TH13682A - New Quaternary Nitrogen-containing Phosphonate Compound, Pharmaceutical Formulation And how to treat calcium and phosphate metabolism disorders - Google Patents

Abstract

This invention is about phosphonate compounds. Containing nitrogens Quaternary, and tolerable salts and esters Get it in the pharmaceutical industry at There is a general formula like this (chemical formula) where m is an integer from 0-10, and n is an integer from 1-10, m + n is from 1-10 (a) .R1 is selected from a group containing zero, -. SR6, -R9SR6, Hydrogen, C1-C8 Alkyls Replaced or Not Replaced, -OR3; -CO2R3; -O2CR3; NR32; -N (R3) C (O) R3; -C (O) N (R3) 2; Nitrogen, halogen, hydroxyl, mono-acrylic ring Or polycyclic The saturated Substituted or non-displaced, saturated monocyclic or polyacrylic rings, which are replaced or not replaced (b) R5 are selected from groups containing -SR6, -R9SR6. , Hydrogen, C1-C8 Alkyls Replaced or Not Replaced -OR3, -CO2R3, -O2CR3, -NR32; -N (R3) C (O) 3; -C (O) N (R3) 2. , Helogen, -C (O) R3, Nitrogen, Hydroxyl, Monocyclic ring Or the saturated heterocyclic polyacrylamide that has been replaced Or not replaced, mono-acrylic rings Or a saturated saturated polysaccharide Or not replaced, mono-acrylic rings Or polycyclic, heterocyclic, unsaturated To be replaced or not replaced And integration Their combination (c). Each R2 is selected from a group consisting of C1-C8 substituted or non-substituted alkyl, non-substituted phenyl. Or is replaced, benzyl, or R9SR6 (d) R3 is selected from the hydrogen-containing group, C1-C8 alkyl. Or replaced, R9SR6 (e) R6 is selected from a group containing -H; -C (O) R7; -C (S) R7; -C (O) N (R7) 2; -C (O) OR7; C (S) N (R7) 2; -C (S) OR7; Where R7 is a hydrogen or C1-C8 alkyl that is not replaced or replaced (f) R is selected from the group containing -COOH; -SO3H; -PO3H2; And -P (O) (OH) R4, where R4 is an alkyl group containing 1-3 carbon (g). R9 is C1-C8. Replaced or non-displaced alkyl (h) R8 is selected from Group containing hydrogen, halogen, SR6, R9SR6, amino, hydroxyl, C1-C8 substituted and non-substituted alkyls. In this general structure, the quaternary nitrogen atom has to be connected to a phosphonic acid composed of carbon atoms through a connection chain.It cannot be bonded directly to the phospholipids. Anic acid containing carbon atoms This invention is also associated with A pharmaceutical formulation containing Safe dosage And the efficacy of the compounds of this invention, and the pharmaceutical impregnation agents. And in the end This invention deals with methods for the treatment or prevention of pathologies characterized by abnormal calcium and phosphate metabolism in humans or in mammals. Others This method consists of giving the compound Or a mixture of this invention Into the human body Or other mammals that need such treatment In safe and effective doses In this general structure, the quaternary nitrogen atom has to be connected to a phosphonic bond composed of carbon atoms through a coupling chain. Anichid composed of carbon atoms. This invention is also associated with Pharmaceutical formulas That preserves a safe environment And effective substances Composition of this invention, and the shaping agent that can Pharmacy acceptable And in the end This invention will About methods for the treatment or prevention of conditions characterized by abnormal calcium and phosphate metabolism in humans or in other mammals, the methods include: Giving compounds or formulas of this invention Enters the body of a human or pet Other mammals who need such therapy in safe and effective doses.

Claims (1)

1. Nitrogen-containing compounds Which is useful in treatment Or prevent disorders of calcium and phosphate metabolism Unusual and its pharmacologically acceptable salts and esters of typical structural characteristics as (chemical formula), where m is a full number of 0–10, and n is an integer from 1. 10, m + n is from 1-10, (a) R1 is selected from the group containing zero, -SR6, -R9SR6; Hydrogen, C1-C8 alkyl substituted. Tag: drug patent.