TH9652C3 - The process of producing hollow chitosan micro particles inside - Google Patents

Abstract

DC60 (10/05/56) The internal hollow chitosan micro-particle product based on this invention was produced by the invention technique. The diffusion process of the first oil-in-water emulsion in the second oil. (oil1-water-in-oil2 emulsion solvent diffusion) with the first oil layer and the second oil layer as an organic solvent and aqueous layer as an impermeable chitosan solution and through crosslinking reaction with Crosslinking ratio and Various crosslinking periods before particle production Using Genipin as a water soluble crosslinking agent. The invention hollow micro-chitosan particle products are manufactured using this invention technique. The diffusion process of the first oil-in-water emulsion in the second oil. (oil1-water-in-oil2 emulsion solvent diffusion) with the first oil layer and the second oil layer as an organic solvent and leading as an impermeable and crosslinked chitosan solution with Crosslinking ratio and Various crosslinking periods before particle production Using Genipin as a water soluble crosslinking agent.

Claims (1)

1.Process for producing hollow chitosan micro particles inside The steps are as follows: a) Drop the organic solvent (first oil layer) into a 0.5% chitosan solution by wt (water layer) under the state of magnetic stirring at the rate 1,500 rpm for 2 minutes produces a first oil-in-water emulsion. B) First oil-in-water emulsion obtained from the A) into the organic solvent (second oil layer) under the state of magnetic stirring at the rate of 900 rpm for 1 hour, the first oil-in-water emulsion was formed. A complete diffusion process is then allowed for 1 hour and the solid particles are suspended. C) separate the particles obtained from the B) Centrifuge at a rate of 3,000 rpm for 10 minutes and dried at 40 ° C for 48 hours.