TR199900267T2 - GnRH-Lökotoksin kimeralari. - Google Patents

GnRH-Lökotoksin kimeralari.

Info

Publication number
TR199900267T2
TR199900267T2 TR1999/00267T TR9900267T TR199900267T2 TR 199900267 T2 TR199900267 T2 TR 199900267T2 TR 1999/00267 T TR1999/00267 T TR 1999/00267T TR 9900267 T TR9900267 T TR 9900267T TR 199900267 T2 TR199900267 T2 TR 199900267T2
Authority
TR
Turkey
Prior art keywords
gnrh
systems
sequences
kotoksin
kimeralar
Prior art date
Application number
TR1999/00267T
Other languages
English (en)
Inventor
Andrew Potter A.
G. Manns John
Original Assignee
University Of Saskatchewan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Saskatchewan filed Critical University Of Saskatchewan
Publication of TR199900267T2 publication Critical patent/TR199900267T2/tr

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6817—Toxins
    • A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
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    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6817—Toxins
    • A61K47/6833—Viral toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
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    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Zoology (AREA)
  • Mycology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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  • Enzymes And Modification Thereof (AREA)

Abstract

Yeni imünolojik sistemleri, bu sistemleri kodlayan DNA ve bu sistemlerin kullanimlari anlatilmistir. Tasiyici sistemler, en azindan bir tekrarlanan GnRH dekapeptid dizisini ya da bir seçilmis GnRH molekülünün en azindan bir epitopuna karsi gelen bir dizinin en azindan bir tekrarlanan birimini içeren bir ya da daha çok seçilmis GnRH multimerine kaynasmis bir lökotoksin polipeptidini kapsayan kimerik proteinleri kapsamaktadir. Bulusa göre, seçilmis GnRH dizilerinin hepsi ayni olabilir, ya da bunlar, GnRH dizileri bir bagisiklik karsiligini ortaya çikarabildigi sürece, GnRH'nin farkli türevleri, analoglari, varyantlari ya da epitoplarina karsi gelebilmektedir. Lökotoksin, kendisine kaynasmis GnRH multimerlerinin imünogenikligini arttirma yönünde islev görmektedir.
TR1999/00267T 1996-08-09 1997-08-08 GnRH-Lökotoksin kimeralari. TR199900267T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/694,865 US5837268A (en) 1991-10-16 1996-08-09 GnRH-leukotoxin chimeras

Publications (1)

Publication Number Publication Date
TR199900267T2 true TR199900267T2 (tr) 2000-09-21

Family

ID=24790566

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/00267T TR199900267T2 (tr) 1996-08-09 1997-08-08 GnRH-Lökotoksin kimeralari.

Country Status (20)

Country Link
US (3) US5837268A (tr)
EP (1) EP0920510B1 (tr)
JP (1) JP2001502887A (tr)
KR (1) KR20000029911A (tr)
CN (1) CN1328381C (tr)
AT (1) ATE300616T1 (tr)
AU (1) AU725233B2 (tr)
BR (1) BR9711123A (tr)
CA (1) CA2262524A1 (tr)
DE (1) DE69733823T2 (tr)
DK (1) DK0920510T3 (tr)
ES (1) ES2247637T3 (tr)
HU (1) HUP0001538A3 (tr)
IL (1) IL128123A0 (tr)
NO (1) NO990533L (tr)
NZ (1) NZ333999A (tr)
PL (1) PL331537A1 (tr)
PT (1) PT920510E (tr)
TR (1) TR199900267T2 (tr)
WO (1) WO1998006848A1 (tr)

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CN1328381C (zh) 2007-07-25
DK0920510T3 (da) 2005-11-28
DE69733823T2 (de) 2006-06-08
CA2262524A1 (en) 1998-02-19
HUP0001538A2 (hu) 2000-08-28
NO990533D0 (no) 1999-02-04
EP0920510A1 (en) 1999-06-09
HUP0001538A3 (en) 2002-01-28
US5837268A (en) 1998-11-17
AU3843797A (en) 1998-03-06
BR9711123A (pt) 2000-01-11
US6521746B1 (en) 2003-02-18
KR20000029911A (ko) 2000-05-25
NZ333999A (en) 2000-07-28
PL331537A1 (en) 1999-07-19
AU725233B2 (en) 2000-10-12
IL128123A0 (en) 1999-11-30
ES2247637T3 (es) 2006-03-01
JP2001502887A (ja) 2001-03-06
WO1998006848A1 (en) 1998-02-19
PT920510E (pt) 2005-11-30
US6022960A (en) 2000-02-08
ATE300616T1 (de) 2005-08-15
EP0920510B1 (en) 2005-07-27
DE69733823D1 (de) 2005-09-01
CN1233288A (zh) 1999-10-27
NO990533L (no) 1999-04-09

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