FI945598A0 - Quaternary nitrogen-containing phosphonate compounds for the treatment of abnormal calcium and phosphate metabolism - Google Patents

Quaternary nitrogen-containing phosphonate compounds for the treatment of abnormal calcium and phosphate metabolism

Info

Publication number
FI945598A0
FI945598A0 FI945598A FI945598A FI945598A0 FI 945598 A0 FI945598 A0 FI 945598A0 FI 945598 A FI945598 A FI 945598A FI 945598 A FI945598 A FI 945598A FI 945598 A0 FI945598 A0 FI 945598A0
Authority
FI
Finland
Prior art keywords
treatment
quaternary nitrogen
phosphonate compounds
phosphate metabolism
abnormal calcium
Prior art date
Application number
FI945598A
Other languages
Finnish (fi)
Swedish (sv)
Other versions
FI945598A (en
Inventor
Frank Hallock Ebetino
Susan Mary Kaas
Marion David Francis
Original Assignee
Procter & Gamble Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble Pharma filed Critical Procter & Gamble Pharma
Publication of FI945598A0 publication Critical patent/FI945598A0/en
Publication of FI945598A publication Critical patent/FI945598A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3839Polyphosphonic acids
    • C07F9/3873Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/3804Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
    • C07F9/3808Acyclic saturated acids which can have further substituents on alkyl
    • C07F9/3821Acyclic saturated acids which can have further substituents on alkyl substituted by B, Si, P or a metal
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576Six-membered rings
    • C07F9/59Hydrogenated pyridine rings
FI945598A 1992-05-29 1994-11-28 Quaternary nitrogen-containing phosphonate compounds for the treatment of abnormal calcium and phosphate metabolism FI945598A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89135592A 1992-05-29 1992-05-29
PCT/US1993/004469 WO1993024494A1 (en) 1992-05-29 1993-05-11 Quaternary nitrogen-containing phosphonate compounds, for treating abnormal calcium and phosphate metabolism

Publications (2)

Publication Number Publication Date
FI945598A0 true FI945598A0 (en) 1994-11-28
FI945598A FI945598A (en) 1995-01-25

Family

ID=25398040

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945598A FI945598A (en) 1992-05-29 1994-11-28 Quaternary nitrogen-containing phosphonate compounds for the treatment of abnormal calcium and phosphate metabolism

Country Status (16)

Country Link
EP (1) EP0642517A1 (en)
JP (1) JPH07507305A (en)
KR (1) KR950701927A (en)
CN (1) CN1085906A (en)
AU (1) AU675224B2 (en)
CA (1) CA2136819A1 (en)
CZ (1) CZ296694A3 (en)
FI (1) FI945598A (en)
HU (1) HUT69732A (en)
IL (1) IL105831A0 (en)
MX (1) MX9303245A (en)
NZ (1) NZ252587A (en)
RU (1) RU94046139A (en)
SK (1) SK144594A3 (en)
WO (1) WO1993024494A1 (en)
ZA (1) ZA933758B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
IL115041A0 (en) * 1995-08-23 1995-12-08 Yissum Res Dev Co Novel bisphosphonates process for their preparation and pharmaceutical compositions containing them

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2534391C2 (en) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkane-1,1-diphosphonic acids
DE4011777A1 (en) * 1989-04-14 1990-10-18 Ciba Geigy Ag New tri:alkyl:ammonio 1-hydroxy-alkane-1,1-di:phosphonic acids - are calcium metabolism regulants e.g. for treating osteoporosis of calcium deposition in blood vessels

Also Published As

Publication number Publication date
AU4245393A (en) 1993-12-30
CN1085906A (en) 1994-04-27
HUT69732A (en) 1995-09-28
ZA933758B (en) 1994-01-20
CZ296694A3 (en) 1995-12-13
FI945598A (en) 1995-01-25
HU9403406D0 (en) 1995-02-28
IL105831A0 (en) 1993-09-22
AU675224B2 (en) 1997-01-30
CA2136819A1 (en) 1993-12-09
RU94046139A (en) 1996-09-27
JPH07507305A (en) 1995-08-10
WO1993024494A1 (en) 1993-12-09
NZ252587A (en) 1997-02-24
SK144594A3 (en) 1995-07-11
EP0642517A1 (en) 1995-03-15
KR950701927A (en) 1995-05-17
MX9303245A (en) 1994-05-31

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