TR200401671T1 - Piridin benzimidazol sülfinil bileşiklerinin sentesi sırasında oluşan sulfon analoglarının elimine edilmesi yöntemi - Google Patents

Piridin benzimidazol sülfinil bileşiklerinin sentesi sırasında oluşan sulfon analoglarının elimine edilmesi yöntemi

Info

Publication number
TR200401671T1
TR200401671T1 TR2004/01671T TR200401671T TR200401671T1 TR 200401671 T1 TR200401671 T1 TR 200401671T1 TR 2004/01671 T TR2004/01671 T TR 2004/01671T TR 200401671 T TR200401671 T TR 200401671T TR 200401671 T1 TR200401671 T1 TR 200401671T1
Authority
TR
Turkey
Prior art keywords
eliminating
formula
sulfone
synthesis
compounds
Prior art date
Application number
TR2004/01671T
Other languages
English (en)
Inventor
Ünsal Şerafetti̇n
Original Assignee
Ulkar Ki̇mya Sanayi̇i̇ Ve Ti̇caret A.Ş.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ulkar Ki̇mya Sanayi̇i̇ Ve Ti̇caret A.Ş. filed Critical Ulkar Ki̇mya Sanayi̇i̇ Ve Ti̇caret A.Ş.
Publication of TR200401671T1 publication Critical patent/TR200401671T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FORMUL I Omeprazol,lansoprazol ve pantoprazol gibi Formül-1 de yapisi verilen piridinbenzimidazol sülfinil bilesiklerinin üretim prosesidir. Kimyasal yapida A halkasi opsiyonel olarak sübstitüe edilebilen bir gruptur; R1 hidrojen veya azotu koruyan bir gruptur, R2,R3,R4 ten herbiri 1) hidrojen atomu 2) gerektiginde halojen atomu veya atomlari ile sübstitüe edilebilen bir alkil grubu veya 3)halojen atomu veya atomlari veya alkoksi grubu ile sübstitüe edilebilen bir alkoksi grubu olup ayrica tuzlarini ihtiva eder. Genel yapisi formül 1 de verilen bu bilesikler, karsiliklari olan sülfitlerin oksidasyonu ile elde edilirken reaksiyon sirasinda sülfoksit ile birlikte bir yan ürün olarak sülfon olusur. Bu bulus, olusan sülfon impüritelerinin bilesikten elimine edilmesi metodunu içermektedir. Bu söz konusu saflastirma metodu, yari saf haldeki ürününün alkol ortaminda yüksek derecelerde çözünüp kati halde K2CO3 kristalleri ile muamele edilmesine dayanir.
TR2004/01671T 2002-01-23 2002-10-01 Piridin benzimidazol sülfinil bileşiklerinin sentesi sırasında oluşan sulfon analoglarının elimine edilmesi yöntemi TR200401671T1 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR200200186 2002-01-23
PCT/TR2002/000058 WO2003062223A1 (en) 2002-01-23 2002-10-01 A method of eliminating sulfone analog in the synthesis of pyridine-benzimidazole sulfoxides

Publications (1)

Publication Number Publication Date
TR200401671T1 true TR200401671T1 (tr) 2005-04-21

Family

ID=27607405

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2004/01671T TR200401671T1 (tr) 2002-01-23 2002-10-01 Piridin benzimidazol sülfinil bileşiklerinin sentesi sırasında oluşan sulfon analoglarının elimine edilmesi yöntemi

Country Status (4)

Country Link
EP (1) EP1476441B1 (tr)
DE (1) DE60220448T2 (tr)
TR (1) TR200401671T1 (tr)
WO (1) WO2003062223A1 (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1572680A2 (en) 2002-12-19 2005-09-14 Eva Pharmaceutical Industries Ltd. Solid states of pantoprazole sodium, known pantoprazole sodium hydrates, processes for their preparation.
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
EP1716136A1 (en) * 2004-02-11 2006-11-02 Ulkar Kimya Sanayii Ve Ticaret A.S. Pyridine benzimidazole sulfoxides of high purity
ES2281292B1 (es) * 2006-03-08 2008-06-16 Quimica Sintetica S.A. Nuevas sales de esomeprazol. procedimiento de preparacion y composiciones farmaceuticas que las comprenden.
ES2294931B1 (es) * 2006-06-29 2008-12-16 Quimica Sintetica, S.A. Sal de l-arginina de esomeprazol, procedimiento de preparacion y composiciones farmaceuticas que la comprenden.
JP2010519284A (ja) 2007-02-21 2010-06-03 シプラ・リミテッド エソメプラゾールマグネシウム二水和物の調製方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6245913B1 (en) * 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole

Also Published As

Publication number Publication date
WO2003062223A1 (en) 2003-07-31
EP1476441A1 (en) 2004-11-17
DE60220448D1 (de) 2007-07-12
DE60220448T2 (de) 2008-03-20
EP1476441B1 (en) 2007-05-30

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