TR201808037T4 - Tek bir döngüde kombine koşullandırma ve kemo seçimine yönelik yöntem. - Google Patents

Tek bir döngüde kombine koşullandırma ve kemo seçimine yönelik yöntem. Download PDF

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Publication number
TR201808037T4
TR201808037T4 TR2018/08037T TR201808037T TR201808037T4 TR 201808037 T4 TR201808037 T4 TR 201808037T4 TR 2018/08037 T TR2018/08037 T TR 2018/08037T TR 201808037 T TR201808037 T TR 201808037T TR 201808037 T4 TR201808037 T4 TR 201808037T4
Authority
TR
Turkey
Prior art keywords
hprt
subject
purine base
cells
deficient
Prior art date
Application number
TR2018/08037T
Other languages
English (en)
Turkish (tr)
Inventor
Kasahara Noriyuki
Robert Schiestl H
Hacke Katrin
Szakmary Akos
Gay Crooks M
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of TR201808037T4 publication Critical patent/TR201808037T4/tr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Transplantation (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TR2018/08037T 2011-04-20 2012-04-20 Tek bir döngüde kombine koşullandırma ve kemo seçimine yönelik yöntem. TR201808037T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161477440P 2011-04-20 2011-04-20

Publications (1)

Publication Number Publication Date
TR201808037T4 true TR201808037T4 (tr) 2018-06-21

Family

ID=47041955

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2018/08037T TR201808037T4 (tr) 2011-04-20 2012-04-20 Tek bir döngüde kombine koşullandırma ve kemo seçimine yönelik yöntem.

Country Status (11)

Country Link
US (1) US9439928B2 (enExample)
EP (3) EP3384912B1 (enExample)
JP (4) JP5997257B2 (enExample)
AU (3) AU2012245269B2 (enExample)
CA (1) CA2861440C (enExample)
DK (1) DK2699247T3 (enExample)
ES (1) ES2672693T3 (enExample)
PL (1) PL2699247T3 (enExample)
RU (2) RU2728867C2 (enExample)
TR (1) TR201808037T4 (enExample)
WO (1) WO2012145723A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9682106B2 (en) * 2011-04-20 2017-06-20 The Regents Of The University Of California Method for combined conditioning and chemoselection in a single cycle
EP3384912B1 (en) * 2011-04-20 2020-11-11 The Regents of The University of California Method for combined conditioning and chemoselection in a single cycle
US20170209447A1 (en) * 2014-08-07 2017-07-27 Nitor Therapeutics Use of PNP Inhibitor to Treat Relapse of Malignancy after Hematopoietic Stem Cell Transplant
US20180140606A1 (en) * 2016-11-18 2018-05-24 Calimmune, Inc. In Vivo Chemoselection with Low Dose Thioguanine
JP6783674B2 (ja) 2017-01-20 2020-11-11 株式会社日立ハイテク 自動分析装置、自動分析装置における廃液方法、及び、三方電磁弁
EP4190339B1 (en) * 2017-07-18 2025-07-02 CSL Behring Gene Therapy, Inc. A modulatable switch for selection of donor modified cells
EP3655534B1 (en) * 2017-07-18 2025-07-16 CSL Behring Gene Therapy, Inc. Compositions and methods for treating beta-hemoglobinopathies
CN111511376B (zh) * 2017-10-09 2025-02-25 斯托瓦斯医学研究所 用于扩增细胞群的方法和组合物
CN113543848A (zh) * 2018-12-23 2021-10-22 美国杰特贝林生物制品有限公司 具有杀伤开关的供体t细胞
WO2020139796A1 (en) * 2018-12-23 2020-07-02 Csl Behring L.L.C. Haematopoietic stem cell-gene therapy for wiskott-aldrich syndrome

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965126A (en) 1996-03-25 1999-10-12 The Penn State Research Foundation use of mutant alkyltransferases for gene therapy to protect from toxicity of therapeutic alkylating agents
WO1997043900A1 (en) * 1996-05-24 1997-11-27 The President And Fellows Of Harvard College In vivo selection
AU7605796A (en) 1996-11-04 1998-05-29 Saint Jude Children's Research Hospital (in vivo) selection of primitive hematopoietic cells
ATE439137T1 (de) 1997-11-14 2009-08-15 Gen Hospital Corp Behandlung von hämatologischen störungen
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
US7094885B2 (en) * 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
US20030032003A1 (en) 2000-02-02 2003-02-13 Schiestl Robert H. In vivo selection
CA2428721A1 (en) 2000-11-14 2002-05-23 The General Hospital Corporation Blockade of t cell migration into epithelial gvhd target tissues
US7037900B2 (en) 2001-10-12 2006-05-02 Supergen, Inc. Composition and method for treating graft-versus-host disease
EP3384912B1 (en) * 2011-04-20 2020-11-11 The Regents of The University of California Method for combined conditioning and chemoselection in a single cycle

Also Published As

Publication number Publication date
EP2699247B1 (en) 2018-03-07
AU2018200967A1 (en) 2018-03-01
EP2699247A1 (en) 2014-02-26
AU2012245269B2 (en) 2016-09-29
RU2013151632A (ru) 2015-05-27
EP2699247A4 (en) 2014-11-19
EP3384912B1 (en) 2020-11-11
AU2012245269A1 (en) 2013-12-05
HK1256048A1 (en) 2019-09-13
US9439928B2 (en) 2016-09-13
JP2017008090A (ja) 2017-01-12
WO2012145723A1 (en) 2012-10-26
JP6560332B2 (ja) 2019-08-14
JP2019199476A (ja) 2019-11-21
DK2699247T3 (en) 2018-06-14
RU2728867C2 (ru) 2020-07-31
RU2611396C2 (ru) 2017-02-21
AU2018200967B2 (en) 2019-08-15
CA2861440C (en) 2022-11-15
EP3799876A1 (en) 2021-04-07
JP2014512391A (ja) 2014-05-22
AU2016259368A1 (en) 2016-12-08
JP6799117B2 (ja) 2020-12-09
US20140154225A1 (en) 2014-06-05
EP3384912A1 (en) 2018-10-10
JP6266716B2 (ja) 2018-01-24
RU2017104621A3 (enExample) 2020-06-04
ES2672693T3 (es) 2018-06-15
AU2016259368B2 (en) 2017-12-14
RU2017104621A (ru) 2018-08-15
JP5997257B2 (ja) 2016-09-28
CA2861440A1 (en) 2012-10-26
JP2018044007A (ja) 2018-03-22
PL2699247T3 (pl) 2018-09-28

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