SU845787A3 - Способ получени 7-метокси-3-бром-МЕТилцЕфЕМОВ - Google Patents
Способ получени 7-метокси-3-бром-МЕТилцЕфЕМОВ Download PDFInfo
- Publication number
- SU845787A3 SU845787A3 SU772462784A SU2462784A SU845787A3 SU 845787 A3 SU845787 A3 SU 845787A3 SU 772462784 A SU772462784 A SU 772462784A SU 2462784 A SU2462784 A SU 2462784A SU 845787 A3 SU845787 A3 SU 845787A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- methoxy
- bromomethylcephems
- preparing
- bromomethyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Description
1
Изобретение относитс к новому способу получени 7-метокси-З-бромметилцефемов общей формулы (I)
ОСИ,
R2 JH2COl lH
.:tr .)
COORi
где R - бензгидрил или 4-нитробензил; Rj - феноксигруппа, 2-тиенил или
5-бр9м-2-тиенил,
которые наход т применение в качестве полупроводников в синтезе антибиотиков цефалоспоринового р да и Moryt сами найти применение в качестве антибиотиков.
Известен способ получени 7-метокси-3-бромметилцефемов , заключающийс в том, что соответствующее 7-метокси-3-метилцефемпроизводные обрабатывают бромирующим агентом, как Nбромсукцинимид , в присутствии органи ческой перекиси, как бензоил- или трет.-бутил- пероксид, при кип чении в среде органического растворител С О
8 Недостатком этого способа вл етс необходимость предварительного получени 7-метокси-З-метилцефемового соединени 7-метоксилированием. Известен способ получени 7-меШ токси-3-метил(или замещенный метил)-цефемов , заключающийс в том, что соответствующее 3-метил(или замещенный метил/цефемпроизводное подвергают взаимодействию с 2-6 эквивалентами метилата лити в присутствии избытка метанола в среде инертного безводного растворител при температуре от (-)120 до (-) с последующей обработкой реакционной смеси 1-5 эквивалентами трет.-бутнлгипохлорита 2,
Claims (2)
1.Патент С1М № 3867378,
кл. 260-243 С, опублик. 1975 (прототип ).
2.Патент США № 3897424, кл. 260243 С, опублик. 1975.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/669,366 US4048160A (en) | 1976-03-22 | 1976-03-22 | Process for preparation of 7-alkoxy-3-bromomethylcephems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU845787A3 true SU845787A3 (ru) | 1981-07-07 |
Family
ID=24686087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772462784A SU845787A3 (ru) | 1976-03-22 | 1977-03-21 | Способ получени 7-метокси-3-бром-МЕТилцЕфЕМОВ |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US4048160A (ru) |
| JP (1) | JPS52113995A (ru) |
| AR (1) | AR225589A1 (ru) |
| AT (1) | AT352274B (ru) |
| AU (1) | AU505100B2 (ru) |
| BE (1) | BE852669A (ru) |
| BG (1) | BG27756A3 (ru) |
| CA (1) | CA1108121A (ru) |
| CH (1) | CH632514A5 (ru) |
| CS (1) | CS198233B2 (ru) |
| DD (1) | DD129914A5 (ru) |
| DE (1) | DE2711955C2 (ru) |
| DK (1) | DK148097B (ru) |
| ES (1) | ES457058A1 (ru) |
| FR (1) | FR2345455A1 (ru) |
| GB (1) | GB1573933A (ru) |
| GR (1) | GR66421B (ru) |
| HU (1) | HU174436B (ru) |
| IE (1) | IE44695B1 (ru) |
| IL (1) | IL51431A (ru) |
| NL (1) | NL7703062A (ru) |
| NZ (1) | NZ183308A (ru) |
| PH (1) | PH12745A (ru) |
| PL (1) | PL108100B1 (ru) |
| PT (1) | PT66316B (ru) |
| RO (1) | RO70257A (ru) |
| SE (1) | SE428926B (ru) |
| SU (1) | SU845787A3 (ru) |
| YU (1) | YU68377A (ru) |
| ZA (1) | ZA77712B (ru) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1241657A (en) * | 1967-08-21 | 1971-08-04 | Glaxo Lab Ltd | Improvements in or relating to cephalosporin compounds |
| US3637678A (en) * | 1969-01-13 | 1972-01-25 | Lilly Co Eli | Delta-2 cephalosporin compounds |
| US3705897A (en) * | 1970-07-07 | 1972-12-12 | Lilly Co Eli | Method for converting delta**2 cephalosporin to delta**3 cephalosporin |
| BE794554A (fr) * | 1972-01-31 | 1973-07-26 | Lilly Co Eli | Nouveaux derives de penicilline et de cephalusporine |
| US3883518A (en) * | 1972-05-15 | 1975-05-13 | Merck & Co Inc | 3-Methylene cephalosporins |
| US3897424A (en) * | 1973-07-23 | 1975-07-29 | Lilly Co Eli | Process for 7-{62 -amino-7-{60 -methoxy-cephalosporanic acid esters and related compounds |
-
1976
- 1976-03-22 US US05/669,366 patent/US4048160A/en not_active Expired - Lifetime
-
1977
- 1977-02-08 IE IE262/77A patent/IE44695B1/en unknown
- 1977-02-08 ZA ZA00770712A patent/ZA77712B/xx unknown
- 1977-02-09 GR GR52754A patent/GR66421B/el unknown
- 1977-02-09 CA CA271,404A patent/CA1108121A/en not_active Expired
- 1977-02-10 NZ NZ183308A patent/NZ183308A/xx unknown
- 1977-02-11 IL IL51431A patent/IL51431A/xx unknown
- 1977-02-11 AU AU22198/77A patent/AU505100B2/en not_active Expired
- 1977-03-10 SE SE7702735A patent/SE428926B/xx not_active IP Right Cessation
- 1977-03-16 GB GB11149/77A patent/GB1573933A/en not_active Expired
- 1977-03-16 YU YU00683/77A patent/YU68377A/xx unknown
- 1977-03-17 PT PT66316A patent/PT66316B/pt unknown
- 1977-03-17 AR AR266894A patent/AR225589A1/es active
- 1977-03-18 PH PH19571A patent/PH12745A/en unknown
- 1977-03-18 DE DE2711955A patent/DE2711955C2/de not_active Expired
- 1977-03-18 BE BE1008027A patent/BE852669A/xx not_active IP Right Cessation
- 1977-03-18 JP JP3098577A patent/JPS52113995A/ja active Granted
- 1977-03-21 HU HU77EI733A patent/HU174436B/hu unknown
- 1977-03-21 DK DK123077AA patent/DK148097B/da unknown
- 1977-03-21 RO RO7789739A patent/RO70257A/ro unknown
- 1977-03-21 ES ES457058A patent/ES457058A1/es not_active Expired
- 1977-03-21 SU SU772462784A patent/SU845787A3/ru active
- 1977-03-21 AT AT194577A patent/AT352274B/de active
- 1977-03-21 NL NL7703062A patent/NL7703062A/xx not_active Application Discontinuation
- 1977-03-22 BG BG7735758A patent/BG27756A3/xx unknown
- 1977-03-22 DD DD7700197990A patent/DD129914A5/xx unknown
- 1977-03-22 CS CS771899A patent/CS198233B2/cs unknown
- 1977-03-22 CH CH359477A patent/CH632514A5/de not_active IP Right Cessation
- 1977-03-22 FR FR7708524A patent/FR2345455A1/fr active Granted
- 1977-03-22 PL PL1977196821A patent/PL108100B1/pl unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Bryan et al. | Nuclear analogs of. beta.-lactam antibiotics. 2. The total synthesis of 8-oxo-4-thia-1-azabicyclo [4.2. 0] oct-2-ene-2-carboxylic acids | |
| US4710565A (en) | Thesis of 7-halo-7-deoxylincomycins | |
| Martin et al. | Sulfuranes. II. Isolation and characterization of a crystalline dialkoxydiarylsulfurane | |
| Iriuchijima et al. | Organic synthesis gy the Pummerer reaction. I. Synthesis of. alpha.-hydroxyaldehydes from. beta.-hydroxy sulfoxides | |
| DE1795188B2 (de) | 3-Alkoxymethylcephalosporine, Verfahren zu deren Herstellung und die diese enthaltenden pharmazeutischen Zusammensetzungen | |
| PL127858B1 (en) | Process for preparing 3-iodomethylcephalosporins | |
| SE7712060L (sv) | Forfarande for framstellning av furokumariner | |
| SU845787A3 (ru) | Способ получени 7-метокси-3-бром-МЕТилцЕфЕМОВ | |
| CA1126275A (en) | Antiinflammatory 4,5-diaryl-2-(substituted-thio)- pyrroles and their corresponding sulfoxides and sulfones | |
| SU656526A3 (ru) | Способ получени производных изомеров цефалоспорановой кислоты | |
| ES8307235A1 (es) | Un procedimiento para la preparacion de ranitidina. | |
| SU845790A3 (ru) | Способ получени -метокси- -ХлОРМЕТилцЕфЕМОВ | |
| Gronowitz et al. | Sulfur derivatives of 1‐methylpyrrole | |
| GB1505020A (en) | Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides | |
| US3468900A (en) | Process for preparing isoxazole compounds | |
| IE42190L (en) | 3-methylenecephams. | |
| EP0133670A2 (de) | Verfahren zur Herstellung von 7-Acylamino-3-hydrocy-cephem-4-carbonsäuren und 7-Acylamino-3-hydroxy-1-de-thia-1-oxacephem-4-carbonsäuren | |
| US3939151A (en) | Displacement of the thiazolidine ring in penicillin with the formation of a biologically active cephem system | |
| SU1721051A1 (ru) | Способ получени 2-галоидпроизводных фурана | |
| SU649710A1 (ru) | Способ получени 4,4-бис-4-хлорфенилтио-дифенилсульфона | |
| Abe et al. | A NOVEL METHOD FOR THE PREPARATION OF THIOLSULFONATES | |
| SU1707016A1 (ru) | Способ получени 3-хлоризоксазолов или 3-хлоризоксазолинов | |
| Hayes | 2-Nitro-4-furaldehyde semicarbazone, an isomer of furacin | |
| US4243596A (en) | (5-Nitro-2-furyl)vinylene-2-trimethylammonium bromide and method of preparing same | |
| GB1456946A (en) | 6-phenyl-4h-imidazo-1,2-a-1,4-benzodiazepines |