SU856378A3 - Способ получени 7-(N-алкиламино)-производных 6,7,8,9-тетрагидро-7-фенил-5н-бензоциклогептена или их солей - Google Patents

Способ получени 7-(N-алкиламино)-производных 6,7,8,9-тетрагидро-7-фенил-5н-бензоциклогептена или их солей Download PDF

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Publication number
SU856378A3
SU856378A3 SU792754653A SU2754653A SU856378A3 SU 856378 A3 SU856378 A3 SU 856378A3 SU 792754653 A SU792754653 A SU 792754653A SU 2754653 A SU2754653 A SU 2754653A SU 856378 A3 SU856378 A3 SU 856378A3
Authority
SU
USSR - Soviet Union
Prior art keywords
salts
phenyl
alkyl
alkylamino
tetrahydro
Prior art date
Application number
SU792754653A
Other languages
English (en)
Inventor
Бастиан Жан-Мишель
Original Assignee
Сандос Аг (Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH632177A external-priority patent/CH628870A5/de
Priority claimed from CH632077A external-priority patent/CH635310A5/de
Application filed by Сандос Аг (Фирма) filed Critical Сандос Аг (Фирма)
Application granted granted Critical
Publication of SU856378A3 publication Critical patent/SU856378A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Description

(54) СПОСОБ ПОЛУЧЕНИЯ 7-(N-АЛКИЛАМИНО) ПРОИЗВОДНЫХ 6,7,6,9- ТЕТРАГИДРО-7-ФЕНИЛ-5Н-БЕНЗОЦИКЛОГЕПТЕНА ИЛИ ИХ СОЛЕЙ
Изобретение относитс  к способу получени  7-(N-алкиламино)производных 6,7,8,9-тетрагидро-7-фенил-5Н-беизоциклогептена формулы Г
где R имеет указанное значение, отщеплением бензильной группы и при необходимости переведением полученных соединений формулы Т в их соли.
Отщепление бенэильной группы от соединений формулы II осуществл етс  известными методами, предпочтительно гид рогеноли3ом С
Соединени  формулы I, полученные
10 согласно изобретению, могут находитьс  -в форме свободных оснований или их аддитивных солей. Дл  образовани  гцздитивных солей можно примен ть , как правило, например, следующие кислоты: хлористоводородную, серную, фумаровую, малеиновую или нафталин-1,5-дисульфокислоту.
Исходные соединени  формулы П можно получить,подверга  взаимодействию 20 известным способом соединени  формулы П - - dlT
Г-сЫгИГ
I и.
25 где к имеет з казсшноё значение, с соединени ми Гринь ра формулы fv
JO ,где X хлорг бром,или,йод.

Claims (1)

  1. Формула изобретения
    Способ получения 7-(N-алкиламино)производных 6,7,8,9~тетрагидро-7-фенил-5 Н-бе нзоциклогептен а формулы £ где R - алкил с 1-4 атомами углерода, или их солей, отличающийс я тем, что в соединении формулы И где R имеет указанное значение, отщепляют бензильную группу гидрогенолизом и выделяют целевой продукт в виде свободного основания или соли.
SU792754653A 1977-05-23 1979-04-19 Способ получени 7-(N-алкиламино)-производных 6,7,8,9-тетрагидро-7-фенил-5н-бензоциклогептена или их солей SU856378A3 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH632177A CH628870A5 (en) 1977-05-23 1977-05-23 Process for the preparation of benzocycloheptene derivatives
CH632077A CH635310A5 (en) 1977-05-23 1977-05-23 Process for preparing novel benzocycloheptene derivatives

Publications (1)

Publication Number Publication Date
SU856378A3 true SU856378A3 (ru) 1981-08-15

Family

ID=25699361

Family Applications (1)

Application Number Title Priority Date Filing Date
SU792754653A SU856378A3 (ru) 1977-05-23 1979-04-19 Способ получени 7-(N-алкиламино)-производных 6,7,8,9-тетрагидро-7-фенил-5н-бензоциклогептена или их солей

Country Status (17)

Country Link
JP (1) JPS53144560A (ru)
AU (1) AU517587B2 (ru)
CA (1) CA1091231A (ru)
DE (1) DE2740857A1 (ru)
DK (1) DK390477A (ru)
ES (1) ES462647A1 (ru)
FI (1) FI772729A (ru)
FR (1) FR2391992A1 (ru)
GB (1) GB1589776A (ru)
IE (1) IE45771B1 (ru)
IL (1) IL52929A (ru)
NL (1) NL7710247A (ru)
NZ (1) NZ185162A (ru)
PH (1) PH17683A (ru)
PT (1) PT67052B (ru)
SE (1) SE7710009L (ru)
SU (1) SU856378A3 (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2931986B2 (ja) * 1989-02-17 1999-08-09 武田薬品工業株式会社 アラルキルアミン誘導体

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2319332A1 (fr) * 1975-07-28 1977-02-25 Roussel Uclaf Nouveaux derives de l'aminobenzocycloheptene et leurs sels, procede de preparation et application a titre de medicaments desdits produits

Also Published As

Publication number Publication date
IE45771L (en) 1978-11-23
NL7710247A (nl) 1978-11-27
IE45771B1 (en) 1982-11-17
SE7710009L (sv) 1978-11-24
NZ185162A (en) 1980-03-05
FI772729A (fi) 1978-11-24
CA1091231A (en) 1980-12-09
FR2391992B1 (ru) 1981-02-06
GB1589776A (en) 1981-05-20
PT67052A (fr) 1977-10-01
AU2883177A (en) 1979-03-22
IL52929A (en) 1981-06-29
PT67052B (fr) 1979-05-14
IL52929A0 (en) 1977-11-30
AU517587B2 (en) 1981-08-13
FR2391992A1 (fr) 1978-12-22
PH17683A (en) 1984-11-02
DE2740857A1 (de) 1978-12-07
JPS53144560A (en) 1978-12-15
DK390477A (da) 1978-11-24
ES462647A1 (es) 1978-12-16

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