RU94046139A - Quaternary nitrogen-containing phosphonate compounds for treatment of anomal calcium and phosphate metabolism, pharmaceutical composition - Google Patents

Quaternary nitrogen-containing phosphonate compounds for treatment of anomal calcium and phosphate metabolism, pharmaceutical composition

Info

Publication number
RU94046139A
RU94046139A RU94046139/04A RU94046139A RU94046139A RU 94046139 A RU94046139 A RU 94046139A RU 94046139/04 A RU94046139/04 A RU 94046139/04A RU 94046139 A RU94046139 A RU 94046139A RU 94046139 A RU94046139 A RU 94046139A
Authority
RU
Russia
Prior art keywords
treatment
calcium
quaternary nitrogen
anomal
phosphonate compounds
Prior art date
Application number
RU94046139/04A
Other languages
Russian (ru)
Inventor
Х.Ибитино Франк
Us]
М.Каас Сюзн
Дэвид Фрэнсиз Марион
Original Assignee
Дзе Проктер энд Гэмбл Фармасьютикалз
Дзе Проктер энд Гэмбл Фармасьютикалз, Инк.
Инк. (US)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Дзе Проктер энд Гэмбл Фармасьютикалз, Дзе Проктер энд Гэмбл Фармасьютикалз, Инк., Инк. (US) filed Critical Дзе Проктер энд Гэмбл Фармасьютикалз
Publication of RU94046139A publication Critical patent/RU94046139A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821—Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

FIELD: organic chemistry. SUBSTANCE: product: quaternary nitrogen-containing phosphonate compounds and their pharmaceutically acceptable salts and esters of the general formula (I). Also, invention relates to pharmaceutical compositions containing safety and effective amount of proposed compound and pharmaceutically acceptable filling agents. Then, invention relates to the methods of treatment or prophylaxis of pathological states exhibiting anomal calcium and phosphate metabolism, for example, osteoporosis and arthritis in human and other mammalian. Method involves administration of safety and effective amount of proposed compound or composition to human or other mammalian. EFFECT: improved method of synthesis, enhanced effectiveness.

Claims (1)

Изобретение относится к содержащим четвертичный азот фосфонатным соединениям и их фармацевтически-приемлемым солям и сложным эфирам, имеющим общую формулу, указанную в описании. Кроме того, изобретение относится к фармацевтическим композициям, содержащим безопасное и эффективное количество соединения настоящего изобретения и фармацевтически-приемлемые наполнители, и к способам лечения или профилактики патологических состояний, характеризуемых аномальным кальциевым и фосфатным метаболизмом, таким как остеопороз и артрит, особенно ревматоидный артрит и остеоартрит, у людей и других млекопитающих. Этот способ включает введение человеку или другому млекопитающему при необходимости такого лечения безопасного и эффективного количества соединения или композиции изобретения.The invention relates to quaternary nitrogen-containing phosphonate compounds and their pharmaceutically acceptable salts and esters having the general formula as described. The invention further relates to pharmaceutical compositions comprising a safe and effective amount of a compound of the present invention and pharmaceutically acceptable excipients, and to methods for treating or preventing pathological conditions characterized by abnormal calcium and phosphate metabolism, such as osteoporosis and arthritis, especially rheumatoid arthritis and osteoarthritis in humans and other mammals. This method comprises administering to a human or other mammal, if necessary, such a treatment a safe and effective amount of a compound or composition of the invention.
RU94046139/04A 1992-05-29 1993-05-11 Quaternary nitrogen-containing phosphonate compounds for treatment of anomal calcium and phosphate metabolism, pharmaceutical composition RU94046139A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89135592A 1992-05-29 1992-05-29
US07/891355 1992-05-29

Publications (1)

Publication Number Publication Date
RU94046139A true RU94046139A (en) 1996-09-27

Family

ID=25398040

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046139/04A RU94046139A (en) 1992-05-29 1993-05-11 Quaternary nitrogen-containing phosphonate compounds for treatment of anomal calcium and phosphate metabolism, pharmaceutical composition

Country Status (16)

Country Link
EP (1) EP0642517A1 (en)
JP (1) JPH07507305A (en)
KR (1) KR950701927A (en)
CN (1) CN1085906A (en)
AU (1) AU675224B2 (en)
CA (1) CA2136819A1 (en)
CZ (1) CZ296694A3 (en)
FI (1) FI945598A (en)
HU (1) HUT69732A (en)
IL (1) IL105831A0 (en)
MX (1) MX9303245A (en)
NZ (1) NZ252587A (en)
RU (1) RU94046139A (en)
SK (1) SK144594A3 (en)
WO (1) WO1993024494A1 (en)
ZA (1) ZA933758B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
IL115041A0 (en) * 1995-08-23 1995-12-08 Yissum Res Dev Co Novel bisphosphonates process for their preparation and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534391C2 (en) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkane-1,1-diphosphonic acids
DE4011777A1 (en) * 1989-04-14 1990-10-18 Ciba Geigy Ag New tri:alkyl:ammonio 1-hydroxy-alkane-1,1-di:phosphonic acids - are calcium metabolism regulants e.g. for treating osteoporosis of calcium deposition in blood vessels

Also Published As

Publication number Publication date
NZ252587A (en) 1997-02-24
MX9303245A (en) 1994-05-31
ZA933758B (en) 1994-01-20
JPH07507305A (en) 1995-08-10
CN1085906A (en) 1994-04-27
IL105831A0 (en) 1993-09-22
AU675224B2 (en) 1997-01-30
KR950701927A (en) 1995-05-17
EP0642517A1 (en) 1995-03-15
FI945598A0 (en) 1994-11-28
CZ296694A3 (en) 1995-12-13
SK144594A3 (en) 1995-07-11
HU9403406D0 (en) 1995-02-28
WO1993024494A1 (en) 1993-12-09
FI945598A (en) 1995-01-25
AU4245393A (en) 1993-12-30
CA2136819A1 (en) 1993-12-09
HUT69732A (en) 1995-09-28

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