SU793385A3 - Способ получени полипептида - Google Patents
Способ получени полипептида Download PDFInfo
- Publication number
- SU793385A3 SU793385A3 SU772541703A SU2541703A SU793385A3 SU 793385 A3 SU793385 A3 SU 793385A3 SU 772541703 A SU772541703 A SU 772541703A SU 2541703 A SU2541703 A SU 2541703A SU 793385 A3 SU793385 A3 SU 793385A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- gly
- ala
- pro
- gln
- asn
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 10
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 8
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 6
- 238000000034 method Methods 0.000 title claims description 6
- 150000001875 compounds Chemical class 0.000 claims abstract 8
- 150000001413 amino acids Chemical class 0.000 claims abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 21
- 239000000243 solution Substances 0.000 claims 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000002244 precipitate Substances 0.000 claims 6
- 239000000047 product Substances 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000000843 powder Substances 0.000 claims 5
- RDOXTESZEPMUJZ-UHFFFAOYSA-N anisole Chemical compound COC1=CC=CC=C1 RDOXTESZEPMUJZ-UHFFFAOYSA-N 0.000 claims 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N ethyl acetate Substances CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 229920005654 Sephadex Polymers 0.000 claims 3
- 239000012507 Sephadex™ Substances 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 229910000040 hydrogen fluoride Inorganic materials 0.000 claims 3
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 claims 2
- 239000005695 Ammonium acetate Substances 0.000 claims 2
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims 2
- VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 claims 2
- 229940024606 amino acid Drugs 0.000 claims 2
- 229940043376 ammonium acetate Drugs 0.000 claims 2
- 235000019257 ammonium acetate Nutrition 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 238000001816 cooling Methods 0.000 claims 2
- 238000010828 elution Methods 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
- 239000004471 Glycine Substances 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- 125000000769 L-threonyl group Chemical group [H]N([H])[C@]([H])(C(=O)[*])[C@](O[H])(C([H])([H])[H])[H] 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims 1
- 239000004473 Threonine Substances 0.000 claims 1
- MHLMRBVCMNDOCW-UHFFFAOYSA-N acetic acid;butan-1-ol;hydrate Chemical compound O.CC(O)=O.CCCCO MHLMRBVCMNDOCW-UHFFFAOYSA-N 0.000 claims 1
- MTEUMURLJRZUKD-UHFFFAOYSA-N acetic acid;butan-1-ol;pyridine;hydrate Chemical compound O.CC(O)=O.CCCCO.C1=CC=NC=C1 MTEUMURLJRZUKD-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 claims 1
- 229960003767 alanine Drugs 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 229960005261 aspartic acid Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical class N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 1
- 150000001718 carbodiimides Chemical class 0.000 claims 1
- 235000011089 carbon dioxide Nutrition 0.000 claims 1
- 239000007859 condensation product Substances 0.000 claims 1
- 238000010908 decantation Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 239000004220 glutamic acid Substances 0.000 claims 1
- COTNUBDHGSIOTA-UHFFFAOYSA-N meoh methanol Chemical compound OC.OC COTNUBDHGSIOTA-UHFFFAOYSA-N 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- XELZGAJCZANUQH-UHFFFAOYSA-N methyl 1-acetylthieno[3,2-c]pyrazole-5-carboxylate Chemical compound CC(=O)N1N=CC2=C1C=C(C(=O)OC)S2 XELZGAJCZANUQH-UHFFFAOYSA-N 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- 239000012452 mother liquor Substances 0.000 claims 1
- 230000000144 pharmacologic effect Effects 0.000 claims 1
- 229960005190 phenylalanine Drugs 0.000 claims 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 claims 1
- 230000001681 protective effect Effects 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
- 239000013049 sediment Substances 0.000 claims 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 1
- WHRNULOCNSKMGB-UHFFFAOYSA-N tetrahydrofuran thf Chemical compound C1CCOC1.C1CCOC1 WHRNULOCNSKMGB-UHFFFAOYSA-N 0.000 claims 1
- WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 claims 1
- 229960002898 threonine Drugs 0.000 claims 1
- 239000004474 valine Substances 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Biological Depolymerization Polymers (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LV930447A LV5221A3 (lv) | 1976-11-11 | 1993-06-01 | Panemiens polipeptida iegusanai |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13467776A JPS5359688A (en) | 1976-11-11 | 1976-11-11 | Production of novel polypeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU793385A3 true SU793385A3 (ru) | 1980-12-30 |
Family
ID=15133977
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU772541703A SU793385A3 (ru) | 1976-11-11 | 1977-11-10 | Способ получени полипептида |
| SU792711904A SU1028662A1 (ru) | 1976-11-11 | 1979-01-16 | Полипептид,обладающий способностью уменьшать содержание кальци в сыворотке |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU792711904A SU1028662A1 (ru) | 1976-11-11 | 1979-01-16 | Полипептид,обладающий способностью уменьшать содержание кальци в сыворотке |
Country Status (15)
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0070675A1 (en) * | 1981-07-15 | 1983-01-26 | Celltech Therapeutics Limited | Human calcitonin precursor polyprotein structural gene |
| JPH089639B2 (ja) * | 1982-05-20 | 1996-01-31 | サントリー株式会社 | Ｃ末端アミド化ペプチドの前駆体およびその製造法 |
| FI82266C (fi) * | 1982-10-19 | 1991-02-11 | Cetus Corp | Foerfarande foer framstaellning av il-2 -mutein. |
| US4663309A (en) * | 1983-06-29 | 1987-05-05 | University Patents, Inc. | Novel peptide hormones with calcitonin-like activity |
| JPS61112099A (ja) * | 1984-11-06 | 1986-05-30 | Mitsubishi Petrochem Co Ltd | 新規ポリペプチド及びその製造法 |
| KR920002329Y1 (ko) * | 1988-02-13 | 1992-04-09 | 금성알프스전자 주식회사 | 푸시버튼 스위치 |
| WO1991007433A1 (fr) * | 1989-11-08 | 1991-05-30 | Daicel Chemical Industries, Ltd. | Peptide et procede de preparation d'un peptide cyclique |
| US5962270A (en) | 1996-02-06 | 1999-10-05 | Bionebraska, Inc. | Recombinant preparation of calcitonin fragments and use thereof in the preparation of calcitonin and related analogs |
| EP2762150A1 (en) | 2009-03-12 | 2014-08-06 | Nordic Bioscience A/S | Treatment of Diabetes and Metabolic Syndrome |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51128993A (en) * | 1975-05-01 | 1976-11-10 | Tanpakushitsu Kenkyu Shiyoureikai | Process for preparing new polypeptides |
-
1976
- 1976-11-11 JP JP13467776A patent/JPS5359688A/ja active Granted
-
1977
- 1977-11-03 AU AU30495/77A patent/AU512714B2/en not_active Expired
- 1977-11-08 SE SE7712634A patent/SE7712634L/ not_active Application Discontinuation
- 1977-11-09 HU HUTO001065 patent/HU180539B/hu not_active IP Right Cessation
- 1977-11-09 FR FR7733742A patent/FR2370720A1/fr active Granted
- 1977-11-10 GB GB4691177A patent/GB1590645A/en not_active Expired
- 1977-11-10 NL NL7712386A patent/NL7712386A/xx not_active Application Discontinuation
- 1977-11-10 DK DK498777A patent/DK498777A/da unknown
- 1977-11-10 NZ NZ18565877A patent/NZ185658A/xx unknown
- 1977-11-10 SU SU772541703A patent/SU793385A3/ru active
- 1977-11-10 AT AT0804377A patent/AT365165B/de not_active IP Right Cessation
- 1977-11-10 CA CA290,642A patent/CA1094051A/en not_active Expired
- 1977-11-10 BE BE182520A patent/BE860698A/xx not_active IP Right Cessation
- 1977-11-10 CH CH1373377A patent/CH633566A5/de not_active IP Right Cessation
- 1977-11-11 DE DE19772750567 patent/DE2750567A1/de not_active Ceased
-
1979
- 1979-01-16 SU SU792711904A patent/SU1028662A1/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| ATA804377A (de) | 1981-05-15 |
| DK498777A (da) | 1978-05-12 |
| DE2750567A1 (de) | 1978-05-24 |
| HU180539B (en) | 1983-03-28 |
| SE7712634L (sv) | 1978-05-12 |
| AU3049577A (en) | 1979-05-17 |
| JPS5359688A (en) | 1978-05-29 |
| NZ185658A (en) | 1980-08-26 |
| AT365165B (de) | 1981-12-28 |
| SU1028662A1 (ru) | 1983-07-15 |
| CA1094051A (en) | 1981-01-20 |
| NL7712386A (nl) | 1978-05-16 |
| JPS5761730B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-12-25 |
| AU512714B2 (en) | 1980-10-23 |
| GB1590645A (en) | 1981-06-03 |
| CH633566A5 (en) | 1982-12-15 |
| BE860698A (fr) | 1978-05-10 |
| FR2370720A1 (fr) | 1978-06-09 |
| FR2370720B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1980-10-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4368192A (en) | Peptides | |
| US4353821A (en) | Method of preparing thymosin α1 and derivatives thereof | |
| JPS5849350A (ja) | 免疫調節に影響を与えるペプチド | |
| CA1182448A (en) | Peptides and a process for their preparation | |
| SU793385A3 (ru) | Способ получени полипептида | |
| Urry et al. | Studies on the conformations and interactions of elastin. Proton magnetic resonance of the repeating tetramer | |
| IE49289B1 (en) | Tripeptides,process for their preparation,therapeutic compositions containing them and methods for their use | |
| Wang et al. | SOLID PHASE SYNTHESIS OF BOVINE PITUITARY GROWTH HORMONE‐(123–131) NONAPEPTIDE | |
| US4264491A (en) | Analgesic compounds | |
| CA1137467A (en) | Process for the preparation of somatostatin | |
| EP0016612B1 (en) | Peptides having ubiquitin-like activity, process for their preparation, therapeutic compositions containing them and their use | |
| US3917578A (en) | Process for producing somatostatin and intermediates | |
| US4280953A (en) | Glycosylated analogs of somatostatin | |
| US3749703A (en) | Asn15-bovine thyrocalcitonin | |
| US4647553A (en) | Gonadoliberin derivatives and process for the preparation thereof | |
| YAJIMA et al. | Studies on Peptides. XXXII. The Use of N-Ethoxycarbonyl-2-ethoxy-1, 2-dihydro-quinoline as a Coupling Reagent of Peptide-Fragments on Polymer Support | |
| US3917581A (en) | Derivatives of somatostatin and process therefor | |
| JPS6220200B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | ||
| US3801561A (en) | Derivatives of salmon thyrocalcitonin | |
| Ikemura et al. | Synthesis of a heat-stable enterotoxin (STh) produced by a human strain SK-1 of enterotoxigenic Escherichia coli. | |
| US4301066A (en) | Preparation of (D-Trp 6)-LH-RH via the heptapeptide H-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 | |
| EP0001174B1 (en) | A peptide and the salts thereof, processes for their preparation and compositions containing them | |
| JPS61191696A (ja) | 血清胸腺因子ペプチド類似体 | |
| US3814746A (en) | Mannich base of tetracycline and polypeptides | |
| US4018754A (en) | Novel polypeptides having ACTH-like action |