TR200000440T2 - 4-İkameliğ-1h-indol-3-glioksamitleri hazırlama yöntemi. - Google Patents

4-İkameliğ-1h-indol-3-glioksamitleri hazırlama yöntemi.

Info

Publication number
TR200000440T2
TR200000440T2 TR2000/00440T TR200000440T TR200000440T2 TR 200000440 T2 TR200000440 T2 TR 200000440T2 TR 2000/00440 T TR2000/00440 T TR 2000/00440T TR 200000440 T TR200000440 T TR 200000440T TR 200000440 T2 TR200000440 T2 TR 200000440T2
Authority
TR
Turkey
Prior art keywords
glioxamides
preparation
indole
substitution
useful
Prior art date
Application number
TR2000/00440T
Other languages
English (en)
Inventor
Van Khau Vien
John Martinelli Michael
Matthew Pawlak Joseph
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of TR200000440T2 publication Critical patent/TR200000440T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/22—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an aralkyl radical attached to the ring nitrogen atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SPLA2 inhibasyonunda faydali 1H-Indol-3-glioksamitleri ve bu tür bilesiklerin hazirlanmasinda faydali yeni ara mamulleri hazirlamaya iliskin bir yöntemdir.
TR2000/00440T 1997-06-26 1998-06-22 4-İkameliğ-1h-indol-3-glioksamitleri hazırlama yöntemi. TR200000440T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5089197P 1997-06-26 1997-06-26
US5087797P 1997-06-26 1997-06-26

Publications (1)

Publication Number Publication Date
TR200000440T2 true TR200000440T2 (tr) 2000-07-21

Family

ID=26728795

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00440T TR200000440T2 (tr) 1997-06-26 1998-06-22 4-İkameliğ-1h-indol-3-glioksamitleri hazırlama yöntemi.

Country Status (24)

Country Link
US (1) US5986106A (tr)
EP (1) EP0887342A3 (tr)
JP (1) JP2002506460A (tr)
KR (1) KR20010014167A (tr)
CN (2) CN1268119A (tr)
AR (1) AR013137A1 (tr)
AU (1) AU735516B2 (tr)
BR (1) BR9810481A (tr)
CA (1) CA2293459A1 (tr)
CO (1) CO4950517A1 (tr)
EA (1) EA002119B1 (tr)
EG (1) EG22077A (tr)
HU (1) HUP0003019A3 (tr)
ID (1) ID24356A (tr)
IL (1) IL133624A0 (tr)
NO (1) NO996432L (tr)
NZ (1) NZ501780A (tr)
PE (1) PE84199A1 (tr)
PL (1) PL337690A1 (tr)
TR (1) TR200000440T2 (tr)
TW (1) TW455581B (tr)
UA (1) UA56245C2 (tr)
WO (1) WO1999000360A1 (tr)
ZA (1) ZA985561B (tr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1066290A1 (en) 1998-03-31 2001-01-10 Shionogi & Co., Ltd. PYRROLO[1,2-a]PYRAZINE sPLA 2 INHIBITOR
US6133453A (en) * 1998-05-15 2000-10-17 Pharm-Eco Laboratories, Inc. Method for making substituted indoles
EP1085021A4 (en) 1998-05-21 2003-01-08 Shionogi & Co DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2?
DE69931963D1 (de) * 1998-10-14 2006-07-27 Shionogi & Co Spla2-inhibitoren zur behandlung von ischämischen reperfusionsschäden
US6380397B1 (en) * 1999-04-15 2002-04-30 Eli Lilly And Company Process for preparing 4-substituted-1H-indole-3-glyoxamides
DE19962300A1 (de) * 1999-12-23 2001-06-28 Asta Medica Ag Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung
US20040092750A1 (en) * 2001-03-01 2004-05-13 Tomoyuki Hasegawa 2-methylindole-4-acetic acid, process for producing the same, and process for producing intermediate therefor
CN104292145A (zh) * 2014-10-12 2015-01-21 湖南华腾制药有限公司 一种6-溴吲哚衍生物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2145573A1 (de) * 1971-09-11 1973-03-15 Thiemann Chem Pharm Fab Indol-verbindungen, derivate derselben und verfahren zu ihrer herstellung
JPS55127367A (en) * 1979-03-23 1980-10-02 Shiono Koryo Kk Novel process for preparation of 4-(2-hydroxy-3- isopropylaminopropoxy)indole
PL180523B1 (pl) * 1994-04-01 2001-02-28 Eli Lilly & Co Nowy zwiazek, pochodna 1H-indolo-3-glioksylamidu i srodek farmaceutyczny PL PL PL PL PL PL PL PL PL PL
US5705501A (en) * 1994-11-17 1998-01-06 Molecular Geriatrics Corporation Certain substituted 1-aryl-3-morpholinopropanones to treat Alzheimer's Disease

Also Published As

Publication number Publication date
EA002119B1 (ru) 2001-12-24
EA200000069A1 (ru) 2000-06-26
EP0887342A2 (en) 1998-12-30
CO4950517A1 (es) 2000-09-01
US5986106A (en) 1999-11-16
KR20010014167A (ko) 2001-02-26
ZA985561B (en) 2000-01-10
EG22077A (en) 2002-07-31
AU735516B2 (en) 2001-07-12
HUP0003019A2 (hu) 2001-01-29
JP2002506460A (ja) 2002-02-26
EP0887342A3 (en) 1999-01-07
PL337690A1 (en) 2000-08-28
HUP0003019A3 (en) 2001-02-28
TW455581B (en) 2001-09-21
AR013137A1 (es) 2000-12-13
NO996432D0 (no) 1999-12-23
ID24356A (id) 2000-07-13
AU7961398A (en) 1999-01-19
NO996432L (no) 2000-02-09
WO1999000360A1 (en) 1999-01-07
NZ501780A (en) 2002-08-28
CN1343662A (zh) 2002-04-10
BR9810481A (pt) 2000-09-12
CA2293459A1 (en) 1999-01-07
UA56245C2 (uk) 2003-05-15
CN1268119A (zh) 2000-09-27
PE84199A1 (es) 1999-09-11
IL133624A0 (en) 2001-04-30

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