TR200103391T2 - Amlodipin ve atorvastatinin ön ilaçları. - Google Patents

Amlodipin ve atorvastatinin ön ilaçları.

Info

Publication number
TR200103391T2
TR200103391T2 TR2001/03391T TR200103391T TR200103391T2 TR 200103391 T2 TR200103391 T2 TR 200103391T2 TR 2001/03391 T TR2001/03391 T TR 2001/03391T TR 200103391 T TR200103391 T TR 200103391T TR 200103391 T2 TR200103391 T2 TR 200103391T2
Authority
TR
Turkey
Prior art keywords
prodrugs
amlodipine
atorvastatin
relates
compositions
Prior art date
Application number
TR2001/03391T
Other languages
English (en)
Inventor
Chang George
Seiichi Hamanaka Ernest
Lawrence Lamattina John
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of TR200103391T2 publication Critical patent/TR200103391T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Bu bulus amlodipin ve atorvastatinin müsterek ön ilaçlari ve bunlarin farmasötik kompozisyonlari ile ilgilidir. Bu bulus, ayni zamanda, bu ön ilaçlari ve kompozisyonlari kullanmak sureti ile bir memelide anjin pektoris, ateroskleroz, ve hipertansiyon ve hiperlipideminin tedavi edilmesine yönelik metodlarla da ilgilidir. Bu bulus, yine, bu ön ilaçlari ve kompozisyonlari uygulamak sureti ile kardiyak semptomlari sergileyen bir memeli yaratikta (insanlar da dahil) kardiyak riskinin yönetilmesine iliskin metodlarla da ilgilidir.
TR2001/03391T 1999-05-27 2000-03-20 Amlodipin ve atorvastatinin ön ilaçları. TR200103391T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13660899P 1999-05-27 1999-05-27

Publications (1)

Publication Number Publication Date
TR200103391T2 true TR200103391T2 (tr) 2002-04-22

Family

ID=22473579

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03391T TR200103391T2 (tr) 1999-05-27 2000-03-20 Amlodipin ve atorvastatinin ön ilaçları.

Country Status (41)

Country Link
US (1) US6486182B1 (tr)
EP (1) EP1180102B9 (tr)
JP (1) JP2003500487A (tr)
KR (1) KR20020012247A (tr)
CN (1) CN1352640A (tr)
AP (1) AP2001002345A0 (tr)
AR (1) AR022344A1 (tr)
AT (1) ATE268764T1 (tr)
AU (1) AU3313900A (tr)
BG (1) BG106149A (tr)
BR (1) BR0011006A (tr)
CA (1) CA2375372C (tr)
CO (1) CO5170457A1 (tr)
CZ (1) CZ20014229A3 (tr)
DE (1) DE60011424T2 (tr)
DK (1) DK1180102T3 (tr)
DZ (1) DZ3048A1 (tr)
EA (1) EA200101130A1 (tr)
EE (1) EE200100631A (tr)
ES (1) ES2220426T3 (tr)
GT (1) GT200000078A (tr)
HK (1) HK1046282A1 (tr)
HN (1) HN2000000075A (tr)
HR (1) HRP20010856A2 (tr)
HU (1) HUP0201433A2 (tr)
IL (1) IL145947A0 (tr)
IS (1) IS6135A (tr)
MA (1) MA26736A1 (tr)
MX (1) MXPA01012125A (tr)
NO (1) NO20015756L (tr)
OA (1) OA11950A (tr)
PA (1) PA8495701A1 (tr)
PE (1) PE20010169A1 (tr)
PL (1) PL353483A1 (tr)
PT (1) PT1180102E (tr)
SK (1) SK16792001A3 (tr)
SV (1) SV2002000082A (tr)
TN (1) TNSN00113A1 (tr)
TR (1) TR200103391T2 (tr)
WO (1) WO2000073298A1 (tr)
ZA (1) ZA200109691B (tr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT199800127A (es) * 1997-08-29 2000-02-01 Combinaciones terapeuticas.
GB0027410D0 (en) * 2000-11-09 2000-12-27 Pfizer Ltd Mutual prodrug of amlodipine and atorvastatin
US6737430B2 (en) 2000-11-09 2004-05-18 Pfizer, Inc. Mutual prodrug of amlodipine and atorvastatin
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
MXPA03011566A (es) * 2001-06-11 2004-10-28 Xenoport Inc Formas de dosificacion de profarmacos de analogos de gaba administrados oralmente que tienen toxicidad reducida.
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
DE10140421A1 (de) * 2001-08-17 2003-03-06 Bayer Ag Neue Kombination
US7670612B2 (en) 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
US20040053842A1 (en) * 2002-07-02 2004-03-18 Pfizer Inc. Methods of treatment with CETP inhibitors and antihypertensive agents
US7071210B2 (en) * 2002-07-02 2006-07-04 Pfizer Inc. CETP inhibitors in combination with antihypertensive agents and uses thereof
NZ554737A (en) 2004-11-04 2011-04-29 Xenoport Inc Gabapentin prodrug sustained release oral dosage forms
WO2007016306A2 (en) * 2005-08-01 2007-02-08 Psivida Inc. HMGCoA REDUCTASE INHIBITOR CODRUGS AND USES THEREOF
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
US8354116B2 (en) * 2007-06-18 2013-01-15 Biochemics, Inc. Bifunctional synthetic molecules

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK161312C (da) 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en) 1986-04-04 1986-05-08 Pfizer Ltd Pharmaceutically acceptable salts
US4681893A (en) 1986-05-30 1987-07-21 Warner-Lambert Company Trans-6-[2-(3- or 4-carboxamido-substituted pyrrol-1-yl)alkyl]-4-hydroxypyran-2-one inhibitors of cholesterol synthesis
FI94339C (fi) 1989-07-21 1995-08-25 Warner Lambert Co Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi
US5155120A (en) 1991-01-14 1992-10-13 Pfizer Inc Method for treating congestive heart failure
GT199800127A (es) * 1997-08-29 2000-02-01 Combinaciones terapeuticas.

Also Published As

Publication number Publication date
KR20020012247A (ko) 2002-02-15
PA8495701A1 (es) 2001-12-14
DE60011424T2 (de) 2005-08-25
CA2375372A1 (en) 2000-12-07
NO20015756L (no) 2002-01-24
DZ3048A1 (fr) 2004-03-27
HK1046282A1 (zh) 2003-01-03
NO20015756D0 (no) 2001-11-26
HN2000000075A (es) 2001-02-02
HRP20010856A2 (en) 2002-12-31
BG106149A (en) 2002-05-31
AU3313900A (en) 2000-12-18
CA2375372C (en) 2007-01-09
WO2000073298A1 (en) 2000-12-07
EE200100631A (et) 2003-02-17
EP1180102B9 (en) 2005-03-02
BR0011006A (pt) 2002-02-19
OA11950A (en) 2006-04-13
SV2002000082A (es) 2002-02-05
PE20010169A1 (es) 2001-02-10
US6486182B1 (en) 2002-11-26
PT1180102E (pt) 2004-08-31
PL353483A1 (en) 2003-11-17
ES2220426T3 (es) 2004-12-16
DE60011424D1 (de) 2004-07-15
ATE268764T1 (de) 2004-06-15
DK1180102T3 (da) 2004-09-06
JP2003500487A (ja) 2003-01-07
MA26736A1 (fr) 2004-12-20
IS6135A (is) 2001-10-30
GT200000078A (es) 2001-11-16
CZ20014229A3 (cs) 2003-01-15
EA200101130A1 (ru) 2002-04-25
CN1352640A (zh) 2002-06-05
IL145947A0 (en) 2002-07-25
CO5170457A1 (es) 2002-06-27
AR022344A1 (es) 2002-09-04
EP1180102B1 (en) 2004-06-09
EP1180102A1 (en) 2002-02-20
ZA200109691B (en) 2002-11-26
HUP0201433A2 (en) 2002-08-28
TNSN00113A1 (fr) 2005-11-10
SK16792001A3 (sk) 2003-03-04
AP2001002345A0 (en) 2001-12-31
MXPA01012125A (es) 2002-06-04

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