TR200103333T2 - Dayanıklığı ve biyolojik uygunluğu iyileştiren yardımcı ilaç (SBA) - Google Patents

Dayanıklığı ve biyolojik uygunluğu iyileştiren yardımcı ilaç (SBA)

Info

Publication number
TR200103333T2
TR200103333T2 TR2001/03333T TR200103333T TR200103333T2 TR 200103333 T2 TR200103333 T2 TR 200103333T2 TR 2001/03333 T TR2001/03333 T TR 2001/03333T TR 200103333 T TR200103333 T TR 200103333T TR 200103333 T2 TR200103333 T2 TR 200103333T2
Authority
TR
Turkey
Prior art keywords
sba
adjuvant
biological compatibility
immune response
auxiliary drug
Prior art date
Application number
TR2001/03333T
Other languages
English (en)
Inventor
Helmut Müller Rainer
Grubhofer Nikolaus
Olbrich Carsten
Original Assignee
Pharmasol Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmasol Gmbh filed Critical Pharmasol Gmbh
Publication of TR200103333T2 publication Critical patent/TR200103333T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Abstract

Bulus, bir veya birçok antijenle birlikte enjekte edildiginde vücut sivilarindan ileri gelen ve selüler bagisiklik tepkisini arttiran dayanikligi ve biyolojik uygunlugu iyilestirilmis bir yardimci ilaç (SBA) içermektedir. Yardimci ilaç kati lipitler ya da kati lipit karisimlari bazinda partiküllerden olusmaktadir. Kullanim olanaklari, daha etkili ve hazmi daha kolay asi maddeleri üretmek, insanlarin ve hayvanlarin asilanmasi, ayni zamanda antikorlarin kazanilmasidir. Partikül büyüklügünun, yükünün ve üst yüzey özelliklerinin seçimiyle bagisiklik tepkisinin gücü hedefli modüle edilebilir ve ilaveten türe uygunlastirilabilir. SBA'ya baska yardimci ilaçlar da örnegin GMDP gibi moleküler yardimci ilaçlar eklenebilir, böylece selüler bagisiklik tepkisi ilaveten arttirilir.
TR2001/03333T 1999-05-20 2000-05-19 Dayanıklığı ve biyolojik uygunluğu iyileştiren yardımcı ilaç (SBA) TR200103333T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19923256 1999-05-20

Publications (1)

Publication Number Publication Date
TR200103333T2 true TR200103333T2 (tr) 2002-04-22

Family

ID=7908697

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/03333T TR200103333T2 (tr) 1999-05-20 2000-05-19 Dayanıklığı ve biyolojik uygunluğu iyileştiren yardımcı ilaç (SBA)

Country Status (11)

Country Link
EP (1) EP1183045A2 (tr)
JP (1) JP2003500365A (tr)
KR (1) KR20020012221A (tr)
AU (2) AU5214200A (tr)
BR (1) BR0010823A (tr)
CA (1) CA2373239A1 (tr)
DE (1) DE10024788A1 (tr)
MX (1) MXPA01011660A (tr)
TR (1) TR200103333T2 (tr)
WO (2) WO2000071154A2 (tr)
ZA (1) ZA200109147B (tr)

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CA2373239A1 (en) * 1999-05-20 2000-11-30 Pharmasol Gmbh Stability, biocompatibility optimized adjuvant (sba) for enhancing humoral and cellular immune response
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
US7883709B2 (en) * 2003-10-23 2011-02-08 Novartis Ag Stabilised compositions
FR2873386B1 (fr) 2004-07-22 2011-01-14 Agence Francaise De Securite Sanitaire Des Aliments Afssa Composition vaccinale contre le rhodococcus equi
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR101306384B1 (ko) 2004-08-23 2013-09-09 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는디케토디옥산염
JP5465878B2 (ja) 2005-09-14 2014-04-09 マンカインド コーポレイション 活性薬剤に対する結晶性微粒子表面の親和性を増大させることに基づく薬物処方の方法
CN104383546B (zh) 2006-02-22 2021-03-02 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CN104689432B (zh) 2008-06-13 2018-07-06 曼金德公司 干粉吸入器和用于药物输送的系统
JP5479465B2 (ja) 2008-06-20 2014-04-23 マンカインド コーポレイション 吸入努力をリアルタイムにプロファイルする対話式機器および方法
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
EP2440184B1 (en) 2009-06-12 2023-04-05 MannKind Corporation Diketopiperazine microparticles with defined specific surface areas
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
DK2694402T3 (en) 2011-04-01 2017-07-03 Mannkind Corp BLISTER PACKAGE FOR PHARMACEUTICAL CYLINDER AMPULS
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
WO2013165909A1 (en) 2012-04-30 2013-11-07 Ossur Hf Prosthetic device, system and method for increasing vacuum attachment
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
BR112016000937A8 (pt) 2013-07-18 2021-06-22 Mannkind Corp formulações farmacêuticas de pó seco, método para a fabricação de uma formulação de pó seco e uso de uma formulação farmacêutica de pó seco
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
BE1024228B1 (fr) * 2015-12-08 2017-12-21 Glaxosmithkline Biologicals Sa Nouvelles formulations d'adjuvants

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19745950A1 (de) * 1997-10-17 1999-04-22 Dds Drug Delivery Service Ges Arzneistoffträgerpartikel für die gewebespezifische Arzneistoffapplikation
JP2002521423A (ja) * 1998-07-31 2002-07-16 コリア インスティチュート オブ サイエンス アンド テクノロージ 遺伝子又は薬物運搬体としての脂質エマルジョン及び固形脂質微粒子
CA2373239A1 (en) * 1999-05-20 2000-11-30 Pharmasol Gmbh Stability, biocompatibility optimized adjuvant (sba) for enhancing humoral and cellular immune response

Also Published As

Publication number Publication date
JP2003500365A (ja) 2003-01-07
DE10024788A1 (de) 2000-11-23
AU5809100A (en) 2000-12-12
ZA200109147B (en) 2002-05-08
CA2373239A1 (en) 2000-11-30
WO2000071154A2 (de) 2000-11-30
MXPA01011660A (es) 2004-04-05
EP1183045A2 (de) 2002-03-06
KR20020012221A (ko) 2002-02-15
AU5214200A (en) 2000-12-12
WO2000071077A2 (en) 2000-11-30
BR0010823A (pt) 2002-03-05
WO2000071154A3 (de) 2001-06-28

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