TR201910239T4 - Periton diyalizine yönelik amaçlanan glukoz polimerlerinin elde edilmesine yönelik hammadde olarak kullanılan nişastanın dekontaminasyonuna yönelik optimize edilen proses. - Google Patents
Periton diyalizine yönelik amaçlanan glukoz polimerlerinin elde edilmesine yönelik hammadde olarak kullanılan nişastanın dekontaminasyonuna yönelik optimize edilen proses. Download PDFInfo
- Publication number
- TR201910239T4 TR201910239T4 TR2019/10239T TR201910239T TR201910239T4 TR 201910239 T4 TR201910239 T4 TR 201910239T4 TR 2019/10239 T TR2019/10239 T TR 2019/10239T TR 201910239 T TR201910239 T TR 201910239T TR 201910239 T4 TR201910239 T4 TR 201910239T4
- Authority
- TR
- Turkey
- Prior art keywords
- starch
- concentration
- porosity
- decontamination
- raw material
- Prior art date
Links
- 229920002472 Starch Polymers 0.000 title abstract 5
- 235000019698 starch Nutrition 0.000 title abstract 5
- 239000008107 starch Substances 0.000 title abstract 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title abstract 2
- 238000005202 decontamination Methods 0.000 title abstract 2
- 230000003588 decontaminative effect Effects 0.000 title abstract 2
- 238000000502 dialysis Methods 0.000 title abstract 2
- 239000008103 glucose Substances 0.000 title abstract 2
- 229920000642 polymer Polymers 0.000 title abstract 2
- 239000002994 raw material Substances 0.000 title abstract 2
- 238000013386 optimize process Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000004382 Amylase Substances 0.000 abstract 1
- 229920002261 Corn starch Polymers 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 239000008120 corn starch Substances 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 239000002952 polymeric resin Substances 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 229920003002 synthetic resin Polymers 0.000 abstract 1
- 238000000108 ultra-filtration Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/04—Extraction or purification
- C08B30/042—Extraction or purification from cereals or grains
- C08B30/044—Extraction or purification from cereals or grains from corn or maize
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
- C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
- C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/14—Preparation of compounds containing saccharide radicals produced by the action of a carbohydrase (EC 3.2.x), e.g. by alpha-amylase, e.g. by cellulase, hemicellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01001—Alpha-amylase (3.2.1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01025—Beta-mannosidase (3.2.1.25), i.e. mannanase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
Mevcut buluş, periton diyalizine yönelik amaçlanan glukoz polimeri preparatına yönelik bir hammadde olarak kullanılan nişastaların dekontaminasyonuna yönelik bir yöntem ile ilgilidir, yöntem, aşağıdaki adımları içerir: - bir Waxy mısır nişastasının hazırlanması, - yaklaşık 5 ile yaklaşık 6 arasında bulunan, özellikle yaklaşık 5,5 olan bir pH değerinde bir proses suyu içinde kuru maddenin %20'si ile 40'ı arasında bulunan bir konsantrasyonda Waxy nişastasının süspanse edilmesi, - 100 ile 500 ppm arasında bulunan, tercih edildiği üzere 300 ppm'e sahip bir konsantrasyonda bir perasetik asit solüsyonu yoluyla nişasta süspansiyonunun muamele edilmesi, - nişastanın suyunun giderilmesi akabinde yaklaşık 5 ile yaklaşık 6 arasında bulunan, özellikle yaklaşık 5,5 olan bir pH değerine ve kuru maddenin %20'si ile 40'ı arasında bulunan bir konsantrasyona ayarlanan demineralize su içinde çözündürülmesi, - 107°C'ye sıcaklığın yükseltilmesi, akabinde 15 dakika boyunca bir α#&-amilazın eklenmesi, - isteğe bağlı olarak, deterjan ve arındırma özelliklerine sahip bir enzimatik preparat yoluyla muamele edilmesi, - iki atomlu bir yatak üzerinde süspansiyonun filtrelenmesi, - oldukça yüksek adsorpsiyon kapasitesine, farmasötik kaliteye ve « mikrogözenekli » porozitesine sahip bir aktif karbon yoluyla muamele edilmesi, - « mezogözenekli » poroziteye sahip bir ikinci aktif karbon yoluyla muamele edilmesi, - isteğe bağlı olarak, 100 angstrom'dan fazla bir poroziteye sahip, makrogözenekli bir adsorban polimer reçineye geçirilmesi, - isteğe bağlı olarak, 5000 Da'da sürekli ultrafiltrasyonun gerçekleştirilmesi, - 0,22 µm'lik poroziteye sahip bir steril filtre üzerinde güvenlik filtrasyonunun gerçekleştirilmesidir.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1555077A FR3037063B1 (fr) | 2015-06-04 | 2015-06-04 | Procede optimise de decontamination de l'amidon utilise comme matiere premiere pour l'obtention de polymeres de glucose destines a la dialyse peritoneale |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR201910239T4 true TR201910239T4 (tr) | 2019-07-22 |
Family
ID=54007863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2019/10239T TR201910239T4 (tr) | 2015-06-04 | 2016-06-03 | Periton diyalizine yönelik amaçlanan glukoz polimerlerinin elde edilmesine yönelik hammadde olarak kullanılan nişastanın dekontaminasyonuna yönelik optimize edilen proses. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20180148754A1 (tr) |
| EP (1) | EP3303409B1 (tr) |
| JP (1) | JP6967972B2 (tr) |
| CN (1) | CN107709569B (tr) |
| ES (1) | ES2738699T3 (tr) |
| FR (1) | FR3037063B1 (tr) |
| MX (1) | MX2017015429A (tr) |
| PL (1) | PL3303409T3 (tr) |
| TR (1) | TR201910239T4 (tr) |
| WO (1) | WO2016193634A1 (tr) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL132852C (tr) * | 1960-10-24 | |||
| US3912590A (en) * | 1973-01-03 | 1975-10-14 | Novo Industri As | Procedure for liquefying starch |
| US6077836A (en) * | 1983-01-12 | 2000-06-20 | Ml Laboratotries, Plc | Peritoneal dialysis and compositions for use therein |
| EP0207676B1 (en) | 1985-06-22 | 1994-06-01 | M L Laboratories Plc | Polymers for use in continuous peritoneal dialysis |
| US5180669A (en) * | 1991-03-27 | 1993-01-19 | Genencor International, Inc. | Liquefaction of granular-starch slurries using alpha-amylase in the presence of carbonate ion |
| FR2716199B1 (fr) | 1994-02-15 | 1996-04-26 | Roquette Freres | Procédé de fabrication d'un hydrolysat d'amidon à faible indice de polymolécularité, nouvel hydrolysat d'amidon ainsi obtenu et son utilisation en dialyse péritonéale. |
| US6060269A (en) * | 1995-06-30 | 2000-05-09 | Md Foods Amba | Method of producing a peptide mixture |
| EP1977252B1 (en) | 2005-12-22 | 2012-12-05 | Baxter International Inc. | Improved monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products |
| US20090239819A1 (en) | 2008-03-20 | 2009-09-24 | Run Wang | Peritoneal dialysis solution test method |
| FR2945043B1 (fr) * | 2009-04-30 | 2019-07-26 | Roquette Freres | Procede de purification de polymeres de glucose destines aux solutions de dialyse peritoneale |
| FR2966843B1 (fr) * | 2010-11-03 | 2013-04-26 | Roquette Freres | Procede de decontamination d'hydrolysats d'amidon pour la preparation de polymeres de glucose destines a la dialyse peritoneale |
| CN103492878B (zh) | 2011-04-08 | 2015-11-25 | 罗盖特兄弟公司 | 用于检测含葡萄糖聚合物溶液中污染物的方法 |
| WO2013178931A1 (fr) | 2012-05-29 | 2013-12-05 | Roquette Freres | Méthodes de décontamination des circuits de production de polymères de glucose et d'hydrolysats de polymères de glucose |
| EP3119813B1 (fr) * | 2014-03-21 | 2023-01-04 | Roquette Frères | Procede optimise de decontamination de production de polymeres de glucose et d'hydrolysats de polymeres de glucose |
-
2015
- 2015-06-04 FR FR1555077A patent/FR3037063B1/fr not_active Expired - Fee Related
-
2016
- 2016-06-03 MX MX2017015429A patent/MX2017015429A/es active IP Right Grant
- 2016-06-03 JP JP2017562690A patent/JP6967972B2/ja active Active
- 2016-06-03 EP EP16741056.2A patent/EP3303409B1/fr active Active
- 2016-06-03 TR TR2019/10239T patent/TR201910239T4/tr unknown
- 2016-06-03 PL PL16741056T patent/PL3303409T3/pl unknown
- 2016-06-03 WO PCT/FR2016/051325 patent/WO2016193634A1/fr active Application Filing
- 2016-06-03 US US15/578,152 patent/US20180148754A1/en not_active Abandoned
- 2016-06-03 CN CN201680030446.6A patent/CN107709569B/zh active Active
- 2016-06-03 ES ES16741056T patent/ES2738699T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3303409A1 (fr) | 2018-04-11 |
| JP6967972B2 (ja) | 2021-11-17 |
| MX2017015429A (es) | 2018-03-28 |
| FR3037063B1 (fr) | 2017-05-19 |
| CN107709569B (zh) | 2021-07-09 |
| PL3303409T3 (pl) | 2020-03-31 |
| CN107709569A (zh) | 2018-02-16 |
| JP2018516086A (ja) | 2018-06-21 |
| WO2016193634A1 (fr) | 2016-12-08 |
| ES2738699T3 (es) | 2020-01-24 |
| FR3037063A1 (fr) | 2016-12-09 |
| EP3303409B1 (fr) | 2019-05-22 |
| US20180148754A1 (en) | 2018-05-31 |
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