 步驟。即，從花上採集的作原料的花粉，由 混入塵埃等雜物，所以第1步驟是將其放入 洗淨，除去污物和塵埃等雜物的步驟。 使用吸引採集到的自然附在花上的花粉作 明加工方法的第2步驟是花粉的殺菌步驟。 洗淨的花粉，由於從花上採集時附著很多雜 步驟是例如投入至紫外線殺菌線中對上述花 步驟。 使用吸引採集到的自然附著在花上的花粉 發明加工方法的第3步驟是懸濁液調整步驟 驟是，用濾器過濾將上述經過殺菌步驟的花 5 0 μ m以下的微顆粒狀花粉顆粒，然後，將1 較佳為2 0重量％的上述花粉顆粒添加混入到 較佳為8 0重量％的純水或鹼離子水中，攪拌 濁液調整，調整到使上述花粉顆粒均勻地分 或鹼離子水中，使花粉顆粒和純水或鹼離子 物。 由於使用從花上採集的花粉作原料的本發 的第4步驟〜第7步驟與以蜜蜂花粉團為原料 法相同，所以省略其說明。 圖9〜圖1 1是構成本發明中所使用的超微； 的第1、第2圓板的另一實施形態的右側視圖 312/發明說明書(補件)/92-10/92119930 作原料的本 的花粉的洗淨 於附著污物， 水中進行循環 原料的本發 即，上述經過 菌，所以第2 粉進行殺菌的 作原料的本 。即，第3步 粉，取出粒徑 5〜2 5重量％、 75〜85重量％、 混合，進行懸 散在上述純水 水形成流體狀 明加工方法 的花粉加工方 頃粒化裝置Μ 和左側視圖。 16 200427412 在上述圖3〜圖7中所示的第1圓板1 6和第2圓板 分別設置了各兩個透孔1 6 a、1 6 b及1 7 a、1 7 b，同 設置了各一個連接透孔16a、16b及透孔17a、17b 狀導引槽1 6 c、1 7 c。與其相反，如圖9、圖1 0所示 1圓板3 6、第2圓板3 7上，分別以縱橫格子狀設置 透孔3 6 a、3 7 a，同時，分別設置多條連接該多個透； 3 7a的狹縫狀導引槽36c、37c。在圖中，36d、37d 用的透孑L 。 圖1 1是表示將由上述結構構成的第1圓板3 6和 板37重合、多個透孔36a、37a和多條導引槽36c 的重合狀態的示意圖。在圖1 1中，實線所示部分』 圓板3 6的透孔3 6 a和導引槽3 6 c，虛線所示部分是 板37的透孔37a和導引槽37c。 即，上述另一實施形態中的第1、第2圓板3 6、 上述第1、第2圓板1 6、1 7 —樣，以十字狀地垂直 方式分別將各條導引槽3 6 c、3 7 c重合固定。而且， 及效果與上述第1、第2圓板1 6、1 7相同，所以省 明。 將由上述本發明加工方法製得的超微顆粒花粉， 東京都内醫院的1 0 0名患者，每日服用3 g，連服] 對具有花粉症、哮喘、異位性皮膚炎、過敏性皮膚 列膜炎、前列腺肥大、全身疲勞和倦怠等各症狀的 起了極有效的作用。 (發明效果） 312/發明說明書(補件)/92-10/92119930 17中， 時分別 的狹縫 ，在第 了多個 FL 3 6a、 是定位 第2圓 、37c L第1 第2圓 37也與 相交的 其作用 略其說 提供給 .個月， 炎、前 患者， 17 200427412 本發明如上所述，將花粉顆粒和純水或鹼離子水混合的 流體狀物投入超微顆粒化裝置中，使花粉顆粒彼此撞擊， 使全部含殼花粉形成奈米尺寸的超微顆粒，並將花粉殼破 碎掉，同時，抽出花粉中的内容成分，將含殼的花粉成分 以流體狀物取出，對該流體狀物進行冷凍乾燥，除去水分， 從而可防止維生素類受熱而被破壞掉，並可僅取出花粉成 分。藉由將上述取出的花粉成分形成粉末狀或顆粒狀，人 們可將花粉成分作為健康食品使用，達成促進人體健康的 優良效果。 【圖示簡單說明】 圖1為本發明花粉加工方法中所使用之超微顆粒化裝置 的整體系統圖。 圖2為本發明花粉加工方法中所使用之超微顆粒化裝置 的概略縱向剖視圖。 圖3為構成本發明花粉加工方法中所使用之超微顆粒化 裝置的第1圓板的右側視圖。 圖4為圖3中的A-A縱向剖視圖。 圖5為構成本發明花粉加工方法中所使用之超微顆粒化 裝置的第2圓板的左側視圖。 圖6為圖5中的B-B縱向剖視圖。 圖7為構成本發明花粉加工方法中所使用之超微顆粒化 裝置的第1圓板和第2圓板的立體圖。 圖8為本發明花粉加工方法中所使用之超微顆粒化裝置 的主要部分縱向剖視圖。 18 312/發明說明書(補件)/92-10/92119930 200427412 圖9為構成本發明花粉加工方法中所使用之超微顆粒化 裝置的另一實施形態的第1圓板的右側視圖。 圖1 0為構成本發明花粉加工方法中所使用之超微顆粒 化裝置的另一實施形態的第2圓板的左側視圖。 圖1 1是構成本發明花粉加工方法中所使用之超微顆粒 化裝置的另一實施形態的第1圓板和第2圓板相重合、多 個透孔和多條導引槽重合狀態的示意圖。 (元件符號說明） Μ 超微顆粒化裝置 11 供給容器 12 高壓泵 13 超微顆粒化構件 14 貯存槽 15 箱體 16 第1圓板 1 6 a、1 6 b 透孔 16c 第1導引槽 16d、17d 定位用透孔 17 第2圓板 1 7 a、1 7 b 透孔 17c 第2導引槽 18 流出路 19 引導路 2 0 混合路 19 312/發明說明書(補件)/92-10/92119930 200427412 2 1 流 出 路 22 第 1 圓 桶體 23 第 2 圓 桶體 22a、 23a 開 1 口 部 24 螺 栓 36 第 1 圓 板 3 6a 透 孔 36c 導 引 槽 36d、 37d 定位用透 37 第 2 圓 板 37a 透 孔 37c 導 引 槽 312/發明說明書(補件)/92_ 10/9211993〇200427412 发明 Description of the invention: [Technical field to which the invention belongs] The present invention relates to a method for crushing a pollen shell, so that all pollen containing the shell is formed into nano-sized ultrafine particles, and pollen that is an effective ingredient in the pollen can be taken out processing method. [Previous technology] Pollen is a sex cell of a plant. Bees seek honey and sneak into the flower. Adhesive pollen adheres to their body hair. The bees concentrate the pollen on the hind limbs and condense the pollen into pellets at the part called “squeezing” between the limbs and limbs, forming a bee pollen mass (bee pollen lotus) with a particle size of about 1 mm. It deforms in the outer part of the limb and is surrounded by hair. In this part called "pollen basket", the above-mentioned bee pollen mass is stored. The amount of bee pollen stored in the "pollen basket" mentioned above is said to reach about 20 to 30 mg. Bees store the pollen mass and honey in the nest. In order to raise male bees into adults, it is said that an average of 145 g of pollen is required. This means that pollen contains nutrients essential for bees to survive and reproduce. However, the diameter of the pollen is 10 ~ 100 μm, and a hard double structure shell is guarding it. Even if aqua regia, strong acid and strong alkali are used, the shell cannot be destroyed, as long as the shell of the pollen is not destroyed. , We humans cannot enjoy the benefits of its excellent nutrients. In order to destroy the pollen shell, enzyme treatment, fermentation treatment, and mechanical treatment are currently used to destroy the pollen shell. Further, as a method for processing pollen to obtain pollen components by destroying the pollen shell, Japanese Patent Laid-Open Nos. 2000-119 1 have been disclosed. 6 312 / Invention Specification (Supplement) / 92-10 / 92119930 200427412 [Patent Document 1] [Japanese Patent Laid-Open No. 2 0 0 1-1 1 9] [Content of the Invention] (Problems to be Solved by the Invention) As described in Patent Document 1, the currently used enzyme treatment method, fermentation treatment method, and crushing treatment method each have their advantages and disadvantages, but there is still a problem that the pollen cannot be formed into ultrafine particles. Patent Document 1 discloses that fluid matter such as pollen and liquid is flowed into an ultrafine granulation device under high pressure, and the device is used to destroy the pollen shell, fine-grained pollen components, liquid, and the like, and to flow as a fluid. Then, liquid and the like are removed from the fluid, and pollen components are taken out. However, according to the above-mentioned patent document 1, a pollen processing method is disclosed, and a manufacturing method thereof is not specifically disclosed. In the method disclosed in this patent document 1, there is indeed a so-called inability to break all the pollen containing a pollen shell into fine particles. The problem is that the pollen component cannot be taken out, and according to the description in paragraph [0 0 1 4] of Patent Document 1, as a method of removing liquid from the fluid substance of the pollen component, the hot air is evaporated to remove the liquid. The so-called spray-drying method has a problem that the heat-resistant vitamins in the pollen component are destroyed. The present invention was developed to solve the above-mentioned problems, and an object thereof is to provide a method for processing pollen, that is, press-feed a fluid substance in which pollen particles are mixed with pure water or alkaline ionized water into an ultrafine granulation device to make the fluid The pollen particles in the collision collide with each other, destroying the pollen shell, and at the same time, all the pollen containing the shell is formed into nano-sized ultrafine particles, the pollen component is extracted, and the shell containing shell 7 312 / Invention Specification (Supplement) / 92 -10/92119930 200427412 The pollen is taken out as a fluid. The fluid is freeze-dried to remove water and prevent vitamins from being destroyed by heat. You can only remove the pollen components. (Means for solving the problem) The present invention adopts a method including the following processing steps: In the first step, the bee pollen mass collected by the bee is washed to remove dirt and debris; in the second step, the first step is washed Bee pollen pellets are broken into micro-granular pollen particles, and the broken pollen particles are sterilized; in the third step, the broken and sterilized pollen particles in the second step are filtered with a filter, and the particle diameter is taken to be less than 50 μm 15 to 25% by weight of the above-mentioned pollen particles are added to 75 to 85% by weight of pure water or alkaline ion water, and the suspension is adjusted to make the above-mentioned pollen particles uniform Disperse the pollen particles in pure water or alkaline ionized water to form a fluid; and in the fourth step, disperse the pollen particles in pure water or alkaline ionized water in the third step. The object is put into an ultra-fine granulation device, so that all the pollen particles in the fluid substance are ultra-granulated, and when the shell is broken, the content components in the pollen surrounded by the shell are extracted; In step 4, it is checked whether microorganisms are present in the fluid which is ultra-granulated in the fourth step and contains pollen particles extracted from the pollen content. In step 6, it is confirmed that there is no microorganism in the fluid in the fifth step. Freeze drying the material, evaporate the water in the fluid, and take out the ultra-granulated pollen particles as a block of dry pollen components; and 8 312 / Invention Specification (Supplement) / 92-10 / 92119930 200427412 Section 7 In the step, the dried pollen component taken out in a block form in the sixth step is crushed to form a predetermined particle size. Alternatively, a processing method including the following steps is used: In the first step, the pollen attracted and collected on the flower is washed to remove dirt and debris. In the second step, the pollen washed in the first step is performed. Sterilize; in the third step, filter the pollen particles sterilized in the second step with a filter, take out the pollen particles with a particle size of 50 μm or less, and then add 15 to 25% by weight of the above-mentioned pollen particles to 7 5 ~ 8 5% by weight of pure water or ion test water, adjust the suspension so that the pollen particles are evenly dispersed in the pure water or alkali ion water, and the pollen particles form a fluid with pure water or alkali ion water Step 4: Put the fluid substance in which the pollen particles were dispersed in pure water or alkaline ion water in the third step into the ultrafine granulation device, and make all the pollen particles in the fluid substance ultrafine particles. The shell is broken, and the content of the pollen surrounded by the shell is extracted at the same time; the fifth step is to check the superfine granulation in the above 4th step, which contains the pollen particles extracted from the content of the pollen Whether there are microorganisms in the body; Step 6: freeze-dry the fluid substance in which the microorganisms are not found in the above Step 5, evaporate the water in the fluid substance, and divide the ultra-micronized pollen particles into blocks. The dried pollen component is taken out in a shape; and in a seventh step, the dried pollen component taken out in a block shape in the sixth step is crushed to form a predetermined particle size. 9 312 / Invention Specification (Supplement) / 92-10 / 92119930 200427412 [Embodiment] The embodiment of the present invention will be described in detail below. In the present invention, bee pollen clusters having a particle diameter of about 1 mm collected by bees, and pollen collected by naturally attracting flowers can be used as raw materials. Since the bee pollen mass and the pollen particle size are different, the manufacturing steps are also different. First, a pollen processing method using honey bee pollen mass as a raw material will be described. The first step of the processing method of the present invention is a washing step of washing bee pollen mass. That is, the first step is that the bee pollen mass, which is the raw material collected by the bees, is contaminated and mixed with dust and other debris. Therefore, the bee pollen mass is put into water and washed in a cycle to remove dirt and dust. Thing. The second step of the processing method of the present invention is a step of crushing and sterilizing the bee pollen mass. That is, the second step is that the bee pollen mass that has completed the above washing step has a large particle size, and when the bee collects pollen, it consolidates into agglomerates with germs attached. Therefore, a water jet with a particle size of about 1 mm is used. The bee pollen mass is broken to form micro-granular pollen particles, and then the pollen particles are put into an ultraviolet sterilization line, for example, to sterilize the broken bee pollen mass. The third step of the processing method of the present invention is a suspension adjustment step. That is, the third step is to filter the pollen particles that have completed the crushing and sterilizing steps with a filter, take out the pollen particles with a particle size of 50 μm or less, and then apply 15 to 25% by weight, preferably 20% by weight. The above-mentioned pollen particles are added and mixed into 75-85% by weight, preferably 80% by weight of pure water or alkaline ionized water, stirred and mixed, and the suspension is adjusted to adjust the above-mentioned pollen particles to be uniformly dispersed in In the above pure water or ion detection water, the pollen particles and the pure water or ion detection water form 10 312 / Invention Specification (Supplement) / 92-10 / 92119930 200427412. In addition, pure water or alkaline ion water is used instead of tap water because the use of water that does not contain impurities such as air can obtain high-quality pollen components. The fourth step of the processing method of the present invention is a step of crushing the shell and extracting the content components. That is, in the fourth step, the pollen particles and the fluid formed by pure water or alkaline ionized water that have undergone the suspension adjustment step are put into an ultrafine granulation device, and all of the pollen particles in the fluid are ultrafine. Granulate, destroy the outer shell, and at the same time extract the contents of the pollen surrounded by the shell. The ultrafine-granulation device M is not particularly limited, but the devices shown in Figs. 1 to 8 are preferably used. As shown in FIG. 1, the structure of the ultrafine granulating device M is: the supply container 11 for the fluid substance; a high-pressure pump 12 for pressurizing the fluid substance; and a fluid state to be pressure-fed by the high-pressure pump 12. Under the action of high-frequency and ultrasonic waves, the object collides, destroys the shell, and forms all the pollen containing the shell into nano-sized ultra-fine-granulated components 1; and stores the ultra-fine-granulated components 1 3 Discharge the storage tank 1 4 containing the pollen-containing fluid that has been broken into shells and ultra-micronized. The above-mentioned ultra-fine-grained member 13 is filled with a first circular plate 16 and a second circular plate 17 in a casing 15, and is closely overlapped and fixed. On the surface of the plate, through-holes 16a, 16b, 17a, and 17b having widths through which the fluid substance can pass, and slot-shaped guide grooves connecting the through-holes 16a, 16b, and 17a, 17b are formed, respectively. 1 6 c and 1 7 c form the following inflow path 18, guide path 19, mixing chamber 20 and outflow path 21 as described below. The above-mentioned first and second circular plates 16 and 17 will be described with reference to FIGS. 2 to 6. Each of the circular plates 16 and 17 is made of abrasion resistance such as sintered diamond and single crystal diamond. 11 312 / Invention Specification (Supplementary Document) ) / 92-10 / 92119930 200427412 and the same diameter. As shown in FIG. 2, FIG. 3 and FIG. 6, the above-mentioned first circular plate 16 penetrates through holes 16 a and 16 b of the same diameter in a vertically symmetrical position with respect to the center of the plate surface. A first guide groove 16 c that communicates with the opposite end sides of the through holes 16 a and 16 b is provided on a surface where the circular plates 17 are joined. As shown in FIG. 3 to FIG. 7, the second circular plate 17 is provided with the first guide groove 16 of the first circular plate 16 on an opposite surface that is combined with the first circular plate 16. c perpendicularly intersects the second guide groove 1 7 c, and at the same time, penetrating holes 1 7 a and 1 7 b for the same-diameter outflow are formed at both ends of the second guide groove 1 7 c. The first and second circular plates 16 and 17 constituted by the above structure are tightly overlapped so that the first guide groove 16 c and the second guide groove 17 c intersect perpendicularly in a cross shape, and are installed and fixed. In the case 15 formed by integrally connecting the first cylindrical body 22 and the second cylindrical body 23 with bolts 24. Furthermore, the opening 22a on the side of the first cylindrical body 22 constituting the casing 15 is connected to the high-pressure pump 12, and at the same time, the opening 23a on the other side of the second cylindrical body 23 is connected to the storage tank. 1 4 connections. The first guide plate 16 and the second guide plate 17 of the first circular plate 16 and the second circular plate 17 tightly overlapped and fixed in the box 15 intersect perpendicularly in a cross shape. The center portions of the circular plates 1, 2 and 16 form a mixing chamber 20. The above-mentioned inflow through holes 16a, 16b form an inflow path 18, and the first guide groove 16c forms a guide path 19 toward the center, and the second guide groove 17c and an outflow channel The through holes 1 7 a and 1 7 b form an outflow path 21. Therefore, as shown in FIG. 8, a liquid passage through which the fluid substance flows is formed in the order of the inflow path 18, the guide path 19, the mixing chamber 20, and the outflow path 21. 12 312 / Description of the Invention (Supplement) / 92-10 / 92119930 200427412 In addition, 16 d and 17 d in the figure are through holes for positioning provided on the first and second circular plates 16 and 17 respectively. When the first and second circular plates 16 and 17 are fixed in a closed and superposed manner, they are overlapped so as to penetrate through the positioning through holes 16d and 17d, and a pin (not shown) is fixed to the positioning. In the through holes 16d and 17d, the above-mentioned first and second guide grooves 16c and 17c can accurately form a cross-shaped vertical intersection, and the first and second circular plates 16, 17 can be fixed. . The operation of the ultrafine-granulation device M having the above structure will be described below. The high-pressure pump 12 is used to press the above-mentioned fluid substance introduced into the supply container 11 to the opening at the side of the box 15 constituting the ultrafine-granulated member 13 at a pressure of about 130 MPa. Department 2 2 a. The fluid substance pressurized to the opening portion 2 2 a on the one side flows in at a high speed through the two inflow holes 16 a and 16 b of the first disc 16, and further flows in through the inflow through hole. The holes 1 6 a, 1 6 b, and the inflow path 18 formed at both ends of the first guide groove 1 6 c flow at a high speed, and then the flow direction is changed to flow into the second circular plate 1 7 plate surface and The first guide grooves 16 c are formed in the guide paths 19 and 19 whose pressure feeding directions are opposite to each other. In the mixing chamber 20 formed at the center portion where the first guide groove 16c and the second guide groove 17c perpendicularly intersect, the two fluid objects facing in the direction of pressure feeding form a fierce collision, and in a cross shape When the second guide groove 17 c perpendicularly intersects changes in the direction of 90 degrees, the fluid object collides and forms a turbulent flow, and then hits the wall surface of the second guide groove 17 c to generate a cavity ( Voiding). When the hollow portion of the cavity collapses, a very high pressure difference is locally generated, thereby breaking up the solid particles (pollen particles) in the fluid. This 13 312 / Explanation of the Invention (Supplement) / 92-10 / 92119930 200427412 The solid particle breakage phenomenon occurs in such a very short time of a few microseconds. The body applies instantaneous powerful energy, and this energy makes the entire The pollen of the shell forms nano-sized ultrafine particles, which breaks the outer shell and contains the internal components of each pollen. As described above, when the entire pollen containing the pollen shell is formed into ultrafine particles, the outer shell is broken, and the fluid components of the internal components of each pollen are extracted. The second guide groove 1 7 c and the first disc 16 have a plate surface and The outflow path 21 formed by the outflow through-holes 17 £ is easily discharged through the opening on the other side of the box 15 and stored in the storage tank 14. While passing through the above-mentioned outflow reservoir, the fluid substance hits the wall surface of the second guide groove 17 c, that is, the wall surface of the portion facing the mixing chamber 20 and the end portion communicating with the outflow through-hole 17 a. The wall surface is further fine-grained. In other words, the ultrafine granulating device M is configured to overlap and fix two circular plates 16 and 17 in the flow path of the fluid material, so that the fluid material passes through the overlapping surfaces of the discs 16 and 17. The formed slit-shaped guide grooves 1 6 c and 1 7 c collide with the wall surface and fluid objects while changing their flow direction. When the pollen shell is broken, all the flowers containing the shell become superfine. The granules are discharged out of the box 15 and moved to the fifth step. The fifth step of the processing method of the present invention is a microbiological inspection step. That is, in the 5 step, the shell-containing pollen is completely formed in the above-mentioned ultra-micro-granulation step, and the micro-granulation is performed to check the presence of microorganisms in a fluid state containing the content content of the broken pollen particles. The sixth step of the processing method of the present invention is a drying step. That is, the sixth step is to confirm that there is no 312 / Invention Specification (Supplement) / 92-10 / 92119930 convection pollen extracted from the fluid during the above microbiological inspection step by n 17b 23a " 1 impact 17b close to the Each of them is powder-shaped, the first printed matter, and the step of micro-biology 14 200427412. When the fluid is inspected, it is freeze-dried, and the water in the fluid is evaporated to make the ultra-fine granulated pollen particles block. The dried pollen component was taken out. In the pollen processing method of the present invention, instead of spray drying and heat drying, freeze drying is used. In other words, freeze-drying is to freeze the fluid to about -40 ° C, then slowly return to normal temperature within 12 hours, evaporate the water in the fluid, and remove the pollen particles. This freeze-drying prevents the active ingredients such as vitamins, which are the content of pollen, from being destroyed by heat. On the other hand, in the heat-drying by spray-drying at a temperature of about 180 ° C, since the above-mentioned effective ingredients such as vitamins are destroyed by heat, it is not used in the pollen processing method of the present invention. The seventh step of the processing method of the present invention is a step of crushing the dried pollen components. That is, the seventh step is to form a block-shaped dry powder-free component after the moisture is lost in the drying step in the above-mentioned step 6. In order to turn the dry powder-free component into a powdery final product or to form an ingot to form an ingot In the final product such as a dosage form, the above-mentioned block-shaped dried pollen component is crushed to a fine particle size by a pulverizer or the like. After the seventh step is finished, the final product is directly packaged according to the properties of the final product, or ingots are formed by an ingot making mechanism to form the final product. The following is a description of a pollen processing method that uses collected pollen that is naturally attached to flowers as a raw material in another embodiment of the present invention. The diameter of the pollen ball is different, and it is about 20 μm to 100 μm. As a method for processing the pollen using the bee pollen as the raw material, only the first to third steps are slightly different, and the subsequent steps Are the same. 15 312 / Invention Specification (Supplement) / 92-1 〇 / 9211993〇 200427412 Use the pollen naturally attracted to flowers collected by suction The first step of the invention processing method is to clean and collect this collection step. That is, the pollen collected from the flowers as a raw material is mixed with dust and other debris, so the first step is to wash it and remove dirt and dust. The second step of using the collected pollen naturally attached to the flower as a processing method is a step of sterilizing the pollen. The washed pollen has a lot of impurities attached when it is collected from the flower. For example, the pollen is put into an ultraviolet sterilization line to the flower step. The third step of the invention processing method that uses the collected pollen that naturally adheres to the flower is the suspension adjustment step. The filter is used to filter the micro-particulate pollen particles below 50 μm through the sterilization step. Then, 1 and preferably 20% by weight of the above-mentioned pollen particles are added to and mixed with 80% by weight of pure water or alkali ion water, and the turbidity is adjusted to adjust the pollen particles to be evenly divided or alkali ions. In water, make pollen particles and pure water or alkali ions. Steps 4 to 7 of the present invention using pollen collected from flowers as a raw material are the same as the method using bee pollen balls as a raw material, so description thereof is omitted. 9 to 11 are right side views of another embodiment of the first and second circular plates constituting the supermicro used in the present invention 312 / Invention specification (Supplement) / 92-10 / 92119930 as raw materials The pollen of the present is washed on the dirt, and the raw material of the raw material is circulated in water, that is, the above-mentioned bacteria are passed through, so the second powder is sterilized as the raw material. That is, in the third step, take out a particle size of 5 to 25% by weight, 75 to 85% by weight, mix, and carry out the pollen processing granulation device M and the left side view, which are suspended in the pure water to form a fluid-like bright processing method. . 16 200427412 The first circular plate 16 and the second circular plate shown in FIG. 3 to FIG. 7 are respectively provided with two through holes 16 a, 16 b, and 1 7 a, 1 7 b. One connection through-hole 16a, 16b and one through-hole 17a, 17b-shaped guide grooves 16c, 17c are provided. In contrast, as shown in FIG. 9 and FIG. 10, 1 circular plate 3 6 and second circular plate 37 are provided with through holes 3 6 a and 3 7 a in a vertical and horizontal grid shape, respectively. At the same time, a plurality of connecting holes are provided respectively. A plurality of slit-shaped guide grooves 36c, 37c. In the figure, 36d and 37d are used for transparent L. FIG. 11 is a schematic view showing a state where the first circular plate 36 and the plate 37 constituted by the above-mentioned structure are overlapped, and a plurality of through holes 36a, 37a and a plurality of guide grooves 36c are overlapped. In FIG. 11, the portion shown by the solid line is the through hole 36 a of the circular plate 36 and the guide groove 3 6 c, and the portion shown by the dotted line is the through hole 37 a and the guide groove 37 c of the plate 37. That is, the first and second disks 36 in the other embodiment described above, and the first and second disks 16 and 17 in the same manner, each of the guide grooves 3 6 are vertically crossed in a cross shape. c, 3 7 c are coincident and fixed. The effects are the same as those of the first and second circular plates 16 and 17 described above, so they are omitted. The ultra-fine granular pollen prepared by the above-mentioned processing method of the present invention was taken by 100 patients in the Tokyo Metropolitan Hospital, taking 3 g daily, and even served] for patients with hay fever, asthma, atopic dermatitis, and allergic skin. Meningitis, hypertrophy of the prostate, general fatigue and burnout have played a very effective role. (Effects of the Invention) In 312 / Invention Specification (Supplement) / 92-10 / 92119930 17, the respective slits are positioned in the plurality of FL 3 6a, which is the positioning of the second circle, 37c L, the first second circle 37 It also intersects and its effect is provided for a few months. Inflammation, former patients, 17 200427412 As described above, the present invention puts a fluid substance mixed with pollen particles and pure water or alkali ion water into an ultrafine granulation device. , Make the pollen particles collide with each other, so that all the shell-containing pollen form nano-sized ultra-fine particles, and the pollen shell is broken off. At the same time, the content of the pollen is extracted, and the shell-containing pollen component is taken out as a fluid. This fluid is freeze-dried to remove moisture, so that vitamins can be prevented from being destroyed by heat, and only pollen components can be taken out. By forming the pollen component taken out into a powder or granule form, people can use the pollen component as a healthy food and achieve excellent effects to promote human health. [Brief description of the diagram] Fig. 1 is an overall system diagram of the ultra-fine granulation device used in the pollen processing method of the present invention. Fig. 2 is a schematic longitudinal sectional view of an ultrafine-granulation device used in the pollen processing method of the present invention. Fig. 3 is a right side view of a first disc constituting the ultra-fine granulation device used in the pollen processing method of the present invention. Fig. 4 is a longitudinal sectional view taken along A-A in Fig. 3. Fig. 5 is a left side view of a second disc constituting the ultra-fine granulation device used in the pollen processing method of the present invention. Fig. 6 is a longitudinal sectional view taken along the line B-B in Fig. 5. Fig. 7 is a perspective view of a first disc and a second disc constituting the ultra-fine granulation device used in the pollen processing method of the present invention. Fig. 8 is a longitudinal sectional view of a main part of an ultrafine-granulation device used in the pollen processing method of the present invention. 18 312 / Invention Specification (Supplement) / 92-10 / 92119930 200427412 Fig. 9 is a right side view of a first disc constituting another embodiment of the ultra-fine granulation device used in the pollen processing method of the present invention. Fig. 10 is a left side view of a second disc constituting another embodiment of the ultrafine granulation device used in the pollen processing method of the present invention. FIG. 11 shows a state in which the first circular plate and the second circular plate are overlapped, and a plurality of through holes and a plurality of guide grooves are overlapped, which constitutes another embodiment of the ultrafine granulation device used in the pollen processing method of the present invention. schematic diagram. (Description of element symbols) Μ Ultrafine granulation device 11 Supply container 12 High-pressure pump 13 Ultrafine granulation member 14 Storage tank 15 Box 16 First circular plate 1 6 a, 1 6 b Through hole 16c First guide groove 16d , 17d Through-hole for positioning 17 Second disc 1 7 a, 1 7 b Through-hole 17c Second guide groove 18 Outflow path 19 Guide path 2 0 Mixed path 19 312 / Instruction manual (Supplement) / 92-10 / 92119930 200427412 2 1 Outflow channel 22 1st barrel body 23 2nd barrel body 22a, 23a open 1 mouth 24 bolt 36 1st disc 3 6a through hole 36c guide groove 36d, 37d positioning through 37 2nd circle Plate 37a Through hole 37c Guide slot 312 / Invention manual (Supplement) / 92_ 10/9211993