TR199800636T1 - Pirimidin türevleri. - Google Patents

Pirimidin türevleri.

Info

Publication number
TR199800636T1
TR199800636T1 TR1998/00636T TR9800636T TR199800636T1 TR 199800636 T1 TR199800636 T1 TR 199800636T1 TR 1998/00636 T TR1998/00636 T TR 1998/00636T TR 9800636 T TR9800636 T TR 9800636T TR 199800636 T1 TR199800636 T1 TR 199800636T1
Authority
TR
Turkey
Prior art keywords
image
alkyl
alkoxy
hydrogen
compounds
Prior art date
Application number
TR1998/00636T
Other languages
English (en)
Inventor
Godel Thierry
Riemer Claus
Edenhofer Albrecht
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199800636T1 publication Critical patent/TR199800636T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Bulus, R1 ve R2 nin; herbirinin tek tek, düsük moleküllü alkil veya aminoyu A' nin; A1, A2, A3, A4, A5, A6 veya A7 yi, B nin; A4 ve A5 ve A6 daki hidrojeni ve A1- A6 daki (i) yi, A4-A6 daki düsük moleküllü alkoksiyi, ve A1- A2 deki düsük moleküllü alkil, stiril, feniletinil veya benzoiloksi- düsük moleküllü- alkili, n' nin; 0-2' yi, m ve p nin; 0,1 ' i ve R3, R4, R5 ve R6 ' nin; herbirinin bagimsiz olarak, hidrojen, halojen, düsük moleküllü alkil, triflorometil, düsük moleküllü alkoksi veya nitro'yu ifade ettigi farmasötik olarak kabul edilebilir ilave tuzlari dahil, genel formül (I)' in bilesikleri ile ilgilidir.
TR1998/00636T 1995-10-10 1996-10-04 Pirimidin türevleri. TR199800636T1 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH285595 1995-10-10
CH162596 1996-06-28

Publications (1)

Publication Number Publication Date
TR199800636T1 true TR199800636T1 (tr) 1998-06-22

Family

ID=25688204

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1998/00636T TR199800636T1 (tr) 1995-10-10 1996-10-04 Pirimidin türevleri.

Country Status (14)

Country Link
US (1) US5688798A (tr)
EP (1) EP0873317B1 (tr)
JP (1) JP3013940B2 (tr)
CN (1) CN1199397A (tr)
AT (1) ATE200486T1 (tr)
BR (1) BR9611037A (tr)
CA (1) CA2233502A1 (tr)
DE (1) DE69612512T2 (tr)
DK (1) DK0873317T3 (tr)
ES (1) ES2157463T3 (tr)
GR (1) GR3036177T3 (tr)
PT (1) PT873317E (tr)
TR (1) TR199800636T1 (tr)
WO (1) WO1997013759A1 (tr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232326B1 (en) 1998-07-14 2001-05-15 Jodi A. Nelson Treatment for schizophrenia and other dopamine system dysfunctions
CA2448080A1 (en) * 2001-05-22 2002-11-28 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted 1-benzyl-4-aryl piperazine analogues
EP1644367B1 (en) * 2003-05-19 2015-10-14 Novartis AG Immunosuppressant compounds and compositions
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
US20050239791A1 (en) * 2004-04-07 2005-10-27 Hutchison Alan J Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
WO2005110982A2 (en) * 2004-04-07 2005-11-24 Neurogen Corporation Substituted 1-benzyl-4-substituted piperazine analogues
TW200609219A (en) * 2004-06-17 2006-03-16 Neurogen Corp Aryl-substituted piperazine derivatives
GB0503646D0 (en) * 2005-02-22 2005-03-30 Novartis Ag Organic compounds
GB0508319D0 (en) 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508318D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
GB0508314D0 (en) * 2005-04-25 2005-06-01 Novartis Ag Organic compounds
US8258139B2 (en) 2010-11-08 2012-09-04 Dainippon Sumitomo Pharma Co., Ltd. Method of treatment for mental disorders
ITFI20110040A1 (it) 2011-03-18 2012-09-19 Paolino Bacci Srl "testa porta-utensili per macchine utensili o centri di lavoro, e macchina comprendente detta testa"
US9732065B2 (en) 2013-05-30 2017-08-15 Sumitomo Dainippon Pharma Co., Ltd. Cyclic aminomethyl pyrimidine derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155572A (en) * 1959-04-13 1964-11-03 Merck & Co Inc Compositions and methods for treating coccidiosis
US3060184A (en) * 1960-11-30 1962-10-23 Merck & Co Inc 1-(4-amino-2-perfluoroalkyl-5-pyrimidinylmethyl)piperazines
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
US5116846A (en) * 1990-03-28 1992-05-26 Du Pont Merck Pharmaceutical Company N-aralkyl piperidine derivatives as psychotropic drugs
US5169855A (en) * 1990-03-28 1992-12-08 Du Pont Merck Pharmaceutical Company Piperidine ether derivatives as psychotropic drugs or plant fungicides
DE4104593A1 (de) * 1991-02-14 1992-08-20 Siemens Ag Ventilanordnung in einer zahnaerztlichen absauganlage
CA2156410A1 (en) * 1993-03-01 1994-09-15 Raymond Baker Pyrrolo-pyridine derivatives

Also Published As

Publication number Publication date
PT873317E (pt) 2001-09-28
CA2233502A1 (en) 1997-04-17
WO1997013759A1 (en) 1997-04-17
BR9611037A (pt) 1999-07-06
DE69612512D1 (de) 2001-05-17
MX9802816A (es) 1998-09-30
DE69612512T2 (de) 2002-03-28
EP0873317A1 (en) 1998-10-28
JPH11500745A (ja) 1999-01-19
CN1199397A (zh) 1998-11-18
ES2157463T3 (es) 2001-08-16
JP3013940B2 (ja) 2000-02-28
EP0873317B1 (en) 2001-04-11
DK0873317T3 (da) 2001-08-06
GR3036177T3 (en) 2001-10-31
ATE200486T1 (de) 2001-04-15
US5688798A (en) 1997-11-18

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