JPS55127367A - Novel process for preparation of 4-(2-hydroxy-3- isopropylaminopropoxy)indole - Google Patents
Novel process for preparation of 4-(2-hydroxy-3- isopropylaminopropoxy)indoleInfo
- Publication number
- JPS55127367A JPS55127367A JP3325179A JP3325179A JPS55127367A JP S55127367 A JPS55127367 A JP S55127367A JP 3325179 A JP3325179 A JP 3325179A JP 3325179 A JP3325179 A JP 3325179A JP S55127367 A JPS55127367 A JP S55127367A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- substituted
- indole
- compound
- hydroxyindole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound useful as a remedy for arrhythmia, etc. from a substituted indole obtained by reacting a compound obtined easily from isopropylamine and a dihaloisopropenyl acetate, with an N-substituted 4-hydroxyindole salt.
CONSTITUTION: A compound of formula I (X is halogen) is reacted with an alkali metal salt of an N-substituted 4-hydroxyindole of formula II in an aprotic solvent to afford a substituted indole of formula III, which is converted to the title compound of formula IV by the simultaneous catalytic reduction, hydrogenation decomposition and hydrolysis in the presence of a catalyst such as Pd, Pt, etc. and a caustic alkali under agitation under the atmosphere of pressurized H2.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3325179A JPS55127367A (en) | 1979-03-23 | 1979-03-23 | Novel process for preparation of 4-(2-hydroxy-3- isopropylaminopropoxy)indole |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3325179A JPS55127367A (en) | 1979-03-23 | 1979-03-23 | Novel process for preparation of 4-(2-hydroxy-3- isopropylaminopropoxy)indole |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55127367A true JPS55127367A (en) | 1980-10-02 |
Family
ID=12381269
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3325179A Pending JPS55127367A (en) | 1979-03-23 | 1979-03-23 | Novel process for preparation of 4-(2-hydroxy-3- isopropylaminopropoxy)indole |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55127367A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0887342A3 (en) * | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
-
1979
- 1979-03-23 JP JP3325179A patent/JPS55127367A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0887342A3 (en) * | 1997-06-26 | 1999-01-07 | Eli Lilly And Company | Process for preparing 4-substituted-1H-indole-3-glyoxamides |
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