SU727199A1 - Ononine producing method - Google Patents
Ononine producing method Download PDFInfo
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- SU727199A1 SU727199A1 SU782638802A SU2638802A SU727199A1 SU 727199 A1 SU727199 A1 SU 727199A1 SU 782638802 A SU782638802 A SU 782638802A SU 2638802 A SU2638802 A SU 2638802A SU 727199 A1 SU727199 A1 SU 727199A1
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- SU
- USSR - Soviet Union
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- ethanol
- evaporated
- evaporation
- ononine
- vol
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ОНОПИНА(54) METHOD OF OBTAINING ONOPIN
II
Изобретение относитс к фармацевтической промышленности и может быть использовано дл получени лекарственных препаратов.The invention relates to the pharmaceutical industry and can be used to produce drugs.
Известен способ получени ононина путем экстрагировани измельченных корней стальника пашенного этанолом, упаривани и кристаллизации 1.A method of obtaining ononin is known by extracting shredded stalk roots of arable ethanol, evaporation and crystallization 1.
Однако известный способ трудоемок и обеспечивает невысокий выход целевого продукта (0,170/о).However, the known method is laborious and provides a low yield of the target product (0,170 / o).
Цель изобретени - повышение выхода и упрощениге технологии производства.The purpose of the invention is to increase the yield and simplify the production technology.
Это достигаетс тем, что экстрагируют измельченные корни стальника пашенного 50° этанолом в соотношении 1:15, упаривают до 1/30 объема, остаток обрабатывают изобутанолом и после упаривани перекристаллизовывают из этанола.This is achieved by extracting the crushed roots of the steamer plowed 50 ° with ethanol in the ratio of 1:15, evaporated to 1/30 of the volume, the residue is treated with isobutanol and after evaporation is recrystallized from ethanol.
Пример. 3 кг измельченных корней стальника пашенного (Onoss ufVe rsi-S ) экстрагируют в перкол торе 45 л 50° этанола. Спирто-водное извлечение упаривают до получени 1,5 л водного остатка. Полученный водный концентрат обрабатывают 10 разExample. 3 kg of crushed plowed roots (Onoss ufVe rsi-S) are extracted in a 45 liter 50 ° ethanol percolator. The aqueous extract was evaporated to give 1.5 liters of the aqueous residue. The resulting aqueous concentrate is treated 10 times
по 1,5 л изобутанолом. Изобутанольные изв течени объедин ют и упаривают в вакууме до 450 мл и оставл ют на 5-10 дн. при температуре ( -)4 - ()6°С, образующийс аморфный осадок отдел ют, промывают спиртом и дважды перекристаллизовывают из 30% этанола с последующим высушиванием в вакуум-пистолете над фосфорным ангидридом в течение 6 час.1.5 liters of isobutanol. Isobutanol fluxes are combined and evaporated in vacuo to 450 ml and left for 5-10 days. at a temperature of (-) 4 - () 6 ° C, the resulting amorphous precipitate is separated, washed with alcohol and recrystallized twice from 30% ethanol, followed by drying in a vacuum gun over phosphoric anhydride for 6 hours.
Получают 9,6 г кремового кристаллического порошка, очень мало растворимого в 95 и 30% спиртах; практически нерастворимого в воде и хлороформе.9.6 g of a creamy crystalline powder very soluble in 95 and 30% alcohols are obtained; practically insoluble in water and chloroform.
Предлагаемый способ позвол ет упростить технологию производства, а используемые дл очистки препарата растворители вновь возвращаютс в технологический процесс . Вы.ход целевого продукта 0,29-0,32% от вз того воздушно-сухого сырь .The proposed method allows to simplify the production technology, and the solvents used for the purification of the preparation are returned to the process again. The yield of the target product is 0.29-0.32% of the air-dry raw material.
2020
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU782638802A SU727199A1 (en) | 1978-05-03 | 1978-05-03 | Ononine producing method |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SU782638802A SU727199A1 (en) | 1978-05-03 | 1978-05-03 | Ononine producing method |
Publications (1)
Publication Number | Publication Date |
---|---|
SU727199A1 true SU727199A1 (en) | 1980-04-15 |
Family
ID=20774486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SU782638802A SU727199A1 (en) | 1978-05-03 | 1978-05-03 | Ononine producing method |
Country Status (1)
Country | Link |
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SU (1) | SU727199A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109180759A (en) * | 2018-10-24 | 2019-01-11 | 青海省青海湖药业有限公司 | A method of isolating and purifying ononin from licorice slag |
-
1978
- 1978-05-03 SU SU782638802A patent/SU727199A1/en active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109180759A (en) * | 2018-10-24 | 2019-01-11 | 青海省青海湖药业有限公司 | A method of isolating and purifying ononin from licorice slag |
CN109180759B (en) * | 2018-10-24 | 2020-12-01 | 青海省青海湖药业有限公司 | Method for separating and purifying formononetin from liquorice waste residue |
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