SU670304A1 - Isocoryn production method - Google Patents

Description

one

This invention relates to the chemical and pharmaceutical industry, namely to the production of substances from plant raw materials.

A known method for producing isocorin by extracting the grass of the crested hen is bent (Corydalis pseudoadunca L.), followed by purification. The yield of the target product is equal to 55% of its content in raw material 1.

However, when using this method, a low yield of the desired product is obtained.

The aim of the invention is to increase the yield of the target product.

This goal is achieved by the fact that the grass of the crested hen is folded and extracted with acidified water, filtered, alkalinized with ammonia, the precipitate is separated, mixed with aluminum oxide in a 1: 1 ratio and treated with chloroform.

The method is carried out as follows.

Example. 25 kg of air-dried crushed raw materials are extracted four times with a 1% solution of sulfuric acid by infusion. The extract is filtered, alkalinized with 25% ammonia solution to RP 9-10. The precipitate was separated in a SGO-100 type centrifuge and

dry up leisure with the addition of alumina in a ratio of 1; 1. The precipitate is treated with chloroform, then extraction is carried out dry. The residue is recrystallized from methanol and receive 50 g of the technical alkaloid a-p-hydrastin (isocorin).

Technical a-r-hydrastin (50 g) is dissolved in 1250 ml of 10% sulfuric acid solution.

acids, alkalinized with 25% ammonia solution to pH 10 and the alkaloids are extracted four times with chloroform.

The extract is concentrated to a dry residue, the residue is recrystallized from methanol. 33 g of apr-hydrastin are obtained. 33 g of a-p-hydrastin is dissolved in 1500 ml of ethyl alcohol, an alcoholic solution of hydrochloric acid is added to pH 2.0-2.5, and the residue is distilled to dryness. Get 36 g

isocorin.

The yield of the target product is 77% of its content in the raw material.

The resulting preparation is a white with a yellowish tinge amorphous powder; easily soluble in water, 95% alcohol and chloroform.

Claims (1)

The proposed method reduces the cost of the target product and increases the yield by 20-25%. 3 The invention The method of obtaining isocorin by extracting the grass of the crested hen is folded (Corydalis pseudoadunca L.) followed by purification, characterized in that, in order to increase the yield of the target product, the raw material is extracted with acidified water, filtered, alkalized with ammonia4, the precipitate is separated mixed with alumina in the ratio of 1: 1 and treated with chloroform. Sources of information taken into account during the examination 1. Ibragimova M. U. et al. Corydalis pseudoadunca and Corydalis gortshahovii alkaloids, “Chemist of natural compounds, No. 4, 1970.